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Andrew F M Johnstone et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 104989-104989 (2020-09-04)
The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins, resulting in neurotoxicity. Twelve chemicals predicted to be neurotoxic were evaluated in vitro in rat dorsal root ganglia (DRG)
Timo Salmen et al.
Annals of medicine, 35(4), 282-288 (2003-07-09)
After the menopause, estrogen synthesis from androgens and androgen precursors by aromatase is the main source of circulating estrogens. To evaluate whether aromatase gene (CYP19)polymorphism affects circulating estradiol (E2) levels, bone mineral density (BMD), BMD change or fracture risk. A
Xiao-Ping Zhou et al.
Human molecular genetics, 11(4), 445-450 (2002-02-21)
Germline PTEN mutations cause Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRR), two hamartoma-tumor syndromes with an increased risk of breast, thyroid and endometrial cancers. Somatic genetic and epigenetic inactivation of PTEN is involved in as high as 93% of sporadic
Carol L Shields et al.
Cornea, 34(1), 42-48 (2014-10-25)
To describe the clinical features, treatment, and outcome of patients with iris metastasis. Retrospective case series of 160 tumors in 107 eyes of 104 patients with iris metastasis from systemic cancer. The median age at presentation with iris metastasis was
Inmaculada Del Rincón et al.
Arthritis and rheumatism, 49(2), 200-208 (2003-04-11)
To assess the extent of ethnic variation in the clinical expression of rheumatoid arthritis (RA) and the role of HLA-DRB1 alleles in this variation. We assessed consecutive RA patients for joint findings, subcutaneous nodules, laboratory and radiographic findings, and treatment.
Justin F Gainor et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(18), 4585-4593 (2016-05-27)
PD-1 inhibitors are established agents in the management of non-small cell lung cancer (NSCLC); however, only a subset of patients derives clinical benefit. To determine the activity of PD-1/PD-L1 inhibitors within clinically relevant molecular subgroups, we retrospectively evaluated response patterns
Bozena Bidzińska et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 16(95), 434-437 (2004-11-03)
Gene PPARgamma is one of the pivotal factors that influence adipocyte differentiation. It is transcriptional factor that plays a crucial role in the regulation of genes involved in lipid utilisation and storage as well as insulin action. The aim of
AnnaCarin Horne et al.
British journal of haematology, 143(1), 75-83 (2008-08-20)
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive lethal condition characterized by fever, cytopenia, hepatosplenomegaly and hemophagocytosis. The hallmark of FHL is defect apoptosis triggering and lymphocyte cellular cytotoxicity. Thus far three disease-causing genes (PRF1, UNC13D, STX11) have been
K A Al-Barazanji et al.
Obesity research, 8(4), 317-323 (2000-08-10)
To investigate whether chronic administration of the long-acting glucagon-like peptide-1 receptor agonist exendin-4 can elicit sustained reductions in food intake and body weight and whether its actions require an intact leptin system. Male lean and obese Zucker (fa/fa) rats were
Elisa Pingiotti et al.
Annals of the New York Academy of Sciences, 1107, 32-41 (2007-09-07)
Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis. Fractalkine, a CX3C/chemokine (CX3CL1), mediates monocytes-macrophage infiltration in activated endothelium, suggesting its specific role in atherosclerosis-related inflammation. In this study, we evaluate the following in early RA patients: the expression of fractalkine
Madelon van Agteren et al.
Therapeutic drug monitoring, 30(4), 439-444 (2008-07-22)
Mycophenolic acid (MPA) is metabolized primarily by glucuronidation to form the biologically inactive 7-O-glucuronide conjugate (MPAG), which is the major urinary excretion product. MPA is also converted to acyl-glucuronide metabolite (AcylMPAG), which has been suggested to be involved in the
Guoliang Yu et al.
Anesthesiology, 133(2), 408-425 (2020-05-21)
Dorsal root ganglion field stimulation is an analgesic neuromodulation approach in use clinically, but its mechanism is unknown as there is no validated animal model for this purpose. The authors hypothesized that ganglion stimulation is effective in reducing pain-like behaviors
Andrew R Leone et al.
Clinical genitourinary cancer, 15(4), e583-e589 (2017-04-16)
We conducted this study to determine if, in appropriately selected elderly patients receiving neoadjuvant chemotherapy (NAC), clinical outcomes including pathologic complete response/downstaging and overall survival were similar to a younger cohort. Chart review was performed on patients receiving NAC for
Helen Dahl et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 46(5), 553-557 (2011-05-28)
Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are sensitive and specific biomarkers for recent alcohol ingestion. This study compared urinary EtG and EtS measurement with self-reports for detection of prior drinking in alcohol-dependent outpatients treated with the anti-craving medication acamprosate
Andrej Potthoff et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(8), 2042-2049 (2015-03-05)
A considerable proportion of patients receiving liver transplants for Budd-Chiari syndrome (BCS) suffer from myeloproliferative neoplasms (MPN). This study evaluated the long-term prognosis of liver-transplanted patients with BCS secondary to MPN and the effect of immunosuppression on MPN progression. A
Sarah Egert et al.
The British journal of nutrition, 107(4), 539-546 (2011-07-22)
The flavonol quercetin, is one of the major flavonoids found in edible plants. The bioavailability of quercetin in humans may be influenced by the food matrix in which it is consumed as well as by its chemical and physical form.
Joel G Fletcher et al.
AJR. American journal of roentgenology, 201(4), 787-794 (2013-09-26)
Cathartic bowel preparation is a major barrier for colorectal cancer screening. We examined noncathartic CT colonography (CTC) quality and performance using four similar bowel-tagging regimens in an asymptomatic screening cohort. This prospective study included 564 asymptomatic subjects who underwent noncathartic
M L Rothenberg et al.
Gynecologic oncology, 82(2), 317-322 (2001-09-05)
The aim of this study was to evaluate the 2-year survival rate in a group of women in complete clinical remission (cCR) from Stage III ovarian cancer following front-line therapy who were then treated with a 6-month course of altretamine.
Micha Tobias Maeder et al.
Wiener klinische Wochenschrift, 120(21-22), 672-678 (2009-01-01)
In patients with clinically stable chronic heart failure, circulating B-type natriuretic peptide (BNP) levels may exhibit considerable variation over a period of a few days. The aim of this study was to evaluate the clinical impact of this phenomenon. In
Derek Baggott et al.
Veterinary parasitology, 179(4), 330-334 (2011-07-23)
Four studies were conducted to show the effectiveness of a novel combination of fipronil, amitraz and (S)-methoprene in a spot-on formulation (CERTIFECT™, Merial Limited, GA, USA) for the therapeutic and preventive control of Ixodid tick species affecting dogs in Europe:
Bozena Bidzińska et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 17(100), 361-364 (2005-02-05)
PPARgamma is one of the pivotal factors that influence adipocyte differentiation. It is transcriptional factor that plays a crucial role in the regulation of genes involved in lipid utilisation and storage as well as insulin action. The objective of this
Caroline Robert et al.
The Lancet. Oncology, 14(8), 733-740 (2013-06-06)
Patients with metastatic melanoma, 50% of whose tumours harbour a BRAF mutation, have a poor prognosis. Selumetinib, a MEK1/2 inhibitor, has shown antitumour activity in patients with BRAF-mutant melanoma and in preclinical models when combined with chemotherapy. This study was
Daniela Matei et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(10), 2285-2293 (2018-03-04)
Purpose: Epigenetic changes are implicated in acquired resistance to platinum. Guadecitabine is a next-generation hypomethylating agent (HMA). Here, we report the clinical results, along with pharmacokinetic (PK) and pharmacodynamic analyses of the phase I study of guadecitabine and carboplatin in
Denise Baratti-Mayer et al.
The Lancet. Global health, 1(2), e87-e96 (2014-08-12)
Noma is a poorly studied disease that leads to severe facial tissue destruction in children in developing countries, but the cause remains unknown. We aimed to identify the epidemiological and microbiological risk factors associated with noma disease. We did a
Martin Reck et al.
The Lancet. Respiratory medicine, 7(5), 387-401 (2019-03-30)
The IMpower150 trial showed significant improvements in progression-free and overall survival with atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP) versus the standard-of-care bevacizumab plus carboplatin plus paclitaxel (BCP) in chemotherapy-naive patients with non-squamous non-small-cell lung cancer. Here, we report
Sean J Pittock et al.
Archives of neurology, 65(5), 629-632 (2008-05-14)
The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders. Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context. To
David Longchamp et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 30(5), 199-204 (2019-06-04)
: Viscoelastic tests and impedance aggregometry allow coagulation evaluation at the bedside, but reference values are scarce in pediatrics. The aim of this study was to establish reference values of thromboelastometry and impedance aggregometry for this population and compare it
Michael S Landau et al.
Human pathology, 45(8), 1704-1712 (2014-06-09)
Reduced CDX2 and cytokeratin 20 (CK20) expression in colorectal carcinoma with BRAF mutation and high-level microsatellite instability (MSI-H) has been well documented. The immunophenotype of BRAF-mutated microsatellite stable (MSS) colorectal carcinoma has not been reported. We analyzed 205 colorectal carcinomas
Wiebke Albrecht et al.
Archives of toxicology, 93(6), 1609-1637 (2019-06-30)
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation
Ayhan Dogukan et al.
Nutrition and cancer, 63(3), 427-434 (2011-03-11)
Cisplatin-induced nephrotoxicity is related to an increase in oxidative stress in the kidney. Lycopene, a carotenoid found in tomatoes, is a potent dietary antioxidant. In the present study, we investigated the effect of the tomato lycopene complex against cisplatin-induced lipid
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