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Madhu S Malo et al.
American journal of physiology. Gastrointestinal and liver physiology, 290(4), G737-G746 (2005-12-31)
Intestinal alkaline phosphatase (IAP) is an enterocyte differentiation marker that functions to limit fat absorption. Zinc finger binding protein-89 (ZBP-89) is a Kruppel-type transcription factor that appears to promote a differentiated phenotype in the intestinal epithelium. The purpose of this
Gabriel Ribas Pereira et al.
Zygote (Cambridge, England), 23(6), 795-801 (2014-09-27)
The objectives of this study were firstly to determine whether the stimulatory function of equine growth hormone (eGH) on equine oocyte maturation in vitro is mediated via cyclic adenosine monophosphate (cAMP); and secondly if the addition of eGH in vitro
Liz Kisslov et al.
Biochimica et biophysica acta, 1821(9), 1224-1234 (2012-06-26)
Cytosolic phospholipase A(2)α (cPLA(2)α) up-regulation has been reported in human colorectal cancer cells, thus we aimed to elucidate its role in the proliferation of the human colorectal cancer cell line, HT-29. EGF caused a rapid activation of cPLA(2)α which coincided
Susumu Ochiai et al.
The Journal of antimicrobial chemotherapy, 60(1), 54-60 (2007-06-02)
In Neisseria gonorrhoeae, the mosaic structure of penicillin-binding protein 2 (PBP 2), composed of fragments of PBP 2 from Neisseria cinerea and Neisseria perflava, was significantly associated with decreased susceptibility to cephalosporins, particularly oral cephalosporins. The aim of this study
Daniel M Halperin et al.
BMC cancer, 19(1), 274-274 (2019-03-30)
There is limited information on changes over time in carcinoid syndrome (CS) symptoms and quality of life (QoL). This study assessed change in CS symptoms and QoL in patients treated with somatostatin analogs (SSAs) using the Functional Assessment of Cancer
Henry Puerta-Guardo et al.
Frontiers in medicine, 9, 916241-916241 (2022-08-09)
Several vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been approved for controlling the coronavirus disease 2019 (COVID-19) pandemic worldwide. Antibody response is essential to understand the immune response to different viral targets after vaccination with different vaccine
Wei-Lien Wang et al.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 15(5), 361-367 (2012-03-01)
Desmoid fibromatosis is a rare, locally aggressive fibroblastic/myofibroblastic tumor that occasionally involves children. We examined a series of pediatric desmoids for CTNNB1 mutations, seen in sporadic tumors, and APC germline mutations, associated with familial adenomatous polyposis (FAP). Forty-four desmoids in
Ramin Hassankhani et al.
Medical oncology (Northwood, London, England), 32(1), 366-366 (2014-11-29)
Colorectal cancer remains often refractory to classic therapies. In consequence, the search for new anti-tumor agents with minimal toxicity is of particular interest in colon cancer treatment. Prodigiosin as a secondary metabolite of Serratia marcescens induces apoptosis in various kinds
Yoshiaki Oshima et al.
Masui. The Japanese journal of anesthesiology, 54(8), 875-880 (2005-08-18)
Continuous epidural administration of droperidol at 2.5 mg x day(-1) or less was performed in 837 patients after surgery. In 4 of these patients, an extrapyramidal reaction occurred. Patient 1 was a 10-year-old girl who developed the symptom 29 hours
Xianxin Wu et al.
Plant disease, 104(8), 2082-2085 (2020-06-20)
Wheat stem rust caused by Puccinia graminis f. sp. tritici is an important wheat disease with sudden and devastating characteristics. The appearance and spread of new P. graminis f. sp. tritici races (Ug99, TKTTF, and TTTTF) have once again renewed
J Mankertz et al.
Cell and tissue research, 336(1), 67-77 (2009-02-14)
Our aim has been to characterize the molecular mechanisms regulating the expression of the channel-forming tight-junctional protein claudin-2 in response to the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha), which is elevated, for example, in active Crohn's disease. TNFalpha caused an
Andrew J Li et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(12), 2919-2922 (2005-12-21)
The androgen receptor (AR) harbors a polymorphic CAG repeat sequence in exon 1, coding for a polyglutamine tract whose length inversely correlates with AR transactivation function. AIB1, an AR coactivator, expresses a similar polymorphic glutamine sequence within the carboxyl-terminal coding
Vladimir Vacic et al.
Nature, 471(7339), 499-503 (2011-02-25)
Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions at 1q21.1 (ref. 2), 3q29 (ref. 3)
John H Peniston et al.
Postgraduate medicine, 124(2), 114-122 (2012-03-23)
Opioids and antidepressants are frequently prescribed for chronic low back pain (cLBP). This post hoc analysis was conducted to assess the tolerability of oxymorphone extended release (ER) for cLBP in patients taking selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake
Michael Poyurovsky et al.
Psychopharmacology, 226(3), 615-622 (2012-12-15)
Combination treatment with reboxetine, a selective norepinephrine reuptake inhibitor, and betahistine, a histamine H1 receptor agonist/H3 antagonist, was developed to produce complementary action in CNS pathways regulating appetite and body weight. In the present placebo-controlled study, we evaluated whether a
G J Tangelder et al.
The American journal of physiology, 268(2 Pt 2), H909-H915 (1995-02-01)
A method is presented to assess in vivo in transparent tissues the leukocyte subtypes that roll in microvessels. In nine rabbits anesthetized with ketamine-xylazine, leukocyte nuclei were stained in situ with acridine yellow (3 mg/kg i.v. for 5 min). Intravital
Chang He et al.
Talanta, 164, 503-510 (2017-01-22)
Flame retardants are associated to numerous adverse health effects, can accumulate in humans and have been used intensively worldwide. Recently, dust has been identified as a major human exposure route for flame retardants. The aim of this study was to
Punit Sharma et al.
Clinical nuclear medicine, 40(7), e351-e356 (2015-03-19)
The aim of this study was to evaluate the role of ⁶⁸Ga DOTANOC PET/CT imaging in patients with multiple endocrine neoplasia (MEN) syndromes. Data of 33 patients (age, 33.5 [13.8] years; male 14/female 19) with MEN syndromes (MEN 1, 9;
G W Philpott et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 36(10), 1818-1824 (1995-10-01)
Detection of tumor foci may be improved by combining the selective tumor-targeting properties of a monoclonal antibody with the superior sensitivity and contrast resolution of PET. An anti-colorectal carcinoma monoclonal antibody (MAb 1A3) was labeled with 64Cu, a positron-emitting radionuclide
Tri Q Nguyen et al.
Diabetes care, 29(1), 83-88 (2005-12-24)
Levels of connective tissue growth factor (CTGF; CCN-2) in plasma are increased in various fibrotic disorders, including diabetic nephropathy. Recently, several articles have reported a strong increase of urinary CTGF excretion (U-CTGF) in patients with diabetic nephropathy. However, these studies
G E Reid et al.
Analytical biochemistry, 200(2), 301-309 (1992-02-01)
2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) has been adapted for use as a coupling reagent for tert-butyloxycarbonyl (Boc) amino acids in automated solid-phase peptide synthesis. When compared to the existing preformed symmetrical anhydride procedure employing dicyclohexyl-carbodiimide (DCC), the use of TBTU in the
Sahar Ghassem-Zadeh et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Identification of disease-associated autoantibodies is of high importance. Their assessment could complement current diagnostic modalities and assist the clinical management of patients. We aimed at developing and validating high-throughput protein microarrays able to screen patients' sera to determine disease-specific autoantibody-signatures
Sam W Moore et al.
Journal of pediatric surgery, 45(2), 393-396 (2010-02-16)
Hirschsprung disease (HSCR) is associated with the later development of multiple endocrine neoplasia (MEN2), because RET gene variations are associated with both conditions. Specifically, HSCR-MEN2 cosegregation mostly relates to the cysteine-rich area at the RET-620 (the "Janus gene"). The aim
Takao Hiraki et al.
BioMed research international, 2014, 152087-152087 (2014-07-06)
This review examines studies of radiofrequency ablation (RFA) of nonsmall cell lung cancer (NSCLC) and discusses the role of RFA in treatment of early-stage NSCLC. RFA is usually performed under local anesthesia with computed tomography guidance. RFA-associated mortality, while being
Deep Sharma et al.
Clinical journal of the American Society of Nephrology : CJASN, 9(12), 2079-2088 (2014-11-14)
Muscle wasting is common among patients with ESRD, but little is known about differences in muscle mass in persons with CKD before the initiation of dialysis. If sarcopenia was common, it might affect the use of body mass index for
Ghislaine Holswilder et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 29(12), 105326-105326 (2020-10-04)
Cardiac emboli are important causes of (recurrent) ischaemic stroke. Aorta atherosclerosis might also be associated with an increased risk of stroke recurrence. This study aimed to evaluate the yield and clinical implications of CT-angiography (CTA) of the heart and aorta
H Reuter et al.
Diabetologia, 49(12), 3067-3074 (2006-10-20)
The angiotensin II (type 1) (AT1) receptor mediates many biological effects of the renin-angiotensin system (RAS), leading to remodelling of cardiac tissue. The present study was designed to analyse changes in the function and expression of the AT1 receptor as
Mary Helen Black et al.
Diabetes, 57(4), 1048-1056 (2007-12-29)
We hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes-related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. The BetaGene project genotyped PPARG2 Pro12Ala and
Selina Khatun et al.
PLoS neglected tropical diseases, 9(7), e0003907-e0003907 (2015-07-15)
The first identified Chikungunya outbreak occurred in Bangladesh in 2008. In late October 2011, a local health official from Dohar Sub-district, Dhaka District, reported an outbreak of undiagnosed fever and joint pain. We investigated the outbreak to confirm the etiology
Tamás Szerafin et al.
Circulation research, 99(5), e12-e17 (2006-08-19)
Based on findings of experimental models of diabetes mellitus (DM) showing increased expression of vascular cyclooxygenase-2 (COX-2), we hypothesized that in patients with DM changes in COX-2-dependent prostaglandin synthesis affect vasomotor responses of coronary arterioles. Arterioles were dissected from the
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