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显示 31-60 共 622 条结果 关于 "95-15-8" 范围 论文
Takahisa Furuta et al.
European journal of clinical pharmacology, 65(7), 693-698 (2009-03-05)
Maintenance therapy of gastroesophageal reflux disease (GERD) is usually performed with a low dose of a proton-pump inhibitor (PPI). Because PPIs are metabolized by CYP2C19 in the liver, we investigated whether a patient's CYP2C19 genotype was associated with symptomatic recurrence
Ronen Loebstein et al.
Blood, 109(6), 2477-2480 (2006-11-18)
CYP2C9 and VKORC1 genetic variants are associated with low and intermediate warfarin dose requirements, but markers of high doses are less well characterized. We analyzed the VKORC1 coding sequence and known CYP2C9 and VKORC1 polymorphisms in 15 selected warfarin-resistant (dose
Michelle Petri et al.
Arthritis and rheumatism, 65(7), 1865-1871 (2013-04-05)
To investigate whether an increase in vitamin D levels in patients with systemic lupus erythematosus (SLE) was associated with improvement in disease activity. A total of 1,006 SLE patients were monitored over 128 weeks. SLE patients with low levels of
Pyry A Välitalo et al.
British journal of clinical pharmacology, 83(9), 1966-1975 (2017-04-22)
Although ketorolac analgesia is linked only to the S-enantiomer, there is limited information on the stereo-selective pharmacokinetics of this agent. We studied the stereo-selective pharmacokinetics of ketorolac in a pooled dataset of two studies, with women at delivery and 4-5 months
K Schwarz et al.
The Journal of biological chemistry, 276(1), 773-779 (2000-10-12)
Mammalian lipoxygenases constitute a heterogeneous family of lipid-peroxidizing enzymes, and the various isoforms are categorized with respect to their positional specificity of arachidonic acid oxygenation into 5-, 8-, 12-, and 15-lipoxygenases. Structural modeling suggested that the substrate binding pocket of
J-C Becher et al.
Journal of medical genetics, 43(5), 414-418 (2005-09-27)
The apolipoprotein E (ApoE) polymorphism has been well studied in the adult human population, in part because the e4 allele is a known risk factor for Alzheimer's disease. Little is known of the distribution of ApoE alleles in newborns, and
Sandra Blankenburg et al.
European journal of human genetics : EJHG, 13(2), 253-255 (2004-10-21)
Xeroderma pigmentosum (XP) patients exhibit a 1000-fold increased risk for developing skin cancers including malignant melanoma. We investigated the role of three variant alleles of the DNA repair gene XPC and one variant allele of the XPG gene in a
Sonja Y Hess et al.
The British journal of nutrition, 114(11), 1829-1837 (2015-09-29)
The objective of the present study was to assess the impact of providing small-quantity lipid-based nutrient supplements (SQ-LNS) on the I status of young Burkinabe children. In total, thirty-four communities were assigned to intervention (IC) or non-intervention cohorts (NIC). IC
Takashi Sasaki et al.
Anticancer research, 33(6), 2619-2622 (2013-06-12)
To evaluate the treatment outcomes of irinotecan monotherapy for patients with advanced biliary tract cancer refractory to gemcitabine, cisplatin, and oral fluoropyrimidine. Irinotecan (100 mg/m(2)) was administered intravenously on days 1, 8, and 15, repeated every four weeks. Thirteen patients
K Greveling et al.
The British journal of dermatology, 176(1), 81-86 (2016-07-06)
Pain is a common adverse effect of dermatological laser procedures. Currently, no standard topical anaesthetic cream exists for deeper dermal laser procedures. To compare the efficacy of lidocaine/tetracaine cream and lidocaine/prilocaine cream in reducing self-reported pain during deeper dermal laser
Jessica Magnusson et al.
The Journal of allergy and clinical immunology, 136(5), 1247-1253 (2015-07-15)
Rhinitis is one of the most common diseases in childhood. Fish, polyunsaturated fatty acid (PUFA), and vitamin D intakes have been hypothesized to affect the risk of allergic disease; however, it is unclear whether these are linked to the development
James C Yao et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 35(15), 1695-1703 (2017-04-07)
Purpose Treatment options for neuroendocrine tumors (NETs) remain limited. This trial assessed the progression-free survival (PFS) of bevacizumab or interferon alfa-2b (IFN-α-2b) added to octreotide among patients with advanced NETs. Patients and Methods Southwest Oncology Group (SWOG) S0518, a phase
Ulla Wilking et al.
Breast cancer research and treatment, 125(2), 553-561 (2010-07-16)
This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2
Phuc Felix Nguyen-Tan et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(34), 3858-3866 (2014-11-05)
We tested the efficacy and toxicity of cisplatin plus accelerated fractionation with a concomitant boost (AFX-C) versus standard fractionation (SFX) in locally advanced head and neck carcinoma (LA-HNC). Patients had stage III to IV carcinoma of the oral cavity, oropharynx
Alain Viallon et al.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 15(1), 26-33 (2008-01-09)
To assess the potential role of procalcitonin and tumor necrosis factor-alpha, interleukin-6 and interleukin-8, in the prognosis of patients with sepsis. Prospective study. The emergency unit of a teaching hospital. We included 131 patients with sepsis: 15 (12%) with septic
Junshik Hong et al.
Cancer chemotherapy and pharmacology, 67(6), 1323-1331 (2010-08-25)
To evaluate the efficacy and safety of S-1 in combination with oxaliplatin in a biweekly schedule as first-line treatment in metastatic colorectal cancer and the association between genetic polymorphisms and treatment outcomes. Eligibility included age 18-75 years, at least one
C Reichert et al.
Clinical toxicology (Philadelphia, Pa.), 52(6), 629-634 (2014-05-23)
Seizures during intoxications with pharmaceuticals are a well-known complication. However, only a few studies report on drugs commonly involved and calculate the seizure potential of these drugs. To identify the pharmaceutical drugs most commonly associated with seizures after single-agent overdose
Charles J Glueck et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 12(4), 427-439 (2006-09-27)
Buerger's disease (BD) etiologies are poorly understood. Beyond smoking cessation, medical-surgical treatments have limited success. We hypothesized that mutations associated with arterial vasospasm (stromelysin-1 5A/6A, eNOS T-786C) and C677T-A1298C methylene tetrahydrofolate reductase (MTHFR) interacted with cigarette-cannabis smoking, reducing vasodilatory nitric
Nature genetics, 42(5), 441-447 (2010-04-27)
Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic
Naminatsu Takahara et al.
Cancer chemotherapy and pharmacology, 71(1), 85-92 (2012-10-12)
The aim of this study was to evaluate the efficacy and safety of irinotecan monotherapy in patients with advanced pancreatic cancer (APC). Patients with APC refractory to gemcitabine and S-1 were included. Irinotecan (100 mg/m(2)) was administered on days 1
Neil Featherstone et al.
Journal of pediatric urology, 9(6 Pt A), 915-918 (2013-01-22)
To determine whether the adrenoceptor agonist, ephedrine hydrochloride, is an effective treatment for resistant non-neurogenic daytime urinary incontinence in children. From 2000 to 2010, eighteen children with resistant non-neurogenic daytime urinary incontinence were treated with oral ephedrine hydrochloride at our
Bryan Kestenbaum et al.
Journal of the American College of Cardiology, 58(14), 1433-1441 (2011-09-24)
The aim of this study was to evaluate associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) concentrations separately and in combination with incident cardiovascular events and mortality during 14 years of follow-up in the CHS (Cardiovascular Health Study). Vitamin
Nicola Veronese et al.
Journal of the American Medical Directors Association, 19(11), 981-988 (2018-07-30)
Slow gait speed may be associated with premature mortality, cardiovascular disease (CVD), and cancer, although a comprehensive meta-analysis is lacking. In this systematic review and meta-analysis, we explored potential associations between gait speed and mortality, incident CVD, and cancer. A
Michelle Furtado et al.
British journal of haematology, 168(1), 55-62 (2014-08-26)
The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP +
Cristina Masseria et al.
Human vaccines & immunotherapeutics, 11(5), 1175-1183 (2015-02-26)
The Advisory Committee on Immunization Practices recommends administering diphtheria, tetanus and acellular pertussis (DTaP) vaccines to children at 2, 4, 6, 15-18 months, and 4-6 y of age; preferably with the same-brand vaccine for the whole series. We estimated age-appropriate
Tetsuya Sato et al.
Journal of cardiology, 70(1), 35-40 (2016-11-12)
Although some studies have examined platelet reactivity (PR) during prasugrel treatment, little is known about PR during the early treatment period and its clinical significance in Japan. We investigated the early and medium-term efficacy and safety of prasugrel in patients
G Zhang et al.
Thrombosis research, 104(3), 187-195 (2001-10-24)
The mutations in homocysteine (Hcy) metabolism-related enzyme genes including methylenetetrahydrofolate reductase (MTHFR) C677T, cystathionine beta-synthase (CBS) 844ins68, and methionine synthase (MS) A2756G have been identified as genetic risk factors for thromboembolic events. It has been noticed that these gene mutations
Hulya Yazici et al.
Human mutation, 20(1), 28-34 (2002-07-12)
Ovarian cancer is a clinically important cancer in Turkey. The contribution of BRCA1 and BRCA2 to ovarian cancer in Turkish patients has not previously been described. In this study we investigated the presence of BRCA1 and BRCA2 mutations in 102
David A Elkins et al.
The Prostate, 56(1), 30-36 (2003-05-15)
Circulating testosterone plays an important role in maintenance and growth of prostate cells. Luteinizing hormone (LH), secreted from the anterior pituitary, signals testicular Leydig cells to secrete testosterone. A genetic variant of the LH-beta protein, LH-betaV, exists in up to
A Xanthopoulos et al.
International journal of cardiology, 230, 248-254 (2017-01-08)
The use of many acute heart failure (AHF) risk scores is cumbersome. We therefore developed a simple AHF risk score (AHFRS) for early risk stratification. The study consisted of a prospective derivation cohort (PDC; N=104; age, 77[21] years; LVEF (%)
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