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T L Peeters et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(2), 202-208 (1991-02-01)
Recent studies suggested that certain erythromycin A (EM-A) derivatives are motilin receptor agonists. As proposed by Itoh they may be called "motilides". We have investigated the Ca2(+)-dependence of contractions induced by two potent motilides, ME-34 [de(N-methyl) 8,9-anhydroeryhtromycin A 6,9-hemiacetal] and
H Hauner et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 34(9), 475-480 (2002-10-18)
The recently discovered C825T polymorphism of the G-protein beta 3 subunit has been reported to be associated with the development of hypertension and obesity. The aim of our study was to investigate the relationship between the C825T polymorphism and functional
M Sridharan et al.
Calcified tissue international, 87(5), 398-405 (2010-09-15)
Uncertainties exist regarding whether FGF-23 production is influenced by PTH and its involvement in bone formation. We evaluated FGF-23 response and its relation to changes in biomarkers of bone formation following intermittent PTH treatment. Twenty-seven women with a mean [SD]
Ankita Bhattacharjee et al.
Pharmaceutical biology, 54(3), 433-444 (2015-05-15)
Nicotine is an abundant and most significant component of cigarette smoke. Epidemiological evidence strongly suggests an association between cigarette smoking and pancreatic injury, although effects of smoking on endocrine pancreas are still controversial. We examined the impact and underlying mechanisms
S Bagchi et al.
The Journal of biological chemistry, 262(4), 1558-1565 (1987-02-05)
Many murine cells express two mRNAs with markedly different sizes (2.0 and 3.1 kilobases (kb)) that hybridize with cDNA probes for cytosolic malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40). A series of overlapping cDNA clones corresponding to 3129 nucleotides
Bianca A W Hoeben et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(4), 532-540 (2013-01-25)
This prospective study used sequential PET with the proliferation tracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to monitor the early response to treatment of head and neck cancer and evaluated the association between PET parameters and clinical outcome. Forty-eight patients with head and neck
Laura A Schaap et al.
Clinical endocrinology, 63(2), 152-160 (2005-08-03)
The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women. Cross-sectional population-based study
Shi-Jing Qu et al.
The protein journal, 25(2), 167-173 (2006-07-25)
Human plasma phospholipid transfer protein (PLTP) contains six potential N-glycosylation sites (Asn-X-Ser). To study the role of these sites on PLTP structure and function, seven variants in which asparagine (N) residues were converted to glycine (G) were prepared by site-directed
John J You et al.
Trials, 16, 296-296 (2015-07-15)
No head-to-head randomized controlled trials have demonstrated the superiority of one colorectal screening modality over another in reducing colorectal cancer mortality. We conducted a pilot randomized controlled trial of fecal occult blood testing (FOBT), optical colonoscopy (OC), and virtual colonoscopy
T S Rumsey et al.
Journal of animal science, 56(1), 125-131 (1983-01-01)
An experiment with eight beef steers was conducted to determine the patterns of change for plasma concentrations of thyroxine (T4), triiodothyronine (T3), cholesterol and total lipid following the addition or withdrawal of the organophosphate, ronnel, from the diet. Steers were
I Matinlauri et al.
Transplantation proceedings, 38(10), 3601-3604 (2006-12-19)
Increased pre- and posttransplantation values of soluble CD30 (sCD30) have been shown to be associated with acute kidney transplant rejection. We sought to study whether high sCD30 could predict rejection early after liver transplantation. The study population included 54 consecutive
Keita Saito et al.
Journal of chromatography. A, 1220, 1-6 (2011-12-20)
A simple and sensitive method for the determination of ochratoxins A and B in nuts and grain samples was developed using an automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-mass spectrometry (LC-MS). Ochratoxins were separated within 5 min by
Sandra S Wise et al.
Environmental and molecular mutagenesis, 42(4), 274-278 (2003-12-16)
Hexavalent chromium (Cr(VI)) compounds are widely accepted as human lung carcinogens. However, there have been few investigations of the genotoxicity of Cr(VI) in human lung cells. Moreover, our knowledge of the effects of Cr(VI) in human lung cells is further
Michel Ducreux et al.
European journal of cancer (Oxford, England : 1990), 50(18), 3098-3106 (2014-12-03)
Neuroendocrine tumours are highly vascular neoplasms known to overexpress vascular endothelial growth factor (VEGF) and its receptor. Bevacizumab, an inhibitor of VEGF, was assessed in combination with chemotherapy in pancreatic neuroendocrine tumour (P-NET). BETTER was a multicentre, open-label, non-randomised, two-group
A Weisz et al.
Biochemistry, 23(23), 5393-5397 (1984-11-06)
When rat liver cytosol containing [3H]dexamethasone-glucocorticoid receptor complex is exposed to immobilized heparin (Sepharose-heparin; Seph-hep) the steroid receptor complex binds to the substituted Sepharose avidly [Kd = 3.5 (+/- 1.7) X 10(-10) M], and 80-90% of the receptor present is
Sylvestre Le Moulec et al.
Bulletin du cancer, 100(12), 30-37 (2013-12-10)
The combination of paclitaxel and bevacizumab was EMA-approved as first-line therapy in metastatic breast cancer. Moreover, in vitro studies showed a potential antiangiogenic synergistic effect of paclitaxel and bevacizumab. Between November 2008 and March 2010, this case series study included
A Caroli et al.
Animal genetics, 32(4), 226-230 (2001-09-05)
Data on genetic differences at CSN3 in goat breeds including a DNA based typing method and the mutations responsible for variation on protein and DNA level are presented here. Isoelectric focusing (IEF) in ultrathin polyacrylamide gels with carrier ampholytes was
Veronika I Butvilovskaya et al.
Cancer medicine, 5(7), 1361-1372 (2016-03-20)
Colorectal cancer (CRC) is the third most common malignancy in industrialized countries. Despite the advances in diagnostics and development of new drugs, the 5-year survival remains only 60-65%. Our approach to early diagnostics of CRC is based on the determination
Bumsup Lee et al.
European journal of pharmacology, 589(1-3), 306-314 (2008-06-10)
The aim of the present research was to characterize the pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel quinazolinone-based dipeptidyl peptidase-4 (DPP-4) inhibitor. Alogliptin potently inhibited human DPP-4 in vitro (mean IC(50), ~ 6.9 nM) and exhibited > 10,000-fold
Elizabeth Maunsell et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(14), 1427-1436 (2014-04-09)
Exemestane, a steroidal aromatase inhibitor, reduced invasive breast cancer incidence by 65% among 4,560 postmenopausal women randomly assigned to exemestane (25 mg per day) compared with placebo in the National Cancer Institute of Canada (NCIC) Clinical Trials Group MAP.3 (Mammary
Susanne Lindskov et al.
Nutritional neuroscience, 19(1), 11-20 (2015-09-05)
Parkinson's disease (PD) has traditionally been associated with weight loss. However, recent studies have not found any evidence of underweight in PD. Nevertheless, few studies have addressed nutritional status changes over time in relation to other clinical PD features. Here
Amnon Zung et al.
European journal of endocrinology, 170(5), 749-758 (2014-02-19)
Characterization of pubertal progression is required to prevent unnecessary intervention in unsustained or slowly progressive (SP) precocious puberty (PP), while delivering hormonal suppression in rapidly progressive (RP) PP. We aimed to assess the diagnostic value of first-voided urinary LH (ULH)
Rafael Igual-Adell et al.
Expert opinion on pharmacotherapy, 5(12), 2615-2619 (2004-12-02)
Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases. Ivermectin has been shown to be more effective for treating
OnabotulinumtoxinA for the Treatment of Poststroke Distal Lower Limb Spasticity: A Randomized Trial.
Theodore Wein et al.
PM & R : the journal of injury, function, and rehabilitation, 10(7), 693-703 (2018-01-14)
Poststroke distal lower limb spasticity impairs mobility, limiting activities of daily living and requiring additional caregiver time. To evaluate the efficacy, safety, and sustained benefit of onabotulinumtoxinA in adults with poststroke lower limb spasticity (PSLLS). A multicenter, randomized, double-blind, phase
Giovanna Masci et al.
The oncologist, 20(6), 586-592 (2015-05-08)
Due to its rarity, male breast cancer (mBC) remains an inadequately characterized disease, and current evidence for treatment derives from female breast cancer (FBC). We retrospectively analyzed the clinicopathological characteristics, treatment patterns, and outcomes of mBCs treated from 2000 to
T Kimpimäki et al.
The Journal of clinical endocrinology and metabolism, 86(10), 4782-4788 (2001-10-16)
Little is known about the timing of the etiological events and the preclinical process of type 1 diabetes during the first years of life in the general population. In this population-based prospective birth cohort study, the appearance of diabetes-associated autoantibodies
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
Véronique Habauzit et al.
The American journal of clinical nutrition, 102(1), 66-74 (2015-05-29)
The consumption of citrus fruits is associated with health benefits. However, clinical data regarding the effects of grapefruit flavanone consumption on vascular function are lacking. The objective of the present study was to address the role of flavanones in the
Ferdinando Pasquale et al.
Circulation. Cardiovascular genetics, 5(1), 10-17 (2011-12-07)
Hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene (TNNT2) has been associated with a high risk of sudden cardiac death (SCD) and mild left ventricular hypertrophy. However, previous studies are limited by sample size, cross-sectional design, and
Jason V Baker et al.
PloS one, 7(10), e46894-e46894 (2012-10-20)
Treatments that reduce inflammation and cardiovascular disease (CVD) risk among individuals with HIV infection receiving effective antiretroviral therapy (ART) are needed. We conducted a 2 × 2 factorial feasibility study of lisinopril (L) (10 mg daily) vs L-placebo in combination
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