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Luisa Borgianni et al.
Antimicrobial agents and chemotherapy, 54(8), 3197-3204 (2010-05-26)
Metallo-beta-lactamase (MBL)-producing bacteria are emerging worldwide and represent a formidable threat to the efficacy of relevant beta-lactams, including carbapenems, expanded-spectrum cephalosporins, and beta-lactamase inactivator/beta-lactam combinations. VIM-2 is currently the most widespread MBL and represents a primary target for MBL inhibitor
Laura Cendron et al.
The Journal of biological chemistry, 282(25), 18182-18189 (2007-04-13)
The complete degradation of uric acid to (S)-allantoin, as recently elucidated, involves three enzymatic reactions. Inactivation by pseudogenization of the genes of the pathway occurred during hominoid evolution, resulting in a high concentration of urate in the blood and susceptibility
Giovanna Masci et al.
The oncologist, 20(6), 586-592 (2015-05-08)
Due to its rarity, male breast cancer (mBC) remains an inadequately characterized disease, and current evidence for treatment derives from female breast cancer (FBC). We retrospectively analyzed the clinicopathological characteristics, treatment patterns, and outcomes of mBCs treated from 2000 to
Hai-qi Mu et al.
Zhonghua yi xue za zhi, 92(6), 392-396 (2012-04-12)
To explore the effects and mechanism of thymoquinone in the growth inhibition of bladder cancer both in vitro and in vivo. After the treatment of thymoquinone, the cellular proliferation of human bladder cancer cell line BIU-87 was detected by the
Sun Och Yoon et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(8), 1102-1112 (2009-05-19)
Appendiceal mucinous neoplasms have been the focus of considerable debate in recent years. We histologically classified 70 appendiceal mucinous neoplasms into three categories: 32 mucinous adenoma, 23 mucinous neoplasm of uncertain malignant potential, and 15 mucinous adenocarcinomas. Immunohistochemistry was performed
Jan Laco et al.
Pathology, research and practice, 204(8), 545-552 (2008-04-29)
A total of 88 samples of laryngeal lesions (23 vocal cord nodules (VCNs), 23 papillomas (PAs), 18 dysplasias (DYs), and 24 carcinomas (CAs)) were analyzed for p16INK4a protein (p16) expression by immunohistochemistry and for high-risk human papillomavirus (HR-HPV) infection using
Marie Hudson et al.
The Journal of rheumatology, 30(11), 2385-2391 (2003-12-17)
To explore the effect of multiple prothrombotic risk factors in individuals with anticardiolipin antibodies (aCL), we evaluated immunologic, coagulation, and genetic prothrombotic abnormalities in a cohort of individuals with different aCL titers. We recruited 87 individuals into 4 categories (normal
Yugal Behl et al.
The American journal of pathology, 172(5), 1411-1418 (2008-04-12)
Retinal microvascular cell loss plays a critical role in the pathogenesis of diabetic retinopathy. To examine this further, type 1 streptozotocin-induced diabetic rats and type 2 Zucker diabetic fatty rats were treated by intravitreal injection of the tumor necrosis factor-specific
Barbara M Norquist et al.
Cancer, 116(22), 5261-5271 (2010-07-29)
BRCA1 or BRCA2 (BRCA1/2)-mutated ovarian carcinomas may originate in the fallopian tube. The authors of this report investigated alterations in BRCA1/2 tubal epithelium to define the molecular pathogenesis of these carcinomas. Tubal epithelium was evaluated from 31 BRCA1/2 mutation carriers
Suhair S Eid et al.
Clinical laboratory science : journal of the American Society for Medical Technology, 17(4), 200-202 (2004-11-24)
Thrombophilia is now considered a multi-causal condition, with interplay of acquired genetic risk factors. In order to estimate the frequency of the factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in the Jordanian population, we screened 200 healthy Jordanian
L Jensen et al.
The Journal of physiology, 557(Pt 2), 571-582 (2004-03-17)
The effect of intense training on endothelial proliferation, capillary growth and distribution of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was examined in human skeletal muscle. Two intermittent knee extensor training protocols (at approximately 150% (Study
L Bornstein-Quevedo et al.
Human pathology, 32(11), 1252-1256 (2001-12-01)
Carcinoid tumors of the ampulla of Vater (ACs) differ from duodenal carcinoid tumors (DCs). A search for AC and DC was made between 1980 and 2000. The clinicopathologic features and follow-up were assessed. Immunohistochemistry for panneuroendocrine markers, hormone products, proliferating
Eric Lawitz et al.
The New England journal of medicine, 368(20), 1878-1887 (2013-04-24)
In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection. We conducted two phase 3 studies in previously untreated patients with HCV infection.
Yoon Kyung Jeon et al.
Human pathology, 46(7), 981-990 (2015-04-25)
Nodal peripheral T-cell lymphoma, not otherwise specified, is a heterogeneous entity with variable biologic behavior. We analyze the clinicopathological features of 15 patients with Epstein-Barr virus-positive (EBV+) nodal T/NK-cell lymphoma, including 9 males and 6 females, with a median age
Bin Wu et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 24(4), 364-366 (2002-11-01)
To study the expression of bcr/abl hybridized gene in chronic myeloid leukemia (CML), acute lymphatic leukemia (ALL) and polycythemia vera (PV), and its clinical significance. The bcr/abl hybridized gene of interphase metaphase cells of bone marrow in 67 such patients
Michael L Eisenberg et al.
European urology, 57(4), 622-629 (2009-04-21)
The prognostic meaning of an undetectable ultrasensitive prostate-specific antigen (USPSA) level after prostatectomy remains unclear. To determine whether an undetectable USPSA level obtained after surgery is a predictor of biochemical recurrence (BCR)-free survival. From the Urologic Oncology Database at the
Dipankar Ray et al.
Neoplasia (New York, N.Y.), 13(5), 439-444 (2011-05-03)
The concept of targeting G(1) cyclin-dependent kinases (CDKs) in breast cancer treatments is supported by the fact that the genetic ablation of Cdk4 had minimal impacts on normal cell proliferation in majority of cell types, resulting in near-normal mouse development
Dong H Sinn et al.
Journal of gastroenterology and hepatology, 26(9), 1374-1379 (2011-04-20)
A single nucleotide polymorphism near the interleukin-28B (IL28B) gene has been shown to predict hepatitis C virus (HCV) treatment response. We aim to determine the role of the IL28B genotype in Asian patients. A total of 118 patients (all Korean
Andrew M Shaw et al.
The Analyst, 145(16), 5638-5646 (2020-07-09)
An evaluation of a rapid portable gold-nanotechnology measuring SARS-CoV-2 IgM, IgA and IgG antibody concentrations against spike 1 (S1), spike 2 (S) and nucleocapsid (N) was conducted using serum samples from 74 patients tested for SARS-CoV-2 RNA on admission to
Eyob Wondu et al.
Polymers, 11(12) (2019-11-27)
In this study water-soluble polyurethane (WSPU) was synthesized from isophorone diisocyanate (IPDI), and polyethylene glycol (PEG), 2-bis(hydroxymethyl) propionic acid or dimethylolpropionic acid (DMPA), butane-1,4-diol (BD), and triethylamine (TEA) using an acetone process. The water solubility was investigated by solubilizing the
Jana Pachlopnik Schmid et al.
Blood, 117(5), 1522-1529 (2010-12-02)
X-linked lymphoproliferative syndromes (XLP) are primary immunodeficiencies characterized by a particular vulnerability toward Epstein-Barr virus infection, frequently resulting in hemophagocytic lymphohistiocytosis (HLH). XLP type 1 (XLP-1) is caused by mutations in the gene SH2D1A (also named SAP), whereas mutations in
Jori O Ruuskanen et al.
Molecular biology and evolution, 21(1), 14-28 (2003-09-02)
The alpha(2)-adrenergic receptors (alpha(2)-ARs) belong to the large family of rhodopsinlike G-protein-coupled receptors that share a common structure of seven transmembrane (TM) alpha-helices. The aims of this study were (1) to determine the number of alpha(2)-AR genes in a teleost
Daniel H Kim et al.
Familial cancer, 8(2), 153-158 (2008-10-16)
A growing body of research describes cancers other than breast and ovarian in families with BRCA1/2 mutations, but the prevalence and characteristics of pancreatic cancer in these families has not been well described. This study was designed to: (1) estimate
Jelle L G Haitsma Mulier et al.
PloS one, 13(6), e0197967-e0197967 (2018-06-12)
Acute kidney injury (AKI) complicates shock. Diagnosis is based on rising creatinine, a late phenomenon. Intrarenal vasoconstriction occurs earlier. Measuring flow resistance in the renal circulation, Renal Resistive Index (RRI), could become part of vital organ function assessment using Doppler
F Bartel et al.
International journal of cancer, 95(3), 168-175 (2001-04-18)
The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing.
Amanda W Pong et al.
Epilepsia, 53(9), 1503-1510 (2012-07-21)
Glut 1 deficiency syndrome (DS) is defined by hypoglycorrhachia with normoglycemia, acquired microcephaly, episodic movements, and epilepsy refractory to standard antiepileptic drugs (AEDs). Gold standard treatment is the ketogenic diet (KD), which provides ketones to treat neuroglycopenia. Our purpose is
Michael R Da Rosa et al.
Journal of magnetic resonance imaging : JMRI, 41(1), 220-225 (2014-07-22)
In active surveillance (AS) patients: (i) To compare the ability of a multiparametric MRI (mpMRI)-ultrasound biopsy system to detect clinically significant (CS) prostate cancer with systematic 12-core biopsy (R-TRUSBx), and (ii) To assess the predictive value of mpMRI with biopsy
JianCai Zhu et al.
Journal of agricultural and food chemistry, 63(34), 7499-7510 (2015-08-11)
The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active compounds in tea infusions. The results
Alberto Alvarez-Larrán et al.
Annals of hematology, 93(12), 2037-2043 (2014-07-02)
Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan
Takafumi Tomida et al.
Toxicology letters, 236(1), 16-24 (2015-05-03)
The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for
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