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Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Aysun Kara Tuncer et al.
Journal of endodontics, 38(6), 860-863 (2012-05-19)
The purpose of this study was to evaluate the effects of different solutions used for final irrigation on sealer penetration into dentinal tubules. Thirty-two recently extracted human mandibular premolar teeth were treated with sodium hypochlorite (NaOCl) irrigation. The samples were
Kuo-Liang Su et al.
Bioorganic & medicinal chemistry, 17(15), 5414-5419 (2009-07-15)
Fumarate, a four-carbon trans dicarboxylic acid, is the allosteric activator of the human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME). In this paper, we discuss the effects of the structural analogues of fumarate on human m-NAD(P)-ME. Succinate, a dicarboxylic acid with a
G Strasser et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 218(2), 93-95 (1982-01-01)
The long-term effect of timolol maleate on lacrimal secretion was tested by investigating the concentration of lysozyme and albumin in tears before the start of treatment and after different follow-up periods. A total of 25 patients (45 eyes) were treated
Guang Hong et al.
Dental materials journal, 31(1), 139-149 (2012-01-27)
The purpose of this study was to investigate the use of different plasticizers in soft acrylic resin materials to reduce leaching of the plasticizer and thus increase the durability of tissue conditioners. Samples were prepared containing different combinations of three
C N Chen et al.
Journal of dentistry, 30(5-6), 189-194 (2002-11-27)
This study attempted to find a method of restoring the tensile bond strength of glass ionomer cement (GIC) to saliva contaminated enamel under unrinse condition. One hundred and thirty human non-carious permanent teeth were divided into two major groups. Either
Hsin-Chang Chen et al.
Talanta, 136, 9-14 (2015-02-24)
A rapid and simple on-line solid-phase extraction coupled with isotope dilution-liquid chromatography-tandem mass spectrometry (SPE-ID-LC-MS/MS) method was developed to quantitate maleic acid in serum and urine of SpragueDawley (SD) rats. The aforementioned biological samples were spiked with (13)C2-maleic acid, vigorously
Detergent-free formation and physicochemical characterization of nanosized lipid-polymer complexes: Lipodisq.
Marcella C Orwick et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012-04-05)
V Arjunan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 107, 90-101 (2013-02-19)
The structural investigations of the molecular complex of melamine with maleic acid, namely melaminium maleate monohydrate have been carried out by quantum chemical methods in addition to FTIR, FT-Raman and far-infrared spectral studies. The quantum chemical studies were performed with
Waka Kamichatani et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 28(11), 1109-1111 (2012-11-15)
The effect of the mobile phase pH on the control of the electrostatic interaction was evaluated on a column packed with water-holding adsorbent on which diallylamine-maleic acid copolymers were immobilizing. The adsorbent showed extraordinary retention behaviors of water-soluble solutes under
Alaa A Salem et al.
Talanta, 88, 104-114 (2012-01-24)
Selective, rapid and accurate quantitative proton nuclear magnetic resonance (qHNMR) method for the determination of levofloxacin, metronidazole benzoate and sulfamethoxazole in aqueous solutions was developed and validated. The method was successfully applied to the determinations of the drugs and their
Vijaykumar K Parmar et al.
Pharmaceutical development and technology, 18(2), 443-453 (2012-06-13)
Co-crystallization approach for modification of physicochemical properties of hydrochloride salt is presented. The objective of this investigation was to study the effect of co-crystallization with different co-crystal formers on physicochemical properties of fluoxetine hydrochloride (FH). FH was screened for co-crystallization
Yang Liu et al.
Journal of glaucoma, 15(3), 255-259 (2006-06-17)
Measurement of intraocular pressure is affected by the shape and thickness of the cornea, and corneal shape is thought to be maintained by contraction of corneal fibroblasts. The effects of the antiglaucoma drugs latanoprost, timolol maleate, and pilocarpine on the
Marlena K Sheridan et al.
Food chemistry, 177, 17-22 (2015-02-11)
Wine tannins undergo modifications during fermentation and storage that can decrease their perceived astringency and increase color stability. Acetaldehyde acts as a bridging compound to form modified tannins and polymeric pigments that are less likely to form tannin-protein complexes than
Miller AW
Elements of Chemistry: Theoretical and Practical, Volume 3, 3(6) (1880)
H Yoshida et al.
Hepato-gastroenterology, 46(28), 2612-2615 (1999-10-16)
A 54 year-old man was admitted to our hospital and diagnosed with inoperable cancer in the body and tail of the pancreas. The spleen was embolized at its hilum with a coil to infuse an anti-tumor agent selectively into the
Jianbin Zhang et al.
AAPS PharmSciTech, 15(3), 731-740 (2014-02-21)
The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed
Clare A Daykin et al.
Analytical biochemistry, 304(2), 220-230 (2002-05-16)
Blood plasma is the major vehicle by which metabolites are transported around the body in mammalian species, and chemical analysis of plasma can provide a wealth of information relating to the biochemical status of an individual and is important for
Zeid A Al Othman et al.
Molecules (Basel, Switzerland), 16(12), 10443-10456 (2011-12-17)
Agricultural wastes have great potential for the removal of heavy metal ions from aqueous solution. The contamination of water by toxic heavy metals is a worldwide environmental problem. Unlike organic pollutants, the majority of which are susceptible to biological degradation
Sha Liu et al.
Biochemical and biophysical research communications, 455(3-4), 353-357 (2014-12-03)
It has been demonstrated that acid sensing ionic channels (ASICs) are present in the central and peripheral nervous system of mammals, including the retina. However, it remains unclear whether the zebrafish retina also expresses ASICs. In the present study, the
Nidambur Vasudev Ballal et al.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 112(5), 696-700 (2011-08-30)
The aim of this study was to evaluate the antimicrobial efficacy of 7% maleic acid (MA) and 17% ethylenediaminetetraacetic acid (EDTA) in elimination of Enterococcus faecalis, Candida albicans, and Staphylococcus aureus at different time intervals. Transfer culture of microbial strains
Theresia Klose et al.
Colloids and surfaces. B, Biointerfaces, 51(1), 1-9 (2006-06-27)
The adsorption of human serum albumin (HSA) and lysozyme (LSZ) on pure as well as maleic acid (MA) copolymer coated spherical soda lime glass particles was investigated under flowing conditions. Coating the glass particles with two different maleic acid copolymers
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Hong-Lei Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 27(16), 9880-9889 (2011-07-20)
Multilayers of manganese(III) porphyrin-linked poly(vinylpyridinium) (MnTMPyP-PVPMe) polyelectrolyte and poly(styrenesulfonic acid-o-maleic) acid (PSS) have been assembled on gold, quartz, and indium tin oxide surfaces by a layer-by-layer (LBL) technique. The assembly process was monitored by measuring their absorption spectra and frequency
Alfredo Cabrera-Orefice et al.
Biochimie, 102, 124-136 (2014-03-25)
Physiological uncoupling of mitochondrial oxidative phosphorylation (OxPhos) was studied in Debaryomyces hansenii. In other species, such as Yarrowia lipolytica and Saccharomyces cerevisiae, OxPhos can be uncoupled through differential expression of branched respiratory chain enzymes or by opening of a mitochondrial
Oliver Wahl et al.
Journal of pharmaceutical and biomedical analysis, 95, 1-10 (2014-03-19)
For the impurity profiling of the mucolytic and anti-inflammatory drug carbocisteine a high performance liquid chromatographic (HPLC) method using corona charged aerosol detection (CAD) was developed and fully validated following the ICH guideline Q2(R1). The response was linear (R²>0.995) over
Nrupa Borkar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 216-223 (2014-12-17)
Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and investigating their in vitro degradation in biorelevant media before and
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Philipp Malsch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9845-9856 (2014-07-25)
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and nervous system. IL-6-like cytokines are not only key regulators of
O O Glazunova et al.
Membrane & cell biology, 12(3), 401-409 (1999-02-20)
The effect of the synthetic polycation VMII-DEMA (a potential antiheparin agent) on the ion transport through erythrocyte membranes was studied using ion-selective electrodes. We found that the passive ionic permeability of erythrocyte membranes in the presence of VMII-DEMA noticeably increased
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