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T Yin et al.
The Journal of biological chemistry, 269(43), 26614-26617 (1994-10-28)
Interleukin (IL)-4 and IL-9 regulate the proliferation of T lymphocytes through interactions with their receptors. Previous studies have shown that unknown tyrosine kinases are involved in the proliferative signaling triggered by IL-4 and IL-9. Here we show that IL-4 and
Malcolm A Lyons et al.
Physiological genomics, 17(2), 114-121 (2004-02-12)
To determine the genetic contribution to variation among lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) analyses on an intercross between mouse strains RIIIS/J and 129S1/SvImJ. Male mice of the parental strains and the reciprocal F1 and F2 populations
Tomoko Miyata-Takata et al.
Histopathology, 73(6), 1030-1038 (2018-08-14)
Although the neoplastic cells of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) usually do not express T-cell antigens, the T-cell receptor (TCR) gene might be rearranged and TCR protein expressed. The aim is to elucidate the expression of the downstream TCR
A Leonardi et al.
Ophthalmic research, 22(4), 209-219 (1990-01-01)
The ocular late-phase reaction (LPR) is a mast cell-dependent, delayed inflammatory reaction developing 4-12 h after the early-phase reaction (EPR). We developed a passive IgG1 antibody-dependent guinea pig model that clinically reproduced the biphasic reaction of ocular EPR and LPR.
W Nelson Beyer et al.
Ambio, 42(1), 83-89 (2012-09-25)
The finding of dieldrin (88 ng/g), DDE (52 ng/g), and heptachlor epoxide (19 ng/g) in earthworms from experimental plots after a single moderate application (9 kg/ha) 45 years earlier attests to the remarkable persistence of these compounds in soil and their continued uptake by soil
J Glenn et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6(3), 462-468 (1988-03-01)
By radioimmunoassay we determined circulating levels of a tumor-associated antigen, CA 19-9, in 47 patients with pancreatic adenocarcinoma, to learn if serial testing was useful in predicting prognosis or in detecting disease progression. Before treatment, 42 (89%) had an abnormal
Chounghun Kang et al.
Free radical biology & medicine, 47(10), 1394-1400 (2009-08-19)
The peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha)-activated signal transduction pathway has previously been shown to stimulate mitochondrial biogenesis in skeletal muscle in response to endurance exercise. In vitro data indicate that PGC-1alpha signaling may be sensitive to reactive oxygen species (ROS)
C B Anderson et al.
Annals of surgery, 187(2), 194-204 (1978-02-01)
Venous angiography of subcutaneous arteriovenous (A-V)) hemodialysis fistulas involves venous injection of radiographic contrast material which spreads throughout the venous system and into the arteries via the A-V anastomosis when blood flow to the extremity is temporarily occluded. Direct arterial
Daniel Brugger et al.
The British journal of nutrition, 116(3), 425-433 (2016-05-28)
This study investigated the effects of short-term subclinical Zn deficiency on exocrine pancreatic activity and changes in digestive capacity. A total of forty-eight weaned piglets were fed ad libitum a basal diet (maize and soyabean meal) with adequate Zn supply
Daniel Brugger et al.
The British journal of nutrition, 116(3), 425-433 (2016-05-28)
This study investigated the effects of short-term subclinical Zn deficiency on exocrine pancreatic activity and changes in digestive capacity. A total of forty-eight weaned piglets were fed ad libitum a basal diet (maize and soyabean meal) with adequate Zn supply
Lingjie Ma et al.
Molecular medicine reports, 15(3), 1243-1251 (2017-01-19)
The guinea pig is a useful model for investigating infectious and non‑infectious lung diseases due to the sensitivity of its respiratory system and susceptibility to infectious agents. Toll‑like receptors (TLRs) are important components of the innate immune response and are
Sandra S Strautnieks et al.
Gastroenterology, 134(4), 1203-1214 (2008-04-09)
Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic liver disease. We characterized mutations of ABCB11 (encoding BSEP) in such patients and correlated genotypes with residual protein detection and risk of malignancy. Patients with
Gulsah Cecener et al.
Cellular and molecular neurobiology, 30(2), 301-307 (2009-09-18)
Molecular studies have an important role in the elucidation of the mechanisms involved in Glioblastoma multiforme (GBM) development. The occurrence of FHIT gene alterations, which has an important role in different cancers, has not yet been studied well in GBM.
Freya Droege et al.
Journal of clinical medicine, 9(3) (2020-03-18)
Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated
M Asefi et al.
The British journal of dermatology, 167(6), 1279-1286 (2012-07-28)
Paraoxonase 1 (PON1) is a serum high-density lipoprotein-bound enzyme with antioxidant function. It hydrolyses lipid peroxides, protecting low-density lipoproteins from oxidative modifications. Patients with psoriasis are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism.
Charles J Glueck et al.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 109(4), 548-553 (2010-02-27)
We hypothesized that, similar to idiopathic hip osteonecrosis, the T-786C mutation of the endothelial nitric oxide synthase (eNOS) gene affecting nitric oxide (NO) production was associated with neuralgia-inducing cavitational osteonecrosis of the jaws (NICO). In 22 NICO patients, not having
Hyesun Kim et al.
Ophthalmic surgery, lasers & imaging retina, 46(4), 423-427 (2015-05-15)
To evaluate punctate hyperfluorescent spots on indocyanine green angiography (ICGA) in eyes with polypoidal choroidal vasculopathy (PCV). Retrospective observation case series of 88 eyes of 81 patients (63 men and 18 women) analyzing fundus photography, fluorescein angiography, ICGA, and spectral-domain
J V Brugniaux et al.
The European respiratory journal, 37(4), 880-887 (2010-10-16)
Erythropoietin (EPO) and soluble EPO receptors (sEPOR) have been proposed to play a central role in the ventilatory acclimatisation to continuous hypoxia in mice. In this study, we demonstrated for the first time in humans (n = 9) that sEPOR
Anja I Pekkarinen et al.
Journal of agricultural and food chemistry, 50(13), 3849-3855 (2002-06-13)
The fungal disease Fusarium head blight occurs on wheat (Triticum spp.) and barley (Hordeum vulgare L.) and is one of the worldwide problems of agriculture. It can be caused by various Fusarium species. We are characterizing the proteinases of F.
Helene Freiser et al.
The Journal of nutrition, 139(5), 884-889 (2009-03-20)
The metabolism of gamma-tocotrienol (gamma-TE) and gamma-tocopherol (gamma-T) was investigated in human A549 cells and in rats. Similar to gamma-T, A549 cells metabolized gamma-TE to sulfated 9'-, 11'-, and 13'-carboxychromanol and their unconjugated counterparts. After 72-h incubation with the cells
Denise Baratti-Mayer et al.
The Lancet. Global health, 1(2), e87-e96 (2014-08-12)
Noma is a poorly studied disease that leads to severe facial tissue destruction in children in developing countries, but the cause remains unknown. We aimed to identify the epidemiological and microbiological risk factors associated with noma disease. We did a
Grzegorz Helbig et al.
Medical oncology (Northwood, London, England), 29(4), 2379-2384 (2012-03-03)
The prevalence of JAK2V617F tyrosine kinase mutation differs between various variants of myelofibrosis with the higher detection rate for patients with post-polycythemia vera myelofibrosis (post-PV MF; 91%) if compared to primary myelofibrosis (PMF; 45%) and post-essential thrombocythemia myelofibrosis (post-ET MF;
Shishir K Maithel et al.
Annals of surgical oncology, 18(9), 2699-2705 (2011-03-02)
Increased tumor expression of excision repair cross-complementing gene-1 (ERCC1) is associated with decreased survival in patients with various cancers. Its effect in pancreatic adenocarcinoma (PAC) is not defined. Ninety-five patients were selected from a prospective database of all patients (nxa0=xa0220)
Bianca A W Hoeben et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(4), 532-540 (2013-01-25)
This prospective study used sequential PET with the proliferation tracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to monitor the early response to treatment of head and neck cancer and evaluated the association between PET parameters and clinical outcome. Forty-eight patients with head and neck
Cristina Ballesteros et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(22), 1997-2002 (2010-06-15)
Iophenoxic acid and its derivatives (methyl, ethyl, and propyl) are organic chemicals used as markers in baiting campaigns to deliver vaccines, pharmaceuticals, contraceptives or poisons to wildlife. In this study we develop a method of detection of IPA derivatives by
Anne E Cust et al.
Journal of medical genetics, 48(4), 266-272 (2011-02-18)
CDKN2A mutations confer a substantial risk of cutaneous melanoma; however, the magnitude of risk is uncertain. The study estimated the hazard ratio (HR) and the average age specific cumulative risk (ie, penetrance) of reported melanoma for CDKN2A mutation carriers in
Maryam B Lustberg et al.
Cancer chemotherapy and pharmacology, 70(1), 49-56 (2012-06-26)
Suramin, a polysulfonated naphthylurea, inhibits the actions of polypeptide growth factors including acidic and basic fibroblast growth factors (aFGF and bFGF), which confer broad spectrum chemotherapy resistance. We hypothesized that suramin at non-cytotoxic doses in combination with weekly paclitaxel would
Patrick Waters et al.
Neurology(R) neuroimmunology & neuroinflammation, 2(3), e89-e89 (2015-03-31)
To optimize sensitivity and disease specificity of a myelin oligodendrocyte glycoprotein (MOG) antibody assay. Consecutive sera (n = 1,109) sent for aquaporin-4 (AQP4) antibody testing were screened for MOG antibodies (Abs) by cell-based assays using either full-length human MOG (FL-MOG)
Shih-Min Wang et al.
Pediatric pulmonology, 39(3), 219-223 (2005-01-07)
Hand, foot, and mouth disease and herpangina are the major clinical manifestations of enterovirus 71 (EV71) infections. Brain-stem encephalitis and pulmonary edema are severe complications that can lead to death. This study was designed to evaluate the potential therapeutic effect
Maria Vittoria Pitzalis et al.
Journal of hypertension, 21(8), 1491-1496 (2003-07-23)
Abnormalities in the natriuretic peptide system could play a key role in the genesis of hypertension. We evaluated the associations between a family history of hypertension, cardiovascular phenotype and allelic variants of Npr1 and Npr3, two candidate genes that codify
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