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Marilyn Cyr et al.
Behavioural brain research, 278, 107-114 (2014-09-27)
Cholinergic neurons of the pedunculopontine tegmental nucleus (PPTg) are thought to be involved in cognitive functions such as sustained attention, and lesions of these cells have been documented in patients showing fluctuations of attention such as in Parkinson's disease or
Ingrid R Cordeiro et al.
Biology open, 4(9), 1180-1193 (2015-09-01)
Human adipose-derived stromal cells (hADSC) are a heterogeneous cell population that contains adult multipotent stem cells. Although it is well established that hADSC have skeletal potential in vivo in adult organisms, in vitro assays suggest further differentiation capacity, such as
Miyoun Yoo et al.
Research in microbiology, 162(7), 724-728 (2011-05-18)
Hydroxylation of the non-growth substrate biphenyl by recombinant o-xylene dioxygenases from Rhodococcus sp. strain DK17 was studied through bioconversion experiments. The metabolites from the biphenyl hydroxylation by each enzyme were identified and quantified by gas chromatography-mass spectrometry. The L266F mutant
L Marcellin et al.
Human reproduction (Oxford, England), 30(2), 392-405 (2014-11-30)
Are the fetal membranes of women affected with endometriosis similar to those from disease-free women? Decidua of women with endometriosis is able to generate endometriotic-like lesions in contact with the fetal membranes. Eutopic endometrium of women affected with endometriosis presents
Sonal Dalvi et al.
Applied and environmental microbiology, 80(21), 6664-6676 (2014-08-26)
Arhodomonas sp. strain Seminole was isolated from a crude oil-impacted brine soil and shown to degrade benzene, toluene, phenol, 4-hydroxybenzoic acid (4-HBA), protocatechuic acid (PCA), and phenylacetic acid (PAA) as the sole sources of carbon at high salinity. Seminole is
Annette Tennstaedt et al.
Biomaterials, 44, 143-154 (2015-01-27)
Human neural stem cells (hNSCs) hold great promise for the treatment of neurological diseases. Considerable progress has been made to induce neural differentiation in the cell culture in vitro and upon transplantation in vivo [2] in order to explore restoration
D Brouard et al.
Vox sanguinis, 108(2), 197-204 (2014-12-04)
The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and
Christopher M Peters et al.
Anesthesiology, 122(4), 895-907 (2015-01-13)
Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical
Marta Zamarbide et al.
Hippocampus, 24(7), 733-739 (2014-02-20)
GPR40, the free fatty acid receptor 1, is expressed strongly in the primate pancreas and brain. While the role of pancreatic GPR40 in glucose homeostasis has been extensively studied, the absence of this G-protein-coupled receptor from the brain of rodents
Summer L Gibbs et al.
Molecular imaging, 14 (2015-03-31)
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high. Computer-assisted image analysis of H&E sections holds
Ruchi Mishra et al.
International journal of biological sciences, 11(11), 1325-1336 (2015-11-05)
This work studies osteoinduction and bone conduction in polyvinyl alcohol-tetraethylorthosilicate-alginate-calcium oxide (PTAC) biocomposite cryogels along with the synergistic effect of electrical stimulation. In vitro osteoinduction of C2C12 myoblast towards osteogenic lineage is demonstrated through alkaline phosphatase assay, scanning electron microscopy
Su Young Kim et al.
International journal of medical sciences, 12(2), 92-99 (2015-01-16)
Syndecan-1 (SDC1) is reported to modulate several key processes of tumorigenesis and has variable expression in many cancers. To date, the cause of altered expression has not been elucidated. In this study, we compared SDC1 expression with various clinicopathological parameters
Xi Chen et al.
Molecular cancer, 14, 31-31 (2015-02-05)
An increasing amount of evidence has revealed that microRNAs regulate various biological processes, including cell differentiation, cell proliferation, apoptosis, drug resistance, and fat metabolism. Studies have shown that miR-93's targetome in cancer has not been fully defined. Moreover, the role
C Egloff et al.
Osteoarthritis and cartilage, 22(11), 1886-1893 (2014-08-12)
Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination
Enrique N García et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(10), 483-490 (2015-07-26)
Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical and subtropical countries. The pathophysiology of this poisoning mainly involves an abnormal glycoprotein metabolism. The aim of this study was to describe the potential toxicity
Lin Guo et al.
Chemical research in toxicology, 28(3), 431-439 (2014-12-18)
Epidemiological studies imply a significantly positive association between particulate matter (PM) level and ischemic stroke hospitalization. However, considering that PM10 is highly heterogeneous and varies with season within the same location, existing experimental evidence remained low. In the present study
Samaneh Dehghan et al.
Life sciences, 122, 108-115 (2014-12-23)
Attempts are aimed to introduce new approaches toward enhancing the brain's potential for repair in neurodegenerative diseases and traumatic injuries. Here we report an increased expression of pluripotency and progenitor markers within the brain following pretreatment with valproic acid (VPA)
Ulrich Thormann et al.
BioMed research international, 2015, 943603-943603 (2015-02-27)
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study
Shin Ae Park et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(3), 368-380 (2014-05-23)
The excisional dorsal full-thickness skin wound model with or without splinting is widely utilized in wound healing studies using diabetic or normal mice. However, the effects of splinting on dermal wound healing have not been fully characterized, and there are
R Cameron Brownley et al.
PloS one, 10(11), e0141432-e0141432 (2015-11-07)
Heterotopic ossification (HO) is the growth of extra-skeletal bone which occurs following trauma, burns, and in patients with genetic bone morphogenetic protein (BMP) receptor mutations. The clinical and laboratory evaluation of HO is dependent on radiographic imaging to identify and
Masaru Ishibashi et al.
Frontiers in neurology, 6, 120-120 (2015-06-18)
A hallmark of the waking state is a shift in EEG power to higher frequencies with epochs of synchronized intracortical gamma activity (30-60 Hz) - a process associated with high-level cognitive functions. The ascending arousal system, including cholinergic laterodorsal (LDT)
Yu-Sheng Fang et al.
Nature communications, 5, 4824-4824 (2014-09-13)
Proteinaceous inclusions are common hallmarks of many neurodegenerative diseases. TDP-43 proteinopathies, consisting of several neurodegenerative diseases, including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS), are characterized by inclusion bodies formed by polyubiquitinated and hyperphosphorylated full-length and truncated TDP-43.
W Saskia van der Hel et al.
The European journal of neuroscience, 40(12), 3711-3719 (2014-10-29)
Mesiotemporal sclerosis (MTS), the most frequent form of drug-resistant temporal lobe epilepsy, often develops after an initial precipitating injury affecting the immature brain. To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced
Vicky J Young et al.
PloS one, 9(9), e106773-e106773 (2014-09-11)
Transforming growth factor-β (TGF-β) is believed to play a major role in the aetiology of peritoneal endometriosis. We aimed to determine if the peritoneum is a source of TGF-β and if peritoneal TGF-β expression, reception or target genes are altered
Patricia A Kabitzke et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1924-1932 (2014-02-21)
To survive, all mammalian species must recognize and respond appropriately to threatening stimuli. In adults, the prelimbic medial prefrontal cortex (mPFC) appears to be involved in fear expression, whereas the infralimbic mPFC mediates fear extinction. In juvenile rats (PN26), the
Payam Pournazari et al.
Human pathology, 45(8), 1582-1587 (2014-05-27)
Poly(ADP-ribose) polymerase-1 (PARP-1) and Bcl-2 are emerging as therapeutic targets in various cancers. The former is a DNA repair protein associated with genomic stability and apoptosis, whereas the latter is an antiapoptotic protein having a DNA repair function through inhibition
Xiao Yan Chen et al.
Applied and environmental microbiology, 80(18), 5752-5760 (2014-07-13)
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in piglets; ETEC cells colonize the intestinal mucosa with adhesins and deliver toxins that cause fluid loss. This study determined the antiadhesive properties of bacterial exopolysaccharides (reuteran and levan) and
Liza J Raggatt et al.
The American journal of pathology, 184(12), 3192-3204 (2014-10-07)
The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus formation were investigated. A murine femoral fracture model [internally fixed using a flexible plate (MouseFix)] was used to facilitate reproducible fracture reduction. IHC
Robert Patterson et al.
Vaccine, 33(46), 6199-6205 (2015-10-20)
Porcine circovirus type 2 (PCV2) is now endemic in every major pig producing country, causing PCV-associated disease (PCVAD), linked with large scale economic losses. Current vaccination strategies are based on the capsid protein of the virus and are reasonably successful
Javed Iqbal et al.
Toxicology mechanisms and methods, 24(8), 544-551 (2014-07-26)
Advancement in the field of analytical food-chemistry has explored various experimental techniques for aflatoxins (AFs) quantification. The present study was aimed to compare four different techniques; thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-linked
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