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Nils Habbe et al.
Cancer biology & therapy, 8(4), 340-346 (2008-12-25)
Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor lesions of pancreatic cancer. Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented. Relative expression levels of a
A DeVries et al.
Pharmacotherapy, 18(3), 581-587 (1998-06-10)
We conducted a critical review of the literature on ketoconazole in preventing acute respiratory distress syndrome (ARDS), a serious disorder associated with high mortality. Two double-blind, prospective, placebo-controlled, randomized trials compared ketoconazole with placebo for prophylaxis of ARDS. In one
Yonglan He et al.
Abdominal imaging, 40(8), 3104-3116 (2015-08-20)
To discuss the diverse imaging features of pancreatic and extra-pancreatic lesions of IgG4-related disease (IgG4-RD) on multi-detector CT (MDCT). This retrospective study was approved by our institutional research ethics board, and informed consent was waived. From 2008 to 2013, 159
N Iwasaki et al.
Diabetes, 46(9), 1504-1508 (1997-09-01)
Recent studies have shown that mutations in the hepatocyte nuclear factor (HNF)-1alpha gene are the cause of maturity-onset diabetes of the young type 3 (MODY3). We have screened 193 unrelated Japanese subjects with NIDDM for mutations in this gene: 83
P W Ferguson et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 4(1), 14-21 (1984-02-01)
The influence of carbofuran metabolism on acetylcholinesterase inhibition has been defined after low dose (50 micrograms/kg, iv and oral) [carbonyl-14C]carbofuran exposures to male Sprague-Dawley rats. Red blood cell acetylcholinesterase (RBC AchE) inhibition (83% at 2 min, 37% at 15 min
Thomas Ravn Lassen et al.
Basic research in cardiology, 112(3), 26-26 (2017-03-30)
Left ventricular (LV) remodeling following a myocardial infarction (MI) involves formation of reactive oxygen species (ROS). Paroxetine, a selective serotonin reuptake inhibitor, has an antioxidant effect in the vascular wall. We investigated whether paroxetine reduces myocardial ROS formation and LV
T A Ishunina et al.
Maturitas, 57(1), 20-22 (2007-03-14)
In a series of studies we showed that menopause in women causes alterations not only in the neuronal expression of estrogen receptors (ER) alpha and beta, but also in local estrogen production in several brain areas and in the rate
Amanda J Jenkins et al.
Journal of forensic and legal medicine, 16(2), 64-66 (2009-01-13)
Hydrocodone (HC) has received renewed interest in the US due to reported increases in opiate related deaths involving psychotherapeutic drugs. The relative contribution of dihydrocodeine (DHC) in these deaths is unknown since little testing of this compound is performed. The
Sayaka Kawano et al.
Internal medicine (Tokyo, Japan), 50(9), 975-981 (2011-05-03)
Eosinophilic myocarditis is a rare clinical entity characterized by eosinophilia and myocardial inflammation with infiltrating eosinophils. The prognosis of patients with eosinophilic myocarditis is difficult to determine due the disease's rarity and varied causes; consequently, standard treatment has not been
Akira Kuriyama et al.
Clinical neuropharmacology, 34(6), 241-247 (2011-10-15)
To assess patient and medication factors that contribute to metronidazole toxicity. We searched PUBMED from 1965 through April 7, 2011, and performed a hand search of bibliographies. Case reports or case series reporting metronidazole-induced central nervous toxicity. Two authors independently
Ananth Shankar et al.
British journal of haematology, 165(4), 534-544 (2014-04-24)
The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]
F Latif et al.
Human genetics, 99(3), 334-341 (1997-03-01)
Recently, human chromosome band 3p21.3 was shown to undergo overlapping homozygous deletions in several small cell lung cancer lines further defining a putative tumor suppressor gene(s) region. We report the cloning and mutational analysis of a novel human gene, SKMc15
Pilvi Riihilä et al.
The Journal of investigative dermatology, 135(2), 579-588 (2014-09-04)
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising worldwide. We have examined the role of complement components in the progression of cSCC. Analysis of cSCC cell lines (n=8) and normal human epidermal keratinocytes (n=11) with whole transcriptome profiling
Maryline Bonnet et al.
The Lancet. Infectious diseases, 13(4), 303-312 (2013-02-26)
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at
Petra Matoulková et al.
Acta poloniae pharmaceutica, 70(2), 333-338 (2013-04-26)
Convenient access to a large variety of OTC medicines presents patients with the opportunity for the self-treatment of many health problems. Yet this also brings on other health risks, especially to the elderly. A pointed lack of information about the
Ja Young Kang et al.
The Korean journal of hepatology, 16(4), 383-388 (2011-03-19)
Transarterial chemoembolization (TACE) improves the survival of patients with unresectable hepatocellular carcinoma (HCC) and has been recommended as a first-line therapy for nonsurgical patients with large or multifocal HCC. The long-term outcome of HCC patients receiving TACE prior to hepatic
Yosuke Nakatani et al.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 48(1), 81-88 (2016-11-07)
The purpose of this study was to investigate the relationship between the accessory pathway location and brain natriuretic peptide (BNP) level in patients with Wolff-Parkinson-White (WPW) syndrome. We divided 102 WPW syndrome patients with normal left ventricular systolic function into
T R Robeck et al.
Reproduction (Cambridge, England), 138(2), 391-405 (2009-06-06)
The reproductive physiology of the Pacific white-sided dolphin, Lagenorhynchus obliquidens, was characterized to facilitate the development of artificial insemination (AI) using cryopreserved spermatozoa. Specific objectives were to: 1) describe reproductive seasonality of the Pacific white sided dolphins; 2) describe urinary
Fernando S Velayos et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 9(3), 329-335 (2005-03-08)
MLH1 promoter hypermethylation has been described as the primary mechanism for high-frequency microsatellite instability (MSI-H) in sporadic colorectal cancers (CRCs). The underlying molecular mechanism for microsatellite instability (MSI) in synchronous and metachronous CRCs is not well described. A total of
Barbara Goeggel Simonetti et al.
Clinical neuroradiology, 29(1), 143-151 (2017-11-04)
Knowledge about the localization and outcome of iatrogenic dissection (ID) during endovascular treatment of acute ischemic stroke (AIS) is limited. We aimed to determine the frequency, clinical aspects and morphology of ID in endovascular AIS treatment and to identify predictors
Camille Lassale et al.
The British journal of nutrition, 113(6), 953-962 (2015-03-17)
New technologies are promising for the use of short-term instruments for dietary data collection; however, innovative tools should be validated against objective biomarkers. The aim of the present study was to investigate the validity of a Web-based, self-administered dietary record
Kenneth S Bode et al.
Journal of spinal disorders & techniques, 28(10), E590-E594 (2013-11-20)
Randomized trial. This study described practical magnetic resonance imaging (MRI) characteristics to assist in the identification of these tumors including the corresponding statistics. Identification of vascular spinal tumors using MRI allows the opportunity for angiography and preoperative embolization (PE) to
Ke Wu et al.
The British journal of nutrition, 123(8), 841-848 (2020-01-23)
Human milk fat is specially tailored to supply the developing infant with adequate and balanced nutrients. The present study aimed to quantify the composition of fatty acids, tocopherols and carotenoids in human milk, with special emphasis on the lactational changes.
Stuart A Scott et al.
Leukemia research, 28(12), 1293-1301 (2004-10-12)
Epigenetic silencing of downstream components of the transforming growth factor beta pathway including the cyclin-dependent kinase inhibitors (CDKIs) p15INK4B, p27KIP1 and p21CIP1 is implicated in the pathogenesis of some hematological malignancies. Loss of p15INK4B expression due to promoter methylation occurs
Catherine S Giess et al.
AJR. American journal of roentgenology, 208(6), 1378-1385 (2017-03-08)
The purpose of this study was to determine the clinical utility of breast MRI for diagnosing malignancy in women with equivocal mammographic findings but no symptoms. Retrospective review of an institutional MRI database of 7332 contrast-enhanced breast MRI examinations from
Tobias Broger et al.
The Lancet. Infectious diseases, 19(8), 852-861 (2019-06-04)
Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. The only commercially available tuberculosis point-of-care test (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clinical practice. The novel
Kent W Small et al.
Ophthalmology, 121(4), 952-958 (2014-02-11)
To report a series of cases with fungal endophthalmitis occurring after intravitreal injection of triamcinolone derived from a single lot prepared by a compounding pharmacy. Retrospective, observational case series. Seventeen eyes treated with triamcinolone obtained from a single lot subsequently
D K McGregor et al.
The American journal of surgical pathology, 25(12), 1485-1492 (2001-11-22)
The diagnosis of primary or metastatic renal cell carcinoma (RCC) can be difficult, especially in small biopsies, because of the wide variety of histologic appearances and clinical presentations that RCC can assume. An immunomarker specific for RCC is currently not
Ashraf Badros et al.
Blood, 130(10), 1189-1197 (2017-05-04)
Programmed death 1 (PD-1) receptor and its ligand (PD-L1) facilitate immune evasion in multiple myeloma (MM). We hypothesized that pembrolizumab, PD-1-antibody, can enhance antimyeloma cellular immunity generated by pomalidomide, leading to improved clinical responses. In this single-center, phase 2 study
Petr Ostadal et al.
Journal of translational medicine, 13, 266-266 (2015-08-16)
The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy. Five swine (body weight 45 kg) underwent VA ECMO implantation under general
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