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关键词:'856568'
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Amrit Paudel et al.
Journal of pharmaceutical sciences, 102(4), 1249-1267 (2013-01-30)
The present study investigates the effect of changing spray drying temperature (40°C-120°C) and/or atomizing airflow rate (AR; 5-15 L/min) on the phase structure, physical stability, and performance of spray-dried naproxen-polyvinylpyrrolidone (PVP) K 25 amorphous solid dispersions. The modulated differential scanning
Markéta Julinová et al.
Water environment research : a research publication of the Water Environment Federation, 84(12), 2123-2132 (2013-01-25)
Polyvinylpyrrolidone (PVP) is a frequently used polymer in the pharmaceutical and foodstuff industries. Because it is not subject to metabolic changes and is virtually nondegradable, trace concentrations of PVP are often found in community wastewaters. The literature finds that the
Nicole M Sanders et al.
American journal of physiology. Endocrinology and metabolism, 294(5), E853-E860 (2008-03-13)
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate hypoglycemia. We hypothesized that SSRIs might increase the risk of hypoglycemia by
Seungyong Han et al.
Advanced materials (Deerfield Beach, Fla.), 28(46), 10257-10265 (2016-10-08)
Mechanically reinforced skin-electronics are presented by exploiting networked nanocomposite elastomers where high quality metal nanowires serve as conducting paths. Theoretical and experimental studies show that the established skin-electronics exhibit superior mechanical enhancements against crack and delamination phenomena. Device applications include
Synthesis and optical properties of cubic gold nanoframes
Au L, et al.
Nano Research, 1(6), 441-449 (2008)
S R Santosh Kumar et al.
Indian journal of experimental biology, 50(12), 910-917 (2013-08-31)
An in vitro regeneration protocol has been standardized via direct and indirect methods from excised root explants of C. bonduc, a threatened woody legume used for the treatment of contagious diseases, inflammation, leprosy, antiperiodic, febrifuge, anthelmenthic, urinary disorders, leucorrhoea, piles
Lauretta Maggi et al.
International journal of pharmaceutics, 454(1), 568-572 (2013-07-23)
Nateglinide is an oral antidiabetic agent that should be administered 10-30 min before the meal, but it shows low and pH-dependent solubility that may reduce its oral bioavailability. To improve nateglinide dissolution rate, the active was co-milled with three different
Qunyou Tan et al.
Drug development and industrial pharmacy, 39(9), 1364-1371 (2012-09-22)
The purpose of this study was to evaluate the taste masking potential of novel solid dispersions (SDs) using Eudragit® EPO as the excipient when incorporated into the orally disintegrating tablets (ODTs) for delivering a highly soluble drug with an extremely
Seung-min Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(37), 15549-15554 (2009-09-01)
Nanofluidics represents a promising solution to problems in fields ranging from biomolecular analysis to optical property tuning. Recently a number of simple nanofluidic fabrication techniques have been introduced that exploit the deformability of elastomeric materials like polydimethylsiloxane (PDMS). These techniques
K Yamashita et al.
Die Pharmazie, 68(1), 54-57 (2013-03-01)
The fullerene C60 is used in consumer products such as cosmetics owing to its antioxidative effects and is being developed for nanomedical applications. However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here, we examined
Vassiliki A Kosma et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2175-2191 (2013-03-19)
Solution growth of apatite its precursors in the presence of urea commercial gelatin is found to lead, under appropriate conditions, to a rich spectrum of morphologies, among them high aspect ratio needles in uniform sturdy spherulitic assemblies resulting from a
Iu P Mukha et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 215-223 (2013-06-26)
Conditions for obtaining stable silver nanoparticles smaller than 10 nm were developed using a binary stabilizer polyvinylpyrrolidone/sodium dodecylsulphate in optimal ratio. Optical spectra, morphology and dependence of size of the nanoparticles on the amount of reducing agent were studied. Colloidal
Y Barak et al.
Human fertility (Cambridge, England), 4(2), 99-103 (2001-10-10)
The technique of intracytoplasmic sperm injection (ICSI) requires mechanical immobilization of the sperm that are to be injected; damage thus caused to the sperm membrane is considered to be necessary to activate the sperm for fertilization. Mechanical immobilization and the
Eduardo Caldelas Cuéllar et al.
Acta ortopedica mexicana, 21(5), 234-238 (2007-12-28)
The jumper's knee or patellar tendonitis is a common injury in the athlete with an incidence between 14% and 16% among high-performance athletes. In addition to an overuse injury, there are some intrinsic factors for its development. Conservative treatment is
X C Qin et al.
Journal of photochemistry and photobiology. B, Biology, 120, 156-162 (2013-01-30)
Nanographene oxide (NGO), a new type of nanomaterial for anticancer drugs delivery and near-infrared (NIR)-mediated photothermal ablation of tumors, has been used in the combination of photothermal therapy and chemotherapy. Herein, targeted chemo-photothermal therapy based on polyvinylpyrrolidone (PVP) functionalized NGO
Yujie Xiong et al.
Journal of the American Chemical Society, 127(48), 17118-17127 (2005-12-01)
The rapid reduction of Na(2)PdCl(4) by ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP) has recently been demonstrated as a convenient method of generating Pd cubooctahedra and twinned nanoparticles. Here we describe a new procedure where Pd triangular or
Rapid synthesis of small silver nanocubes by mediating polyol reduction with a trace amount of sodium sulfide or sodium hydrosulfide.
Siekkinen AR, et al.
Chemical Physics Letters, 432(4-6), 491- 496 null
Aaron R Jex et al.
Journal of clinical microbiology, 46(7), 2252-2262 (2008-05-02)
In the present study, we analyzed genetic variation in Cryptosporidium species from humans (n = 62) with clinical cryptosporidiosis in South Australia. Sequence variation was assessed in regions within the small subunit of nuclear rRNA (p-SSU), the 70-kDa heat shock
Morphological Evolution of Single-Crystal Ag Nanospheres During the Galvanic Replacement Reaction with HAuCl4
Kim MH, et al.
The Journal of Physical Chemistry C, 112(21), 78772-77876 (2008)
Robinson BV, et al. et al.
PVP: A critical review of the kinetics and toxicology of polyvinlypyrrolidone (Povidone) (1990)
Yu-Tsai Yang et al.
Pharmaceutical development and technology, 19(7), 806-812 (2013-09-21)
The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit® RL PO and α-tocopherol. D-optimal mixture
Martin Kuentz et al.
Drug development and industrial pharmacy, 39(9), 1476-1483 (2012-10-10)
An automated version of uniaxial powder flow testing has recently been developed and there is a need for experimental data from pharmaceutical powders. To compare the novel testing method with an annular shear cell using different pharmaceutical excipients. A particular
Sung Neung Lee et al.
Archives of pharmacal research, 36(1), 79-85 (2013-01-19)
A novel surface-attached, spray-dried solid dispersion containing poorly water-soluble carvedilol (CV) without any change in the crystallinity was prepared using water, polyvinylpyrrolidone (PVP K30) and Tween 80. The solid dispersion was optimized by investigating the effects of the weight ratios
Norman Chieng et al.
International journal of pharmaceutics, 454(1), 167-173 (2013-07-23)
The purpose of this study is to investigate the use of multivariate data analysis for powder X-ray diffraction-pair-wise distribution function (PXRD-PDF) data to detect phase separation in freeze-dried binary amorphous systems. Polymer-polymer and polymer-sugar binary systems at various ratios were
Rozhin Penjweini et al.
Biochimica et biophysica acta, 1843(5), 855-865 (2014-02-01)
PVP-Hypericin (PVP: polyvinylpyrrolidone) is a potent anti-cancer photosensitizer for photodynamic diagnosis (PDD) and therapy (PDT). However, cellular targets and mechanisms involved in the cancer-selectivity of the photosensitizer are not yet fully understood. This paper gives new insights into the differential
K Kogermann et al.
International journal of pharmaceutics, 444(1-2), 40-46 (2013-02-02)
The main purpose of this study was to investigate the effect of different polymers, with varying physicochemical properties and molecular weight on the stability and dissolution of co-milled amorphous solid dispersions (ASDs) of piroxicam (PRX). The stability of amorphous PRX
Dritan Hasa et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 50(1), 56-68 (2013-03-26)
The aim of the research was to investigate three "critical steps" that deserve particular attention during the mechanochemical activation of vincamine. The first step consisted in the selection of the best polymeric carrier/most affine stabiliser between linear PVP and NaCMC
Bin Li et al.
Carbohydrate polymers, 92(2), 2033-2040 (2013-02-13)
Amorphous solid dispersions (ASD) of quercetin (Que) in cellulose derivative matrices, carboxymethylcellulose acetate butyrate (CMCAB), hydroxypropylmethylcellulose acetate succinate (HPMCAS), and cellulose acetate adipate propionate (CAAdP) were prepared with the goal of identifying an ASD that effectively increased Que aqueous solution
Helen Thomas et al.
Journal of chromatography. A, 1285, 48-56 (2013-03-16)
In protein chromatography, the size of the protein determines which fraction of pores it can access within a resin and at which rate of diffusion. Moreover, in the presence of grafted polymers like in advanced materials, adsorbed proteins and electrolytes
Gamal M El Maghraby et al.
Pharmaceutical development and technology, 19(6), 641-650 (2013-07-12)
Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fast disintegrating tablets
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