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显示 31-60 共 863 条结果 关于 "95-11-4" 范围 论文
Christiane F S Marques et al.
Oral oncology, 42(6), 632-637 (2006-02-21)
Xenobiotic metabolizing enzymes are involved in the detoxification of many carcinogens and may be important in modulating cancer susceptibility. CYP1A1, CYP2E1, GSTM3, and NAT2 polymorphisms were determined in peripheral blood DNA of 231 oral cancer patients and 212 hospital controls
Aurel C Allabi et al.
British journal of clinical pharmacology, 56(6), 653-657 (2003-11-18)
To investigate the distribution of cytochrome P450 2C9 (CYP2C9) and 2C19 (CYP2C19) genotype frequencies in the Beninese and Belgian Caucasian populations. Beninese (n = 111) and Belgian (n = 121) were genotyped for CYP2C9*2, *3, *4, *5, and *11 as
Andrew Tutt et al.
Lancet (London, England), 376(9737), 235-244 (2010-07-09)
Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of
Graça Varzim et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 64(3), 206-212 (2002-05-31)
Our aim was to examine the role of NAT1 and NAT2 polymorphisms in human larynx cancer susceptibility. Genotype tests for NAT1 alleles *4, *10 and *11, and NAT2 alleles *4, *5, *6A and *7A, using PCR-RFLP analysis, were performed in
Simon Chun Ho Yu et al.
Journal of neurointerventional surgery, 6(3), 212-218 (2013-03-22)
Symptomatic brain hemorrhage was a significant cause of periprocedural stroke or death following stenting in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis trial, which called into question the safety of Wingspan stenting for intracranial
Hiroyuki Unoki et al.
Nature genetics, 40(9), 1098-1102 (2008-08-20)
We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type
Liang Du et al.
BMC medical genetics, 14, 46-46 (2013-04-20)
The associations between the polymorphisms in Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) gene and Graves' disease (GD) have been extensively investigated in Chinese population. However, the results were inconsistent. The objective of this study is to investigate the associations between the
J C Durack et al.
Clinical radiology, 73(12), 1057-1057 (2018-09-18)
To evaluate arterial cone-beam computed tomography (A-CBCT) automated analysis software for identification of vessels supplying tumours during transarterial hepatic embolisation (TAE). This study was approved by the institutional review board, with waiver of consent. Consecutive TAE procedures using arterial mapping
A Bozkurt et al.
Clinical pharmacology and therapeutics, 55(4), 399-401 (1994-04-01)
Debrisoquin hydroxylation polymorphism was studied in 326 unrelated healthy Turkish volunteers. Debrisoquin sulfate (10 mg) was administered to subjects, and debrisoquin and 4-hydroxydebrisoquin were determined in the 0- to 8-hour urine samples. Debrisoquin oxidation was polymorphic, with 11 subjects (3.37%;
Adel E El-Tarras et al.
Molecular biology reports, 39(12), 11081-11086 (2012-10-19)
Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders characterized by inattention, hyperactivity and impulsivity. In Saudi Arabia the prevalence of combined ADHD is 16.4 %. ADHD etiology is not clear and not completely understood.
Houssam E Mardini et al.
Digestive diseases and sciences, 50(12), 2316-2322 (2006-01-18)
Limited data exist on the specific association between gastroduodenal Crohn's disease (GDCD) and NOD2/CARD15 gene polymorphisms. The aim of this study was to assess the association between NOD2 polymorphisms and GDCD, and to assess the specific association between each of
Ze-Dong Wang et al.
The lancet. HIV, 4(4), e177-e188 (2017-02-06)
Worldwide, 30% of the world's population have antibodies to the intracellular protozoan parasite Toxoplasma gondii and about 36·7 million people are infected with HIV, but little is known about the prevalence of co-infection with T gondii and HIV. We aimed
M Merker et al.
Der Anaesthesist, 60(5), 432-440 (2010-12-15)
The aim of the present study was to conduct a meta-analysis of the results from randomized controlled trials investigating the relative efficacy of droperidol versus metoclopramide for the prevention of postoperative nausea and vomiting (PONV). A systematic literature search for
Daniel K Benjamin et al.
JAMA, 311(17), 1742-1749 (2014-05-06)
Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown. To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis
T Skaaby et al.
The British journal of dermatology, 171(6), 1407-1414 (2014-03-19)
Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead
Jose Falantes et al.
Leukemia research, 39(1), 52-57 (2014-12-10)
Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. This study retrospectively analyzes the role of azacitidine in LR-MDS with adverse risk score and compared to an historical cohort treated with best supportive care
Fang Fang Yuan et al.
Immunology and cell biology, 86(3), 268-270 (2008-01-09)
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and a major cause of morbidity and mortality throughout the world. It has been a major research priority to identify gene polymorphisms responsible for/associated with susceptibility and severity of S.
A Nieters et al.
Genes and immunity, 7(8), 615-624 (2006-09-15)
Interactions between environment and immune system play an essential role in the aetiology of immunopathologies, including lymphomas. Toll-like receptors (TLR) belong to a group of pattern recognition receptors, with importance for innate immune response and inflammatory processes. Interleukin-10 (IL-10) is
Martin D Tobin et al.
Hypertension (Dallas, Tex. : 1979), 52(5), 974-979 (2008-09-24)
WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as well as blood pressure change with age, in a longitudinal childhood study. Associations between single nucleotide polymorphisms in
W Kruis et al.
Alimentary pharmacology & therapeutics, 37(7), 680-690 (2013-02-19)
Robust evidence regarding medical intervention for symptomatic uncomplicated colonic diverticular disease (DD) is sparse. To investigate mesalazine (Salofalk granules) in this setting. In a double-blind, placebo-controlled, multicentre, 6-week trial, patients were randomised to mesalazine 1000 mg three times daily or placebo.
Shilpa Grover et al.
JAMA, 308(5), 485-492 (2012-08-02)
Patients with multiple colorectal adenomas may carry germline mutations in the APC or MUTYH genes. To determine the prevalence of pathogenic APC and MUTYH mutations in patients with multiple colorectal adenomas who had undergone genetic testing and to compare the
W P Witjes et al.
European urology, 36(6), 576-581 (1999-11-24)
This European phase III clinical trial was part of an intercontinental study which was closed prematurely by the sponsor. The study was designed to compare the effects of oral bropirimine with intravesical BCG, the current standard treatment in patients with
Luis Rodríguez-Rodríguez et al.
Arthritis and rheumatism, 63(2), 365-372 (2011-02-01)
Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the influence of this polymorphism on the risk of rheumatoid arthritis (RA). RA patients (n = 5,579)
Lei Zhou et al.
Medical care, 53(5), 463-470 (2015-03-21)
Medicare Part D claims are commonly used for research, but missing claims could compromise their validity. This study assessed 2 possible causes of missing claims: veteran status and Generic Drug Discount Programs (GDDP). We merged medication self-reports from telephone interviews
Claudine Angela Blum et al.
Lancet (London, England), 385(9977), 1511-1518 (2015-01-23)
Clinical trials yielded conflicting data about the benefit of adding systemic corticosteroids for treatment of community-acquired pneumonia. We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia. In this double-blind, multicentre
T Jónsson et al.
Scandinavian journal of rheumatology, 42(1), 45-47 (2012-09-21)
To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD). HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of
Man Li et al.
Journal of gastroenterology and hepatology, 27(7), 1159-1166 (2012-03-15)
The cytotoxic T-lymphocyte antigen 4 (CTLA4) is an inhibitory receptor expressed on activated and regulatory T lymphocytes. Polymorphisms could have remarkable effects on susceptibility to autoimmunity. However, the associations between CTLA-4 polymorphisms and primary biliary cirrhosis (PBC) remain ambiguous. The
Ajay Vora et al.
The Lancet. Oncology, 14(3), 199-209 (2013-02-12)
Minimal residual disease (MRD) is the most sensitive and specific predictor of relapse risk in children with acute lymphoblastic leukaemia (ALL) during remission. We assessed whether treatment intensity could be adjusted for children and young adults according to MRD risk
Stefan K Barta et al.
Clinical lymphoma, myeloma & leukemia, 19(6), 356-364 (2019-04-29)
Programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are frequently expressed in T-cell lymphomas. This provides a rationale for exploration of immune checkpoint inhibitors in the management of T-cell lymphomas. In this phase II single-arm multicenter trial, patients with
Raquel Lebrero et al.
Bioresource technology, 109, 38-45 (2012-02-09)
The performance and microbiology of a biotrickling filter (BTF) treating methyl mercaptan, toluene, alpha-pinene and hexane at the mg m(-3) level was studied at empty bed residence times (EBRT) of 50, 30, 11 and 7 s. Removal efficiencies (REs) higher
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