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Ghazi Ben Messaoud et al.
Soft matter, 16(10), 2540-2551 (2020-02-26)
Lipid lamellar hydrogels are a class of soft materials composed of a defectuous lipid lamellar phase, where defects are classically stabilized by polymer or surfactant inclusions in lipid membranes. We have recently shown that bolaform microbial glucolipids, composed of a
Mingming Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(25), 7509-7518 (2018-06-01)
This article reports a high-yield procedure for preparing microsized (giant) Janus liposomes via gel-assisted lipid swelling and clustering behavior of these liposomes directed by biotin-avidin affinity binding. Confocal fluorescence microscopy reveals in detail that these new lipid colloidal particles display
Mudassar Mumtaz Virk et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 395-405 (2017-12-13)
Hybrid vesicles, comprising blends of amphiphilic block copolymers and phospholipids, have attracted significant attention recently because of their unique combination of chemical and physical properties. We report a method to make unilamellar hybrid vesicles with diameters of 100 nm by
Megan B Miller et al.
The Journal of biological chemistry, 290(21), 13541-13555 (2015-04-12)
Previous studies revealed an essential role for the lipid-binding Sec14 domain of kalirin (KalSec14), but its mechanism of action is not well understood. Because alternative promoter usage appends unique N-terminal peptides to the KalSec14 domain, we used biophysical, biochemical, and
A triple chain polycationic peptide-mimicking amphiphile - efficient DNA-transfer without co-lipids.
Shashank Reddy Pinnapireddy et al.
Biomaterials science, 8(1), 232-249 (2019-11-05)
Non-viral gene delivery in its current form is largely dependent upon the ability of a delivery vehicle to protect its cargo in the extracellular environment and release it efficiently inside the target cell. Also a simple delivery system is required
Sathish Ramakrishnan et al.
Langmuir : the ACS journal of surfaces and colloids, 34(20), 5849-5859 (2018-04-26)
In vivo membrane fusion primarily occurs between highly curved vesicles and planar membranes. A better understanding of fusion entails an accurate in vitro reproduction of the process. To date, supported bilayers have been commonly used to mimic the planar membranes.
Margrethe A Boyd et al.
Biophysical journal, 115(7), 1307-1315 (2018-09-17)
Cells dynamically regulate their membrane surface area during a variety of processes critical to their survival. Recent studies with model membranes have pointed to a general mechanism for surface area regulation under tension in which cell membranes unfold or take
Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)
Laure Gibot et al.
Cancers, 12(2) (2020-02-13)
The use of nanocarriers for hydrophobic photosensitizers, in the context of photodynamic therapy (PDT) to improve pharmacokinetics and bio-distribution, is well-established. However, the mechanisms at play in the internalization of nanocarriers are not well-elucidated, despite its importance in nanocarrier design.
Wajih Anwer et al.
Biophysical journal, 118(5), 1032-1043 (2020-02-07)
Excessive accumulation of acylcarnitines (ACs), often caused by metabolic disorders, has been associated with obesity, arrhythmias, cardiac ischemia, insulin resistance, etc. Mechanisms whereby elevated ACs might contribute to pathophysiological effects remain largely unexplored. We have aimed to gain insight into
Spatiotemporal control of coacervate formation within liposomes
Deshpande S, et al.
Nature Communications, 10(1), 1800-1800 (2019)
Mart G F Last et al.
ACS nano, 14(4), 4487-4498 (2020-04-03)
Membraneless organelles formed by liquid-liquid phase separation are dynamic structures that are employed by cells to spatiotemporally regulate their interior. Indeed, complex coacervation-based phase separation is involved in a multitude of biological tasks ranging from photosynthesis to cell division to
Qing Wang et al.
Biophysical journal, 115(4), 664-678 (2018-08-08)
Using Förster resonance energy transfer, raft/liquid-ordered-domain formation was assessed in asymmetric vesicles containing outer leaflets composed of high-Tm (melting temperature) saturated phosphatidylcholines (diC18:0PC, diC16:0PC, diC15:0PC, or diC14:0PC), low-Tm unsaturated dioleoylphosphatidylcholine (DOPC) and cholesterol, and inner leaflets composed of lipids that
Yasunori Watanabe et al.
The Journal of biological chemistry, 295(10), 3257-3268 (2020-02-02)
Eukaryotic cells are compartmentalized to form organelles, whose functions rely on proper phospholipid and protein transport. Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transfer phosphatidylserine, at 2.2 Å resolution. We
Samuel T Hess et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(44), 17370-17375 (2007-10-26)
Organization in biological membranes spans many orders of magnitude in length scale, but limited resolution in far-field light microscopy has impeded distinction between numerous biomembrane models. One canonical example of a heterogeneously distributed membrane protein is hemagglutinin (HA) from influenza
Hudson P Pace et al.
Analytical chemistry, 90(21), 13065-13072 (2018-10-24)
Over the last two decades, supported lipid bilayers (SLBs) have been extensively used as model systems to study cell membrane structure and function. While SLBs have been traditionally produced from simple lipid mixtures, there has been a recent surge in
Erdem Karatekin et al.
Nature protocols, 7(5), 903-920 (2012-04-21)
Many biological processes rely on membrane fusion, and therefore assays to study its mechanisms are necessary. Here we report an assay with sensitivity to single-vesicle, and even to single-molecule events using fluorescently labeled vesicle-associated v-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein
Huan Bao et al.
Nature, 554(7691), 260-263 (2018-02-09)
The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (proteins that mediate
A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim W, et al.
Nature, 556(7699), 103-103 (2018)
Daichi Yamaura et al.
Langmuir : the ACS journal of surfaces and colloids, 34(19), 5615-5622 (2018-04-18)
Artificial bilayer lipid membranes (BLMs) provide well-defined systems for investigating the fundamental properties of membrane proteins, including ion channels, and for screening the effect of drugs that act on them. However, the application of this technique is limited due to
Stabilization of liposomes against stress using polyelectrolytes: Interaction mechanisms, influence of pH, molecular weight, and polyelectrolyte structure
Rinaudo M, et al.
International Journal of Polymer Analysis and Characterization, 14(8), 667-677 (2009)
Shuo Lu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(19), 10313-10321 (2020-04-29)
The H+/Ca2+ (calcium ion) antiporter (CAX) plays an important role in maintaining cellular Ca2+ homeostasis in bacteria, yeast, and plants by promoting Ca2+ efflux across the cell membranes. However, how CAX facilitates Ca2+ balance in response to dynamic cytosolic Ca2+
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance JE and Tasseva G
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831(3), 543-554 (2013)
Non Miyata et al.
The Journal of cell biology, 214(1), 77-88 (2016-06-30)
Phosphatidylethanolamine (PE) is an essential phospholipid for mitochondrial functions and is synthesized mainly by phosphatidylserine (PS) decarboxylase at the mitochondrial inner membrane. In Saccharomyces cerevisiae, PS is synthesized in the endoplasmic reticulum (ER), such that mitochondrial PE synthesis requires PS
Stuart A Whitehead et al.
Bioconjugate chemistry, 28(4), 923-932 (2017-03-02)
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion, oxo-dibenzocyclooctyne (ODIBO)-lipid 1 was designed, synthesized, and studied alongside azadibenzocyclooctyne
Ataru Seimei et al.
Journal of colloid and interface science, 569, 211-218 (2020-03-01)
We investigated the formation behavior of supported lipid bilayers (SLBs) on polyelectrolyte multilayers (PEMs) prepared using the layer-by-layer method. The SLBs were formed using the liposome fusion method, which was driven by electrostatic interactions. We used three types of cationic
Shuangshuang Zeng et al.
Langmuir : the ACS journal of surfaces and colloids, 36(6), 1446-1453 (2020-01-24)
Solid-state nanopores provide a highly versatile platform for rapid electrical detection and analysis of single molecules. Lipid bilayer coating of the nanopores can reduce nonspecific analyte adsorption to the nanopore sidewalls and increase the sensing selectivity by providing possibilities for
Oliver Goldmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 316, 292-301 (2019-11-13)
Staphylococcus aureus is a major cause of severe invasive infections. The increasing incidence of infections caused by antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA), calls for exploration of new approaches to treat these infections. Mupirocin is an antibiotic with
Thuc T Le et al.
BMC cancer, 9, 42-42 (2009-02-03)
Lipid-rich tumours have been associated with increased cancer metastasis and aggressive clinical behaviours. Nonetheless, pathologists cannot classify lipid-rich tumours as a clinically distinctive form of carcinoma due to a lack of mechanistic understanding on the roles of lipids in cancer
Oskar Staufer et al.
Small (Weinheim an der Bergstrasse, Germany), e1906424-e1906424 (2020-02-23)
Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics. However, bottom-up synthetic biology also offers great potential to study subcellular structures like organelles.
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