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显示 31-60 共 107 条结果 关于 "94-18-8" 范围 论文
Mark C Royer et al.
Archives of otolaryngology--head & neck surgery, 136(3), 240-242 (2010-03-17)
To determine the relationship between hOGG1 loss of heterozygosity (LOH), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Hashimoto thyroiditis is an autoimmune mediated chronic inflammatory disease previously shown to coexist with papillary PTC. To further define the relationship between
Abdelouahid Samadi et al.
Bioorganic & medicinal chemistry, 19(2), 951-960 (2010-12-31)
The synthesis, structure, theoretical and experimental in vitro antioxidant properties using the DPPH, ORAC, and benzoic acid, as well as preliminary in vitro pharmacological activities of (Z)-α-aryl and heteroaryl N-alkyl-nitrones 6-15, 18, 19, 21, and 23, is reported. In the
Jessica A Hemminger et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(2), 282-288 (2012-09-01)
Liposarcomas are a heterogenous group of fat-derived sarcomas, and surgery with or without chemoradiation therapy remains the main stay of treatment. NY-ESO-1 is a cancer-testis antigen expressed in various cancers where it can induce both cellular and humoral immunity. Immunotherapy
Dana Haves-Zburof et al.
Journal of cellular and molecular medicine, 15(11), 2421-2429 (2010-12-15)
Cathepsins are involved in a variety of physiological processes including antigen processing and presentation and extracellular matrix degradation. In the present study, we evaluated whether expression levels of cathepsins S and B and their inhibitors cystatins B and C are
Junkichi Takemoto et al.
Human pathology, 85, 162-167 (2018-11-24)
The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas
Thomas E Hutson et al.
The Lancet. Oncology, 14(13), 1287-1294 (2013-11-12)
In previous clinical trials of patients with metastatic renal-cell carcinoma, patients treated with axitinib as second-line therapy had longer median progression-free survival than those treated with sorafenib. We therefore undertook a phase 3 trial comparing axitinib with sorafenib in patients
S Rachel Skinner et al.
Lancet (London, England), 384(9961), 2213-2227 (2014-09-06)
Although adolescent girls are the main population for prophylactic human papillomavirus (HPV) vaccines, adult women who remain at risk of cervical cancer can also be vaccinated. We report data from the interim analysis of the ongoing VIVIANE study, the aim
Wei-Shen Chen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(2), 184-193 (2013-07-28)
The malignant peripheral nerve sheath tumor is a relatively uncommon type of soft tissue sarcoma arising from a peripheral nerve or extraneural soft tissues and showing nerve sheath differentiation. The diagnosis of malignant peripheral nerve sheath tumor is one of
Isabelle Koné-Paut et al.
Rheumatology (Oxford, England), 48(7), 840-842 (2009-05-26)
To assess the clinical characteristics of patients living in France and carrying a single MEFV mutation. A retrospective chart review of patients referred to us for recurrent fevers. Genetic testing: systematic screening of exons 2 and 10 was performed in
Clarisse Lopes de Castro Lobo et al.
British journal of haematology, 161(6), 852-860 (2013-04-18)
Although evidence is accumulating that hydroxycarbamide decreases mortality among adults with sickle cell disease (SCD), there are no published data regarding the effect of hydroxycarbamide on mortality among children. The Paediatric Hydroxycarbamide Program was established to treat children with SCD
Stefan Krüger et al.
Human mutation, 21(4), 445-446 (2003-03-26)
Germline mutations in mismatch repair genes are responsible for hereditary nonpolyposis colorectal cancer (HNPCC), the most common hereditary cancer-susceptibility syndrome. We report six novel germline mutations, three in MSH2 and three in MLH1. All but one mutation have been found
Ron C Gaba et al.
AJR. American journal of roentgenology, 202(6), 1355-1360 (2014-05-23)
The purpose of this study was to assess the efficacy and safety of flow-directed catheter thrombolysis for treatment of submassive pulmonary embolism (PE). In this single-institution retrospective study, 19 patients (nine men and 10 women; mean age [± SD], 54
Daisuke Takada et al.
Journal of human genetics, 47(12), 656-664 (2003-01-11)
Lipid and lipoprotein concentrations in plasma generally reflect complex influences of multiple genetic loci. Even an autosomal dominant disorder, familial hypercholesterolemia (FH), is characterized by phenotypic heterogeneity, as low-density lipoprotein (LDL) levels vary widely within the same pedigree. Molecular screening
Selami Sozubir et al.
The Journal of urology, 183(6), 2373-2379 (2010-04-20)
The testicular hormone Insl3 is critical for mouse gubernacular development. Knockout mice exhibit bilateral intra-abdominal cryptorchidism with absent gubernaculum. Prior studies described torsion of the vas deferens in Insl3 mutant mice. We performed a detailed anatomical analysis of the vas
Zachary C Landis et al.
ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(2), 127-132 (2014-12-11)
The optimal timing of left ventricular assist device (LVAD) implantation in the management of advanced heart failure remains controversial. We hypothesize that in patients with cardiogenic shock, the severity of end-organ dysfunction as determined by the sequential organ failure assessment
Fatimah S Dawood et al.
The New England journal of medicine, 360(25), 2605-2615 (2009-05-09)
On April 15 and April 17, 2009, novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from two epidemiologically unlinked patients in the United States. The same strain of the virus was identified in Mexico, Canada, and
Bernhard Sandig et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15835-15842 (2015-10-24)
Mesoporous monolithic hybrid cellulose-2.5-acetate (CA)/polymer supports were prepared under solvent-induced phase separation conditions using cellulose-2.5-acetate microbeads 8-14 μm in diameter, 1,1,1-tris(hydroxymethyl)propane and 4,4'-methylenebis(phenylisocyanate) as monomers as well as THF and n-heptane as porogenic solvents. 4-(Dimethylamino)pyridine and dibutyltin dilaurate (DBTDL), respectively, were
Renata T Simões et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(8), 1075-1082 (2009-05-02)
Human papillomavirus (HPV) infection is etiologically associated with low- (LSIL) and high-grade squamous intraepithelial lesions (HSIL) and with cervical cancer. The progression or regression of the lesions may depend, among other factors, on the host heritable immune response. Because human
Anne Minert et al.
Anesthesiology, 132(3), 535-550 (2019-12-19)
The brainstem mesopontine tegmental anesthesia area is a key node in circuitry responsible for anesthetic induction and maintenance. Microinjecting the γ-aminobutyric acid-mediated (GABAergic) anesthetic pentobarbital in this nucleus rapidly and reversibly induces general anesthesia, whereas lesioning it renders the animal
L M Koeth et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 37(6), 1047-1053 (2018-04-01)
Ceftazidime-avibactam disk studies were performed for disk mass selection and for establishing EUCAST quality control ranges and zone diameter breakpoints. The disk mass study included disk diffusion testing with ceftazidime-avibactam 10-4 and 10-6 μg disks and broth microdilution MIC testing for
Tobias Broger et al.
The Lancet. Infectious diseases, 19(8), 852-861 (2019-06-04)
Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. The only commercially available tuberculosis point-of-care test (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clinical practice. The novel
Wenxin Zheng et al.
The American journal of surgical pathology, 32(2), 304-315 (2008-01-29)
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. The aim of this study is to determine the expression of IMP3 in
Robert E Goldsby et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(24), 15560-15565 (2002-11-14)
Mutations are a hallmark of cancer. Normal cells minimize spontaneous mutations through the combined actions of polymerase base selectivity, 3' --> 5' exonucleolytic proofreading, mismatch correction, and DNA damage repair. To determine the consequences of defective proofreading in mammals, we
J S McPhee et al.
Experimental physiology, 96(7), 699-707 (2011-05-17)
Skeletal muscles improve their oxidative fatty acid and glucose metabolism following endurance training, but the magnitude of response varies considerably from person to person. In 20 untrained young women we examined interindividual variability in training responses of metabolic enzymes following
Benjamin Speich et al.
The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)
Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy
Leonel Maldonado et al.
Oncotarget, 5(14), 5218-5233 (2014-07-02)
By a candidate gene approach, we analyzed the promoter methylation (PM) of 8 genes genes (ARF, TIMP3, RAR-β2, NID2, CCNA1, AIM1, CALCA and CCND2) by quantitative methylation specific PCR (QMSP) in DNA of 17 non-recurrent and 19 recurrent noninvasive low
Andrew J Lovy et al.
AJR. American journal of roentgenology, 200(4), 805-811 (2013-03-26)
The purpose of this article is to assess the diagnostic performance of the unenhanced and contrast-enhanced phases separately in patients imaged with CT for suspected acute aortic syndromes. All adults (n = 2868) presenting to our emergency department from January
Riccardo Asero et al.
International archives of allergy and immunology, 131(3), 195-200 (2003-07-24)
A subset of drug-intolerant patients show a marked propensity to react to several chemically unrelated antibacterial drugs. This condition is termed multiple drug allergy syndrome (MDAS). The pathogenesis of MDAS is still unclear. A possible mechanism is that a nonspecific
Hsiang-Yu Lin et al.
Journal of inherited metabolic disease, 33(5), 619-624 (2010-09-08)
Newborn screening for Fabry disease in Taiwan Chinese has revealed a high incidence of the late-onset GLA mutation IVS4 + 919G→A (∼1 in 1,500-1,600 males). We studied 94 adults with this mutation [22 men, 72 women; mean age: men 57.8 ± 6.0 (range 42-68)
Deyuan Zhang et al.
PeerJ, 7, e7079-e7079 (2019-06-21)
Previous studies have shown that a variety of biomarkers are closely related to the occurrence and development of early-stage diabetic nephropathy (DN) in patients. The aim of this study was to evaluate the role of multiple sera and urinary biomarkers
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