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Zijun Lin et al.
Frontiers in neuroscience, 14, 737-737 (2020-08-28)
Epilepsy is one of the most common chronic neurological diseases in the world, with a high incidence, a high risk of sudden unexplained death, and diagnostic challenges. Exosomes are nanosized extracellular vesicles that are released into physical environments and carry
A A Barragan et al.
Journal of dairy science, 103(12), 11713-11722 (2020-10-05)
The objective was to assess the effect of oral administration of acetylsalicylic acid after calving on the concentrations of substance P (SP), haptoglobin (HP), and cortisol in lactating dairy cows. Holstein dairy cows (n = 152) from 3 organic herds
Patricia E Carreira et al.
Arthritis and rheumatism, 52(10), 3015-3019 (2005-10-04)
To assess whether an interleukin-1 receptor antagonist gene (IL1RN) polymorphism is associated with disease susceptibility and/or severity in a Spanish population of patients with rheumatoid arthritis (RA). An 86-bp variable-number tandem repeat polymorphism within IL1RN intron 2 was analyzed by
Qianting Yang et al.
Thorax, 75(7), 576-583 (2020-03-24)
Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is not efficient in diagnosing TB, especially for patients who lack aetiological evidence of the disease. We
Seon-Young Park et al.
Journal of neurogastroenterology and motility, 16(1), 71-76 (2010-06-11)
Cholecystokinin (CCK) belongs to a group of endogenous molecules known as brain-gut neuropeptides and functions as a neuropeptide as well as a gut hormone. It remains unclear whether genetic variation of the CCK receptor plays a role in irritable bowel
Antti-Pekka Elomaa et al.
BMC psychiatry, 12, 2-2 (2012-01-11)
Inflammatory mediators in both the peripheral circulation and central nervous system (CNS) are dysregulated in major depressive disorder (MDD). Nevertheless, relatively little is known about the role of the T-helper (Th)-2 effector cytokines interleukin (IL)-5 and IL-13 in MDD. We
Mathew Weinstock et al.
British journal of haematology, 169(6), 851-858 (2015-04-03)
Extramedullary disease (EMD), defined as an infiltrate of clonal plasma cells at an anatomic site distant from the bone marrow, is an uncommon manifestation of multiple myeloma. Six hundred and sixty-three consecutive patients with multiple myeloma who underwent stem cell
Carey Farquhar et al.
AIDS research and human retroviruses, 20(7), 692-697 (2004-08-17)
Human leukocyte antigen (HLA) molecules regulate the cellular immune system and may be determinants of infant susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. Molecular HLA typing for class I alleles was performed on infants followed in a Kenyan
Javier I Bardagí et al.
The Journal of organic chemistry, 73(12), 4491-4495 (2008-05-21)
From the commercial 6-chloro-2,4-dimethoxypyrimidine (1) and by a photostimulated reaction with Me(3)Sn(-) ions, 2,4-dimethoxy-6-(trimethylstannyl)pyrimidine (2) was obtained in 95% yield. By the cross-coupling reaction of 2 with 1-iodonaphthalene as electrophile catalyzed by Pd (Stille reaction), 2,4-dimethoxy-6-(naphthalen-1-yl)pyrimidine (9) was obtained in
Behnam Nowrouzi-Kia et al.
Vaccine, 32(30), 3830-3834 (2014-05-20)
Understanding factors affecting trainee physician choices about vaccination may permit the design of more effective vaccination programmes. To identify factors associated with seasonal and pandemic influenza vaccination, an online questionnaire based on the health belief model was sent to trainee
Tarayn Fairlie et al.
Obstetrics and gynecology, 121(3), 570-577 (2013-05-03)
To estimate the effectiveness against early-onset group B streptococcal (GBS) disease of intrapartum antibiotic prophylaxis among term and preterm deliveries, deliveries with fewer than 4 hours of antibiotics, and deliveries receiving clindamycin regimens. We performed a secondary analysis of the
Julie C Brown et al.
Archives of pediatrics & adolescent medicine, 156(1), 27-32 (2002-01-12)
To estimate the prevalence of perinatal Listeria monocytogenes and enterococcal infections in outpatient febrile infants and to evaluate the need to treat with ampicillin. Online bibliographies were searched for articles related to serious bacterial infection and fever in infants. Reference
R Huttunen et al.
Journal of internal medicine, 270(1), 32-40 (2011-02-22)
Urokinase-type plasminogen activator receptor (uPAR) is expressed on a variety of different immune cells and vascular endothelial cells during inflammation. Previous studies indicate that a high plasma concentration of the soluble form of the receptor (suPAR) predicts poor outcome in
J A Schneider et al.
Stroke, 36(5), 954-959 (2005-03-19)
Studies investigating the relation of the apolipoprotein E (apoE) epsilon4 allele to clinical stroke and to vascular changes on magnetic resonance imaging have been conflicting. Little data are available regarding the relation of apoE epsilon4 to cerebral infarctions documented on
Victoria Sundblad et al.
Human reproduction (Oxford, England), 21(5), 1154-1160 (2006-01-07)
Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin alpha-subunit (INHalpha) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. Polymorphism -16C>T of INHalpha gene was
Li-Ya He et al.
Zhongguo shi yan xue ye xue za zhi, 17(3), 729-733 (2009-06-25)
The aim of study was to investigate the relationship between polymorphisms of FCGR2B232 1/T oligonucleotide and the susceptibility of children with idiopathic thrombocytopenic purpura (ITP). DNA from 76 patients with ITP and 37 controls was extracted. The SNPs of FCGR2B-232
Sally N Adebamowo et al.
International journal of stroke : official journal of the International Stroke Society, 10(7), 1093-1100 (2015-06-06)
Intakes of magnesium, potassium, and calcium have been inversely associated with the incidence of hypertension, a known risk factor for stroke. However, only a few studies have examined intakes of these cations in relation to risk of stroke. The aim
Association of baseline dyslipidemia with stroke recurrence within five-years after ischemic stroke.
Emre Kumral et al.
International journal of stroke : official journal of the International Stroke Society, 9 Suppl A100, 119-126 (2014-08-05)
The association between dyslipidemia (DL) and stroke recurrence is unclear, but may be influenced by different subtypes of stroke. This study aims to explore whether DL contributes to the recurrence of certain subtypes of ischemic stroke. Data from the Ege
Chakradhari Inampudi et al.
The American journal of cardiology, 114(1), 79-82 (2014-05-23)
Although randomized controlled trials have demonstrated benefits of aldosterone antagonists for patients with heart failure and reduced ejection fraction (HFrEF), they excluded patients with serum creatinine >2.5 mg/dl, and their use is contraindicated in those with advanced chronic kidney disease (CKD).
Tor D Wager et al.
The New England journal of medicine, 368(15), 1388-1397 (2013-04-12)
Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures of pain, but brain measures that are sensitive and specific to physical
Miles D Witham et al.
Journal of hypertension, 32(8), 1693-1699 (2014-06-01)
Orthostatic hypotension commonly accompanies supine hypertension, and is associated with low 25-hydroxyvitamin D levels. We tested whether high-dose intermittent oral vitamin D therapy could ameliorate orthostatic hypotension in older patients with isolated systolic hypertension. We conducted a subgroup analysis of
Keisuke Aoe et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2783-2790 (2014-08-31)
Although thoracic irradiation (TRT) is a standard treatment for elderly patients with locally advanced non-small-cell lung cancer (LA-NSCLC), treatment outcomes are poor. We previously reported a phase I trial combining S-1, an oral 5-fluorouracil derivative, and thoracic radiation, which yielded
Douglas H Campbell et al.
PloS one, 13(4), e0196017-e0196017 (2018-04-20)
While measurement of serum prostate specific antigen (PSA) is an important screening tool for prostate cancer, new biomarkers are necessary for better discrimination between presence and absence of disease. The MIL-38 monoclonal antibody is specific for the membrane glycoprotein glypican
E Bria et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 34(5), 593-598 (2007-08-19)
Survivin is a member of the inhibitors of apoptosis (IAP) gene family that acts through pathways different from those involving the bcl-2 family. Largely undetectable in normal adult tissues, survivin is deregulated in most human cancers including non-small-cell lung cancer
U Haug et al.
British journal of cancer, 96(9), 1329-1334 (2007-04-05)
Stool testing based on tumour-derived markers might offer a promising approach for non-invasive colorectal cancer (CRC) screening. The aim of this study was to estimate the potential of a new test for faecal tumour M2-PK to discriminate patients with CRC
X Wang et al.
American journal of medical genetics. Part A, 158A(12), 3061-3064 (2012-09-12)
Neurofibromatosis type 1 (NF1) is one of the most common cancer predisposing syndromes with an incidence of 1 in 3,500 worldwide. Certain neoplasms or malignancies are over-represented in individuals with NF1; however, an increased risk of breast cancer has not
Minae Kawashima et al.
Sleep, 33(7), 869-874 (2010-07-10)
Recent studies have found increased autoantibodies against Tribbles homolog 2 (anti-TRIB2) and anti-streptolysin O (ASO) in narcolepsy. In this study, we replicated this finding with a primary focus on recent onset cases. Participants included (1) 90 cases with cataplexy, (2)
James V Lacey et al.
Gynecologic oncology, 120(2), 167-173 (2010-11-26)
We assessed whether common genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2-genes that reportedly are frequently altered in endometrial cancer-was associated with risk of endometrial cancer. Using data from a population-based case-control study in Poland (PECS) of 417 cases
Lisa Y Cho et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 18(3), 495-503 (2014-08-01)
The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Among 76 gastric cancer
Jorge Cortes et al.
Blood, 120(13), 2573-2580 (2012-08-17)
Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase
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