94-18-8

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A postimplantation lethal mutation induced by transgene insertion on mouse chromosome 8.

D D Pravtcheva et al.

Genomics, 30(3), 529-544 (1995-12-10)

We have produced three lines of transgenic mice that contain additional copies of the mouse phosphoglycerate kinase 1 (Pgk1) gene. Two of these lines, 94-A and 94-K, which are descendants of a common founder, did not produce liveborn progeny carrying

Four days a week or less on appropriate anti-HIV drug combinations provided long-term optimal maintenance in 94 patients: the ICCARRE project.

Jacques Leibowitch et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2223-2234 (2015-04-03)

Short, intraweekly cycles of anti-HIV combinations have provided intermittent, effective therapy (on 48 patients) (1). The concept is now extended to 94 patients on treatment, 4 days per week or less, over a median of 2.7 discontinuous treatment years per

GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats.

Josiane C Cruz et al.

Autonomic neuroscience : basic & clinical, 146(1-2), 47-55 (2009-01-10)

GABAergic, nitrergic and glutamatergic mechanisms in the PVN on the baseline mean arterial pressure (MAP), heart rate (HR) and on the cardiovascular responses to chemoreflex activation in awake rat were evaluated. Chemoreflex was activated with KCN before and after microinjections

Sera from different age cohorts in Belgium show limited cross-neutralization between the mumps vaccine and outbreak strains.

T Vermeire et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 25(7), 907-907 (2018-12-07)

Mumps used to affect children between 2 and 15 years old. The mumps-measles-rubella (MMR) vaccine is available, with vaccine coverage rate of about 85% after two vaccine doses. Recently new mumps outbreaks have emerged in highly vaccinated populations; the causes for

Detection of feline upper respiratory tract disease pathogens using a commercially available real-time PCR test.

A Litster et al.

Veterinary journal (London, England : 1997), 206(2), 149-153 (2015-09-02)

Feline herpesvirus (FHV-1), feline calicivirus (FCV), Bordetella bronchiseptica (Bb), Chlamydia felis (Cf) and Mycoplasma felis (Mf) are common infectious agents identified in cats with upper respiratory tract disease (URTD). Each of these agents can either act as primary pathogens or

Point-of-care serological assays for delayed SARS-CoV-2 case identification among health-care workers in the UK: a prospective multicentre cohort study.

Scott J C Pallett et al.

The Lancet. Respiratory medicine, 8(9), 885-894 (2020-07-28)

Health-care workers constitute a high-risk population for acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the

Pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease.

Jaume Sauleda et al.

International journal of chronic obstructive pulmonary disease, 3(4), 719-725 (2008-01-01)

The potential role of growth factors in chronic obstructive pulmonary disease (COPD) has begun to be addressed only recently and is still poorly understood. For this study, we investigated potential abnormalities of hepatocyte growth factor (HGF) and keratinocyte growth factor

Abnormalities associated with progressive aortic vascular dysfunction in chronic kidney disease.

Omar Z Ameer et al.

Frontiers in physiology, 6, 150-150 (2015-06-05)

Increased stiffness of large arteries in chronic kidney disease (CKD) has significant clinical implications. This study investigates the temporal development of thoracic aortic dysfunction in a rodent model of CKD, the Lewis polycystic kidney (LPK) rat. Animals aged 12 and

Detection of recurrent prostate cancer with 18F-fluorocholine PET/CT in relation to PSA level at the time of imaging.

Sandi A Kwee et al.

Annals of nuclear medicine, 26(6), 501-507 (2012-05-03)

To evaluate fluorine-18 fluorocholine (FCH) PET/CT for the detection of recurrent prostate cancer in relation to prostate-specific antigen (PSA) level. FCH PET/CT was performed in 50 patients with rising PSA levels at follow-up of primary treatment of prostate cancer (radical

Treatment of hairy cell leukemia: long-term results in a developing country.

Guillermo J Ruiz-Delgado et al.

Hematology (Amsterdam, Netherlands), 17(3), 140-143 (2012-06-06)

Twenty-nine consecutive patients with hairy cell leukemia (HCL) were treated in two institutions with interferon (IFN, n = 18) or cladribine (n = 11), between July 1987 and May 2011. Median age was 62 (range 29-83) years; there were 21

18F-fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin αvβ6.

Benjamin J Hackel et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(7), 1101-1105 (2013-05-15)

Integrin αvβ6 is a cell surface receptor minimally expressed by healthy tissue but elevated in lung, colon, skin, ovarian, cervical, and pancreatic cancers. A molecular PET agent for integrin αvβ6 could provide significant clinical utility by facilitating both cancer staging

Detection of genetic variations of regulator of G-protein signaling 2 in hypertensives by sequencing.

Zhang Ju-hong et al.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 33(2), 200-204 (2011-05-03)

To investigate the new genetic variations of regulator of G-protein signalling 2 (RGS2) gene in Kazakh hypertensives. Totally 94 Kazakh patients with essential hypertension were enrolled and genomic DNA was extracted from their peripheral blood leukocytes. All the exon regions

Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents.

M A Pfaller et al.

Diagnostic microbiology and infectious disease, 12(6), 467-471 (1989-11-01)

Terconazole is a triazole ketal derivative with potent, broad-spectrum antifungal activity. We investigated the in vitro activity of terconazole, miconazole, and clotrimazole, against 94 clinical isolates of Candida spp.: C. albicans (n = 68), C. tropicalis (n = 18), and

Mid-gestational lethality in mice lacking keratin 8.

H Baribault et al.

Genes & development, 7(7A), 1191-1202 (1993-07-01)

Keratin 8 (mK8) and its partner keratin 18 (mK18) are the first intermediate filament proteins expressed during mouse embryogenesis. They are found in most extraembryonic and embryonic simple epithelia, including trophectoderm, visceral yolk sac, gastrointestinal tract, lungs, mammary glands, and

CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis.

Benjamin Wilde et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(1), 161-171 (2008-08-30)

An increased CD4(+) CD25(+) T-cell population is observed in Wegener's granulomatosis (WG). This T-cell population is not well characterized yet and their contribution to the disease pathogenesis remains obscure. Thirty patients with WG and 18 healthy controls (HC) were included

In vivo efficacy of humanized exposures of Ceftazidime-Avibactam in comparison with Ceftazidime against contemporary Enterobacteriaceae isolates.

Shawn H MacVane et al.

Antimicrobial agents and chemotherapy, 58(11), 6913-6919 (2014-09-17)

Ceftazidime-avibactam is a β-lactam β-lactamase inhibitor combination under investigation for the treatment of serious Gram-negative infections. When combined with avibactam, a novel non-β-lactam β-lactamase inhibitor, ceftazidime has activity against isolates that produce Ambler class A, class C, and some class

(123)I-BZA2 as a melanin-targeted radiotracer for the identification of melanoma metastases: results and perspectives of a multicenter phase III clinical trial.

Florent Cachin et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 15-22 (2013-11-23)

Our group has developed a new radiopharmaceutical, (123)I - N-(2-diethylaminoethyl)-2-iodobenzamide ((123)I-BZA2), a benzamide derivative able to bind to melanin pigment in melanoma cells. In a prospective and multicentric phase III clinical study, the value of (18)F-FDG PET/CT and (123)I-BZA2 scintigraphy

Syndecan-1 expression--a novel prognostic marker in pancreatic cancer.

Anne Juuti et al.

Oncology, 68(2-3), 97-106 (2005-05-12)

Syndecan-1 is a transmembrane receptor that participates in cell-cell and cell-matrix interactions, cell proliferation and cell migration. Expression of syndecan-1 is downregulated in many cancers, but in pancreatic ductal adenocarcinoma it is upregulated. We studied the immunohistochemical expression of syndecan-1

A Validated Method for Cholesterol Determination in Turkey Meat Products Using Relative Response Factors.

Simona Grasso et al.

Foods (Basel, Switzerland), 8(12) (2019-12-19)

The objective of this study was to develop a precise and accurate method to quantify cholesterol in turkey meat products using relative response factors, based on a modification of a previously published method for plant sterols determination. Validation was performed

The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: a case-control study.

Marinez F Matos et al.

Thrombosis research, 128(3), 216-220 (2011-05-31)

Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of

Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction.

Guangwen Long et al.

PloS one, 7(12), e50926-e50926 (2012-12-14)

MicroRNAs (miRNAs) play key roles in diverse biological and pathological processes, including the regulation of proliferation, apoptosis, angiogenesis and cellular differentiation. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. This study investigated miR-30a, miR-195 and

Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1- yl)purines as potential prodrugs of penciclovir.

D K Kim et al.

Bioorganic & medicinal chemistry, 7(8), 1715-1725 (1999-09-11)

A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines (9-12) were synthesized as potential prodrugs of penciclovir. Treatment of 6-deoxypenciclovir with trimethyl orthoacetate or triethyl orthopropionate (1.2 equiv) in DMF in the presence of p-TsOH.H2O (0.1 equiv) followed by quenching

Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake.

Arline D Salbe et al.

The Journal of clinical endocrinology and metabolism, 89(6), 2951-2956 (2004-06-08)

Ghrelin is a novel GH secretagogue with orexigenic effects. We hypothesized that high fasting plasma ghrelin concentrations (FxGhr) might predict high ad libitum food intake. FxGhr were measured in 30 normoglycemic subjects: 15 Pima Indians (8 male/7 female; age, 32

Acceptance, satisfaction and cost of an integrative anthroposophic program for pediatric respiratory diseases in a Swiss teaching hospital: An implementation report.

Tido von Schoen-Angerer et al.

Complementary therapies in medicine, 40, 179-184 (2018-09-17)

For the pilot phase of an integrative pediatric program, we defined inpatient treatment algorithms for bronchiolitis, asthma and pneumonia, using medications and nursing techniques from anthroposophic medicine (AM). Parents could choose AM treatment as add-on to conventional care. To evaluate

Stereocontrolled synthesis of cis-dibenzoquinolizine chlorofumarates: curare-like agents of ultrashort duration.

I Kaldor et al.

The Journal of organic chemistry, 66(10), 3495-3501 (2001-05-12)

The quaternizations of dibenzoquinolizines 9 and 14 with 3-halo-1-propanols are highly cis-selective (94-100% cis), results consistent with the N-methylation of O-methylcapaurine (7b), but in contrast to the proposed trans-stereochemistry of dibenzo[a,h]quinolizine methiodide 10 and the analogous quaternizations of 1-benzyl- and

Molecular analysis of phenylketonuria (PKU) in newborns from Texas.

Y Yang et al.

Human mutation, 17(6), 523-523 (2001-06-01)

This study describes the mutations at the phenylalanine hydroxylase (PAH) locus in patients with the diagnosis of classic PKU (n=18), hyperphenylalaninemia (HPA) variant (n=9) and benign persistent hyperphenylalaninemia (HPA) (n=13) who were identified by the Texas Newborn Screening Program. Blinded

Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.

Daisuke Nonaka et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 192-200 (2007-12-18)

Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these

Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.

N S Sturm et al.

Journal of medicinal chemistry, 41(15), 2693-2700 (1998-07-21)

We have designed and synthesized eight compounds 2-9 which incorporate various amino acid residues in positions 17, 18, and 21 of the glucagon molecule: 2, [Lys17]glucagon amide; 3, [Lys18]glucagon amide; 4, [Nle17,Lys18,Glu21]glucagon amide; 5, [Orn17,18, Glu21]glucagon amide; 6, [d-Arg17]glucagon; 7

Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives.

Sara Thulin Hedberg et al.

Antimicrobial agents and chemotherapy, 53(4), 1561-1566 (2009-02-04)

Up-to-date information regarding the antibiotic susceptibility of Neisseria meningitidis strains from African countries is highly limited. Our aim was to comprehensively describe the antibiotic susceptibilities of a selection of N. meningitidis isolates recovered between 2000 and 2006 from 18 African

Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.

Abdelouahid Samadi et al.

Bioorganic & medicinal chemistry, 19(2), 951-960 (2010-12-31)

The synthesis, structure, theoretical and experimental in vitro antioxidant properties using the DPPH, ORAC, and benzoic acid, as well as preliminary in vitro pharmacological activities of (Z)-α-aryl and heteroaryl N-alkyl-nitrones 6-15, 18, 19, 21, and 23, is reported. In the

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