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Samir Olatunji et al.
Nature communications, 11(1), 140-140 (2020-01-11)
Antimicrobial resistance is a major global threat that calls for new antibiotics. Globomycin and myxovirescin are two natural antibiotics that target the lipoprotein-processing enzyme, LspA, thereby compromising the integrity of the bacterial cell envelope. As part of a project aimed
Sandeep Kumar et al.
The journal of physical chemistry. B, 122(26), 6763-6770 (2018-06-08)
The interaction of amphiphilic ionic liquids containing an 1-alkyl-3-methylimidazolium cation ([C12MIM]+), which shows acute cytotoxicity toward marine and bacterial life, with zwitterionic 1-palmitoyl-2-oleoyl- sn-glycero-3-phospho-choline (POPC) and anionic 1-palmitoyl-2-oleoyl- sn-glycero-3-phospho- rac-glycerol (POPG) membranes was investigated. Biophysical parameters of this interaction were
Aishwarya Agarwal et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(2), 140324-140324 (2019-11-20)
Excitation energy migration via homo-Förster resonance energy transfer (homo-FRET) can serve as an intermolecular proximity ruler within complex biomolecular assemblies. Here we present a unique case to demonstrate that energy migration can be a novel and sensitive readout to capture
Fozia Saleem et al.
Prion, 8(2) (2014-05-14)
The conformational conversion of the cellular prion protein (PrP(C)) to the β-rich infectious isoform PrP(Sc) is considered a critical and central feature in prion pathology. Although PrP(Sc) is the critical component of the infectious agent, as proposed in the "protein-only"
Thais A Enoki et al.
Langmuir : the ACS journal of surfaces and colloids, 34(5), 2014-2025 (2017-12-29)
Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine
Anastasiia A Zakharova et al.
Scientific reports, 9(1), 16034-16034 (2019-11-07)
The one-sided addition of fengycin (FE) to planar lipid bilayers mimicking target fungal cell membranes up to 0.1 to 0.5 μM in the membrane bathing solution leads to the formation of well-defined and well-reproducible single-ion channels of various conductances in the
Tânia Silva et al.
Langmuir : the ACS journal of surfaces and colloids, 34(5), 2158-2170 (2018-01-07)
An understanding of the mechanism of action of antimicrobial peptides is fundamental to the development of new and more active antibiotics. In the present work, we use a wide range of techniques (SANS, SAXD, DSC, ITC, CD, and confocal and
Sungsoo Lee et al.
Journal of visualized experiments : JoVE, (77), e50436-e50436 (2013-07-31)
To study the lipid-protein interaction in a reductionistic fashion, it is necessary to incorporate the membrane proteins into membranes of well-defined lipid composition. We are studying the lipid-dependent gating effects in a prototype voltage-gated potassium (Kv) channel, and have worked
Lipids
Medical Biochemistry, 99-119 (2017)
Bishoy Khairalla et al.
Bioelectrochemistry (Amsterdam, Netherlands), 132, 107443-107443 (2019-12-24)
Planar asymmetric lipid bilayers composed of phosphatidylethanolamine and phosphatidylglycerol lipids are transferred onto a gold electrode surface. Lipids containing two saturated, one monounsaturated and two monounsaturated hydrocarbon chains compose the model membranes. Results of electrochemically controlled polarization modulation infrared reflection
Nareh Movsesian et al.
Langmuir : the ACS journal of surfaces and colloids, 34(30), 9025-9035 (2018-07-03)
In this study, we prepare giant lipid vesicles using vapor-deposited charged microporous poly(methacrylic acid- co-ethylene glycol diacrylate) polymer membranes with different morphologies and thicknesses. Our results suggest that vesicle formation is favored by thinner, more structured porous hydrogel substrates. Electrostatic
Wenting Wang et al.
The journal of physical chemistry. B, 124(25), 5169-5176 (2020-05-27)
Membrane fusion of the viral and host cell membranes is the initial step of virus infection and is catalyzed by fusion peptides. Although the β-sheet structure of fusion peptides has been proposed to be the most important fusion-active conformation, it
William A Johnson et al.
Photosynthesis research (2019-12-16)
The heliobacterial reaction center (HbRC) is the simplest known photochemical reaction center, in terms of its polypeptide composition. In the heliobacterial cells, its electron donor is a cytochrome (cyt) c553 attached to the membrane via a covalent linkage with a
A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action.
Alexander Komin et al.
Journal of controlled release : official journal of the Controlled Release Society, 324, 633-643 (2020-06-01)
The rate of transport of small molecule drugs across biological barriers, such as the blood-brain barrier, is often a limiting factor in achieving a therapeutic dose. One proposed strategy to enhance delivery across endothelial or epithelial monolayers is conjugation to
Hannah Cetuk et al.
Langmuir : the ACS journal of surfaces and colloids, 36(18), 5065-5077 (2020-04-21)
Piscidins 1 and 3 (P1 and P3) are potent antimicrobial peptides isolated from striped bass. Their mechanism of action involves formation of amphipathic α-helices on contact with phospholipids and destabilization of the microbial cytoplasmic membrane. The peptides are active against
Hui Su et al.
ACS applied materials & interfaces, 11(47), 43799-43810 (2019-10-30)
Membrane biosensors that can rapidly sense pathogen interaction and disrupting agents are needed to identify and screen new drugs to combat antibiotic resistance. Bioelectronic devices have the capability to read out both ionic and electrical signals, but their compatibility with
Mechanism of four de novo designed antimicrobial peptides
Murray B, et al.
Test, 291(49), 25706- 25715 (2016)
Gopal Pandit et al.
Biochimica et biophysica acta. Biomembranes, 1862(4), 183177-183177 (2020-01-19)
The widespread abuse of antibiotics has led to the use of antimicrobial peptides (AMPs) as a replacement for the existing conventional therapeutic agents for combating microbial infections. The broad-spectrum activity and the resilient nature of AMPs has mainly aggrandized their
Wenbo Cao et al.
Analytical chemistry, 90(17), 10286-10292 (2018-08-11)
The presence of carbon-carbon double bonds (C═Cs) in unsaturated phospholipids is closely related to lipid conformations and physiochemical activities. Previously, we have demonstrated that epoxidation reaction facilitated by low-temperature plasma (LTP) enabled the structural analysis of unsaturated fatty acids (FAs).
Ersoy Cholak et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7462-7482 (2020-04-12)
In the brain, α-synuclein (aSN) partitions between free unbound cytosolic and membrane bound forms modulating both its physiological and pathological role and complicating its study due to structural heterogeneity. Here, we use an interdisciplinary, synergistic approach to characterize the properties
Cristina Manatschal et al.
eLife, 8 (2019-12-06)
In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition could be beneficial for the treatment of iron overload disorders. Here we characterize the interaction of aromatic
Bharat Reddy et al.
eLife, 8 (2019-12-28)
Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the membrane. As such, lipid-protein interactions represent the defining molecular process underlying mechanotransduction. Here, we describe cryo-electron microscopy (cryo-EM) structures of the E. coli small-conductance mechanosensitive channel (MscS) in
Membrane Structure and Dynamics
Cell Biology, 227-239 (2017)
Lydie Vamparys et al.
Biophysical journal, 104(3), 585-593 (2013-02-28)
In biological membranes, changes in lipid composition or mechanical deformations produce defects in the geometrical arrangement of lipids, thus allowing the adsorption of certain peripheral proteins. Here, we perform molecular dynamics simulations on bilayers containing a cylindrical lipid (PC) and
Sarah M Fantin et al.
Analytical chemistry, 91(24), 15469-15476 (2019-11-20)
Membrane proteins represent most current therapeutic targets, yet remain understudied due to their insolubility in aqueous solvents and generally low yields during purification and expression. Ion mobility-mass spectrometry and collision induced unfolding experiments have recently garnered attention as methods capable
Ming Li et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183315-183315 (2020-04-19)
The spontaneously formed structures of physiologically relevant lipid model membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) and 1,2-hexanoyl-sn-glycero-3-phosphocholine have been evaluated in depth using small angle neutron scattering. Although a common molar ratio of long- to short- chain phospholipids (~4) as reported
Brandt Bertrand et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183105-183105 (2019-11-05)
The aim of this study was to investigate the factors that govern the activity and selectivity of two potent antimicrobial peptides (AMPs) using lipid membrane models of bacterial, erythrocyte and fungal cells. These models were used in calcein liposome leakage
Taiji Okano et al.
ACS synthetic biology, 7(2), 739-747 (2018-02-01)
The shapes of giant unilamellar vesicles (GUVs) enclosing polymer molecules at relatively high concentration, used as a model cytoplasm, significantly differ from those containing only small molecules. Here, we investigated the effects of the molecular weights and concentrations of polymers
Salma Al-Adwani et al.
Scientific reports, 10(1), 2376-2376 (2020-02-13)
Arginine residues of the antimicrobial peptide LL-37 can be citrullinated by peptidyl arginine deiminases, which reduce the positive charge of the peptide. Notably, citrullinated LL-37 has not yet been detected in human samples. In addition, functional and biophysical properties of
Matteo Runfola et al.
Scientific reports, 10(1), 204-204 (2020-01-16)
The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Emerging evidence indicates that the
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