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Hassan Ghaffar et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(8), 2998-3003 (2003-08-13)
About one-third of sporadic lung adenocarcinomas demonstrates biallelic inactivation of the LKB1 gene, but the timing of this event is not known. We performed LKB1 immunohistochemistry on 35 primary lung adenocarcinomas and 96 atypical adenomatous hyperplasias (AAH), a form of
Anu Suomalainen et al.
The Lancet. Neurology, 10(9), 806-818 (2011-08-09)
Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders because of the lack of sensitive biomarkers in serum. Fibroblast growth factor 21 (FGF-21) is a growth factor with regulatory roles in lipid metabolism and the starvation response, and
Alena Skálová et al.
The American journal of surgical pathology, 39(3), 338-348 (2015-01-13)
This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clear cell
Jinqing Zhou et al.
Organic & biomolecular chemistry, 10(21), 4179-4185 (2012-05-02)
In the current study, a convenient and simple way is presented to synthesize a novel type of supported heterogeneous organocatalyst in 21-81% yield by the copolymerization of 9-amino-9-deoxy-epi-cinchonine organocatalyst with acrylonitrile using AIBN as radical initiator. The chemical compositions (x/y)
Huanwen Wu et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(2), 189-204 (2018-09-13)
Information on the heterogeneity of phosphaturic mesenchymal tumor, a rare entity associated with tumor-induced osteomalacia, is limited. In this retrospective analysis of 222 phosphaturic mesenchymal tumors, 22 cases exhibited mixed mesenchymal and epithelial elements, which we propose to term "phosphaturic
Thomas E Hutson et al.
The Lancet. Oncology, 14(13), 1287-1294 (2013-11-12)
In previous clinical trials of patients with metastatic renal-cell carcinoma, patients treated with axitinib as second-line therapy had longer median progression-free survival than those treated with sorafenib. We therefore undertook a phase 3 trial comparing axitinib with sorafenib in patients
Y Shi et al.
The Biochemical journal, 352 Pt 2, 443-448 (2000-11-22)
FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer. However, the biological function of the Fhit protein has
Monika Sparber-Sauer et al.
Pediatric blood & cancer, 65(12), e27405-e27405 (2018-08-21)
Patients with metastatic alveolar soft-part sarcoma (ASPS) are known to have a very poor prognosis. Little is known about best treatment of primary metastatic disease (MD) or relapsed metastatic disease (rMD). Patients with localized disease (LD), primary MD, and metastatic
Claudia R Figueiredo et al.
American journal of rhinology, 21(2), 231-235 (2007-04-12)
The objective of this study was to investigate the spectrum of inflammatory gene expression in patients with nasal polyposis. The cDNA microarray technique was used to identify gene expression in tissue samples from nasal polyps and adjacent inflammatory nasal mucosa
Martin Markowitz et al.
Journal of acquired immune deficiency syndromes (1999), 66(2), 140-147 (2014-01-25)
To understand whether combination antiretroviral therapy (cART) has been optimized, we asked whether 3-drug protease inhibitor (PI)-based cART intensified with raltegravir and maraviroc and initiated during early infection would improve outcomes when compared with similarly applied 3-drug PI-based cART. Forty
Grzegorz Helbig et al.
Medical oncology (Northwood, London, England), 29(4), 2379-2384 (2012-03-03)
The prevalence of JAK2V617F tyrosine kinase mutation differs between various variants of myelofibrosis with the higher detection rate for patients with post-polycythemia vera myelofibrosis (post-PV MF; 91%) if compared to primary myelofibrosis (PMF; 45%) and post-essential thrombocythemia myelofibrosis (post-ET MF;
M Wilbrink et al.
Xenobiotica; the fate of foreign compounds in biological systems, 21(2), 223-233 (1991-02-01)
1. The occurrence of an as yet unidentified cytochrome P-450 in the microsomal fraction of the digestive gland of the snail, Lymnaea stagnalis was studied. 2. Studies in vivo and in vitro (digestive gland homogenates or the 170,000g fraction) of
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
Punit Sharma et al.
Clinical nuclear medicine, 40(7), e351-e356 (2015-03-19)
The aim of this study was to evaluate the role of ⁶⁸Ga DOTANOC PET/CT imaging in patients with multiple endocrine neoplasia (MEN) syndromes. Data of 33 patients (age, 33.5 [13.8] years; male 14/female 19) with MEN syndromes (MEN 1, 9;
Miao-jing Fan et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)
To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19
J C Aristizabal et al.
European journal of clinical nutrition, 69(7), 831-836 (2014-10-09)
Fat-free mass (FFM) is the major predictor of resting metabolic rate (RMR). As protein supplementation during resistance training may augment gains in FFM, we investigated the effects of resistance training combined with protein supplementation on RMR and whether RMR responses
Glaucia L Veiga et al.
Autonomic neuroscience : basic & clinical, 204, 81-87 (2016-12-10)
It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in
M J Rocha et al.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 115(3), 257-264 (1996-11-01)
Female and male tilapia, Oreochromis mossambicus, were treated with luteinizing hormone-releasing hormone analogue (LH-RHa) and pimozide (PIM) or with human chorionic gonadotropin (hCG) to stimulate gonadal development and sexual maturation. Plasma (both sexes) and urine (males) samples were collected periodically
David Cunningham et al.
Lancet (London, England), 381(9880), 1817-1826 (2013-04-26)
Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks. We investigated whether this survival benefit
Carlos D Rosé et al.
Arthritis and rheumatism, 54(10), 3337-3344 (2006-09-30)
Blau syndrome and its sporadic counterpart, early-onset sarcoidosis, share an identical phenotype featuring the classic triad of arthritis, dermatitis, and uveitis and are associated with mutations of CARD15 in 50-90% of cases. We chose the term "pediatric granulomatous arthritis" to
S Karason et al.
Acta anaesthesiologica Scandinavica, 57(5), 639-645 (2013-02-26)
Bladder catheterisation may be inconvenient for patients, delay mobilisation and risk complications. We hypothesised that by excluding pre-operatively patients at high risk of post-operative urinary retention, the majority of patients could avoid perioperative catheterisation during low-dose spinal anaesthesia. Patients undergoing
Marc Remke et al.
Blood, 114(5), 1053-1062 (2009-05-02)
Precursor T-cell acute lymphoblastic leukemia (T-ALL) in children represents a clinical challenge, because relapses are usually fatal. It is thus necessary to identify high-risk patients as early as possible to effectively individualize treatment. We aimed to define novel molecular risk
D S Garrett et al.
Biochemistry, 31(17), 4347-4353 (1992-05-05)
The secondary structure of human recombinant interleukin-4 (IL-4) has been investigated by three-dimensional (3D) 15N- and 13C-edited nuclear Overhauser (NOE) spectroscopy on the basis of the 1H, 15N, and 13C assignments presented in the preceding paper [Powers, R., Garrett, D.
John W McAllister et al.
AIDS (London, England), 31(9), 1291-1295 (2017-03-17)
Completion rates for HIV postexposure prophylaxis (PEP) are often low. We investigated the adherence and safety of dolutegravir (DTG; 50 mg daily) with tenofovir disoproxil fumarate-emtricitabine (TDF-FTC; 300/200 mg, respectively) as three-drug PEP in gay and bisexual men. Open-label, single-arm study at
Stephanie Heim et al.
The American journal of surgical pathology, 38(1), 106-110 (2013-10-15)
Papillary tumors of the pineal region are rare glial tumors located in the vicinity of the third ventricle, the clinical behavior of which is often aggressive. Little is known about the prognostic markers that might aid to identify patients at
Jianjie Li et al.
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 15(5), 299-304 (2012-05-23)
It has been proven that epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) significantly benefits advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations in progression-free survival time with better tolerance. This study is undertaken to analyze efficacy and tolerance
Filippo Russo et al.
British journal of haematology, 166(1), 118-129 (2014-03-29)
We explored activity and safety of a dose-dense/dose-intense adriamycin, bleomycin, vinblastine and dacarbazine regimen (ABVDDD-DI ) in 82 patients with advanced Hodgkin Lymphoma. Patients entered a two-stage Bryant-Day Phase II study to receive six cycles of ABVDDD-DI without consolidation radiotherapy.
Markus Feldkötter et al.
American journal of human genetics, 70(2), 358-368 (2002-01-16)
Spinal muscular atrophy (SMA) is a common autosomal recessive disorder in humans, caused by homozygous absence of the survival motor neuron gene 1 (SMN1). SMN2, a copy gene, influences the severity of SMA and may be used in somatic gene
Kristen A Mehl et al.
Journal of applied physiology (Bethesda, Md. : 1985), 98(6), 2219-2225 (2005-05-17)
Moderate-intensity treadmill running can alter male Apc(Min/+) mouse polyp formation. This purpose of this study was to examine whether exercise mode differentially affects Apc(Min/+) mouse intestinal polyp development in male and female mice. Male and female Apc(Min/+) mice were randomly
Santosh Kumar Gupta et al.
Clinical nuclear medicine, 38(3), 188-194 (2013-02-16)
The aim of this work was to calculate the radiation absorbed dose to kidneys, liver, spleen, pituitary gland, and neuroendocrine tumors (NETs) of patients treated with (177)Lu-DOTATATE. We enrolled 61 patients (male/female patients, 40/21) with mean age of 48.1 ±
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