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O O Glazunova et al.
Membrane & cell biology, 12(3), 401-409 (1999-02-20)
The effect of the synthetic polycation VMII-DEMA (a potential antiheparin agent) on the ion transport through erythrocyte membranes was studied using ion-selective electrodes. We found that the passive ionic permeability of erythrocyte membranes in the presence of VMII-DEMA noticeably increased
Spencer.NJ, et al. et al.
Chemistry: Structure and Dynamics, (5) (2010)
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Nrupa Borkar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 216-223 (2014-12-17)
Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and investigating their in vitro degradation in biorelevant media before and
G Strasser et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 218(2), 93-95 (1982-01-01)
The long-term effect of timolol maleate on lacrimal secretion was tested by investigating the concentration of lysozyme and albumin in tears before the start of treatment and after different follow-up periods. A total of 25 patients (45 eyes) were treated
Guang Hong et al.
Dental materials journal, 31(1), 139-149 (2012-01-27)
The purpose of this study was to investigate the use of different plasticizers in soft acrylic resin materials to reduce leaching of the plasticizer and thus increase the durability of tissue conditioners. Samples were prepared containing different combinations of three
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Hsin-Chang Chen et al.
Talanta, 136, 9-14 (2015-02-24)
A rapid and simple on-line solid-phase extraction coupled with isotope dilution-liquid chromatography-tandem mass spectrometry (SPE-ID-LC-MS/MS) method was developed to quantitate maleic acid in serum and urine of SpragueDawley (SD) rats. The aforementioned biological samples were spiked with (13)C2-maleic acid, vigorously
C N Chen et al.
Journal of dentistry, 30(5-6), 189-194 (2002-11-27)
This study attempted to find a method of restoring the tensile bond strength of glass ionomer cement (GIC) to saliva contaminated enamel under unrinse condition. One hundred and thirty human non-carious permanent teeth were divided into two major groups. Either
V Arjunan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 107, 90-101 (2013-02-19)
The structural investigations of the molecular complex of melamine with maleic acid, namely melaminium maleate monohydrate have been carried out by quantum chemical methods in addition to FTIR, FT-Raman and far-infrared spectral studies. The quantum chemical studies were performed with
Alaa A Salem et al.
Talanta, 88, 104-114 (2012-01-24)
Selective, rapid and accurate quantitative proton nuclear magnetic resonance (qHNMR) method for the determination of levofloxacin, metronidazole benzoate and sulfamethoxazole in aqueous solutions was developed and validated. The method was successfully applied to the determinations of the drugs and their
Aysun Kara Tuncer et al.
Journal of endodontics, 38(6), 860-863 (2012-05-19)
The purpose of this study was to evaluate the effects of different solutions used for final irrigation on sealer penetration into dentinal tubules. Thirty-two recently extracted human mandibular premolar teeth were treated with sodium hypochlorite (NaOCl) irrigation. The samples were
Waka Kamichatani et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 28(11), 1109-1111 (2012-11-15)
The effect of the mobile phase pH on the control of the electrostatic interaction was evaluated on a column packed with water-holding adsorbent on which diallylamine-maleic acid copolymers were immobilizing. The adsorbent showed extraordinary retention behaviors of water-soluble solutes under
Detergent-free formation and physicochemical characterization of nanosized lipid-polymer complexes: Lipodisq.
Marcella C Orwick et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012-04-05)
Kuo-Liang Su et al.
Bioorganic & medicinal chemistry, 17(15), 5414-5419 (2009-07-15)
Fumarate, a four-carbon trans dicarboxylic acid, is the allosteric activator of the human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME). In this paper, we discuss the effects of the structural analogues of fumarate on human m-NAD(P)-ME. Succinate, a dicarboxylic acid with a
Philipp Malsch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9845-9856 (2014-07-25)
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and nervous system. IL-6-like cytokines are not only key regulators of
Oliver Wahl et al.
Journal of pharmaceutical and biomedical analysis, 95, 1-10 (2014-03-19)
For the impurity profiling of the mucolytic and anti-inflammatory drug carbocisteine a high performance liquid chromatographic (HPLC) method using corona charged aerosol detection (CAD) was developed and fully validated following the ICH guideline Q2(R1). The response was linear (R²>0.995) over
Bert Wouters et al.
Journal of chromatography. A, 1370, 63-69 (2014-12-03)
The gradient-performance limits of capillary ion chromatography have been assessed at maximum system pressure (34.5 MPa) using capillary columns packed with 4.1 μm macroporous anion-exchange particles coated with 65 nm positively-charged nanobeads. In analogy to the van-Deemter curve, the gradient
Alfredo Cabrera-Orefice et al.
Biochimie, 102, 124-136 (2014-03-25)
Physiological uncoupling of mitochondrial oxidative phosphorylation (OxPhos) was studied in Debaryomyces hansenii. In other species, such as Yarrowia lipolytica and Saccharomyces cerevisiae, OxPhos can be uncoupled through differential expression of branched respiratory chain enzymes or by opening of a mitochondrial
H Yoshida et al.
Hepato-gastroenterology, 46(28), 2612-2615 (1999-10-16)
A 54 year-old man was admitted to our hospital and diagnosed with inoperable cancer in the body and tail of the pancreas. The spleen was embolized at its hilum with a coil to infuse an anti-tumor agent selectively into the
Miller AW
Elements of Chemistry: Theoretical and Practical, Volume 3, 3(6) (1880)
Masao Horie et al.
The European journal of neuroscience, 40(10), 3458-3471 (2014-09-10)
The Dystonin gene (Dst) is responsible for dystonia musculorum (dt), an inherited mouse model of hereditary neuropathy accompanied by progressive motor symptoms such as dystonia and cerebellar ataxia. Dst-a isoforms, which contain actin-binding domains, are predominantly expressed in the nervous
Jiye Feng et al.
Oncology reports, 33(2), 713-720 (2014-12-09)
miR-200a suppresses tumor development and progression; however, its role in tumor growth and metastasis of hepatocellular carcinoma (HCC) and the underlying mechanism have not been elucidated. In the present study, we identified that miR-200a was markedly downregulated in HCC and
Clare A Daykin et al.
Analytical biochemistry, 304(2), 220-230 (2002-05-16)
Blood plasma is the major vehicle by which metabolites are transported around the body in mammalian species, and chemical analysis of plasma can provide a wealth of information relating to the biochemical status of an individual and is important for
Jianbin Zhang et al.
AAPS PharmSciTech, 15(3), 731-740 (2014-02-21)
The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Sha Liu et al.
Biochemical and biophysical research communications, 455(3-4), 353-357 (2014-12-03)
It has been demonstrated that acid sensing ionic channels (ASICs) are present in the central and peripheral nervous system of mammals, including the retina. However, it remains unclear whether the zebrafish retina also expresses ASICs. In the present study, the
Zhengjun Gong et al.
Luminescence : the journal of biological and chemical luminescence, 20(3), 124-128 (2005-06-01)
A simple, accurate, sensitive and selective fluorescence analysis method for rapid determination of trace amounts of ergometrine maleate has been developed. The method is based on the fluorescence of ergometrine maleate. The calibration graph was linear in the range of
Zeid A Al Othman et al.
Molecules (Basel, Switzerland), 16(12), 10443-10456 (2011-12-17)
Agricultural wastes have great potential for the removal of heavy metal ions from aqueous solution. The contamination of water by toxic heavy metals is a worldwide environmental problem. Unlike organic pollutants, the majority of which are susceptible to biological degradation
María García-Díaz et al.
International journal of pharmaceutics, 482(1-2), 84-91 (2014-12-03)
Polymeric nanoparticles are widely investigated as drug delivery systems for oral administration. However, the hydrophobic nature of many polymers hampers effective loading of the particles with hydrophilic macromolecules such as insulin. Thus, the aim of this work was to improve
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