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A V Terry et al.
Neuroscience, 146(3), 1316-1332 (2007-04-17)
First and second generation antipsychotics (FGAs and SGAs) ameliorate psychotic symptoms of schizophrenia, however, their chronic effects on information processing and memory function (i.e. key determinants of long term functional outcome) are largely unknown. In this rodent study the effects
E Maria Donner et al.
Drug and chemical toxicology, 26(2), 125-133 (2003-06-21)
Phenylphosphinic acid was fed in graded concentrations of either 0 (control), 100, 1,000, or 10,000 ppm to rats for 28 days. These concentrations provided average daily doses of 8, 76, and 779 mg/kg (males) and 9, 83, and 859 mg/kg
V E Dosenko et al.
TSitologiia i genetika, 39(2), 49-54 (2005-09-16)
Endothelial NO-synthase (eNOS) gene allelic polymorphism in 221 patients with acute coronary syndrome and in 83 practically healthy people was determined. It was shown that interrelations of normal homozygotes, heterozygotes and pathologic homozygotes in T/C promoter polymorphism analysis accout 48%
R N Fontaine et al.
Biochemistry, 30(28), 7008-7014 (1991-07-16)
The gene encoding the rat pancreatic cholesterol esterase has been isolated and characterized. Analysis of overlapping genomic clones showed that the cholesterol esterase gene spans approximately 8 kb, containing 11 exons interrupted by 10 introns. The exons ranged in size
T Zimmermann et al.
Arzneimittel-Forschung, 45(1), 41-43 (1995-01-01)
The polymorphism of dextromethorphan (CAS 125-71-3) metabolism is dependent on hepatic cytochrom P4502D6 (CYP2D6) activity. The relationship between the CYP2D6 genotype and the dextromethorphan phenotype was studied in 83 healthy unrelated subjects. Genotype was determined by allele-specific polymerase chain reaction
S B Lei et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 11(5), 389-391 (1990-09-01)
Subcellular fractions were isolated from Chinese fetal liver at 4-8 months of age for the determination of glutathione S-transferase (GST). Using 1-chloro-2,4-dinitrobenzene (CDNB) as substrate, GST activity was found to be 66 +/- 34 nmol/(min.mg protein), mainly in the cytosol.
Jinru Shia et al.
The American journal of surgical pathology, 29(1), 96-104 (2004-12-23)
The utility of immunohistochemistry (IHC) as a screening method for the identification of persons with mutations in the DNA mismatch repair (MMR) genes in hereditary nonpolyposis colorectal cancer (HNPCC) remains to be defined. In this study, we analyzed the value
J Marín et al.
British journal of pharmacology, 124(3), 473-478 (1998-07-01)
1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz
Mateusz Dezor et al.
Folia neuropathologica, 49(2), 123-131 (2011-08-17)
The aim of the study was to determine the extent of oxidative DNA damage (levels of 8-oxo2dG) and expression of OGG1 and p53 and TNF-α proteins in lymphocytes of Alzheimer's disease (AD) patients and a control group. The studies were
Gregory W Charville et al.
The American journal of surgical pathology, 40(10), 1305-1315 (2016-08-16)
Rhabdomyosarcoma, the most common soft tissue malignancy of childhood, is a morphologically variable tumor defined by its phenotype of skeletal muscle differentiation. The diagnosis of rhabdomyosarcoma often relies in part on the identification of myogenic gene expression using immunohistochemical or
Sunil Kumar et al.
Journal of gastroenterology and hepatology, 27(12), 1825-1830 (2012-09-20)
Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms. A total of 150 IBS
Michelle Furtado et al.
British journal of haematology, 168(1), 55-62 (2014-08-26)
The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP +
F T Stevenson et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(15), 7245-7249 (1993-08-01)
The cytokine interleukin 1 alpha (IL-1 alpha) is a critical mediator of the immune and inflammatory responses. A unique determinant of its activity as compared with IL-1 beta may be its association with the plasma membrane. While the biologic activity
Cheryl N Onwuchuruba et al.
American journal of obstetrics and gynecology, 210(4), 352-352 (2014-04-01)
The objective of the study was to analyze a large number of patients receiving vancomycin chemoprophylaxis and evaluate the maternal and neonatal cord blood levels at the time of delivery. Every mother who entered labor with a positive group B
M Matejková-Behanová et al.
Physiological research, 53(2), 187-190 (2004-03-30)
Variability in the number of tandem repeats of the insulin gene (INS VNTR) is probably involved in the genetic regulation of insulin secretion. The aim of this study was to investigate the association of INS VNTR polymorphism with the presence
M B Skaddan et al.
Journal of medicinal chemistry, 43(23), 4552-4562 (2000-11-23)
A series of 31 compounds based on the piperidyl or pyrrolidyl benzilate scaffold were prepared from methyl benzilate and 4-piperidinol, (R)-(+)-3-piperidinol, or (R)-(+)-3-pyrrolidinol. Amine substituents included alkyl and aralkyl groups. In vitro K(i) values ranged from 0.05 nM to >100
Hulya Akgun et al.
Anticancer research, 22(3), 1459-1461 (2002-08-10)
Estrogen receptor-beta (ER-B) has been identified in benign and malignant tissues of a variety of human organs including the colon. In breast carcinoma, ER-B was found to be a significant predictor of response to adjuvant hormonal therapy with tamoxifen. The
Marie Hilderman et al.
Clinical kidney journal, 8(5), 599-605 (2015-09-29)
The cholinergic anti-inflammatory pathway (CAP) modulates inflammatory responses through the vagus nerve and the α-7-nicotinic acetylcholine receptor (α7nAChR) on macrophages and immune cells. Sympathetic/parasympathetic imbalance and chronic inflammation are both linked to poor outcome in dialysis patients. The aim of
Amberly L Nunez et al.
American journal of clinical pathology, 137(3), 423-428 (2012-02-18)
CD138 (syndecan-1), a cell surface proteoglycan, is sensitive and specific for plasmacytic differentiation in hematologic disorders. Expression of CD138 has been observed in a majority of epithelial neoplasms and, rarely, soft tissue tumors. However, its expression in bone tumors has
Andrés J M Ferreri et al.
Neurology, 82(15), 1370-1373 (2014-03-19)
We report updated results at a median follow-up of 12 years of a phase II trial assessing first-line MATILDE chemotherapy and response-tailored radiotherapy in patients with primary CNS lymphomas (PCNSL). Forty-one HIV-negative patients (18-70 years; Eastern Cooperative Oncology Group performance
J van Deursen et al.
Biochimica et biophysica acta, 1185(3), 327-335 (1994-05-18)
To evaluate the effects of phosphocreatine (PCr) and creatine (Cr) depletion on skeletal muscles of mice deficient in muscle creatine kinase (M-CK), we have fed mutant mice a diet containing the creatine analogue beta-guanidinopropionic acid (beta GPA). After 8-10 weeks
Meena P Desai et al.
Indian journal of pediatrics, 79(7), 875-883 (2011-10-22)
To detect growth hormone GH-1 gene deletions (6.7 kb, 7.6 kb, 7 kb) in familial/nonfamilial isolated growth hormone deficiency (IGHD) and note their clinical and investigative profile. Thirty (M16,F14) prepubertal IGHD patients aged 0.25 to 14 y, from 25 families
James Fung et al.
The American journal of gastroenterology, 108(6), 942-948 (2013-05-01)
The long-term outcomes of oral antiviral therapy without hepatitis B immune globulin (HBIG) in prevention of reinfection with hepatitis B after liver transplantation are not known. We aimed to determine the long-term outcomes from a large population of chronic hepatitis
Andre Plass et al.
The Thoracic and cardiovascular surgeon, 63(4), 270-276 (2014-12-03)
Coronary angiography (CA) remains the standard for preoperative planning for surgical revascularization. However, besides anatomical imaging, current guidelines recommend additional functional imaging before a therapy decision is made. We assess the impact of functional imaging on the strategy of coronary
Amelia Szymanowska et al.
Lung cancer (Amsterdam, Netherlands), 52(1), 9-14 (2006-02-28)
The aim of this study was to assess whether the TP53 Arg72Pro polymorphism is associated with an increased risk of non-small cell lung cancer (NSCLC). Additionally, in NSCLC patients, we investigated a potential association between this polymorphism and somatic TP53
Fausto J Rodriguez et al.
Brain pathology (Zurich, Switzerland), 29(1), 126-140 (2018-09-08)
Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma (PA) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains unclear. Fifty-seven resections from 36 patients
Qing-tao Zhou et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 28(9), 630-634 (2005-10-07)
To investigate the characteristics of airway inflammation in severe asthma and the association with interleukin-17 (IL-17). Sixteen patients with mild persistent asthma, 14 patients with moderate persistent asthma and 18 patients with severe persistent asthma, as well as 15 normal
M R Roby et al.
Environmental health perspectives, 69, 215-220 (1986-11-01)
The excretion and tissue distribution of [1-14C]dichloroacetonitrile and [2-14C]dichloroacetonitrile were studied in male Fischer 344 rats and male B6C3F1 mice. Three dose levels of dichloroacetonitrile (DCAN) (0.2, 2, or 15 mg/kg) were administered to rats and two dose levels of
Pu Dai et al.
Zhonghua yi xue za zhi, 87(36), 2521-2525 (2007-12-11)
To investigate the hot spot mutation of SLC26A4 gene and its incidence among patients with moderate to profound sensorineural hearing loss (SNHL) and to analyze the epidemiology of enlarged vestibular aqueduct syndrome in China. Peripheral blood samples were collected from
Siacia Broos et al.
European journal of applied physiology, 115(8), 1637-1643 (2015-03-13)
This study aimed at determining the influence of the ACTN3 R577X polymorphism on muscle strength and muscle endurance in non-athletic young men. 266 healthy young men were included in this study. Each subject performed maximal isometric, concentric and eccentric contractions
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