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Pia R Kamstrup et al.
Circulation, 117(2), 176-184 (2007-12-19)
Elevated lipoprotein(a) levels are associated with myocardial infarction (MI) in some but not all studies. Limitations of previous studies include lack of risk estimates for extreme lipoprotein(a) levels, measurements in long-term frozen samples, no correction for regression dilution bias, and
Kelly E Dunn et al.
Pain medicine (Malden, Mass.), 18(8), 1505-1515 (2016-09-22)
More than 100 million adults in the United States experience chronic pain, and prescription opioids are the third most widely prescribed class of medications. Current opioid overdose prevention efforts almost exclusively target illicit opioid users, and little is known about
Steven Orlov et al.
Endocrine, 50(1), 130-137 (2015-03-21)
The purpose of this study was to demonstrate the utility of a personalized risk stratification and radioactive iodine (RAI) selection protocol (PRSP) using post-operative stimulated thyroglobulin (Stim-Tg) and neck ultrasound in low- and intermediate-risk papillary thyroid carcinoma (PTC) patients. Patients
Stéphane F Maison et al.
Journal of neurophysiology, 109(6), 1525-1534 (2013-01-04)
Cholinergic inhibition of cochlear hair cells via olivocochlear (OC)-efferent feedback is mediated by Ca(2+) entry through α9-/α10-nicotinic receptors, but the nature of the K(+) channels activated by this Ca(2+) entry has been debated (Yoshida N, Hequembourg SJ, Atencio CA, Rosowski
Eun-Joon Lee et al.
Nucleic acids research, 39(19), e127-e127 (2011-07-26)
We applied a solution hybrid selection approach to the enrichment of CpG islands (CGIs) and promoter sequences from the human genome for targeted high-throughput bisulfite sequencing. A single lane of Illumina sequences allowed accurate and quantitative analysis of ~1 million
M Denorme et al.
Cancer letters, 352(2), 236-244 (2014-07-13)
Pheochromocytomas and paragangliomas are rare neuroendocrine tumors which develop from chromaffin cells of the adrenal medulla and extra-adrenal sites, leading to excess catecholamine release and hypertension. Many of the tumors are characterized by a high vascularity, suggesting the possible implementation
Carol L Shields et al.
Cornea, 34(1), 42-48 (2014-10-25)
To describe the clinical features, treatment, and outcome of patients with iris metastasis. Retrospective case series of 160 tumors in 107 eyes of 104 patients with iris metastasis from systemic cancer. The median age at presentation with iris metastasis was
Jasper van der Slegt et al.
Journal of vascular surgery, 60(1), 120-128 (2014-03-19)
Long-term results of precuffed expanded polytetrafluoroethylene (ePTFE) grafts used for peripheral bypass surgery are lacking. The aim of this study was to obtain the long-term outcomes of precuffed ePTFE grafts compared with autologous saphenous vein (ASV) grafts used in patients
A Palecanda et al.
The Journal of experimental medicine, 189(9), 1497-1506 (1999-05-04)
Alveolar macrophages (AMs) avidly bind and ingest unopsonized environmental particles and bacteria through scavenger-type receptors (SRs). AMs from mice with a genetic deletion of the major macrophage SR (types AI and AII; SR-/-) showed no decrease in particle binding compared
Chang Hee Jung et al.
Clinical endocrinology, 77(5), 699-706 (2012-01-04)
The ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1) has been reported to be associated with the metabolic syndrome (MetS). However, the optimal cut-off value of apoB/A1 ratio for detecting subjects with MetS has remained undetermined. In the present
T Assi et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 21(9), 1135-1141 (2019-01-19)
Limb-sparing surgery in locally advanced soft tissue sarcomas (LA STS) is challenging. The aim of this study is to evaluate upfront isolated limb perfusion (ILP) in untreated patients with LA STS. All consecutive patients with LA STS of the limbs
Jee Hyun Yi et al.
Brain communications, 2(2), fcaa058-fcaa058 (2020-08-09)
Aggregation of amyloid beta and loss of cholinergic innervation in the brain are predominant components of Alzheimer's disease pathology and likely underlie cognitive impairment. Acetylcholinesterase inhibitors are one of the few treatment options for Alzheimer's disease, where levels of available
Sameer A Ansari et al.
Journal of neurointerventional surgery, 3(4), 324-330 (2011-10-13)
Bioactive polyglycolic/polylactic acid (PGLA)-coated Matrix detachable coils were reported to incite intra-aneurysmal inflammation and fibrosis. Multiple large case series with Matrix-1 coils have shown no advantage with respect to aneurysm recurrence. Second-generation Matrix-2 coils were designed with improved platinum support
Peter A Prieto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(7), 2039-2047 (2012-01-25)
Treatment with ipilimumab can cause objective tumor responses in patients with metastatic melanoma. We have treated 177 evaluable patients in three clinical trials and have long-term follow-up to evaluate the durability of responses. Patients with metastatic melanoma were treated in
Rizwan Manzer et al.
DNA and cell biology, 22(5), 329-338 (2003-08-28)
Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role
Philip F Solter et al.
Veterinary journal (London, England : 1997), 206(2), 213-217 (2015-09-02)
The B-type natriuretic peptide prohormone (proBNP) is enzymatically cleaved into an inactive N-terminal peptide and a biologically active C-terminal peptide with many beneficial cardiorenal effects. The purpose of this study was to develop and test in cats with cardiomyopathy an
J Su et al.
The Journal of biological chemistry, 273(28), 17910-17916 (1998-07-04)
We report here a mouse cDNA that encodes a 316-amino acid short-chain dehydrogenase that prefers NAD+ as its cofactor and recognizes as substrates androgens and retinols, i.e. has steroid 3alpha- and 17beta-dehydrogenase and cis/trans-retinol catalytic activities. This cis-retinol/androgen dehydrogenase type
Altaf Mohammed et al.
Neoplasia (New York, N.Y.), 14(12), 1249-1259 (2013-01-12)
Preclinical studies suggest that diets rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be beneficial for prevention of pancreatic cancer. Nutritional intervention studies are often complex, and there is no clear evidence, without potential confounding factors, on whether conversion
Jingcai Chen et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 83-95 (2004-09-16)
Relaxin-3 has recently been identified as a ligand for two structurally related G-protein-coupled receptors, human GPCR135 and GPCR142. This current study reports the characterization of mouse and rat GPCR135 as well as GPCR142 from mouse, monkey, cow, and pig at
Kai F Loewenbrück et al.
Journal of neurology, 265(1), 165-177 (2017-12-01)
To develop specific diagnostic ultrasound (US) models for hereditary motor and sensory neuropathies (HMSN) in patients with primarily demyelinating or axonal polyneuropathies (PNP) according to standard nerve conduction studies (NCS) criteria. Single-centre, examiner-blinded cross-sectional study in acquired PNP (consecutive recruitment
Mikhail Kosiborod et al.
JAMA, 312(21), 2223-2233 (2014-11-18)
Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine. To evaluate the efficacy and safety
Kun Qian et al.
Public health nutrition, 23(14), 2485-2493 (2020-06-11)
To determine which set of BMI cut-offs is the most appropriate to define child and adolescent obesity in urban China. A cross-sectional study was carried out between 1 November and 31 December in 2017. Community Healthcare Center in Minhang District
Nelson G Ordóñez
The American journal of surgical pathology, 27(8), 1031-1051 (2003-07-29)
A large number of immunohistochemical markers that can facilitate the distinction between epithelioid pleural mesotheliomas and pulmonary peripheral adenocarcinomas have recently become available. The aim of this study is to compare the value of these new markers with others that
M R Roby et al.
Environmental health perspectives, 69, 215-220 (1986-11-01)
The excretion and tissue distribution of [1-14C]dichloroacetonitrile and [2-14C]dichloroacetonitrile were studied in male Fischer 344 rats and male B6C3F1 mice. Three dose levels of dichloroacetonitrile (DCAN) (0.2, 2, or 15 mg/kg) were administered to rats and two dose levels of
Kenneth S Bode et al.
Journal of spinal disorders & techniques, 28(10), E590-E594 (2013-11-20)
Randomized trial. This study described practical magnetic resonance imaging (MRI) characteristics to assist in the identification of these tumors including the corresponding statistics. Identification of vascular spinal tumors using MRI allows the opportunity for angiography and preoperative embolization (PE) to
L W Chen et al.
Neuroscience, 106(1), 149-160 (2001-09-21)
We have examined the distribution of dopamine neurons expressing alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits (glutamate receptors 1, 2/3 and 4) in the A8-A15 regions of the rat brain using double immunofluorescence. The distribution of glutamate receptor 1- or 2/3-like immunoreactive
S A Romanski et al.
Mayo Clinic proceedings, 68(5), 419-426 (1993-05-01)
We compared the sensitivity of aurin tricarboxylic acid (ATA) or acid solochrome azurine (ASA) for detecting bone aluminum histochemically in 87 biopsy specimens obtained between 1983 and 1987 from 84 patients receiving dialysis therapy. Two consecutive biopsy sections were stained
Tarek M Mekhail et al.
Urologic oncology, 21(6), 424-430 (2003-12-25)
Limited information is available on the correlation of telomerase activity and the clinical and pathological characteristics, in patients with renal cell carcinoma (RCC). Telomerase repeat amplification protocol (TRAP) was used to measure telomerase activity in frozen RCC specimens from partial/radical
C G Bien et al.
European journal of neurology, 24(1), 175-186 (2016-10-28)
To clarify the relevance of titres of IgG antibodies against contactin-associated protein-2 (CASPR2) in diagnosing anti-CASPR2 encephalitis and to describe features and outcomes. This was a retrospective analysis of 64 patients with CASPR2 antibodies, categorized independently as 'autoimmune encephalitis' or
M Q McCollum et al.
Journal of animal science, 76(10), 2706-2711 (1998-11-14)
To define the interactions between the absorption of glycyl-L-sarcosine (Gly-Sar; .1 mM) and glycine, L-methionylglycine, glycyl-L-leucine, L-carnosine, or L-methionylglycyl-L-methionyl-L-methionine (each at 5 mM), ovine omasal epithelium was collected from eight wethers (average BW=69+/-8.2 kg) and mounted in parabiotic chambers. [1,2]-[14C]Glycyl-L-sarcosine
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