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显示 1-30 共 79 条结果 关于 "94-53-1" 范围 论文
Semra Paydas et al.
Leukemia research, 32(2), 243-250 (2007-08-21)
Survivin (S) is a member of inhibitor of apoptosis family (IAP) and is expressed in the majority of malignant tumors but undetectable in normal differentiated adult tissues. S is an encouraging target for cancer therapy. TSP-1 is a multifunctional protein
Z Lei et al.
The Journal of biological chemistry, 272(22), 14365-14371 (1997-05-30)
We investigated the cis-acting elements and trans-acting proteins required for the transcriptional inhibition of the gonadotropin-releasing hormone (GnRH) gene by human chorionic gonadotropin (hCG) in GT1-7 neurons. Transient transfection of GT1-7 neurons with the 5'-flanking region of the rat GnRH
Earn H Gan et al.
Clinical endocrinology, 75(2), 165-168 (2011-04-28)
Genome-wide association studies have discovered various susceptibility alleles that are shared among different autoimmune conditions, implicating several biochemical pathways in the pathogenesis of autoimmunity. A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor
Camilo G Borrero et al.
Skeletal radiology, 47(2), 203-214 (2017-10-07)
To determine the effect of patient age on the accuracy of primary MRI signs of long head of biceps (LHB) tendon tearing and instability in the shoulder using arthroscopy as a reference standard. Subjects with MRI studies and subsequent arthroscopy
Xian-Qiang Ni et al.
Endocrine, 62(1), 90-106 (2018-06-27)
Endoplasmic reticulum stress (ERS) is involved in the development of abdominal aortic aneurysm (AAA). Since bioactive peptide intermedin (IMD)1-53 protects against AAA formation, here we investigated whether IMD1-53 attenuates AAA by inhibiting ERS. AAA model was induced by angiotensin II
P Franzén et al.
Cell, 75(4), 681-692 (1993-11-19)
A cDNA clone encoding a 53 kd serine/threonine kinase receptor with an overall structure similar to that of the type II receptor for transforming growth factor beta (TGF beta) was obtained. 125I-TGF beta 1 bound to porcine endothelial cells transfected
Helene Thorsen Rønning et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 2120-2130 (2015-09-29)
Lichenysin produced by 53 different Bacillus licheniformis strains has been structurally examined with a qualitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using quadrupole-time-of-flight mass spectrometry. The same lichenysin isoforms are produced from all strains, indicating that the growth conditions have
Okko T Pyykkö et al.
Journal of neurology, neurosurgery, and psychiatry, 83(11), 1119-1124 (2012-09-08)
To investigate the association of apolipoprotein E (APOE) genotype, especially the APOE4 allele, to (1) idiopathic normal pressure hydrocephalus (iNPH) and (2) amyloid-β (Aβ) plaques in cortical brain biopsies of presumed NPH patients with and without a final clinical diagnosis
Matthias Rief et al.
The international journal of cardiovascular imaging, 30(8), 1621-1627 (2014-08-15)
To evaluate computer-aided stenosis detection for computed tomography coronary angiography (CTA) in comparison with human reading and conventional coronary angiography (CCA) as the reference standard. 50 patients underwent CTA and CCA and out of these 44 were evaluable for computer-aided
Michael Schmitt et al.
Experimental hematology, 34(12), 1709-1719 (2006-12-13)
Specific immunotherapies for patients with chronic myeloid leukemia (CML) might eliminate residual CML cells after therapy with imatinib or chemotherapy and might enhance a specific graft-versus-leukemia effect after allogeneic stem cell transplantation. Here, we investigated the mRNA expression and T-cell
Geon Park et al.
Annals of hematology, 90(1), 73-79 (2010-08-20)
Disruption of cell cycle control genes, including p16, is known to contribute to the cancerogenesis of multiple myeloma (MM). We investigated the methylation status of p16 and its association with common cytogenetic changes, clinicolaboratory findings, and survival in MM. Methylation-specific
R Reeves et al.
Gene, 90(2), 303-307 (1990-06-15)
A full-length (6.1-kb) human genomic pim-1 gene, together with its immediate 5'-upstream promoter sequence (Ppim) was isolated and sequenced. The human pim-1 gene shares an overall nucleotide (nt) sequence identity of 53% with the previously reported murine pim-1 gene. It
Isabelle Koné-Paut et al.
Rheumatology (Oxford, England), 48(7), 840-842 (2009-05-26)
To assess the clinical characteristics of patients living in France and carrying a single MEFV mutation. A retrospective chart review of patients referred to us for recurrent fevers. Genetic testing: systematic screening of exons 2 and 10 was performed in
Ulf Thunberg et al.
Lancet (London, England), 360(9349), 1935-1939 (2002-12-21)
The P2X7 receptor is a ligand-gated cation channel that mediates ATP-induced apoptotic death in haemopoietic and chronic lymphocytic leukaemia (CLL) cells. We aimed to investigate the clinical effect of a single nucleotide polymorphism in the P2X7 receptor gene (1513A-->C) and
R E Novy et al.
The Journal of biological chemistry, 266(25), 16917-16924 (1991-09-05)
Overlapping cDNA clones encoding a low M gamma human nonmuscle caldesmon isoform (HUM 1-CaD) span the entire coding region (538 amino acids) as well as 111 base pairs (bp) of 5'-noncoding and 1249 bp of 3'-noncoding region. Northern blot probes
Delphine Détaint et al.
European heart journal, 31(18), 2223-2229 (2010-08-17)
In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery
Mika Bando et al.
Biochimica et biophysica acta, 1829(9), 954-962 (2013-04-09)
S100A9 is a calcium-binding protein and subunit of antimicrobial calprotectin complex (S100A8/A9). Produced by neutrophils, monocytes/macrophages and keratinocytes, S100A9 expression increases in response to inflammation. For example, IL-1α produced by epithelial cells acts autonomously on the same cells to induce
Ian McGilvray et al.
Gastroenterology, 142(5), 1122-1131 (2012-01-31)
Cell-type specific expression patterns of hepatic interferon-stimulated genes (ISGs) and single nucleotide polymorphisms (SNPs) near the IL28B gene are associated with response to interferon-based therapy in patients with chronic hepatitis C virus (HCV) infection. It is not known how the
P A Crossey et al.
Human molecular genetics, 3(8), 1303-1308 (1994-08-01)
Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar and spinal haemangioblastoma, renal cell carcinoma, phaeochromocytoma and pancreatic tumours. We have previously detected large germline
Riadh Ben Gacem et al.
Human pathology, 43(10), 1731-1738 (2012-04-24)
DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a
Nick Bishop et al.
Lancet (London, England), 382(9902), 1424-1432 (2013-08-10)
Children with osteogenesis imperfecta are often treated with intravenous bisphosphonates. We aimed to assess the safety and efficacy of risedronate, an orally administered third-generation bisphosphonate, in children with the disease. In this multicentre, randomised, parallel, double-blind, placebo-controlled trial, children aged
Anil Sapru et al.
Anesthesiology, 110(5), 1086-1091 (2009-04-24)
Higher plasma and pulmonary edema fluid levels of plasminogen activator inhibitor-1 (PAI-1) are associated with increased mortality in patients with pneumonia and acute lung injury. The 4G allele of the 4G/5G polymorphism of the PAI-1 gene is associated with higher
Mika Bando et al.
Biochimica et biophysica acta, 1829(9), 954-962 (2013-04-09)
S100A9 is a calcium-binding protein and subunit of antimicrobial calprotectin complex (S100A8/A9). Produced by neutrophils, monocytes/macrophages and keratinocytes, S100A9 expression increases in response to inflammation. For example, IL-1α produced by epithelial cells acts autonomously on the same cells to induce
S J Lees et al.
Acta physiologica Scandinavica, 181(2), 239-245 (2004-06-08)
Gel electrophoresis revealed a band of molecular weight approximately 160 000 Da associated with the skeletal muscle sarcoplasmic reticulum (SR) vesicle preparations. This investigation sought to examine glycogen debranching enzyme associated with skeletal muscle SR. Sarcoplasmic reticulum samples were also
Ana M de Lucas-Cerrillo et al.
The Journal of biological chemistry, 286(1), 594-606 (2010-11-05)
The neuronal α7 nicotinic receptor subunit gene (CHRNA7) is partially duplicated in the human genome forming a hybrid gene (CHRFAM7A) with the novel FAM7A gene. The hybrid gene transcript, dupα7, has been identified in brain, immune cells, and the HL-60
Thomas Santarius et al.
Genes, chromosomes & cancer, 49(8), 711-725 (2010-06-15)
To identify a novel amplified cancer gene a systematic screen of 975 human cancer DNA samples, 750 cell lines and 225 primary tumors, using the Affymetrix 10K SNP microarray was undertaken. The screen identified 193 amplicons. A previously uncharacterized amplicon
Gorana Mitic et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 16(4), 435-439 (2009-06-13)
Recurrent fetal loss (RFL) is a significant clinical problem, occurring in 1% to 5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50% to 65% of women with history of unexplained fetal loss. The objective of our
Martin Früh et al.
Clinical lung cancer, 14(1), 34-39 (2012-05-29)
Small-cell lung cancer (SCLC) is a highly vascularized tumor. ASA404 is a tumor vascular disrupting agent. This is the first trial to report the effects of combining chemotherapy with ASA404 in SCLC. Patients with untreated metastatic SCLC were treated with
Raeid M M Abed et al.
The ISME journal, 7(9), 1862-1875 (2013-04-12)
Using a combination of process rate determination, microsensor profiling and molecular techniques, we demonstrated that denitrification, and not anaerobic ammonium oxidation (anammox), is the major nitrogen loss process in biological soil crusts from Oman. Potential denitrification rates were 584±101 and
Karen M Edmond et al.
Lancet (London, England), 385(9975), 1315-1323 (2014-12-17)
Results of randomised controlled trials of newborn (age 1-3 days) vitamin A supplementation have been inconclusive. The WHO is coordinating three large randomised trials in Ghana, India, and Tanzania (Neovita trials). We present the findings of the Neovita trial in
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