91-60-1

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The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action.

Ramón A Lorca et al.

Journal of neurochemistry, 85(3), 709-716 (2003-04-16)

Human prion protein fragments (PrP60-67 or PrP59-91) prevented and reversed the inhibition elicited by 5 micro m copper on the P2X4 receptor expressed in Xenopus laevis oocytes. A 60-s pre-application of 5 micro m copper caused a 69.2 +/- 2.6%

Adsorption and degradation of the herbicide nicosulfuron in a stagnic Luvisol and Vermic Umbrisol cultivated under conventional or conservation agriculture.

Sixtine Cueff et al.

Environmental science and pollution research international, 28(13), 15934-15946 (2020-11-28)

The main goals of conservation agriculture are to enhance soil fertility and reduce soil degradation, especially through erosion. However, conservation agriculture practices can increase the risk of contamination by pesticides, mainly through vertical transfer via water flow. Better understanding of

Tandem isomerization/telomerization of long chain dienes.

Laura Torrente-Murciano et al.

Frontiers in chemistry, 2, 37-37 (2014-07-02)

The first example of a tandem reaction involving double-bond migration in combination with telomerization is reported. Homogeneous and heterogeneous Ru catalysts were employed as isomerization catalysts, and telomerization was realized using a homogeneous Pd(0) precursor complex with a N-heterocyclic carbene

CSF biomarker levels in early and late onset Alzheimer's disease.

Femke H Bouwman et al.

Neurobiology of aging, 30(12), 1895-1901 (2008-04-12)

To compare CSF levels of beta-amyloid 1-42 (Abeta(1-42)), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to age. 248 AD patients (48% men) and 127 controls (51% men, 22 volunteers and 105

Expression of gp91phox/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents.

Isabel Murillo et al.

The Biochemical journal, 385(Pt 3), 649-657 (2004-09-21)

We have reported previously that gp91phox, expressed in CHO (Chinese hamster ovary) cells, functions as a voltage-dependent proton channel. However, others have reported that COS-7 cells expressing gp91phox failed to exhibit outward proton currents, and concluded that gp91phox does not

The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil.

Rajendranath Ramasawmy et al.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 10(5), 607-613 (2010-05-01)

Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML. Proinflammatory monocyte chemoattractant protein 1 (MCP-1; encoded by CCL2) is associated with CL. We explore its role in

Repeatability of Oral Sugar Test Results, Glucagon-Like Peptide-1 Measurements, and Serum High-Molecular-Weight Adiponectin Concentrations in Horses.

N Frank et al.

Journal of veterinary internal medicine, 31(4), 1178-1187 (2017-05-26)

Repeatability of the oral sugar test (OST) has not been evaluated. We hypothesized that OST glucose, insulin, active (aGLP-1) and total (tGLP-1) glucagon-like peptide 1, and high-molecular-weight (HMW) adiponectin results would be repeatable. Fifty-three horses from a Tennessee research facility

Sodium salicylate-triggered apoptosis in HL-60 cells depends on caspase-8 activation.

Xiequn Chen et al.

International journal of hematology, 75(4), 407-411 (2002-06-04)

For investigation of the killing and proapoptotic effects of sodium salicylate (Na-Sal) on HL-60 cells, the cytotoxic activity of Na-Sal was measured by means of MTT assay. Apoptosis was identified and analyzed with the help of transmission electron microscopy, annexin

Immunohistochemical localization of EGF, TGF-alpha, TGF-beta, and their receptors in rat corneas during healing of excimer laser ablation.

Sonal S Tuli et al.

Current eye research, 31(9), 709-719 (2006-09-13)

Members of the epidermal growth factor (EGF) and transforming growth factor beta (TGF-beta) families of growth factors and receptors are known to regulate key aspects of corneal wound healing, including epithelial migration and scar formation. To further understand their roles

Possibility of sweet corn synthetic seed production.

P Thobunluepop et al.

Pakistan journal of biological sciences : PJBS, 12(15), 1085-1089 (2009-12-01)

Somatic embryogenesis in sweet corn has been reported by a number of workers. However, the knowledge maintaining storage life, vigor and viability of these somatic embryos are limited. A model system of synchronous somatic embryos production combined with encapsulation to

Characterization of the diatomite binding domain in the ribosomal protein L2 from E. coli and functions as an affinity tag.

Junhua Li et al.

Applied microbiology and biotechnology, 97(6), 2541-2549 (2012-08-29)

The ribosomal protein L2, a constituent protein of the 50S large ribosomal subunit, can be used as Si-tag using silica particles for the immobilization and purification of recombinant proteins (Ikeda et al. (Protein Expr Purif 71:91-95, 2010); Taniguchi et al.

Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB.

Seok Bean Song et al.

Molecular and cellular endocrinology, 199(1-2), 29-36 (2003-02-13)

To investigate the events involved in regulation of the secretogranin II (SgII) gene, luciferase reporter constructs were transfected into gonadotrope-derived, alphaT3-1 cells. DNA between -91 and -60 relative to the transcription start site was found to be required for GnRH

Trace phthalate and adipate esters contaminated in packaged food.

Pamornrat Kueseng et al.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 42(5), 569-576 (2007-06-15)

A method for trace analysis of two plasticizers, di-2-ethylhexyl phthalate (DEHP) and di-2-ethylhexyl adipate (DEHA), contaminated in packaged curry paste were investigated by gas chromatography with flame ionization detector (GC-FID). Curry paste samples were extracted by ultrasonic and solid phase

HIV diversity and drug resistance from plasma and non-plasma analytes in a large treatment programme in western Kenya.

Rami Kantor et al.

Journal of the International AIDS Society, 17, 19262-19262 (2014-11-22)

Antiretroviral resistance leads to treatment failure and resistance transmission. Resistance data in western Kenya are limited. Collection of non-plasma analytes may provide additional resistance information. We assessed HIV diversity using the REGA tool, transmitted resistance by the WHO mutation list

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis.

Rong Liu et al.

Parasites & vectors, 4, 201-201 (2011-10-19)

Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s. In this article, we conducted a systematic review

Optimization and validation of ultrasound-assisted extraction for the determination of micro and macro minerals in non-centrifugal sugar by F AAS.

Jeferson M Dos Santos et al.

Food chemistry, 292, 66-74 (2019-05-06)

In this work, the ultrasound-assisted extraction was employed for the first time as a sample treatment in the determination of Mn, Zn, Fe, Mg and Ca in non-centrifugal sugar by F AAS. Parameters that influence the extraction, such as composition

Evaluation of Cushing's disease remission after transsphenoidal surgery based on early serum cortisol dynamics.

Fabíola Costenaro et al.

Clinical endocrinology, 80(3), 411-418 (2013-07-31)

To evaluate the ability of post-transsphenoidal pituitary surgery (TSS) serum cortisol levels (s-cortisol) to predict surgical remission and recurrence of Cushing's disease (CD). One hundred and three patients with CD from a tertiary referral centre were prospectively analysed over 6·0

Enhanced expression of endoinulinase from Aspergillus niger by codon optimization in Pichia pastoris and its application in inulooligosaccharide production.

Miao He et al.

Journal of industrial microbiology & biotechnology, 41(1), 105-114 (2013-11-26)

In the present study, the endoinulinase gene (EnInu) from Aspergillus niger CICIM F0620 was optimized according to the codon usage of Pichia pastoris and both the native and the optimized gene were expressed in P. pastoris. Use of the optimized

Purification and characterization of a liquefying α-amylase from alkalophilic thermophilic Bacillus sp. AAH-31.

Dae Hoon Kim et al.

Bioscience, biotechnology, and biochemistry, 76(7), 1378-1383 (2012-07-13)

α-Amylase (EC 3.2.1.1) hydrolyzes an internal α-1,4-glucosidic linkage of starch and related glucans. Alkalophilic liquefying enzymes from Bacillus species are utilized as additives in dishwashing and laundry detergents. In this study, we found that Bacillus sp. AAH-31, isolated from soil

Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study.

Surilla Randall et al.

Sleep, 35(11), 1551-1557 (2012-11-02)

To evaluate the long-term (8 months) efficacy of zolpidem in adults with chronic primary insomnia using polysomnography. Randomized, double-blind, placebo-controlled clinical trial. Sleep disorders and research center. Healthy participants (n = 91), ages 23-70, meeting DSM-IV-TR criteria for primary insomnia.

Thrombin activatable fibrinolysis inhibitor and its relationship to fibrinolysis and inflammation during the acute and convalescent phase of ischemic stroke.

Elisabeth Rooth et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 18(4), 365-370 (2007-05-03)

To investigate thrombin activatable fibrinolysis inhibitor (TAFI) in ischemic stroke and its relationship to fibrinolysis and inflammation, we investigated 32 patients with ischemic stroke during the acute phase and after 60 days. TAFI antigen levels, global markers of hemostasis (coagulation

MOR202, a novel anti-CD38 monoclonal antibody, in patients with relapsed or refractory multiple myeloma: a first-in-human, multicentre, phase 1-2a trial.

Marc S Raab et al.

The Lancet. Haematology, 7(5), e381-e394 (2020-03-15)

Treatment of multiple myeloma is not curative, but targeting CD38 improves patient survival. To further explore this therapeutic approach, we investigated the safety and activity of MOR202, a novel monoclonal antibody targeting CD38, in patients with multiple myeloma. This is

Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria.

Douglas S Walsh et al.

The Journal of infectious diseases, 190(8), 1456-1463 (2004-09-21)

We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg (base) daily for 3 days, followed by

Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion.

P H Hutson et al.

European journal of pharmacology, 143(2), 221-228 (1987-11-10)

The putative 5-HT1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY165163, PAPP) (1, 2, 4, 10 mg/kg s.c.) caused a significant and dose-dependent hypothermia in rats, 30 and 60 min after injection. The decreases of temperature were less marked than that caused by 8-OH-DPAT 1

Synthesis of (-)-quinocarcin by directed condensation of alpha-amino aldehydes.

Soojin Kwon et al.

Journal of the American Chemical Society, 127(48), 16796-16797 (2005-12-01)

An enantioselective synthesis of the natural antiproliferative agent quinocarcin was achieved by the directed condensation of optically active alpha-amino aldehyde intermediates. Condensation of the N-protected alpha-amino aldehyde 1, prepared in eight steps (19% yield) from (R,R)-pseudoephedrine glycinamide, with the C-protected

Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of alpha-D-glucose 1-phosphate.

Christiane Goedl et al.

Journal of biotechnology, 129(1), 77-86 (2007-01-12)

Sucrose phosphorylase catalyzes the reversible conversion of sucrose (alpha-D-glucopyranosyl-1,2-beta-D-fructofuranoside) and phosphate into D-fructose and alpha-D-glucose 1-phosphate. We report on the molecular cloning and expression of the structural gene encoding sucrose phosphorylase from Leuconostoc mesenteroides (LmSPase) in Escherichia coli DH10B. The

Anthracyclines during induction therapy in acute myeloid leukaemia: a systematic review and meta-analysis.

Oliver Teuffel et al.

British journal of haematology, 161(2), 192-203 (2013-02-13)

This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in

Enzymatic and molecular characterization of α-1,3-glucanase (AglST2) from Streptomyces thermodiastaticus HF3-3 and its relation with α-1,3-glucanase HF65 (AglST1).

Vipavee Cherdvorapong et al.

The Journal of general and applied microbiology, 65(1), 18-25 (2018-07-18)

Extracellular α-1,3-glucanase HF90 (AglST2), with a sodium dodecyl sulfate (SDS)-PAGE-estimated molecular mass of approximately 91 kDa, was homogenously purified from the culture filtrate of Streptomyces thermodiastaticus HF3-3. AglST2 showed a high homology with mycodextranase in an amino acid sequence and

Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters.

Wen-Chiuan Tsai et al.

Disease markers, 23(3), 153-160 (2007-05-03)

Fascin-1 is an actin-binding protein that promotes cell proliferation, adhesion and motility. We tested the hypothesis that fascin-1 expression correlates with clinicopathological parameters of colorectal adenocarcinomas. Immunohistochemical analysis of fascin-1 was performed in tissue microarrays of 91 surgical specimens, including

Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity.

J Raiko et al.

Diabetes, obesity & metabolism, 17(5), 516-519 (2015-01-15)

The aim of the present study was to determine whether single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) can non-invasively assess triglyceride content in both supraclavicular fat depots and subcutaneous white adipose tissue (WAT) to determine whether these measurements correlate to metabolic

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