850150P

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Fission of SNX-BAR-coated endosomal retrograde transport carriers is promoted by the dynamin-related protein Vps1.

Richard J Chi et al.

The Journal of cell biology, 204(5), 793-806 (2014-02-26)

Retromer is an endosomal sorting device that orchestrates capture and packaging of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs). We report that fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1, a

NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer.

Mariko Yokogawa et al.

The Journal of biological chemistry, 287(42), 34936-34945 (2012-08-24)

Phosphoinositides (PIs) are crucial lipid components of membranes and are involved in a number of cellular processes through interactions with their effector proteins. Recently, we have established a lipid-protein nanoscale bilayer (nanodisc) containing PIs, hereafter referred to as PI-nanodisc and

Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods.

Ricarda A Busse et al.

Autophagy, 9(5), 770-777 (2013-03-01)

We characterized phosphoinositide binding of the S. cerevisiae PROPPIN Hsv2 qualitatively with density flotation assays and quantitatively through isothermal titration calorimetry (ITC) measurements using liposomes. We discuss the design of these experiments and show with liposome flotation assays that Hsv2

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.

Lee Dolat et al.

The Journal of cell biology, 214(5), 517-527 (2016-08-24)

Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular underpinnings of this

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

Etienne Morel et al.

Nature communications, 4, 2250-2250 (2013-08-03)

Defects in endosomal sorting have been implicated in Alzheimer's disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that phosphatidylinositol-3-phosphate is selectively deficient in brain tissue from humans with Alzheimer's

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

Dolat L and Spiliotis ET

The Journal of Cell Biology, 214(5), 517-527 (2016)

Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods

Busse RA, et al.

Autophagy, 9(5), 770-777 (2013)

PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity.

Gerald R V Hammond et al.

Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)

The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

Mechanism of cargo-directed Atg8 conjugation during selective autophagy.

Dorotea Fracchiolla et al.

eLife, 5 (2016-11-24)

Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the

Phosphatidylinositol phosphate, phosphatidylinositol bisphosphate, and the phosphoinositol sphingolipids are found in the plasma membrane and stimulate the plasma membrane H+-ATPase of Saccharomyces cerevisiae

Patton JL and Lester RL

Archives of Biochemistry and Biophysics, 292(1), 70-76 (1992)

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