934-22-5

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A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.

Hideo Nakanishi et al.

PLoS genetics, 5(9), e1000660-e1000660 (2009-09-26)

Myopia is one of the most common ocular disorders worldwide. Pathological myopia, also called high myopia, comprises 1% to 5% of the general population and is one of the leading causes of legal blindness in developed countries. To identify genetic

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues.

Nicolas Gévry et al.

Journal of lipid research, 49(5), 1024-1033 (2008-02-15)

We tested whether sterol-regulatory element binding proteins (SREBPs) mediate sterol-regulated transactivation of the Niemann-Pick C-1 (NPC-1) gene. Loading granulosa cells with 22- or 25-hydroxycholesterol decreased NPC-1 mRNA, whereas culturing in cholesterol-depleted medium or inhibition of cholesterol biosynthesis increased NPC-1 promoter

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