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Silvia de Muga et al.
Cancer biomarkers : section A of Disease markers, 12(1), 21-30 (2013-01-17)
The TMPRSS2-ERG fusion has been reported in 42 to 78% of prostate tumors. More than 90% of ERG-overexpressing tumors harbor the fusion. The relationship between the TMPRSS2-ERG fusion and prognosis is controversial. Different studies have suggested an association between CXCR4
J D Hoyer et al.
American journal of clinical pathology, 108(3), 308-315 (1997-09-18)
The demonstration of tartrate-resistant acid phosphatase (TRAP) activity has long been a cornerstone in the diagnosis of hairy cell leukemia (HCL). Recently a monoclonal antibody to this enzyme has been developed that can be used in an immunoperoxidase method on
Anne M Traynor et al.
Investigational new drugs, 28(1), 91-97 (2009-02-25)
The objective of ECOG 1503 was to determine the response rate of this combination in the second-line treatment of advanced NSCLC. Triapine 105 mg/m(2) IV on days 1, 8, and 15, and gemcitabine 1,000 mg/m(2) on days 1, 8, and
Volker Maus et al.
Cerebrovascular diseases (Basel, Switzerland), 46(1-2), 59-65 (2018-08-10)
One endovascular treatment option of acute ischemic stroke due to tandem occlusion (TO) comprises intracranial thrombectomy and acute extracranial carotid artery stenting (CAS). In this setting, the order of treatment may impact the clinical outcome in this stroke subtype. Retrospective
Emmanuel Njumbe Ediage et al.
Food chemistry, 177, 397-404 (2015-02-11)
An LC-MS/MS method was developed and validated for the detection and quantification of 23 mycotoxins in different varieties of sorghum. The method performance characteristics were as follows: suitable linearity ranges for all 23 mycotoxins with p-value >0.05; limits of detection
I S van Houdt et al.
Histopathology, 51(6), 778-784 (2007-11-29)
Inhibition of apoptosis is important in the pathogenesis of lymphomas. c-FLIP, a regulator of caspase 8-mediated apoptosis, plays an important role in protecting normal B and T cells from apoptosis and possibly also in lymphomas. Because of contradictory reports about
Se Joon Woo et al.
JAMA ophthalmology, 139(1), 68-76 (2020-11-20)
Neovascular age-related macular degeneration is the leading cause of blindness in individuals 50 years or older. The availability of a ranibizumab biosimilar product (SB11) may facilitate access to an effective alternative to this treatment. To demonstrate equivalence of efficacy, similar
Mikkel Christensen et al.
Regulatory peptides, 163(1-3), 96-101 (2010-06-29)
This study investigated the glucagon-releasing properties of the hormones glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) in 8 patients with type 1 diabetes mellitus (T1DM) without paracrine intraislet influence of insulin (C-peptide negative following a 5 g intravenous arginine
Haiyan Liu et al.
Annals of clinical and laboratory science, 43(1), 3-9 (2013-03-07)
The transmembrane protease, serine 2-E twenty-six related gene (TMPRSS2-ERG) fusion leading to ERG overexpression, was detected in approximately 50% of prostate cancers (ranging from 35-70%). However, the published data on ERG expression in tumors from other organs and normal tissues
Rosemary E Morgan et al.
Surgery, 163(1), 218-225 (2017-11-07)
Recently, there has been a move toward decreasing the threshold for liver debulking for metastatic carcinoid tumors from 90% to 70%. The debulking threshold and factors that predict outcomes of liver debulking operations specifically among pancreatic neuroendocrine tumors are not
Esteban Castro-Artavia et al.
Memorias do Instituto Oswaldo Cruz, 112(12), 817-821 (2017-12-07)
Acanthamoeba is the genus of free-living amoebae that is most frequently isolated in nature. To date, 20 Acanthamoeba genotypes have been described. Genotype T4 is responsible for approximately 90% of encephalitis and keratitis cases. Due to the ubiquitous presence of
W Ma et al.
International journal of laboratory hematology, 33(3), 326-331 (2011-01-27)
Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS). We report three novel alternative splicing mutants expressed as the dominant transcripts in patient
A M Montaño et al.
Biochimica et biophysica acta, 1500(3), 323-334 (2000-03-04)
Deficiency of lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS) leads to mucopolysaccharidosis IV A (MPS IV A), for which there is no definitive treatment so far. Although a number of mutations of the GALNS gene of MPS IV A patients have been
Ying Li et al.
Analytical biochemistry, 354(1), 64-69 (2006-05-23)
A flow injection analysis (FIA) system combined with Rayleigh light scattering (RLS) detection is developed for the sensitive and rapid determination of protein concentration in human serum sample. This method is based on the weak intensity of RLS of Eriochrome
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained
Seong-Kyu Han et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(49), 11349-11356 (2005-12-13)
We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse. In the adult male and female mouse, kisspeptin (10-100 nM) evoked a remarkably potent, long-lasting depolarization of >90%
Susan C J Sumner et al.
Journal of applied toxicology : JAT, 23(6), 411-417 (2003-11-25)
Tertiary amyl methyl ether (TAME) is a fuel additive used to reduce carbon monoxide in automobile emissions. Because of the potential for human exposure, this study was conducted to develop methods for the characterization and quantitation of metabolites in expired
Tsin W Yeo et al.
Antimicrobial agents and chemotherapy, 52(12), 4381-4387 (2008-10-08)
Severe malaria is associated with decreased nitric oxide (NO) production and low plasma concentrations of L-arginine, the substrate for NO synthase. Supplementation with L-arginine has the potential to improve NO bioavailability and outcomes. We developed a pharmacokinetic model for L-arginine
Zhan Zhang et al.
Zhonghua fu chan ke za zhi, 45(5), 348-352 (2010-07-22)
To investigate the relationship between human leukocyte antigen-G (HLA-G) gene Exon 8 14 bp deletion polymorphism and the pathogenesis of severe pre-eclampsia. Forty-two pregnant women with severe pre-eclampsia, who admitted to the Third Affiliated Hospital of Zhengzhou University from October
Shozo Yamada et al.
Journal of neurosurgery, 121(6), 1462-1473 (2014-09-23)
The aim of this study was to analyze clinicopathological characteristics and treatment outcomes in a large single-center clinical series of cases of thyrotropin (TSH)-secreting pituitary adenomas. The authors retrospectively reviewed clinical, pathological, and treatment characteristics of 90 consecutive cases of
W S Min et al.
International journal of radiation oncology, biology, physics, 18(1), 147-153 (1990-01-01)
The thermal sensitivities of four B-cell precursor acute lymphoblastic (ALL) cell lines (REH and KM-3 = pre pre B-ALL; NALM-6 and HPB-NULL = pre B-ALL), and 1 B-cell ALL (NAMALWA) cell line were studied and compared to the thermal sensitivity
Xiaoliang Ren et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(5), 358-367 (2012-04-21)
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase closely related to MET and involved in tumorigenesis. We investigated the roles of aberrations in RON and its ligand, macrophage-stimulating protein (MSP), in invasive ductal carcinoma (IDC, n = 81), ductal
Xiaoliang Ren et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(5), 358-367 (2012-04-21)
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase closely related to MET and involved in tumorigenesis. We investigated the roles of aberrations in RON and its ligand, macrophage-stimulating protein (MSP), in invasive ductal carcinoma (IDC, n = 81), ductal
Douglas L Riegert-Johnson et al.
Hereditary cancer in clinical practice, 8(1), 6-6 (2010-06-23)
Cancer risk and Lhermitte-Duclos disease (LDD) risk estimates for Cowden syndrome (CS) are broad and based on a small number of patients. Risk estimates are vital to the development of diagnostic criteria, genetic counseling, and cancer surveillance. To further elaborate
Eva-Katrin Bentz et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(7), 705-709 (2007-11-15)
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100 male-to-female (MtF) transsexuals, 47 female-to-male (FtM) transsexuals, and 1670 controls, the authors assess allele and genotype frequencies of the steroid 5-alpha
Naoki Ishimori et al.
Arteriosclerosis, thrombosis, and vascular biology, 24(1), 161-166 (2003-11-01)
The C57BL/6 (B6) and 129 mouse inbred strains differ markedly in plasma HDL-cholesterol concentrations and atherosclerosis susceptibility after a high-fat diet consumption. To identify loci controlling these traits, we performed quantitative trait loci (QTL) analysis. We fed a high-fat diet
Robert A Augustyniak et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 293(6), R2260-R2266 (2007-09-28)
We have previously shown that acute intravenous injection of the angiotensin-converting enzyme (ACE) inhibitor enalapril in diabetic rats evokes a baroreflex-independent sympathoexcitatory effect that does not occur with angiotensin receptor blockade alone. As ACE inhibition also blocks bradykinin degradation, we
Stephanie Heim et al.
The American journal of surgical pathology, 38(1), 106-110 (2013-10-15)
Papillary tumors of the pineal region are rare glial tumors located in the vicinity of the third ventricle, the clinical behavior of which is often aggressive. Little is known about the prognostic markers that might aid to identify patients at
Keren Tuvia Baron et al.
Emergency radiology, 19(6), 519-525 (2012-08-14)
The objectives of this study were to document the utilization of MRI compared with CT in pregnant patients presenting with acute nontraumatic abdominal pain at our institution and to compare the diagnostic performance of the two modalities. A retrospective review
Petra van der Groep et al.
Breast cancer research and treatment, 111(3), 475-480 (2007-11-22)
Hypoxia is a hallmark of cancer. Hypoxia inducible factor-1alpha (HIF-1alpha) is the key regulator of the hypoxia response. HIF-1alpha is overexpressed during sporadic breast carcinogenesis and correlated with poor prognosis. Little is known on the role of HIF-1alpha in hereditary
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