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Alessandra Luchini et al.
Analytical chemistry, 92(1), 1081-1088 (2019-11-27)
In vitro characterization of membrane proteins requires experimental approaches providing mimics of the microenvironment that proteins encounter in native membranes. In this context, supported lipid bilayers provide a suitable platform to investigate membrane proteins by a broad range of surface-sensitive
Irene S Tobias et al.
The Biochemical journal, 473(4), 509-523 (2015-12-05)
Atypical protein kinase C (aPKC) isoenzymes are key modulators of insulin signalling, and their dysfunction correlates with insulin-resistant states in both mice and humans. Despite the engaged interest in the importance of aPKCs to type 2 diabetes, much less is
Anna Lívia Linard Matos et al.
Cells, 9(5) (2020-05-14)
Annexin A2 (AnxA2) is a cytosolic Ca2+ regulated membrane binding protein that can induce lipid domain formation and plays a role in exocytosis and endocytosis. To better understand the mode of annexin-membrane interaction, we analyzed membrane-bound AnxA2 assemblies by employing
Li-Ping Gao et al.
Biochimica et biophysica acta. General subjects, 1864(1), 129422-129422 (2019-09-07)
Previous studies suggested that fibrillar human IAPP (hIAPP) is more likely to deposit in β-cells, resulting in β-cell injury. However, the changes in the conformation of hIAPP in lipid environment and the mechanism involved in β-cell damage are unclear. Synthetic
Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3, 4, 5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain
Kim E, et al.
Cellular Signalling, 51, 130-138 (2018)
Stefania Zimbone et al.
International journal of molecular sciences, 21(8) (2020-04-25)
Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic diseases, copper homeostasis is altered. Although many details in the pathways involved are still unknown, some copper-specific ligands have
Erick Miranda-Laferte et al.
The Journal of biological chemistry, 289(15), 10387-10398 (2014-02-13)
The β-subunit associates with the α1 pore-forming subunit of high voltage-activated calcium channels and modulates several aspects of ion conduction. Four β-subunits are encoded by four different genes with multiple splice variants. Only two members of this family, β2a and
Kari Kusler et al.
The journal of physical chemistry. B, 120(50), 12883-12889 (2016-12-14)
Phosphatidylserine (PS) has previously been found to bind Cu2+ in a ratio of 1 Cu2+ ion per 2 PS lipids to form a complex with an apparent dissociation constant that can be as low as picomolar. While the affinity of
Jigesh Patel et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183140-183140 (2019-12-04)
There is an on-going debate whether anesthetic drugs, such as isoflurane, can cause meaningful structural changes in cell membranes at clinical concentrations. In this study, the effects of isoflurane on lipid membrane fluidity were investigated using fluorescence anisotropy and spectroscopy.
Hongbing Yao et al.
The Journal of biological chemistry, 283(2), 849-854 (2007-11-16)
Hepatocytes play a crucial role in regulating lipid metabolism by exporting cholesterol and triglyceride into plasma through secretion of very low density lipoproteins (VLDL). VLDL production is also required for release of hepatitis C virus (HCV) from infected hepatocytes. Here
James W P Brown et al.
Nature communications, 10(1), 5662-5662 (2019-12-13)
Single-molecule assays have, by definition, the ultimate sensitivity and represent the next frontier in biological analysis and diagnostics. However, many of these powerful technologies require dedicated laboratories and trained personnel and have therefore remained research tools for specialists. Here, we
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly
Phosphoserine imprinted nanosensor for detection of Cancer Antigen 125
Buyuktiryaki S, et al.
Talanta, 167, 172-180 (2017)
Saba Ghazvini et al.
Langmuir : the ACS journal of surfaces and colloids, 34(3), 1159-1170 (2017-10-12)
Lipid membranes, a major component of cells, are subjected to significant changes in pH depending on their location in the cell: the outer leaflet of the cell membrane is exposed to a pH of 7.4 whereas lipid membranes that make
Stéphanie Jephthah et al.
Biomolecules, 10(4) (2020-04-23)
Magnesium transporter A (MgtA) is an active transporter responsible for importing magnesium ions into the cytoplasm of prokaryotic cells. This study focuses on the peptide corresponding to the intrinsically disordered N-terminal region of MgtA, referred to as KEIF. Primary-structure and
Arnaud Marquette et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183149-183149 (2019-12-10)
Viral protein R (Vpr) is a small accessory protein of 96 amino acids that is present in Human and simian immunodeficiency viruses. Among the very different properties that Vpr possesses we can find cell penetrating capabilities. Based on this and
Jonathan F Tait et al.
Analytical biochemistry, 329(1), 112-119 (2004-05-12)
We developed a method for measuring the binding affinity of annexin V for phospholipid vesicles and cells at very low levels of membrane occupancy. The annexin V-117 mutant was labeled with fluorescein iodoacetamide on its single N-terminal cysteine residue; binding
Sumie Manno et al.
The Journal of biological chemistry, 285(44), 33923-33929 (2010-08-21)
Human erythrocytes are continuously exposed to glucose, which reacts with the amino terminus of the β-chain of hemoglobin (Hb) to form glycated Hb, HbA1c, levels of which increase with the age of the circulating cell. In contrast to extensive insights
Rajan Lamichhane et al.
Structure (London, England : 1993), 28(3), 371-377 (2020-01-25)
G-protein-coupled receptors (GPCRs) mediate a wide range of human physiological functions by transducing extracellular ligand binding events into intracellular responses. GPCRs can activate parallel, independent signaling pathways mediated by G proteins or β-arrestins. Whereas "balanced" agonists activate both pathways equally
Sophia C Goodchild et al.
PloS one, 9(8), e104492-e104492 (2014-08-08)
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β2-microglobulin (β2m), associated with dialysis-related amyloidosis
Renato M S Cardoso et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183157-183157 (2019-12-18)
Association of amphiphiles with biomembranes is important for their availability at specific locations in organisms and cells, being critical for their biological function. A prominent role is usually attributed to the hydrophobic effect, and to electrostatic interactions between charged amphiphiles
Julia Skalska et al.
Nanoscale, 11(48), 23366-23381 (2019-12-04)
One of the most important causes of failure in tumour treatment is the development of resistance to therapy. Cancer cells can develop the ability to lose sensitivity to anti-neoplastic drugs during reciprocal crosstalk between cells and their interaction with the
Fluorophore Labeling, Nanodisc Reconstitution and Single-molecule Observation of a G Protein-coupled Receptor
Lamichhane R, et al.
Bio-protocol, 7(12) (2017)
Carina Drechsler et al.
Biophysical journal, 115(8), 1509-1517 (2018-09-30)
Lipid asymmetries between the outer and inner leaflet of the lipid bilayer exist in nearly all biological membranes. Although living cells spend great effort to adjust and maintain these asymmetries, little is known about the biophysical phenomena within asymmetric membranes
Antti H Rantamäki et al.
Scientific reports, 9(1), 18349-18349 (2019-12-05)
Understanding the toxicity of ionic liquids (ILs) is crucial in the search of greener chemicals. By comparing in vivo toxicity and in vitro interactions determined between compounds and biomimetic lipid membranes, more detailed toxicity vs. structure relation can be obtained.
Adsorption of O-phospho-L-serine and L-serine onto poorly crystalline apatite
Benaziz L, et al.
Journal of Colloid and Interface Science, 238(1), 48-53 (2001)
Guangtao Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(49), 14025-14030 (2016-11-23)
Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid
Jung Ho Lee et al.
Biochemistry, 55(35), 4949-4959 (2016-07-28)
The interaction between α-synuclein (αS) protein and lipid membranes is key to its role in synaptic vesicle homeostasis and plays a role in initiating fibril formation, which is implicated in Parkinson's disease. The natural state of αS inside the cell
Sarah M Fantin et al.
Analytical chemistry, 91(24), 15469-15476 (2019-11-20)
Membrane proteins represent most current therapeutic targets, yet remain understudied due to their insolubility in aqueous solvents and generally low yields during purification and expression. Ion mobility-mass spectrometry and collision induced unfolding experiments have recently garnered attention as methods capable
Wei Zong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes
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