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Jesus A Ramirez et al.
Journal of general internal medicine, 35(5), 1498-1503 (2019-12-04)
Individualized selection of antiretroviral (ARV) therapy is complex, considering drug resistance, comorbidities, drug-drug interactions, and other factors. HIV-ASSIST (www.hivassist.com) is a free, online tool that provides ARV decision support. HIV-ASSIST synthesizes patient and virus-specific attributes to rank ARV combinations based
Edward B Garon et al.
Lancet (London, England), 384(9944), 665-673 (2014-06-17)
Ramucirumab is a human IgG1 monoclonal antibody that targets the extracellular domain of VEGFR-2. We aimed to assess efficacy and safety of treatment with docetaxel plus ramucirumab or placebo as second-line treatment for patients with stage IV non-small-cell-lung cancer (NSCLC)
Nariya Cho et al.
Radiology, 272(2), 385-396 (2014-04-18)
To prospectively compare the performance of dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging using parametric response map (PRM) analysis with that using pharmacokinetic parameters (transfer constant [K(trans)], rate constant [kep ], and relative extravascular extracellular space [ve]) in the
Sing-Huang Tan et al.
Oncology reports, 18(5), 1225-1230 (2007-10-05)
The purpose was to validate the use of RUNX3 as a potential biomarker for detection of cancer in serum samples and to determine its sensitivity alone and in combination with p16, RASSF1A and CDH1 using methylation-specific polymerase chain reaction (MSP).
Chemotherapy Toxicity Risk Score for Treatment Decisions in Older Adults with Advanced Solid Tumors.
Tomohiro F Nishijima et al.
The oncologist, 23(5), 573-579 (2018-01-27)
The decision whether to treat older adults with advanced cancer with standard therapy (ST) or reduced therapy (RT) is complicated by heterogeneity in aging. We assessed the potential utility of the chemotherapy toxicity risk score (CTRS) [J Clin Oncol 2011;29:3457-3465]
R Joppich-Kuhn et al.
International archives of occupational and environmental health, 69(4), 240-246 (1997-01-01)
A method based on gas chromatography/mass spectrometry-negative ion chemical ionization detection (GC/MS-NCI) was developed for the determination of 3,3'-dichlorobenzidine (DCB)-hemoglobin adducts. Adducts were released from hemoglobin by mild alkaline hydrolysis and determined by GC/MS-NCI after extraction and derivatization with heptafluorobutyric
Ruiqing Ni et al.
Brain : a journal of neurology, 136(Pt 7), 2217-2227 (2013-06-13)
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer's disease. The most widely used amyloid-β imaging tracer so far is (11)C-Pittsburgh compound
Taku Omori et al.
JACC. Cardiovascular imaging, 13(10), 2117-2128 (2020-08-11)
This study sought to evaluate the potential of cardiac magnetic resonance T1 mapping to detect load-independent left ventricular (LV) chamber stiffness by histological confirmation. Accurate noninvasive diagnosis of LV diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) remains
Nicolas Massiot et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 60(6), 925-931 (2020-09-08)
Radiation dose in mesenteric stenting (MS) remains under evaluated. Yet, MS can lead to high levels of radiation mainly because lateral angulation is needed. The aim of this study was to evaluate the efficacy of an extra low dose protocol
Renske D M Steenbergen et al.
Journal of the National Cancer Institute, 96(4), 294-305 (2004-02-19)
Cervical carcinogenesis is initiated by infection with high-risk (i.e., carcinogenic) human papillomavirus (HPV) types. The subsequent progression from premalignant cervical intraepithelial neoplasia (CIN) to invasive cancer is driven by both genetic and epigenetic processes. We assessed the role of the
Jia-Yu Tan et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 34(2), 104-108 (2011-03-24)
To investigate the correlation between MD-1 gene single nucleotide polymorphism (SNP) and bronchial asthma in adults of the Han nationality in Southern China as well as their lung functions. From 2006 to 2010, 332 adult asthmatic patients of the Han
P E Bowden et al.
Journal of dermatological science, 7 Suppl, S152-S163 (1994-07-01)
Normal hair growth and differentiation requires co-ordinate expression of many hair specific structural protein genes. It has been established that one of the 4 major groups of hair structural proteins, low-sulphur hair keratins, belongs to the intermediate filament (IF) multigene
Magdolna Tardy et al.
The Cochrane database of systematic reviews, 8(8), CD009230-CD009230 (2014-08-05)
Antipsychotic drugs are the core treatment for schizophrenia. Treatment guidelines state that there is no difference in efficacy between any other antipsychotic compounds, however, low-potency antipsychotic drugs are often perceived as less efficacious than high-potency compounds by clinicians, and they
Alexandra Barabasch et al.
Investigative radiology, 50(6), 409-415 (2015-03-13)
Patients with hepatic metastases who are candidates for Y90-radioembolization (Y90-RE) usually have advanced tumor stages with involvement of both liver lobes. Per current guidelines, these patients have usually undergone several cycles of potentially hepatotoxic systemic chemotherapy before Y90-RE is at
J K Mills et al.
Journal of dairy science, 93(9), 4262-4273 (2010-08-21)
The objective of this study was to determine the effects of feeding calves isocaloric, isonitrogenous diets that varied in the amount and type of fatty acids on growth, response to an insulin challenge, and body composition. Thirty-six calves were assigned
P R Graves et al.
The Journal of biological chemistry, 268(9), 6394-6401 (1993-03-25)
We report the molecular cloning and characterization of a 49-kDa form of casein kinase I from rat testis. A cDNA clone encoding the enzyme, designated casein kinase I delta, contained an open reading frame of 1284 nucleotides that predicts a
S M Thompson et al.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 25(1), 108-111 (2016-08-06)
Injury to the proximal hamstring complex (PHC) is becoming more frequently diagnosed. Patients attending our tertiary referral centre demonstrated 'pathological changes' in the unaffected normal contralateral PHC on MRI. The prevalence of PHC pathology, however, has not been previously documented
Sriram Venneti et al.
The American journal of surgical pathology, 35(10), 1463-1472 (2011-09-17)
Malignant rhabdoid tumors (MRTs) are highly aggressive pediatric tumors associated with loss of expression of SMARCB1, commonly occurring in the central nervous system [referred to as atypical teratoid/rhabdoid tumors (AT/RTs)] and in the kidney and soft tissues. Histologically, MRTs are
Yanping Zheng et al.
Clinical therapeutics, 37(6), 1235-1247 (2015-04-29)
This study aimed to assess the tolerability of the extended use (≤35 days) of MNK-155, a biphasic (immediate-release/extended-release) hydrocodone bitartrate/N-acetyl-p-aminophenol (acetaminophen) (IR/ER HB/APAP) 7.5/325-mg fixed-dose combination analgesic agent, in patients with chronic noncancer pain (CNCP) caused by osteoarthritis or chronic
D Andes et al.
Antimicrobial agents and chemotherapy, 50(4), 1376-1383 (2006-03-30)
PPI-0903 is a new cephalosporin with broad-spectrum activity, including beta-lactam-resistant Streptococcus pneumoniae and Staphylococcus aureus. We used the neutropenic murine thigh and lung infection models to examine the pharmacodynamic characteristics of PPI-0903. Serum drug levels following four fourfold-escalating single doses
Peter A Calabresi et al.
The Lancet. Neurology, 13(7), 657-665 (2014-05-06)
Subcutaneous pegylated interferon (peginterferon) beta-1a is being developed for treatment of relapsing multiple sclerosis, with less frequent dosing than currently available first-line injectable treatments. We assessed the safety and efficacy of peginterferon beta-1a after 48 weeks of treatment in the
Gian Luca Di Tanna et al.
The Lancet. Global health, 7(2), e191-e199 (2019-01-27)
Xpert MTB/RIF, the most widely used automated nucleic acid amplification test for tuberculosis, is available in more than 130 countries. Although diagnostic accuracy is well documented, anticipated improvements in patient outcomes have not been clearly identified. We performed an individual
Maheshi N Ramasamy et al.
Lancet (London, England), 396(10267), 1979-1993 (2020-11-23)
Older adults (aged ≥70 years) are at increased risk of severe disease and death if they develop COVID-19 and are therefore a priority for immunisation should an efficacious vaccine be developed. Immunogenicity of vaccines is often worse in older adults
National Toxicology Program technical report series, (537)(537), 1-320 (2007-06-08)
Dibromoacetic acid is a water disinfection by-product. Dibromoacetic acid was nominated to the National Toxicology Program by the United States Environmental Protection Agency for toxicity and carcinogenicity studies in rats and mice because of widespread human exposure and because a
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