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So-Young Yeo et al.
Oncotarget, 5(23), 12260-12272 (2014-11-07)
Zinc finger protein 282 (ZNF282) is a newly identified transcription factor and little is known about its expression and function. Originally, ZNF282 is known to bind U5RE (U5 repressive element) of HLTV-1 (human T cell leukemia virus type 1) with
Musa Mulongo et al.
Infection and immunity, 83(5), 1992-2000 (2015-03-04)
Contagious bovine pleuropneumonia (CBPP) is a serious respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides. Current vaccines against CBPP induce short-lived immunity and can cause severe postvaccine reactions. Previous studies have identified the N terminus of the transmembrane
Karen D M MaGee et al.
Dalton transactions (Cambridge, England : 2003), 42(12), 4233-4236 (2013-02-13)
The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ring.
Sara Ud-Din et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 901-914 (2015-07-16)
Objective evaluation of cutaneous wounds through use of noninvasive devices has important implications for diagnosis, monitoring treatment efficacy, progression and may lead to development of improved theranostic treatment strategies. However, there is a lack of validation in the use of
Zhi Xu et al.
Scientific reports, 4, 5907-5907 (2014-08-02)
Identifying gene mutations in individual tumors is critical to improve the efficacy of cancer therapy by matching targeted drugs to specific mutations. Gastrointestinal stromal tumors (GIST) are stromal or mesenchymal subepithelial neoplasms affecting the gastrointestinal tract and frequently contain activating
Robert Patterson et al.
Vaccine, 33(46), 6199-6205 (2015-10-20)
Porcine circovirus type 2 (PCV2) is now endemic in every major pig producing country, causing PCV-associated disease (PCVAD), linked with large scale economic losses. Current vaccination strategies are based on the capsid protein of the virus and are reasonably successful
Javed Iqbal et al.
Toxicology mechanisms and methods, 24(8), 544-551 (2014-07-26)
Advancement in the field of analytical food-chemistry has explored various experimental techniques for aflatoxins (AFs) quantification. The present study was aimed to compare four different techniques; thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-linked
Bernhard Baumann et al.
Investigative ophthalmology & visual science, 55(11), 7686-7696 (2014-10-30)
To demonstrate polarization-sensitive (PS) optical coherence tomography (OCT) for noninvasive, volumetric, and quantitative imaging of the birefringent properties of the peripapillary rat sclera; to compare the findings from PS-OCT images to state-of-the-art histomorphometric analysis of the same tissues. A high-speed
Noriko Koganezawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15860-15874 (2015-12-04)
The postrhinal cortex (POR) provides substantial input to the entorhinal cortex, mainly targeting superficial layers of the medial entorhinal cortex (MEC). Major inputs to POR originate in the visual and parietal cortex, thus providing neurons in MEC with a subset
Manish Tandon et al.
Breast cancer research : BCR, 16(1), R16-R16 (2014-02-01)
The Runt-related transcription factor Runx2 is critical for skeletal development but is also aberrantly expressed in breast cancers, and promotes cell growth and invasion. A de-regulated serine/threonine kinase Akt signaling pathway is implicated in mammary carcinogenesis and cell survival; however
N Govender et al.
Placenta, 35(8), 618-624 (2014-06-02)
Hypertensive disorders of pregnancy are the commonest direct cause of maternal deaths in South Africa, 83% being attributed to pre-eclampsia. Elevated placental sFlt-1 levels are linked with angiogenic disruption and subsequent pre-eclampsia development. The impact of HIV infection on pre-eclampsia
Laura Trabalón et al.
Environmental research, 143(Pt B), 116-122 (2015-04-29)
The occurrence of ten synthetic musks in samples of 10 widely consumed fish and shellfish species from Tarragona (Catalonia, Spain) was determined. The most used nitro and polycyclic musks, as well as a well-known transformation product in tissues, were analyzed.
Simon Armbruszt et al.
Acta biologica Hungarica, 66(1), 1-13 (2015-03-06)
Aging is accompanied by changes of several anorexigenic and orexigenic neuropeptides expressed in various brain areas that control food intake and these changes correlate with senescent anorexia. During aging expression of cocaine- and amphetamine-regulated transcript (CART) peptide was reported to
M Kovalska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(6), 767-776 (2015-01-03)
Global brain ischemia-reperfusion causes delayed cell death in hippocampal CA1 (cornus ammonis 1) pyramidal neurons after reperfusion. Ischemic tolerance evoked by preconditioning (IPC) represents a phenomenon of CNS adaptation to any subsequent ischemia. This paper was designed to describe changes
Artur Pałasz et al.
Neuroscience letters, 592, 17-21 (2015-03-05)
The hypothalamus regulates a number of autonomic functions essential for homeostasis; therefore, investigations concerning hypothalamic neuropeptides and their functions and distribution are of great importance in contemporary neuroscience. Recently, novel regulatory factors expressed in the hypothalamus have been discovered, of
Davide Sartini et al.
Biological chemistry, 396(3), 225-234 (2014-09-11)
Lung cancer is the second most commonly diagnosed neoplasm, and represents the leading cause of tumour death worldwide. As patients are often diagnosed at a late stage, current therapeutic strategies have limited effectiveness and the prognosis remains poor. Successful treatment
Sandra Tamosaityte et al.
PloS one, 10(11), e0142660-e0142660 (2015-11-13)
Spinal cord injury (SCI) induces complex biochemical changes, which result in inhibition of nervous tissue regeneration abilities. In this study, Fourier-transform infrared (FT-IR) spectroscopy was applied to assess the outcomes of implants made of a novel type of non-functionalized soft
Marilyn Cyr et al.
Behavioural brain research, 278, 107-114 (2014-09-27)
Cholinergic neurons of the pedunculopontine tegmental nucleus (PPTg) are thought to be involved in cognitive functions such as sustained attention, and lesions of these cells have been documented in patients showing fluctuations of attention such as in Parkinson's disease or
Patricia A Kabitzke et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1924-1932 (2014-02-21)
To survive, all mammalian species must recognize and respond appropriately to threatening stimuli. In adults, the prelimbic medial prefrontal cortex (mPFC) appears to be involved in fear expression, whereas the infralimbic mPFC mediates fear extinction. In juvenile rats (PN26), the
Kazumasa Murata et al.
ACS applied materials & interfaces, 12(23), 26002-26012 (2020-05-21)
Carbon monoxide (CO) molecules are attracting attention as capping agents that control the structure of metal nanoparticles. In this study, we aimed to control the shape and surface structure of Pd particles by reducing the supported Pd precursor with CO.
Anika I Tsuchida et al.
Arthritis research & therapy, 16(5), 441-441 (2014-09-27)
This study aimed to evaluate whether profiles of several soluble mediators in synovial fluid and cartilage tissue are pathology-dependent and how their production is related to in vitro tissue formation by chondrocytes from diseased and healthy tissue. Samples were obtained
Zhikui Liu et al.
International journal of oncology, 46(4), 1710-1720 (2015-01-28)
The retinoic acid-induced protein I (Rig-I/Ddx58), (RIG-I) initiates a signaling cascade that induces innate immune defences which is associated with the production of type I interferons (IFNs) and inflammatory cytokines to establish an antiviral state. Aberrant RIG-I signaling leads to inflammation
Siriporn Lunprom et al.
Bioscience, biotechnology, and biochemistry, 79(12), 1972-1979 (2015-06-18)
Fusarium oxysporum causes wilt disease in many plant families, and many genes are involved in its development or growth in host plants. A recent study revealed that vacuolar amino acid transporters play an important role in spore formation in Schizosaccharomyces
Shin Ae Park et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(3), 368-380 (2014-05-23)
The excisional dorsal full-thickness skin wound model with or without splinting is widely utilized in wound healing studies using diabetic or normal mice. However, the effects of splinting on dermal wound healing have not been fully characterized, and there are
Ingrid R Cordeiro et al.
Biology open, 4(9), 1180-1193 (2015-09-01)
Human adipose-derived stromal cells (hADSC) are a heterogeneous cell population that contains adult multipotent stem cells. Although it is well established that hADSC have skeletal potential in vivo in adult organisms, in vitro assays suggest further differentiation capacity, such as
R Cameron Brownley et al.
PloS one, 10(11), e0141432-e0141432 (2015-11-07)
Heterotopic ossification (HO) is the growth of extra-skeletal bone which occurs following trauma, burns, and in patients with genetic bone morphogenetic protein (BMP) receptor mutations. The clinical and laboratory evaluation of HO is dependent on radiographic imaging to identify and
Samaneh Dehghan et al.
Life sciences, 122, 108-115 (2014-12-23)
Attempts are aimed to introduce new approaches toward enhancing the brain's potential for repair in neurodegenerative diseases and traumatic injuries. Here we report an increased expression of pluripotency and progenitor markers within the brain following pretreatment with valproic acid (VPA)
Masaru Ishibashi et al.
Frontiers in neurology, 6, 120-120 (2015-06-18)
A hallmark of the waking state is a shift in EEG power to higher frequencies with epochs of synchronized intracortical gamma activity (30-60 Hz) - a process associated with high-level cognitive functions. The ascending arousal system, including cholinergic laterodorsal (LDT)
Ulrich Thormann et al.
BioMed research international, 2015, 943603-943603 (2015-02-27)
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study
Liza J Raggatt et al.
The American journal of pathology, 184(12), 3192-3204 (2014-10-07)
The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus formation were investigated. A murine femoral fracture model [internally fixed using a flexible plate (MouseFix)] was used to facilitate reproducible fracture reduction. IHC
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