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Mariko Matsumoto et al.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, (129)(129), 68-75 (2012-01-21)
A chemical category is a group of chemicals whose toxicological properties are expected to be similar or follow a regular pattern as a result of structural similarity. The category approach is beneficial for decreasing in the resource of risk assessment
Ayhan Ozcan et al.
Archives of pathology & laboratory medicine, 136(12), 1541-1551 (2012-12-01)
The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small-needle biopsies. PAX2 and PAX8 transcription factors are known to be expressed by several histologic types of renal neoplasms. To evaluate the diagnostic utility
A Titia Lely et al.
Journal of hypertension, 28(12), 2414-2421 (2010-09-11)
Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype
Joel G Fletcher et al.
AJR. American journal of roentgenology, 201(4), 787-794 (2013-09-26)
Cathartic bowel preparation is a major barrier for colorectal cancer screening. We examined noncathartic CT colonography (CTC) quality and performance using four similar bowel-tagging regimens in an asymptomatic screening cohort. This prospective study included 564 asymptomatic subjects who underwent noncathartic
Suzhao Li et al.
The Journal of biological chemistry, 290(4), 2368-2378 (2014-12-03)
ITF2357 (generic givinostat) is an orally active, hydroxamic-containing histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties, which has been used to treat children with systemic juvenile idiopathic arthritis. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity
Nicholas Gilbo et al.
Transplant international : official journal of the European Society for Organ Transplantation, 31(1), 71-81 (2017-09-05)
Little is known about nonsurgical risk factors for hepatic artery thrombosis (HAT) after liver transplantation (LT). We determined risk factors for HAT occurring within 90 days post-LT and analysed the effect of HAT on graft and patient survival. Donor and
Bartosz Hudzik et al.
European cytokine network, 21(2), 129-135 (2010-05-21)
Contrast media are being widely applied for both diagnostic and therapeutic purposes. This has resulted in increasing incidence of contrast-induced nephropathy (CIN). We aimed to investigate the value of baseline serum IL-6 concentrations in predicting CIN before the rise of
Ulrike Bacher et al.
Blood, 111(5), 2527-2537 (2007-10-30)
We characterized the mutational status of the FLT3 tyrosine kinase domain (FLT3-TLD) in 3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of 3082 (4.8%) patients. Similar to the FLT3 juxtamembrane domain mutations (FLT3-LM), there was a
Christine P Hans et al.
Blood, 103(1), 275-282 (2003-09-25)
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like (GCB), activated B-cell-like (ABC), and type 3 gene expression profiles using a cDNA microarray. Tissue microarray (TMA) blocks were created from 152 cases of
C Foster et al.
British journal of cancer, 86(8), 1209-1216 (2002-04-16)
The aim of this multi-centre UK study is to examine the attributes of a cohort offered predictive genetic testing for breast/ovarian cancer predisposition. Participants are adults unaffected with cancer from families with a known BRCA1/2 mutation. This is the first
T Ohbayashi et al.
Biochemical and biophysical research communications, 255(1), 137-142 (1999-03-20)
TBP is an essential factor for eukaryotic transcription. In this study, we identified a human cDNA encoding 21-kDa TBP-like protein (TLP). The TLP ORF, carrying 186 amino acids, covered the entire 180 amino acids of the C-terminal conserved domain of
Rodolfo Iuliano et al.
Oncogene, 23(52), 8432-8438 (2004-09-21)
We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic phenotype of retrovirally transformed rat thyroid cells. The human homologue gene PTPRJ/DEP-1 is deleted in various tumors. Moreover, the Gln276Pro polymorphism, located in
Sevki Adem et al.
Protein expression and purification, 81(1), 1-4 (2011-09-21)
The enzymes of glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) were purified from rat kidney in one chromatographic step consisting of the use of the 2',5'-ADP Sepharose 4B by using different elution buffers. This purification procedure
S Ansai et al.
The American Journal of dermatopathology, 17(3), 249-255 (1995-06-01)
We investigated immunohistochemically the localization of lysozyme and Leu M1 in normal skin, 76 cases of benign sweat gland tumors, 28 cases of malignant sweat gland tumors, 23 cases of extramammary Paget's disease, 7 cases of sebaceous carcinoma, 6 cases
Rami Kantor et al.
Journal of the International AIDS Society, 17, 19262-19262 (2014-11-22)
Antiretroviral resistance leads to treatment failure and resistance transmission. Resistance data in western Kenya are limited. Collection of non-plasma analytes may provide additional resistance information. We assessed HIV diversity using the REGA tool, transmitted resistance by the WHO mutation list
A J Ouellette et al.
Infection and immunity, 62(11), 5040-5047 (1994-11-01)
Cryptdins are antimicrobial peptides of the defensin family that are produced by intestinal Paneth cells. mRNAs encoding 17 cryptdin isoforms have been characterized from a cDNA library generated from a single jejunal crypt. Six cryptdin cDNAs correspond to known peptides
Mathieu Boulin et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 43(11), 905-911 (2011-08-02)
There is no consensus about the most effective method for transarterial chemoembolisation of hepatocellular carcinoma. The aim of this phase II trial was to compare the efficacy and toxicity of lipiodol transarterial chemoembolisation with amiodarone in association with pirarubicin or
N Appleby et al.
Transfusion medicine (Oxford, England), 27(1), 66-71 (2016-10-08)
Real-world studies of the emergency reversal of warfarin using 4-factor prothrombin complex concentrate (PCC) report unwarranted delays. The delay to receiving PCC was ≥ 8 h in 46·7% of patients with warfarin-associated bleeding (PWAB) treated with a variable PCC dosing
Giulia Veronesi et al.
The European respiratory journal, 45(2), 501-510 (2014-09-28)
Low-dose computed tomography (CT) screening for lung cancer can reduce lung cancer mortality, but overdiagnosis, false positives and invasive procedures for benign nodules are worrying. We evaluated the utility of positron emission tomography (PET)-CT in characterising indeterminate screening-detected lung nodules.
Yueming Tan et al.
ACS applied materials & interfaces, 5(6), 2241-2248 (2013-02-22)
Synthesis of nitrogen-doped carbons with large surface area, high conductivity, and suitable pore size distribution is highly desirable for high-performance supercapacitor applications. Here, we report a novel protocol for template synthesis of ultrathin nitrogen-doped graphitic carbon nanocages (CNCs) derived from
Peter Willatts et al.
The American journal of clinical nutrition, 98(2), 536S-542S (2013-06-21)
Evidence is accumulating that a dietary supply of long-chain polyunsaturated fatty acids (LC-PUFAs) enhances the development of attention and efficient information processing in infants. However, it is uncertain whether LC-PUFAs in infancy influence cognitive development in later childhood. The objective
Javariah Siddiqui et al.
Journal of the American College of Cardiology, 62(22), 2134-2140 (2013-08-21)
This study sought to compare outcomes after surgical valvuloplasty and balloon dilation of the aortic valve in neonates and infants. Surgical techniques of aortic valve repair have improved and there is today controversy on the best approach to treat neonatal
Masaki Maeda et al.
Arzneimittel-Forschung, 61(12), 734-741 (2012-01-28)
Certain kinds of peptide antibiotics are suggested to have immunomodulatory effects; however, few studies have been carried out systemically to evaluate the antiproliferative effects of peptide antibiotics in human lymphoid cells. The suppressive efficacies of nine peptide antibiotics and seven
Sarah Egert et al.
European journal of nutrition, 52(1), 281-288 (2012-03-01)
To investigate the influence of dietary proteins (casein, soy protein) and skimmed milk on the plasma kinetics of green tea (GT) catechins. In a randomized cross-over design with one-week intervals, 24 healthy normal-weight women consumed a test drink containing 1.75
Li-Lan Sun et al.
Acta pharmacologica Sinica, 40(6), 737-745 (2018-10-20)
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated Ca2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Pharmacological enhancement of α7 nAChR function has been suggested for improvement of cognitive deficits. In the present study, we characterized
Rondell P Graham et al.
The American journal of surgical pathology, 37(3), 399-405 (2013-01-26)
Islet-1 (Isl1) is a transcription factor involved in the embryogenesis of islets of Langerhans. Immunohistochemically, Isl1 is a sensitive lineage-specific marker for pancreatic neuroendocrine neoplasms (NENs) and their metastases. Its specificity has not been documented, nor have large numbers of
N Maataoui et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 25(5), 631-631 (2018-08-14)
Acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) by Europeans travelling individually in high-endemicity countries is common. However, how the different ESBL-E strains circulate in groups of travellers has not been studied. We investigated ESBL-E transmission within several groups of French military
Paul A Mead et al.
Clinical science (London, England : 1979), 108(3), 231-236 (2004-11-24)
A polymorphism of the alpha-subunit of adducin, Gly460-->Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The alpha-adducin Gly460-->Trp polymorphism was determined in 242 NC (normal controls) and 73 patients with EH and was related
Yuan Ji et al.
The Journal of pharmacology and experimental therapeutics, 322(2), 529-540 (2007-05-15)
The human hydroxysteroid sulfotransferase (SULT) 2B1 gene is a member of the cytosolic SULT gene superfamily. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b
Z Su et al.
International journal of obesity (2005), 32(7), 1180-1189 (2008-04-17)
To identify the genes controlling body fat, we carried out a quantitative trait locus (QTL) analysis using C57BL/6J (B6) and 129S1/SvImJ (129) mice, which differ in obesity susceptibility after consuming an atherogenic diet. Mice were fed chow until 8 weeks
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