88-60-8

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The role of TLR8 signaling in acute myeloid leukemia differentiation.

James J Ignatz-Hoover et al.

Leukemia, 29(4), 918-926 (2014-10-07)

Acute myeloid leukemia (AML) is an aggressive disease with a poor 5-year survival of 21% that is characterized by the differentiation arrest of immature myeloid cells. For a rare subtype of AML (acute promyeloctyic leukemia, 5-10% of cases), all-trans retinoic

Chemical category approach of genotoxicity studies for branched alkylphenols.

Mariko Matsumoto et al.

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, (129)(129), 68-75 (2012-01-21)

A chemical category is a group of chemicals whose toxicological properties are expected to be similar or follow a regular pattern as a result of structural similarity. The category approach is beneficial for decreasing in the resource of risk assessment

Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro.

Sandrine Lemoine et al.

Experimental biology and medicine (Maywood, N.J.), 235(6), 768-776 (2010-06-01)

We examined the respective role and relationship between protein kinase C (PKC), mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channel and p38 mitogen-activated protein kinase (MAPK) in postconditioning of human myocardium, in vitro. Isometrically contracting, isolated human right atrial trabeculae were exposed

Calcium-calmodulin-dependent protein kinase II and protein kinase C-mediated phosphorylation and activation of D-myo-inositol 1,4, 5-trisphosphate 3-kinase B in astrocytes.

D Communi et al.

The Journal of biological chemistry, 274(21), 14734-14742 (1999-05-18)

D-myo-Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase catalyzes the production of D-myo-inositol 1,3,4,5-tetrakisphosphate from the second messenger Ins (1,4,5)P3. Transient and okadaic acid-sensitive activation of Ins(1,4,5)P3 3-kinase by 8-10-fold is observed in homogenates prepared from rat cortical astrocytes after incubation with either carbachol

Regulation of the MIR155 host gene in physiological and pathological processes.

Terry S Elton et al.

Gene, 532(1), 1-12 (2012-12-19)

MicroRNAs (miRNAs), a family of small nonprotein-coding RNAs, play a critical role in posttranscriptional gene regulation by acting as adaptors for the miRNA-induced silencing complex to inhibit gene expression by targeting mRNAs for translational repression and/or cleavage. miR-155-5p and miR-155-3p

Oral versus intravenous paracetamol: which is better in closure of patent ductus arteriosus in very low birth weight infants?

Selim Sancak et al.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(1), 135-139 (2014-12-05)

To compare the efficacy of oral and intravenous paracetamol for closure of hemodynamically significant patent ductus arteriosus (HSPDA) in very low birth weight (VLBW) preterm infants. Eighteen VLBW infants with HSPDA treated with either intravenous (n = 10) or oral (n = 8) paracetamol

RESOLUTION OF NONINFECTIOUS UVEITIC CYSTOID MACULAR EDEMA WITH TOPICAL DIFLUPREDNATE.

Daniel L Feiler et al.

Retina (Philadelphia, Pa.), 37(5), 844-850 (2016-08-17)

To evaluate the short-term safety and efficacy of topical difluprednate (0.05%) for the treatment of noninfectious uveitic cystoid macular edema. Twenty-seven patients (35 eyes) undergoing treatment with difluprednate 4 times daily for 3 weeks for noninfectious uveitic cystoid macular edema

Distribution of CYP1A1*2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population.

M P Gallegos-Arreola et al.

Blood cells, molecules & diseases, 41(1), 91-94 (2008-01-22)

The effects of the CYP1A1*2A genotype on susceptibility to leukemia have received particular attention in recent years because this enzyme plays a central role in the activation of carcinogens. Several polymorphisms at the CYP1A1 locus have been identified and their

Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome.

K J Griffith et al.

Arthritis and rheumatism, 40(9), 1693-1702 (1997-10-27)

To identify a Golgi complex autoantigen bound by Sjögren's syndrome (SS) autoantibodies. Serum from a patient with secondary SS and anti-Golgi antibodies was used as a probe to isolate a complementary DNA (cDNA) insert from a HeLa cDNA library. A

MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.

Michiho Nishioka et al.

Proceedings of the National Academy of Sciences of the United States of America, 99(19), 12269-12274 (2002-09-05)

Loss of heterozygosity on chromosome 22q has been detected in approximately 60% of advanced nonsmall cell lung carcinoma (NSCLC) as well as small cell lung carcinoma (SCLC), suggesting the presence of a tumor suppressor gene on 22q that is involved

Characterization of the placenta specific bovine mammalian achaete scute-like homologue 2 (Mash2) gene.

D R Arnold et al.

Placenta, 27(11-12), 1124-1131 (2006-03-01)

Mash2, a basic helix-loop-helix transcription factor, stimulates mononucleate trophoblast cell proliferation and inhibits giant/binucleate cell formation. In mice, Mash2 is a maternally expressed imprinted gene. Regulation of bovine Mash2 is unclear due to limited genetic knowledge. Our objectives were to

Profiling of expression of human papillomavirus-related cancer miRNAs in penile squamous cell carcinomas.

Luisa Barzon et al.

The American journal of pathology, 184(12), 3376-3383 (2014-12-03)

Penile squamous cell carcinoma (PSCC) is a rare tumor associated with high-risk human papillomavirus (HR-HPV) infection in 30% to 60% of cases. Altered expression of miRNAs has been reported in HPV-related cervical and head and neck cancers, but such data

Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice.

Malcolm A Lyons et al.

Physiological genomics, 17(2), 114-121 (2004-02-12)

To determine the genetic contribution to variation among lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) analyses on an intercross between mouse strains RIIIS/J and 129S1/SvImJ. Male mice of the parental strains and the reciprocal F1 and F2 populations

Trabulsiella guamensis, a new genus and species of the family Enterobacteriaceae that resembles Salmonella subgroups 4 and 5.

A C McWhorter et al.

Journal of clinical microbiology, 29(7), 1480-1485 (1991-07-01)

In 1985 the vernacular name Enteric Group 90 was coined for a small group of strains that had been referred to our laboratory as probable strains of Salmonella but did not agglutinate in Salmonella typing antisera. By DNA-DNA hybridization (hydroxyapatite

Ribose 5-phosphate glycation reduces cytochrome c respiratory activity and membrane affinity.

Gordon J Hildick-Smith et al.

Biochemistry, 50(51), 11047-11057 (2011-11-19)

Spontaneous glycation of bovine heart cytochrome c (cyt c) by the sugar ribose 5-phosphate (R5P) weakens the ability of the heme protein to transfer electrons in the respiratory pathway and to bind to membranes. Trypsin fragmentation studies suggest the preferential

Novel alkaline- and heat-stable serine proteases from alkalophilic Bacillus sp. strain GX6638.

D R Durham et al.

Journal of bacteriology, 169(6), 2762-2768 (1987-06-01)

An alkalophilic Bacillus sp., strain GX6638 (ATCC 53278), was isolated from soil and shown to produce a minimum of three alkaline proteases. The proteases were purified by ion-exchange chromatography and were distinguishable by their isoelectric point, molecular weight, and electrophoretic

Effects of detergents on Ca(2+)-activated neural proteinase activity (calpain) in neural and non-neural tissue: a comparative study.

N L Banik et al.

Neurochemical research, 17(8), 797-802 (1992-08-01)

Calcium activated neutral proteinase (mcalpain) activity was determined in brain and other tissue of rat. More than 60% of the brain mcalpain activity was present in the particulate fraction while only 30% was in cytosol. In contrast, particulate fractions of

A phase II trial of a neoadjuvant platinum regimen for locally advanced breast cancer: pathologic response, long-term follow-up, and correlation with biomarkers.

Rinat Yerushalmi et al.

Clinical breast cancer, 9(3), 166-172 (2009-08-08)

The purpose of this study is to determine the response, tolerability, and long-term outcome of a neoadjuvant platinum-containing regimen for locally advanced breast cancer (LABC) and to search for a correlation between pathologic complete response (pCR) and predefined biomarkers in

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.

Kirsten Neudoerffer Kangelaris et al.

Chest, 141(5), 1160-1169 (2011-12-31)

Acute lung injury (ALI) mortality is increased among African Americans compared with Americans of European descent, and genetic factors may be involved. A functional T-46C polymorphism (rs2814778) in the promoter region of Duffy antigen/receptor for chemokines (Darc) gene, present almost

Expression of Epithelial and Mesenchymal Differentiation Markers in the Early Human Gonadal Development.

Vlatka Martinovic et al.

Anatomical record (Hoboken, N.J. : 2007), 300(7), 1315-1326 (2016-12-17)

Expressions of cytokeratin 8 (CK8), vimentin, nestin, and alpha-smooth-muscle-actin (alpha-SMA) were analyzed in the developing gonads of 12, 5-9 week old (W) human conceptuses by immunohistochemistry and immunofluorescence. During the investigated period, the number of CK8 positive cells increased from

CD31 and CD34 expression as immunohistochemical markers of endothelial transdifferentiation in human cutaneous melanoma.

A M Pisacane et al.

Cellular oncology : the official journal of the International Society for Cellular Oncology, 29(1), 59-66 (2007-04-13)

Vasculogenic mimicry, as previously described in aggressive melanoma, is characterized by the de novo generation of intratumoral patterned vascular channels, composed of PAS-positive basement membrane in the absence of endothelial cells, providing additional microcirculation, in support to the classic tumoral

Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients.

Gaëtan Lesca et al.

Human mutation, 27(6), 598-598 (2006-05-18)

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease characterized by arteriovenous malformations and resulting from mutations in two major genes: ENG and ACVRL1. The aim of the present study was to estimate the prevalence of the mutations of ENG

Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis.

Xun Zhang et al.

The Journal of clinical endocrinology and metabolism, 87(3), 1262-1267 (2002-03-13)

The underlying molecular pathogenic mechanisms remain unknown in the majority of human pituitary tumors. GADD45 gamma is a member of a growth arrest and DNA damage-inducible gene family that functions in the negative regulation of cell growth. We have found

Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes.

Aristote B Buya et al.

Pharmaceutics, 13(9) (2021-09-29)

Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surfactants, and cosurfactants were screened for their

Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells.

Jing Yang et al.

European journal of pharmacology, 846, 12-22 (2018-12-24)

Acute myeloid leukemia (AML) is a devastating hematological malignancy, characterized by differentiation arrest and unscheduled proliferation of immature cells of the myeloid lineage. Inducing AML cell differentiation has emerged as a promising therapeutic strategy for the therapy of AML. Icariside

Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70.

S U Trost et al.

The Journal of clinical investigation, 101(4), 855-862 (1998-03-21)

Brief ischemic periods lead to myocardial dysfunction without myocardial infarction. It has been shown that expression of inducible HSP70 in hearts of transgenic mice leads to decreased infarct size, but it remains unclear if HSP70 can also protect against myocardial

Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group.

R L Allgren et al.

The New England journal of medicine, 336(12), 828-834 (1997-03-20)

Atrial natriuretic peptide, a hormone synthesized by the cardiac atria, increases the glomerular filtration rate by dilating afferent arterioles while constricting efferent arterioles. It has been shown to improve glomerular filtration, urinary output, and renal histopathology in laboratory animals with

Residue Analysis of 60 Pesticides in Red Swamp Crayfish Using QuEChERS with High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

Shuangyu Song et al.

Journal of agricultural and food chemistry, 66(20), 5031-5038 (2018-01-25)

In this study, a multi-residue analytical method using quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction and dispersive solid-phase extraction (d-SPE) cleanup, followed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), was investigated for rapid determination of 60 pesticide residues

Polymorphisms in the interleukin-10 gene and relation to phenotype in patients with ulcerative colitis.

J L Mendoza et al.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 98(2), 93-100 (2006-03-29)

Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation in inflammatory bowel disease. In our population of Spanish ulcerative colitis (UC) patients, we have previously demonstrated that two polymorphisms (IL-10.G14 microsatellite allele and homozygous for the -1082G allele (guanine

Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer.

R C Niessen et al.

Gut, 55(12), 1781-1788 (2006-04-26)

Patients with early-onset colorectal cancer (CRC) or those with multiple tumours associated with hereditary non-polyposis colorectal cancer (HNPCC) raise suspicion of the presence of germline DNA mismatch repair (MMR) gene mutations. To analyse the value of family history, microsatellite instability

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