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Penghsuan Huang et al.
Analytical chemistry, 92(10), 7139-7145 (2020-04-22)
A series of novel anthranilic acid derivatives I-IV, of which COOH-NH2 (I) and COOH-NHMe (IV) are endowed with acid and base bifunctionality, were designed and synthesized for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications in dual polarity molecular imaging
Nishu Kanwa et al.
Physical chemistry chemical physics : PCCP, 22(6), 3234-3244 (2020-01-30)
In the present contribution, we investigate the interactions of lipid bilayer membranes of different charges and different phase states with aliphatic amino acids of varying charge (aspartic acid, glutamic acid, arginine and lysine) and hydrophobicity (serine, leucine and valine) by
Ling Han et al.
Analytical chemistry, 89(17), 9330-9338 (2017-08-03)
This work describes a versatile analytical approach, which combines the proxy ligand electrospray ionization mass spectrometry (ESI-MS) assay and model membranes of defined composition, to quantify the influence of lipid bilayer composition on protein-glycolipid binding in vitro. To illustrate the
Lydie Vamparys et al.
Biophysical journal, 104(3), 585-593 (2013-02-28)
In biological membranes, changes in lipid composition or mechanical deformations produce defects in the geometrical arrangement of lipids, thus allowing the adsorption of certain peripheral proteins. Here, we perform molecular dynamics simulations on bilayers containing a cylindrical lipid (PC) and
Lipid binding by disordered proteins
Perez Y, et al.
Protocol Exchange, 10 (2013)
Karuppasamy Dharmaraj et al.
European biophysics journal : EBJ, 49(3-4), 279-288 (2020-05-07)
The acid-base and redox properties of the menaquinones MK-4, MK-7, and MK-9 (vitamin K2) have been studied in DMPC monolayers on mercury electrodes. The monolayers were prepared by adhesion-spreading of menaquinone-spiked DMPC liposomes on a stationary mercury drop electrode. All
Giovanna D'Angelo et al.
The journal of physical chemistry. B, 121(6), 1204-1210 (2017-01-25)
Fast thermal fluctuations and low frequency phonon modes are thought to play a part in the dynamic mechanisms of many important biological functions in cell membranes. Here we report a detailed far-infrared study of the molecular subpicosecond motions of phospholipid
Graham J Taylor et al.
Langmuir : the ACS journal of surfaces and colloids, 33(38), 10016-10026 (2017-08-16)
In-plane lipid organization and phase separation in natural membranes play key roles in regulating many cellular processes. Highly cooperative, first-order phase transitions in model membranes consisting of few lipid components are well understood and readily detectable via calorimetry, densitometry, and
Arpita Roy et al.
Langmuir : the ACS journal of surfaces and colloids, 32(20), 5124-5134 (2016-05-03)
It is well-known that sugars protect membrane structures against fusion and leakage. Here, we have investigated the interaction between different sugars (sucrose, trehalose, and maltose) and phospholipid membrane of 1,2-dimyristoyl-sn-glycero-3-phoshpocholine (DMPC) using dynamic light scattering (DLS), transmission electron microscopy (TEM)
Sarah Waldie et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 472-479 (2017-12-13)
Cholesterol is an essential component of mammalian membranes and is known to induce a series of physicochemical changes in the lipid bilayer. Such changes include the formation of liquid-ordered phases with an increased thickness and a configurational order as compared
Lukas Frey et al.
Journal of the American Chemical Society, 140(45), 15402-15411 (2018-10-06)
Membrane protein function fundamentally depends on lipid-bilayer fluidity and the composition of the biological membrane. Although dynamic interdependencies between membrane proteins and the surrounding lipids are suspected, a detailed description is still missing. To uncover lipid-modulated membrane protein backbone dynamics
Lipid binding by disordered proteins
Perez Y, et al.
Protocol Exchange, 10 (2013)
Stephen M Baumler et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 2986-2992 (2017-03-08)
The translational diffusion dynamics of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) at a planar phosphorylated support surface containing metal ions (Mg2+, Ca2+, Ba2+, Ni2+, Zn2+, Cd2+, Zr4+) was investigated using X-ray photoelectron spectroscopy (XPS) and fluorescence recovery after photobleaching (FRAP). Fluorescence
Benjamin R Coyac et al.
Journal of periodontology (2020-04-13)
Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional
Maryam T Hussain et al.
International journal of pharmaceutics, 573, 118722-118722 (2019-11-11)
Technology such as the use of microfluidics to generate liposomes has been well researched, yet the stabilisation of liposomal formulations is a major challenge to their greater implementation. To the best of our knowledge, this is the first study investigating
Nabanita Das et al.
Nature protocols, 8(11), 2256-2270 (2013-10-26)
Solid-state NMR spectroscopy has been used successfully for characterizing the structure and dynamics of membrane proteins as well as their interactions with other proteins in lipid bilayers. Such an environment is often necessary for achieving native-like structures. Sample preparation is
Keitaro Sou et al.
Scientific reports, 9(1), 17991-17991 (2019-12-01)
Thermosensitive fluorescent dyes can convert thermal signals into optical signals as a molecular nanoprobe. These nanoprobes are playing an increasingly important part in optical temperature sensing and imaging at the nano- and microscale. However, the ability of a fluorescent dye
Erik F Kot et al.
Langmuir : the ACS journal of surfaces and colloids, 34(11), 3426-3437 (2018-02-28)
Isotropic phospholipid bicelles are one of the most prospective membrane mimetics for the structural studies of membrane proteins in solution. Recent works provided an almost full set of data regarding the properties of isotropic bicelles; however, one major aspect of
Nidal Muhanna et al.
Endocrine-related cancer, 27(2), 41-53 (2019-11-22)
The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is the primary treatment for thyroid cancer and is highly effective, resulting in 5-year survival rates greater than 98%. However, surgical resection can result
Tomoya Taniguchi et al.
Biotechnology and bioengineering, 117(8), 2469-2478 (2020-05-13)
To facilitate the early diagnosis of Alzheimer's disease and mild cognitive impairment patients, we developed a cantilever-based microsensor that immobilized liposomes of various phospholipids to detect a trace amount of amyloid β (Aβ) protein, and investigated its aggregation and fibrillization
Bruna Neves et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-07)
Nitrated phospholipids have recently been detected in vitro and in vivo and associated with beneficial health effects. They were identified and quantified in biological samples by lipidomics methodologies using liquid chromatography-collision-induced dissociation (CID) tandem mass spectrometry (MS/MS) acquired with the
Sofia Movérare-Skrtic et al.
Nature medicine, 20(11), 1279-1288 (2014-10-13)
The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a
DeeAnn K Asamoto et al.
Biophysical journal, 118(2), 403-414 (2019-12-18)
Nanodiscs (NDs) are an excellent alternative to small unilamellar vesicles (SUVs) for studies of membrane protein structure, but it has not yet been shown that membrane proteins are able to spontaneously fold and insert into a solution of freely diffusing
Philippe Calvez et al.
Journal of the American Chemical Society (2016-10-01)
Recoverin undergoes a calcium-myristoyl switch during visual phototransduction. Indeed, calcium binding by recoverin results in the extrusion of its myristoyl group, which allows its membrane binding. However, the contribution of particular lipids and of specific amino acids of recoverin in
Quantitative assays for esterified oxylipins generated by immune cells.
Morgan AH, et al.
Nature Protocols, 5(12), 1919-1931 (2010)
Dominique Mias-Lucquin et al.
Journal of structural biology, 209(1), 107411-107411 (2019-11-07)
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder
Anik Forest et al.
Journal of proteome research, 17(11), 3657-3670 (2018-09-27)
The goal of this work was to develop a label-free, comprehensive, and reproducible high-resolution liquid chromatography-mass spectrometry (LC-MS)-based untargeted lipidomic workflow using a single instrument, which could be applied to biomarker discovery in both basic and clinical studies. For this
Rosana Ribić et al.
The journal of physical chemistry. B, 124(20), 4132-4145 (2020-04-15)
We present an in-depth investigation of the membrane interactions of peptidoglycan (PGN)-based immune adjuvants designed for lipid-based delivery systems using NMR spectroscopy. The derivatives contain a cargo peptidoglycan (PGN) dipeptide fragment and an adamantyl group, which serves as an anchor
Gregory Brubaker et al.
PloS one, 15(1), e0221915-e0221915 (2020-01-17)
The crystal structure of a C-terminal deletion of apolipoprotein A-I (apoA1) shows a large helical bundle structure in the amino half of the protein, from residues 8 to 115. Using site directed mutagenesis, guanidine or thermal denaturation, cell free liposome
Integrative Medicine - E-Book (2017)
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