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Jia Liu et al.
Metabolism: clinical and experimental, 63(10), 1314-1323 (2014-07-27)
FoxO1 acts as a pivotal transcription factor in insulin signaling. However, in hyperglycemia induced cardiac complications, whether FoxO1 is involved remains unclear. The goal of this study was to delineate the potential role of FoxO1 under high-glucose condition. We investigated
Rungsiri Chaiittianan et al.
Drug development and industrial pharmacy, 40(12), 1597-1606 (2013-09-24)
For potential topical administration, we formulated a nanoemulsion containing phenolic constituents of Phyllanthus emblica branch extract. The nanoemulsion has high entrapment efficiency, small particle size, is stable, and can release its main chemical components. Branches of P. emblica were extracted
Mohsen Alizadeh et al.
Reports of biochemistry & molecular biology, 10(3), 455-461 (2022-01-05)
The available evidence has increasingly demonstrated that a combination of genetic and epigenetic factors, such as DNA methylation, could be considered as causing leukemia. Epigenetic changes and methylation of the suppressor of the cytokine signaling 1 promoter (SOCS1) CpG region
Cornelia Braicu et al.
Journal of nanoscience and nanotechnology, 13(1), 632-637 (2013-05-08)
Previous studies indicate that green tea extract may inhibit breast cancer progression by blocking angiogenesis, although the molecular mechanisms are not well defined. Epigallocatechin-3-gallate (EGCG) is the major biologically active component of green tea. In this study we evaluated the
Suk-Joon Hyung et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3743-3748 (2013-02-22)
Despite the significance of Alzheimer's disease, the link between metal-associated amyloid-β (metal-Aβ) and disease etiology remains unclear. To elucidate this relationship, chemical tools capable of specifically targeting and modulating metal-Aβ species are necessary, along with a fundamental understanding of their
Ghada M Hadad et al.
Journal of chromatographic science, 52(7), 617-623 (2013-07-03)
A high-performance liquid chromatography method employing diode array detection was developed to determine levels of the major catechins, proanthocyanidin (procyanidin B2), caffeine, thymoquinone and carvacrol and its isomer, thymol, which are present in different natural complex matrices found in commercial
Hye-Kyung Na et al.
Molecular nutrition & food research, 50(2), 152-159 (2006-02-14)
Chemoprevention is an attempt to use either naturally occurring or synthetic substances or their mixtures to intervene in the progress of carcinogenesis. Recently, it has been shown that some edible phytochemicals alter gene expression, directly or indirectly, thereby regulating the
Chih-Yeu Fang et al.
International journal of molecular sciences, 16(2), 2530-2558 (2015-01-28)
(-)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, has been shown to inhibit the proliferation of a variety of tumor cells. Epidemiological studies have shown that drinking green tea can reduce the incidence of nasopharyngeal carcinoma (NPC), yet the underlying mechanism
Christina W A Moyle et al.
Molecular nutrition & food research, 59(3), 401-412 (2014-12-30)
Excessive concentrations of vascular endothelial growth factor (VEGF) drive angiogenesis and cause complications such as increased growth of tumours and atherosclerotic plaques. The aim of this study was to determine the molecular mechanism underlying the potent inhibition of VEGF signalling
Alain Zgheib et al.
The Journal of biological chemistry, 288(19), 13378-13386 (2013-04-04)
CSF-2 and CSF-3 confer proangiogenic and immunomodulatory properties to mesenchymal stromal cells (MSCs). Transcriptional regulation of CSF-2 and CSF-3 in concanavalin A-activated MSCs requires MT1-MMP signaling and is inhibited by EGCG. The chemopreventive properties of diet-derived EGCG alter MT1-MMP-mediated intracellular
Mai Furumiya et al.
Drug metabolism and pharmacokinetics, 29(4), 312-316 (2014-02-05)
Myricetin is a flavonoid that has recently been suggested to interfere with the intestinal folate transport system. The present study was conducted to examine that possibility, focusing on its inhibitory effect on proton-coupled folate transporter (PCFT) as the molecular entity
Pavel Novy et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(5), 432-435 (2013-03-15)
Epigallocatechin gallate (EGCG), the major catechin contained in tea leaves, is known to possess the synergistic anti-staphylococcal activity in combination with various β-lactam antibiotics and tetracycline. In the present study, we explored the in vitro combinatory effect of EGCG in
Sabita N Saldanha et al.
Experimental cell research, 324(1), 40-53 (2014-02-13)
Bioactive compounds are considered safe and have been shown to alter genetic and epigenetic profiles of tumor cells. However, many of these changes have been reported at molecular concentrations higher than physiologically achievable levels. We investigated the role of the
Munawwar Ali Khan et al.
Oncology reports, 33(4), 1976-1984 (2015-02-17)
There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature
Dongxu Wang et al.
Toxicology and applied pharmacology, 283(1), 65-74 (2015-01-15)
(-)-Epigallocatechin-3-gallate (EGCG), a constituent of green tea, has been suggested to have numerous health-promoting effects. On the other hand, high-dose EGCG is able to evoke hepatotoxicity. In the present study, we elucidated the responses of hepatic major antioxidant enzymes and
O Kenny et al.
Food chemistry, 161, 79-86 (2014-05-20)
Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial strains. Ethanol extracts from Centaurea scabiosa, Arctium
Thomas Neuhaus et al.
Platelets, 15(7), 455-457 (2005-03-05)
The C-terminal peptide of thrombospondin (4N1-1) stimulates distinct signalling pathways but induces an activation-independent platelet aggregation. This study demonstrates inhibitory effects of epigallocatechin gallate (EGCG), a major flavonoid component of green tea, on 4N1-1-induced aggregation of washed human platelets. Thrombin
Vojtěch Mezera et al.
Digestive diseases and sciences, 59(5), 976-985 (2013-12-10)
Two-thirds partial hepatectomy (PHx) is an established model for the study of liver regeneration after resection. This process is accompanied by oxidative stress. In our study, we tested the effect of epigallocatechin gallate (EGCG), a green tea antioxidant, on the
Guohua An et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1357-1366 (2014-07-09)
Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity is of great
Jifa Zhu et al.
Cell biochemistry and biophysics, 71(2), 897-903 (2014-10-15)
Epigallocatechin-3 gallate (EGCG) is the major catechin in green tea. The aim of this study is to investigate the effects of EGCG on atrial electrical and structural remodeling in a rabbit rapid atrial pacing (RAP) model. New Zealand white rabbits
Shulin Qin et al.
Cytokine, 61(3), 924-932 (2013-01-31)
CCL20 is currently the only known chemokine ligand for the receptor CCR6, and is a mucosal chemokine involved in normal and pathological immune responses. Although nucleotide sequence data are available for ccl20 and ccr6 sequences from multiple species, the ferret
Jian Yang et al.
Life sciences, 92(10), 589-597 (2013-02-12)
Vascular inflammation is a key factor in the pathogenesis of diabetes-related vascular complications. Our previous study showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits high glucose-induced vascular smooth muscle cell proliferation, thus it may have beneficial effects in diabetes and its complications. However
Hanwei Liu et al.
Food chemistry, 141(1), 488-494 (2013-06-19)
Procyanidin dimers, trimers, and tetramers are absorbable, whereas larger oligomers are not. Procyanidins in cranberries are bioactive components that help prevent chronic diseases; however, 85% of cranberry procyanidins are large oligomers or polymers with a degree of polymerization above four.
Katsuyuki Yuki et al.
Mutation research, 757(2), 148-157 (2013-08-31)
The high rate of false-positive or misleading results in in vitro mammalian genotoxicity testing is a hurdle in the development of valuable chemicals, especially those used in cosmetics, for which in vivo testing is banned in the European Union. The
Reem N Abou El Naga et al.
Life sciences, 92(10), 555-561 (2013-01-29)
The present study investigated and compared the potential chemosensitizing effect of indole-3-carbinol (I3C) and epigallocatechin-3-gallate (EGCG) on TRAIL-induced apoptosis in human hepatocellular carcinoma (HCC) HepG2 cells as well as the possible mechanisms underlying these modulatory effects, particularly their effects on
Ting Ye et al.
PloS one, 10(3), e0119543-e0119543 (2015-03-19)
Crescentic glomerulonephritis (GN) is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy with steroids, cytotoxic drugs, and plasmapheresis. We examined the therapeutic efficacy of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG, 50
Gereon Lill et al.
FEBS letters, 546(2-3), 265-270 (2003-07-02)
Epigallocatechin gallate (EGCG), a major component of green tea, has been previously shown to inhibit platelet aggregation. The effects of other green tea catechins on platelet function are not known. Pre-incubation with EGCG concentration-dependently inhibited thrombin-induced aggregation and phosphorylation of
Daniela Valenti et al.
Biochimica et biophysica acta, 1832(12), 2085-2096 (2013-08-06)
Increasing evidence reveals a large dependency of epithelial cancer cells on oxidative phosphorylation (OXPHOS) for energy production. In this study we tested the potential of epigallocatechin-3-gallate (EGCG), a natural polyphenol known to target mitochondria, in inducing OXPHOS impairment and cell
King-Jean Wu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 113(11), 828-832 (2014-02-25)
Transforming growth factor-β (TGF-β) plays an important role in the pathogenesis of cyclosporine A (CsA)-induced gingival overgrowth (GO). Connective tissue growth factor (CTGF/CCN2) acts as a cofactor with TGF-β to induce the maximal profibrotic effects of TGF-β. We investigated the
Viviana Volta et al.
PloS one, 8(3), e58051-e58051 (2013-03-26)
Malignant pleural mesothelioma (MPM) is a poor prognosis disease lacking adequate therapy. We have previously shown that ascorbic acid administration is toxic to MPM cells. Here we evaluated a new combined therapy consisting of ascorbate/epigallocatechin-3-gallate/gemcitabine mixture (called AND, for Active
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