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Pierre D'Amour et al.
Kidney international, 68(3), 998-1007 (2005-08-18)
Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those
Vusumzi Pakade et al.
Journal of chromatography. A, 1230, 15-23 (2012-02-22)
Molecularly imprinted polymers (MIPs) targeting quercetin were prepared from 4-vinylpyridine and ethylene dimethacrylate (EDMA) under various solvent systems with the aim to form MIPs with high recognition for the quercetin molecule in aqueous systems at high temperature. A MIP prepared
M Huang et al.
Life sciences, 32(9), 1009-1014 (1983-02-28)
We have studied the effect of parathyroid hormone (PTH) on adenylate cyclase of microvessels isolated from rat cerebral cortex. Native bovine (b) PTH-(1-84), the synthetic amino-terminal fragment bPTH-(1-34) and the synthetic analog [Nle8,Nle18,Tyr34]-bPTH- (1-34) amide stimulated adenylate cyclase in a
Song Ee Han et al.
International journal of oncology, 24(2), 435-440 (2004-01-14)
Caveolin-1, a tumor suppressor gene, was found to be inactivated by structural abnormalities or epigenetic changes in several types of human cancers. In order to investigate the role of Caveolin-1 in the pathogenesis of human oral squamous cell carcinoma, the
Rajeev I Desai et al.
Behavioural pharmacology, 18(8), 745-754 (2007-11-09)
Dopamine D(1)-like partial agonists antagonize some abuse-related effects of cocaine and have been proposed as candidate medications for psychostimulant abuse. Earlier studies have showed that D(1)-like agonists increase eye blinking in monkeys and that the magnitude of this effect may
C P Babalola et al.
Journal of clinical pharmacy and therapeutics, 35(4), 471-477 (2010-09-14)
Subjects with different CYP2C19 genotypes may metabolize proguanil, a pro-drug used for malaria prophylaxis differently and the frequency of the different alleles may be different in patients with sickle-cell disease (SCD) and normal controls. The objective of this study was
Y S Choy et al.
Annals of human genetics, 63(Pt 5), 383-391 (2000-03-29)
We evaluated denaturing high pressure liquid chromatography (DHPLC) as a scanning method for mutation detection in TSC2, and compared it to conformation-sensitive gel electrophoresis (CSGE) and single-stranded conformation polymorphism analysis (SSCP). The first 20 exons of TSC2 were amplified from
Rhonda Prisby et al.
Bone, 54(1), 68-75 (2013-01-30)
Intermittent PTH administration directly stimulates osteoblasts; however, mechanisms of bone accrual that are independent of the direct actions on osteoblasts may be under-appreciated. Our aims were to decipher (1) whether PTH 1-84 augments vasodilation of the femoral principal nutrient artery
Bozena Dobrzycka et al.
Ginekologia polska, 81(6), 422-425 (2010-08-11)
Angiogenesis is of crucial importance for endometrial tumor growth and Vascular Endothelial Growth Factor (VEGF) is the key mediator of angiogenesis. The purpose of our study was to assess the prognostic value of VEGF and its receptors in relation to
David Goncalves et al.
Clinical & translational immunology, 10(8), e1327-e1327 (2021-08-26)
Impairment of type I interferon (IFN-I) immunity has been reported in critically ill COVID-19 patients. This defect can be explained in a subset of patients by the presence of circulating autoantibodies (auto-Abs) against IFN-I. We set out to improve the
Fatma Özdemir et al.
Journal of food science, 80(6), M1306-M1313 (2015-05-15)
A total of 300 food samples including 180 milk and 120 meat products have been examined for the presence of Yersinia spp. using the ISO 10273 and the cold enrichment method. The overall prevalence of Yersinia spp. was 84 (28%).
Oluwole Fadare et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 30(3), 252-261 (2011-04-06)
Earlier reports have indicated that patients with endometrial clear cell carcinoma (CCC) may have an increased risk for thromboembolic events. Tissue factor is a 47-Kd transmembrane glycoprotein that plays a critical role in platelet activation, fibrinogenesis, blood clot formation, and
S Diment et al.
The Journal of biological chemistry, 264(23), 13403-13406 (1989-08-15)
Most ligands which are taken up by macrophages are transported to lysosomes where they are degraded to their constituents by a concert of acid hydrolases. This process requires a number of intracellular events which result in the transport of ligands
Carol T Bussey et al.
Cardiovascular diabetology, 13, 161-161 (2014-12-17)
Increasing numbers of type 2 diabetic and obese patients with enhanced rates of cardiovascular complications require surgical interventions, however they have a higher incidence of perioperative haemodynamic complications, which has been linked to adrenergic dysfunction. Therefore, we aimed to determine
M J Rapoport et al.
Lupus, 20(14), 1501-1509 (2011-10-07)
Defective expression of Ras guanil releasing protein-1 (RasGRP-1) and increased apoptosis have been reported in lymphocytes from SLE patients. Whether these aberrations are correlated and linked to disease activity has not been elucidated. Expression of normal 90 kDa RasGRP-1, its
A Leyton et al.
Journal of applied microbiology, 127(4), 1069-1079 (2019-06-27)
To evaluate an aqueous extract of Macrocystis pyrifera as a nutrient source for the production of carotenoids by a marine Rhodotorula mucilaginosa isolated from seaweed samples. The effect of different culture conditions on the concentration of biomass and total pigments
Sabrina Opatz et al.
Blood, 122(10), 1761-1769 (2013-07-24)
The t(8;21) and inv(16)/t(16;16) rearrangements affecting the core-binding factors RUNX1 and CBFB, respectively, are found in 15% to 20% of adult de novo acute myeloid leukemia (AML) cases and are associated with a favorable prognosis. Since the expression of the
Diana M Padgett et al.
The American journal of surgical pathology, 32(1), 123-127 (2007-12-29)
Immunohistochemistry using a broad panel of markers is an invaluable tool for diagnosing sarcomatoid mesothelioma. Membranous podoplanin staining has been proposed as a specific and sensitive marker to distinguish epithelioid mesothelioma from adenocarcinoma. We found that cytoplasmic podoplanin staining was
Xiao-xu Han et al.
Zhonghua yi xue za zhi, 92(17), 1159-1164 (2012-08-14)
To explore the human leukocyte antigen (HLA)-associated mutations in Gag protein of B' clade (human immunodeficiency virus-1) HIV-1 infected Han Chinese people and evaluate the impact of HLA associated Gag mutations on the disease progression of HIV infection. A total
Jianglin Peng et al.
Chemosphere, 266, 128933-128933 (2020-11-24)
As a macrolide antibiotic, clarithromycin (CLA) has a high detection rate in surface water and sewage treatment plant effluents worldwide, posing a considerably high ecological risk to aquatic ecosystem. However, algal transcriptome and metabolome in response to CLA remains largely
Yu Sato et al.
Cancers, 12(9) (2020-09-18)
Apolipoprotein A2-ATQ/AT (apoA2-ATQ/AT) has been identified as a minimally invasive biomarker for detecting pancreatic cancer (PC) and high-risk (HR) individuals for PC. To establish an efficient enrichment strategy for HR, we carried out a plasma apoA2-ATQ/AT level-based prospective screening study
V Calderara et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 44(5), 7-13 (2001-11-07)
This paper describes the ozone oxidation kinetics of 1-naphthalene (1 NS), 1,5-naphthalene (1,5NDS), and 3-nitrobenzene (3NBS) sulphonic acid. The presence of hydroxyl radicals and their effect on the overall rate of reaction was studied. Second order kinetic constants of direct
Styliana I Mirallai et al.
The Journal of organic chemistry, 78(17), 8655-8668 (2013-07-31)
Eight 2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitriles 15 are prepared in four steps from N'-arylbenzamidines 11 and tetracyanoethylene (TCNE) in ~70-90% yields. The transformation involves the initial formation of N-aryl-N'-(1,2,2-tricyanovinyl)benzamidines 12 in 87-99% yields, which in MeCN undergo a 5-exodig cyclization to give the 2-[1-aryl-5-imino-2-phenyl-1H-imidazol-4(5H)-ylidene]malononitriles
J F Gregory et al.
The Journal of nutrition, 131(7), 1928-1937 (2001-07-04)
To investigate the effects of pregnancy on folate metabolism, we conducted an 84-d study in second-trimester (gestational wk 14-25) pregnant women (n = 6) and nonpregnant controls (n = 6) with stable-isotopic tracer methods. All subjects were fed a diet
D K Kumbla et al.
Indian heart journal, 66(3), 340-344 (2014-06-30)
Hypertension is a global health problem. Multiple classes of drugs including angiotensin receptor blockers (ARBs) are available for the treatment of hypertension. Olmesartan is a relatively newer ARB used in hypertension management. To assess the efficacy and safety of WIN-BP
J William Harbour et al.
Science (New York, N.Y.), 330(6009), 1410-1413 (2010-11-06)
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in
Hong-Wei Li et al.
Journal of analytical methods in chemistry, 2019, 7590692-7590692 (2020-02-25)
In order to improve the strength and resistance of ordinary nonel tubes, calcium sulfate whiskers (CSW, treated with silane coupling agent) and maleic anhydride grafted polyethylene (PE-g-MAH) are used to control the wall material of the nonel tube that the
B M Ryan et al.
British journal of cancer, 85(10), 1499-1503 (2001-11-27)
The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares some p53-like activity, but in addition, may
M A Sarkar et al.
Biomedical chromatography : BMC, 5(1), 38-42 (1991-01-01)
A high performance liquid chromatographic (HPLC) technique for the determination of three metabolites of theophylline, 3-methylxanthine (3-MX), 1-methylxanthine (1-MX) and 1,3-dimethyluric acid (1,3-DMU) in human liver microsomes is described. The analytes were extracted from human liver microsomes with methylene chloride/isopropanol
Inhye E Ahn et al.
Blood, 129(11), 1469-1479 (2017-01-05)
Disease progression in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib has been attributed to histologic transformation or acquired mutations in BTK and PLCG2. The rate of resistance and clonal composition of PD are incompletely characterized. We report on
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