搜索范围
850355P
应用筛选条件
关键词:'850355P'
显示 1-30 #N/A 168 条结果 关于 "850355P" 范围 论文
Qi Gao et al.
Biochemistry, 59(8), 992-998 (2020-01-10)
The misfolding of amyloid beta (Aβ) is one of the predominant hallmarks in the pathology of Alzheimer's disease (AD). In this study, we showed that the formation of the Aβ ion channel on the membrane depended on the cholesterol concentration.
Benjamin Martial et al.
The journal of physical chemistry. B, 124(17), 3469-3481 (2020-04-02)
α-Synuclein (AS), the protein responsible for Parkinson's disease, contains a 12-residue-long sequence, AS71-82, that is thought to play a crucial role in the α-synuclein aggregation process. Neuronal membranes are direct interacting partners of α-synuclein and play a role in fibrillogenesis
Lu Xu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(29), 8694-8700 (2018-07-04)
The polymorphism of phospholipid monolayers has been extensively studied because of its importance in surface thermodynamics, soft matter physics, and biomembranes. To date, the phase behavior of phospholipid monolayers has been nearly exclusively studied with the classical Langmuir-type film balance.
Wei-Lin Wan et al.
Nature communications, 11(1), 534-534 (2020-01-29)
A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold
Chun Liufu et al.
International journal of nanomedicine, 14, 8923-8941 (2019-12-10)
Cancer stem cells (CSCs) are responsible for cancer therapeutic resistance and metastasis. To date, in addition to surgery, chemotherapy, and radiotherapy, gene delivery has emerged as a potential therapeutic modality for ovarian cancer. Efficient and safe targeted gene delivery is
Nishu Kanwa et al.
Physical chemistry chemical physics : PCCP, 22(6), 3234-3244 (2020-01-30)
In the present contribution, we investigate the interactions of lipid bilayer membranes of different charges and different phase states with aliphatic amino acids of varying charge (aspartic acid, glutamic acid, arginine and lysine) and hydrophobicity (serine, leucine and valine) by
Graham J Taylor et al.
Langmuir : the ACS journal of surfaces and colloids, 33(38), 10016-10026 (2017-08-16)
In-plane lipid organization and phase separation in natural membranes play key roles in regulating many cellular processes. Highly cooperative, first-order phase transitions in model membranes consisting of few lipid components are well understood and readily detectable via calorimetry, densitometry, and
Kevin H Kang et al.
The European physical journal. E, Soft matter, 43(2), 8-8 (2020-02-06)
Environmental temperature has a well-conserved effect on the pulse velocity and excitability of excitable biological systems. The consistency suggests that the cause originates from a fundamental principle. A physical (hydrodynamic) approach has proposed that the thermodynamic state of the hydrated
Javier Hernández-Gil et al.
Chemical science, 10(21), 5603-5615 (2019-07-12)
Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability
Mahsa Moradipour et al.
Colloids and surfaces. B, Biointerfaces, 191, 111028-111028 (2020-04-20)
The potential to impart surfaces with specific lignin-like properties (i.e. resistance to microbes) remains relatively unexplored due to the lack of well-defined lignin-derived small molecules and corresponding surface functionalization strategies. Here, allyl-modified guaiacyl β-O-4 eugenol (G-eug) lignin-derived dimer is synthesized
Xiaowen Zhong et al.
Nanoscale research letters, 14(1), 381-381 (2019-12-18)
High-intensity focused ultrasound (HIFU) is a representative non-invasive method of cancer therapy, but its low therapeutic efficacy and risk of damage to surrounding normal tissue hinder its further clinical development and application. Sonodynamic therapy (SDT) kills tumor cells through reactive
Ling Han et al.
Analytical chemistry, 89(17), 9330-9338 (2017-08-03)
This work describes a versatile analytical approach, which combines the proxy ligand electrospray ionization mass spectrometry (ESI-MS) assay and model membranes of defined composition, to quantify the influence of lipid bilayer composition on protein-glycolipid binding in vitro. To illustrate the
O Yu Selyutina et al.
Archives of biochemistry and biophysics, 686, 108368-108368 (2020-04-22)
Phospholipid bilayer constitutes the basis of the cell membrane. Any changes in its structure and dynamics could significantly affect the properties and functions of the cell membrane and associated proteins. It could, in its turn, affect the mechanism and strength
Yixing Chen et al.
Langmuir : the ACS journal of surfaces and colloids, 34(3), 1042-1050 (2017-10-12)
The molecular structure of zwitterionic and charged monolayers on small oil droplets in aqueous solutions is determined using a combined second harmonic and sum frequency study. From the interfacial vibrational signature of the acyl chains and phosphate headgroups as well
Sen Ye et al.
Journal of materials chemistry. B, 8(3), 447-453 (2019-12-14)
Thrombotic disease is a serious threat to human health. The rapid and accurate detection of thrombosis is still a clinical challenge. To achieve the accurate diagnosis of thrombosis with magnetic resonance imaging (MRI), nanomaterials-based contrast agents have been developed in
Zachary I Imam et al.
Langmuir : the ACS journal of surfaces and colloids, 35(49), 16281-16289 (2019-11-16)
Cytoskeletal filaments and motor proteins are critical components in the transport and reorganization of membrane-based organelles in eukaryotic cells. Previous studies have recapitulated the microtubule-kinesin transport system in vitro to dynamically assemble large-scale nanotube networks from multilamellar liposomes and polymersomes.
A review on phospholipids and their main applications in drug delivery systems
Li J, et al.
Asian Journal of Pharmaceutical Sciences , 10(2), 81-98 (2015)
Tomoya Taniguchi et al.
Biotechnology and bioengineering, 117(8), 2469-2478 (2020-05-13)
To facilitate the early diagnosis of Alzheimer's disease and mild cognitive impairment patients, we developed a cantilever-based microsensor that immobilized liposomes of various phospholipids to detect a trace amount of amyloid β (Aβ) protein, and investigated its aggregation and fibrillization
Mudassar Mumtaz Virk et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 395-405 (2017-12-13)
Hybrid vesicles, comprising blends of amphiphilic block copolymers and phospholipids, have attracted significant attention recently because of their unique combination of chemical and physical properties. We report a method to make unilamellar hybrid vesicles with diameters of 100 nm by
Uyen P N Dao et al.
Pharmaceutical research, 37(3), 53-53 (2020-02-12)
The purpose of this study was to inspect the interactions between an anti-breast cancer, TAM, with model of lipid membranes composed of either zwitterionic DPPC LUVs or anionic DPPG LUVs and how they depend on ionic strength and cholesterol. The
Milan Gautam et al.
Expert opinion on drug delivery, 17(3), 423-434 (2020-02-08)
Background: Phytosterols significantly reduce the risk of cancer by directly inhibiting tumor growth, inducing apoptosis, and inhibiting tumor metastasis. Stigmasterol (STS), a phytosterol, exhibits anticancer effects against various cancers, including breast cancer. Chemotherapeutics, including doxorubicin (DOX), might act synergistically with
Petteri Parkkila et al.
Langmuir : the ACS journal of surfaces and colloids, 34(27), 8081-8091 (2018-06-13)
Supported lipid bilayers (SLBs) have been used extensively as an effective model of biological membranes, in the context of in vitro biophysics research, and the membranes of liposomes, in the context of the development of nanoscale drug delivery devices. Despite
Lu Lai et al.
Langmuir : the ACS journal of surfaces and colloids, 33(9), 2378-2386 (2017-02-10)
The inhibitory effects of CdTe/ZnS quantum dots (QDs) modified with 3-mercaptopropionic acid (negatively charged) or cysteamine (positively charged) on the metabolic activity of Escherichia coli were investigated using biological microcalorimetry. Results show that the inhibitory ratio of positive QDs is
Laura Farkuh et al.
Heliyon, 5(10), e02648-e02648 (2019-11-14)
Lauric acid (LAH) strongly inhibits the growth of acne-causing bacteria. LAH is essentially water-insoluble and the solubility of laurate (LA) salts are medium and temperature dependent. Hence, LAH/LA preparations are difficult to formulate. Here we fully characterized phospholipid vesicles containing
Alessio Ausili et al.
Langmuir : the ACS journal of surfaces and colloids, 34(10), 3336-3348 (2018-02-16)
α-Tocopherol is considered to carry on a very important role as an antioxidant for membranes and lipoproteins and other biological roles as membrane stabilizers and bioactive lipids. Given its essential role, it is very important to fully understand its location
A A Anosov et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183147-183147 (2019-12-10)
Most researchers associate the increase in the permeability of lipid bilayers of artificial and biological membranes observed in various experiments with the formation of hypothetical hydrophobic and hydrophilic pores. Although the existence of hydrophobic defects, as the first stage of
Liposomal thymoquinone effectively combats fluconazole-resistant Candida albicans in a murine model.
Masood Alam Khan et al.
International journal of biological macromolecules, 76, 203-208 (2015-02-25)
The aim of the present study was to develop a novel liposomal formulation of thymoquinone (TQ) to treat fluconazole-susceptible and -resistant Candida albicans (C. albicans) infections. The liposomal preparation of TQ (Lip-TQ) was used against a fluconazole-susceptible or -resistant isolate
Salomé Mielke et al.
Langmuir : the ACS journal of surfaces and colloids, 36(3), 781-788 (2020-01-07)
Semifluorinated alkanes self-assemble into 30-40 nm-large surface domains (hemimicelles) at the air/water interface. They have been drawing increasing attention to stabilize microbubbles coated with lipids, which are used for enhancing the contrast in sonographic imaging. Although previous studies suggested that
Xiuru Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(22), 6628-6635 (2018-05-10)
A hallmark of nanoscience is size-dependent and distance-dependent physical properties. Although most previous studies focused on optical properties, which are often tuned at nanometer scale, we herein report on the interaction between halide-capped gold nanoparticles (AuNPs) and phosphocholine (PC) liposomes
Erik F Kot et al.
Langmuir : the ACS journal of surfaces and colloids, 34(11), 3426-3437 (2018-02-28)
Isotropic phospholipid bicelles are one of the most prospective membrane mimetics for the structural studies of membrane proteins in solution. Recent works provided an almost full set of data regarding the properties of isotropic bicelles; however, one major aspect of
1/6