84-74-2

应用筛选条件

关键词:'84-74-2'

显示 1-30 共 125 条结果关于 "84-74-2" 范围论文

Applying slow-release biocatalysis to the asymmetric reduction of ethyl 4-chloroacetoacetate.

Jer-Yiing Houng et al.

Biotechnology letters, 25(1), 17-21 (2003-07-29)

Amberlite XAD 2 resin enhanced the asymmetric reduction of ethyl 4-chloroacetoacetate (ECA) to S-4-chloro-3-hydroxybutyric acid ethyl ester as catalyzed by Saccharomyces cerevisiae. The absorbed ECA was released slowly to the solution during the reaction so that the substrate inhibition and

Expression of β-tubulin III and survivin in advance stage breast cancer correlates with chemotherapeutic effects of docetaxel.

Shao-Fei Yuan et al.

Asian Pacific journal of cancer prevention : APJCP, 13(1), 361-365 (2012-04-17)

To investigate the relationship between the expression of β-tubulin III and survivin in advanced breast cancers and chemotherapeutic effects of docetaxel. Clinical pathological data of 74 patients with advanced breast cancer were retrospectively analyzed after docetaxel chemotherapy. Expression of β-tubulin

Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2.

Elitza S Theel et al.

Journal of clinical microbiology, 58(8) (2020-06-10)

The role of serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in both the clinical and public health settings, will continue to evolve as we gain increasing insight into our immune response to the virus. Here, we evaluated

Cytochrome P450 CYP2C19 genotypes in Nigerian sickle-cell disease patients and normal controls.

C P Babalola et al.

Journal of clinical pharmacy and therapeutics, 35(4), 471-477 (2010-09-14)

Subjects with different CYP2C19 genotypes may metabolize proguanil, a pro-drug used for malaria prophylaxis differently and the frequency of the different alleles may be different in patients with sickle-cell disease (SCD) and normal controls. The objective of this study was

Real-time polymerase chain reaction with fluorescent hybridization probes for the detection of prevalent mutations causing common thrombophilic and iron overload phenotypes.

S B Parks et al.

American journal of clinical pathology, 115(3), 439-447 (2001-03-13)

We evaluated more than 450 patients with thrombophilia or iron overload for the presence of a factor V Leiden (R506Q), prothrombin G20210A, or HFE C282Y mutation using a standard method (polymerase chain reaction [PCR]-restriction fragment length polymorphism) and a comparative

Msx-2/Hox 8.1: a transcriptional regulator of the rat osteocalcin promoter.

D A Towler et al.

Molecular endocrinology (Baltimore, Md.), 8(11), 1484-1493 (1994-11-01)

We recently defined an element (ACTAATTGG) within the rat osteocalcin (OC) promoter at -84 to -92 which provides approximately 70% of basal promoter activity in osteoblastic cell lines and binds a specific nuclear factor found in OC-producing ROS 17/2.8 osteosarcoma

Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2.

Gokhan Kus et al.

In vitro cellular & developmental biology. Animal, 51(10), 1056-1063 (2015-07-15)

Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential for ceranib-2, a novel ceramidase inhibitor, to affect the

[Multiresidue analysis of PCB, organochlorine pesticides and chlordanes in marine products by GC-micro ECD].

Haruka Ohno et al.

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 52(4), 251-257 (2011-08-30)

A multiresidue method using dual-injection, dual-column, and dual-micro electron capture detection gas chromatography (dual-column GC-µECD) was developed for the determination of PCB, organochlorine pesticides and chlordanes in marine products. The sample was extracted with hexane-acetone (2 : 1), and the

Matrix solid-phase dispersion microextraction and determination by high-performance liquid chromatography with UV detection of pesticide residues in citrus fruit.

A I Valenzuela et al.

Journal of chromatography. A, 839(1-2), 101-107 (1999-05-18)

A multiresidue method based on matrix solid-phase dispersion (MSPD) microextraction was studied to determine the carbamate, benfuracarb, and urea insecticides, diflubenzuron, flufenoxuron hexaflumuron and hexythiazox, used in control of citrus pests. Optimisation of different parameters, such as the type of

Percutaneous absorption of the insecticides fenitrothion and aminocarb in rats and monkeys.

R P Moody et al.

Journal of toxicology and environmental health, 20(1-2), 209-218 (1987-01-01)

The dermal penetration of 14C-ring-labeled fenitrothion and aminocarb was determined in rats and rhesus monkeys. In monkeys, 49 +/- 4% (t1/2 = 14 h) of the fenitrothion and 74 +/- 4% (t1/2 = 25 h) of aminocarb were absorbed from

The combination of rituximab, bendamustine, and cytarabine for heavily pretreated relapsed/refractory cytogenetically high-risk patients with chronic lymphocytic leukemia.

Carlo Visco et al.

American journal of hematology, 88(4), 289-293 (2013-03-02)

Treatment of patients with B-cell chronic lymphocytic leukemia (CLL) relapsed/refractory (R/R) to conventional treatments is particularly challenging. The combination of bendamustine and cytarabine has demonstrated distinct and synergistic mechanisms of action in preclinical studies on cell lines and primary tumor

Efficacy and safety of cefprozil versus other beta-lactam antibiotics in the treatment of lower respiratory tract infections.

P Ball

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 13(10), 851-856 (1994-10-01)

Cefprozil was evaluated in four multicentre comparative studies in the treatment of acute respiratory tract infections. In two studies, cefprozil 500 mg q. 12 hours was compared to cefaclor 500 mg q. eight hours for ten days of therapy. Randomization

Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

D P Cerretti et al.

Molecular immunology, 30(4), 359-367 (1993-03-01)

Interleukin-8 (IL-8), neutrophil activating peptide-2 (NAP-2), and growth regulated gene (GRO, also known as melanoma growth stimulatory activity) are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils. Receptors have been identified for

Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.

R Ollo et al.

Proceedings of the National Academy of Sciences of the United States of America, 78(4), 2442-2446 (1981-04-01)

A 23-kilobase EcoRI DNA fragment coding for the BALB/c immunoglobulin gamma 2a chain was cloned from mouse embryo DNA in the cosmid pJC74, and a nucleotide sequence of 1904 bases was determined for the entire constant region (CH1, CH2, and

Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial.

Eric Lawitz et al.

Lancet (London, England), 383(9916), 515-523 (2013-11-12)

Interferon-based treatment is not suitable for many patients with hepatitis C virus (HCV) infection because of contraindications such as psychiatric illness, and a high burden of adverse events. We assessed the efficacy and safety of an interferon-free regimen--a fixed-dose combination

Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases.

Shozo Yamada et al.

Journal of neurosurgery, 121(6), 1462-1473 (2014-09-23)

The aim of this study was to analyze clinicopathological characteristics and treatment outcomes in a large single-center clinical series of cases of thyrotropin (TSH)-secreting pituitary adenomas. The authors retrospectively reviewed clinical, pathological, and treatment characteristics of 90 consecutive cases of

In vitro activity of colistin in antimicrobial combination against carbapenem-resistant Acinetobacter baumannii isolated from patients with ventilator-associated pneumonia in Vietnam.

Vien Le Minh et al.

Journal of medical microbiology, 64(10), 1162-1169 (2015-08-25)

Acinetobacter baumannii has become one of the major infection threats in intensive care units (ICUs) globally. Since 2008, A. baumannii has been the leading cause of ventilator-associated pneumonia (VAP) in our ICU at an infectious disease hospital in southern Vietnam.

Carotenoids of aleurone, germ, and endosperm fractions of barley, corn and wheat differentially inhibit oxidative stress.

Kabo Masisi et al.

Journal of agricultural and food chemistry, 63(10), 2715-2724 (2015-02-24)

The antioxidant potential of carotenoids from aleurone, germ, and endosperm fractions of barley, corn, and wheat has been evaluated. HPLC analysis confirmed the presence of lutein and zeaxanthin carotenoids (nd-15139 μg/kg) in extracts of cereal grain fractions. The antioxidant properties

Characterisation of male breast cancer: a descriptive biomarker study from a large patient series.

Matthew P Humphries et al.

Scientific reports, 7, 45293-45293 (2017-03-30)

Male breast cancer (MBC) is rare. We assembled 446 MBCs on tissue microarrays and assessed clinicopathological information, together with data from 15 published studies, totalling 1984 cases. By immunohistochemistry we investigated 14 biomarkers (ERα, ERβ1, ERβ2, ERβ5, PR, AR, Bcl-2

Role for cytotoxic chemotherapy in patients with recurrent glioblastoma progressing on bevacizumab: a retrospective case series.

Marc C Chamberlain

Expert review of neurotherapeutics, 12(8), 929-936 (2012-09-26)

One hundred patients, aged 36-84 years (median 62 years) with recurrent glioblastoma (GBM), were treated previously with surgery, concurrent radiotherapy and temozolomide and postradiotherapy temozolomide followed by single-agent bevacizumab (BEV) at either first (60 patients) or second recurrence (40 patients).

[Etiology of urinary tract infections and antimicrobial susceptibility: a study conducted on a population of children hospitalized in the Department of Pediatrics at Warsaw Bielany Hospital; 2004-2006].

Teresa Jackowska et al.

Medycyna wieku rozwojowego, 12(2 Pt 2), 705-712 (2009-05-08)

the basis of urinary tract infection (UTI) diagnosis in children is based on positive results of microbiological tests. The selection of an antimicrobial drug for empirical treatment and prophylaxis of UTI is determined by the susceptibility of bacterial strains isolated

Equations generated to predict iodine value of pork carcass back, belly, and jowl fat.

C B Paulk et al.

Journal of animal science, 93(4), 1666-1678 (2015-05-29)

Data from existing literature were used to generate equations to predict finishing pig back, belly, and jowl fat iodine values (IV) and an experiment was conducted to evaluate these equations. The final database included 24, 21, and 29 papers for

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle.

R J Tate et al.

Cellular signalling, 11(7), 515-522 (1999-07-16)

Members of the type 2 phosphatidic acid phosphatase (PAP2) family catalyse the dephosphorylation of phosphatidic acid (PA), lysophosphatidate and sphingosine 1-phosphate. Here, we demonstrate the presence of a Mg(2+)-independent and N-ethymaleimide-insensitive PAP2 activity in cultured guinea-pig airway smooth muscle (ASM)

[Expression of STK15 gene and chromosomal instability in laryngeal carcinoma].

Ying-Hui Li et al.

Yi chuan xue bao = Acta genetica Sinica, 29(12), 1048-1051 (2003-04-16)

To assess the relationship between expression of STK15 gene and chromosomal instability in laryngeal squamous cell carcinoma, RNA was extracted from 50 cases of laryngeal squamous cell carcinoma and paired normal tissue and Hep-2 cell line. cDNA was synthesized through

Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines.

Song Ee Han et al.

International journal of oncology, 24(2), 435-440 (2004-01-14)

Caveolin-1, a tumor suppressor gene, was found to be inactivated by structural abnormalities or epigenetic changes in several types of human cancers. In order to investigate the role of Caveolin-1 in the pathogenesis of human oral squamous cell carcinoma, the

The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.

Kumiko Goto et al.

Pharmacological research, 61(5), 466-472 (2009-12-17)

RhoA protein is involved in the Ca(2+) sensitization of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA in BSMs has been suggested in allergic bronchial asthma. However, the mechanism of upregulation of RhoA remains poorly understood. In the

Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients.

Yasuo Tsuzaka et al.

International journal of urology : official journal of the Japanese Urological Association, 18(11), 792-795 (2011-09-16)

The aim of the present study was to compare the efficacy of the selective α(1D) -adrenoceptor antagonist naftopidil and the selective α(1A) -adrenoceptor antagonist silodosin (as an example) in the management of ureteral stones in Japanese male patients. A total

The Streptococcus thermophilus protein Wzh functions as a phosphotyrosine phosphatase.

Angela D Cefalo et al.

Canadian journal of microbiology, 59(6), 391-398 (2013-06-12)

Amino acid residues that are important for metal binding and catalysis in Gram-positive phosphotyrosine phosphatases were identified in the Wzh protein of Streptococcus thermophilus MR-1C by using sequence comparisons. A His-tagged fusion Wzh protein was purified from Escherichia coli cultures

Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).

T Kojima et al.

Journal of biochemistry, 120(3), 671-676 (1996-09-01)

Rabphilin 3A and Doc2 alpha are synaptic vesicle-associated proteins, and are thought to function as Ca2+ sensors in neurotransmitter release. If either rabphilin 3A or Doc2 alpha plays a role in membrane trafficking, like the synaptotagmins, then non-neural forms should

Hyposmolarity-induced ErbB4 phosphorylation and its influence on the non-receptor tyrosine kinase network response in cultured cerebellar granule neurons.

Ruth Lezama et al.

Journal of neurochemistry, 93(5), 1189-1198 (2005-06-07)

Exposure of cultured cerebellar granule neurons (24 h serum-starved) during 3 min to 30% hyposmotic medium activated the tyrosine kinase receptor ErbB4 in the absence of its ligand. Hyposmolarity also activated the non-receptor tyrosine kinases, Src, focal adhesion kinase (FAK)

1/5