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Lionel D Lewis et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(11), 3302-3311 (2007-06-05)
Increased clearance of drugs, such as oral cyclosporine, that are CYP3A and/or ABCB1 (P-gp/MDR1) substrates was reported in African-American compared with Caucasian patients. We hypothesized that the pharmacokinetics and pharmacodynamics of docetaxel, an i.v. administered cytotoxic and substrate for CYP3A4
Y Delpech et al.
Breast cancer research and treatment, 135(2), 619-627 (2012-08-15)
We examined whether baseline Ki67 expression in estrogen receptor-positive (ER+) primary breast cancer correlates with clinical benefit and time to progression on first-line endocrine therapy and survival in metastatic disease. Ki67 values and outcome information were retrieved from a prospectively
Derek S Tsang et al.
International journal of radiation oncology, biology, physics, 87(5), 881-887 (2013-10-15)
Reduction of respiratory motion is desirable to reduce the volume of normal tissues irradiated, to improve concordance of planned and delivered doses, and to improve image guided radiation therapy (IGRT). We hypothesized that pretreatment lorazepam would lead to a measurable
Huai-Rong Luo et al.
Biochemical genetics, 40(1-2), 41-51 (2002-05-07)
The tandemly repeated 28-bp sequence in the 5'-terminal regulatory region of human thymidylate synthase (TSER), which has been reported to be polymorphic in different populations, was surveyed in 668 Chinese from 9 Han groups, 8 ethnic populations, and 36 individuals
Peter M Etaware et al.
PloS one, 15(1), e0209306-e0209306 (2020-01-11)
Food poisoning and environmental pollution are products of excessive chemical usage in Agriculture. In Nigeria, cocoa farmers apply fungicides frequently to control black pod disease (BPD), this practice is life threatening and lethal to the environment. The development of a
Oĝuztüzün Serpil et al.
Folia histochemica et cytobiologica, 47(1), 87-92 (2009-05-08)
Adenocarcinomas are the most common cause of malignancy in pleura fluids. Usual primary sites include the lung, breast, gastrointestinal tract, and genitourinary tracts. Predicting the site of origin of an adenocarcinoma can be difficult due to overlapping morphologic characteristics. We
Miriam Adelson et al.
Journal of psychoactive drugs, 45(4), 313-321 (2014-01-01)
The initiation of the first methadone maintenance treatment program (MMT) in Macao was founded in collaboration between MMT clinics in the USA and Israel. All patients admitted into treatment between October 2005 and October 2008 were prospectively followed through March
Juan C Rubio et al.
Neuroscience letters, 422(3), 217-222 (2007-07-17)
The phenotypic manifestation of McArdle disease varies considerably from one individual to the next. The purpose of this study was to assess the possible association between the clinical severity of the disease, and each of the genotypes PYGM (R50X), ACE
Peter A C 't Hoen et al.
European journal of biochemistry, 269(10), 2574-2583 (2002-05-25)
Antisense oligodeoxynucleotides (AS-ODNs) are frequently used for the down-regulation of protein expression. Because the majority of potential antisense sequences lacks effectiveness, fast screening methods for the selection of effective AS-ODNs are needed. We describe a new cellular screening assay for
Piotr Kubler et al.
International journal of cardiology, 129(3), 373-378 (2007-12-07)
Optimal risk stratification in heart failure patients surviving an episode of acute decompensation has not yet been established. We investigated whether a lack of significant decrease in plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) during hospital stay can identify
Jennifer A Sinnott et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(1), 81-87 (2016-09-25)
Gleason score strongly predicts prostate cancer mortality; however, scoring varies among pathologists, and many men are diagnosed with intermediate-risk Gleason score 7. We previously developed a 157-gene signature for Gleason score using a limited gene panel. Using a new whole-transcriptome
Mary A Vogler et al.
Journal of acquired immune deficiency syndromes (1999), 65(5), 542-550 (2014-04-25)
Women with HIV and prior exposure to combination antiretroviral therapy (cART) solely for prevention of mother-to-child transmission (pMTCT) need to know whether they can later be treated successfully with a commonly used regimen of efavirenz (EFV) and coformulated emtricitabine (FTC)
Bin Tang et al.
Chemosphere, 262, 127807-127807 (2020-08-09)
Human hair has been identified as a non-invasive alternative matrix for assessing the human exposure to specific organic contaminants. In the present study, a solvent-saving analytical method for the simultaneous determination of 8 polybrominated diphenyl ethers (PBDEs), 3 hexabromocyclododecanes (HBCDDs)
Yong Wang et al.
Medical oncology (Northwood, London, England), 31(11), 248-248 (2014-09-28)
Borealin/Dasra B, also called cell division cycle associated 8, is a member of the chromosomal passenger complex and plays a crucial role during mitosis and cell division. The expression of this gene has been investigated in several kinds of cancers
Graeme P Currie et al.
British journal of clinical pharmacology, 56(4), 422-426 (2003-09-13)
Cysteinyl leukotrienes are important pro-inflammatory mediators in the pathogenesis of asthma, while leukotriene C4 synthase is a key enzyme in their biosynthesis. Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant
Keeley L Baker et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 32(9), e13894-e13894 (2020-05-30)
Commonly used methods to measure whole gut transit time in rodents have yet to combine high sensitivity, objectivity, and automation. We have developed a novel method using oral gavage of non-toxic fluorescent dye particles and their detection by fluorescence imaging
Margje H Haverkamp et al.
International journal of pediatric otorhinolaryngology, 74(7), 752-754 (2010-04-20)
The annual incidence of nontuberculous mycobacterial (NTM) cervicofacial lymphadenitis in otherwise healthy children is unexpectedly high (8 per million). It mostly arises as localized cervicofacial lymphadenitis. Previous research has suggested environmental risk factors for oral exposure to NTM and a
Hiroaki Niitsu et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 83(6), 308-315 (2016-06-21)
Increased expression of calcineurin in colorectal cancer (CRC) has been reported. Although the oncogenic function has been suggested, the clinical relevance is still unclear. We herein studied calcineurin expression as a prognostic biomarker in patients receiving curative surgery for stages
Scott J C Pallett et al.
The Lancet. Respiratory medicine, 8(9), 885-894 (2020-07-28)
Health-care workers constitute a high-risk population for acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the
Luisa R Bordajandi et al.
Journal of chromatography. A, 1078(1-2), 128-135 (2005-07-13)
The feasibility of comprehensive two-dimensional gas chromatography with electron-capture detection (GC x GC-ECD) for the enantioseparation of chiral PCBs from other possible interfering compounds has been evaluated. Three commercially available enantioselective beta-cyclodextrin-based capillary columns (Chirasil-Dex, BGB-172 and BGB-176SE) have been
Douglas L Riegert-Johnson et al.
Hereditary cancer in clinical practice, 8(1), 6-6 (2010-06-23)
Cancer risk and Lhermitte-Duclos disease (LDD) risk estimates for Cowden syndrome (CS) are broad and based on a small number of patients. Risk estimates are vital to the development of diagnostic criteria, genetic counseling, and cancer surveillance. To further elaborate
Yan-yan Zhao et al.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 46(12), 1066-1070 (2011-01-08)
To analyze the relationship between the gene polymorphism of IL-2R (rs2104286) and IL-7R (rs6897932) and the susceptibility to idiopathic demyelinating optic neuritis (IDON). A case-control study was performed in 72 IDON patients and 81 healthy individuals as the control group.
Hideo Amano et al.
Heart and vessels, 35(6), 750-761 (2019-12-23)
The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty
Frank Edelmann et al.
JAMA, 309(8), 781-791 (2013-02-28)
Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression. To assess the efficacy and safety of long-term aldosterone receptor blockade in heart failure with
Chureeporn Chitchumroonchokchai et al.
The Journal of nutrition, 136(3), 588-594 (2006-02-18)
Zeaxanthin (Zea) and lutein are the only dietary carotenoids that accumulate in the macular region of the retina and lens. It was proposed that these carotenoids protect these tissues against photooxidative damage. Few plant foods are enriched in Zea, and
Boyoung Joung et al.
American heart journal, 150(6), 1213-1219 (2005-12-13)
This study was sought to investigate whether plasma N-terminal pro-brain natriuretic peptide (proBNP) can help identify patients with an elevated left ventricular end-diastolic pressure (LVEDP) or filling pressures in patients with a normal systolic function. The proBNP is a good
Gyan K Kayastha et al.
British journal of haematology, 177(6), 991-999 (2017-04-04)
The Glivec International Patient Assistance Programme makes Glivec (Imatinib mesylate) available to Philadelphia chromosome/BCR-ABL1 positive patients with chronic myeloid leukaemia (CML) in Lower and Middle Income Countries (LMIC). We have established a large cohort of 211 CML patients who are
M J Nahuis et al.
Human reproduction (Oxford, England), 27(12), 3577-3582 (2012-09-25)
Laparoscopic electrocautery of the ovaries and ovulation induction with gonadotrophins are both second line treatments for women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS). Long-term follow-up after electrocautery versus ovulation induction with gonadotrophins has demonstrated at least comparable chances for
F McGarry et al.
Rheumatology (Oxford, England), 40(12), 1359-1364 (2001-12-26)
Genetic factors that predispose individuals to ankylosing spondylitis (AS) are not fully understood, but are unlikely to be restricted to HLA-B27. Proinflammatory cytokines are implicated in the development of sacroiliitis. We have examined the allele frequencies of three polymorphic sites
E Waanders et al.
Leukemia, 25(2), 254-258 (2010-11-26)
Response to therapy as determined by minimal residual disease (MRD) is currently used for stratification in treatment protocols for pediatric acute lymphoblastic leukemia (ALL). However, the large MRD-based medium risk group (MRD-M; 50-60% of the patients) harbors many relapses. We
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