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T Byk et al.
European journal of biochemistry, 254(1), 14-24 (1998-07-04)
The search for intracellular phosphoproteins implicated in the regulation of neuronal differentiation led to the identification of Ulip1, a mammalian protein related to the Caenorhabditis elegans unc-33 gene product [Byk, T., Dobransky, T., Cifuentes-Diaz, C. & Sobel, A. (1996) J.
Carrie E Gifford et al.
Cytometry. Part B, Clinical cytometry, 86(4), 263-271 (2014-03-13)
X-linked lymphoproliferative disease is caused by mutations in two genes, SH2D1A and XIAP/BIRC4. Flow cytometric methods have been developed to detect the gene products, SAP and XIAP. However, there is no literature describing the accuracy of flow cytometric screening performed
Feng-Cai Zhu et al.
Lancet (London, England), 381(9882), 2024-2032 (2013-06-04)
A vaccine for enterovirus 71 (EV71) is needed to address the high burden of disease associated with infection. We assessed the efficacy, safety, immunogenicity, antibody persistence, and immunological correlates of an inactivated alum-adjuvant EV71 vaccine. We did a randomised, double-blind
Jianjie Li et al.
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 15(5), 299-304 (2012-05-23)
It has been proven that epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) significantly benefits advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations in progression-free survival time with better tolerance. This study is undertaken to analyze efficacy and tolerance
Ankur R Sangoi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(5), 660-667 (2009-03-10)
On the basis of recent clinical studies, some urologic oncologists do not offer bladder-sparing therapy for patients diagnosed with micropapillary carcinoma of the urinary bladder, even in the setting superficially invasive disease. Unfortunately, the distinction of invasive micropapillary carcinoma from
Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.
Xavier Farré et al.
International journal of cancer, 112(6), 959-966 (2004-09-24)
Deoxynucleoside analogs are used in the treatment of a variety of solid tumors. Their transport across the plasma membrane may determine their cytotoxicity and thus nucleoside transporter (NT) expression patterns may be of clinical relevance. Lack of appropriate antibodies for
Alessandro Boccanelli et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 8(9), 683-691 (2007-08-19)
Excess aldosterone activity contributes to the pathogenesis and progression of heart failure (HF). Aldosterone antagonists improve clinical outcome in patients with severe HF or left ventricular (LV) dysfunction after myocardial infarction, but knowledge of their impact in mild chronic HF
Y Hashiguchi et al.
Brain research, 694(1-2), 13-20 (1995-10-02)
The greater potency of morphine-6-glucuronide (M6G) as well as the inactivity of morphine-3-glucuronide (M3G) with respect to the antinociceptive effects of the parent molecule, morphine (MOR), have been well established. It has been suggested that M3G is an antagonist of
D A Johnson et al.
The Journal of biological chemistry, 263(6), 2802-2807 (1988-02-25)
We labeled cobra-alpha-toxin (Naja naja siamensis 3) with near stoichiometric quantities of fluorescein isothiocyanate. To reduce labeling of the hyperreactive N epsilon-lysine 23, the alpha-toxin was modified reversibly with citraconic anhydride before fluorescein labeling. The citraconic anhydride was later removed
Olivier Aubert et al.
Transplantation, 97(9), 946-952 (2014-04-25)
This prospective monocentric study investigated the effect of corticosteroids plus bortezomib to reduce anti-HLA antibodies before renal transplantation. Included were 23 patients with stable immunization against HLA and awaiting a kidney transplant (KT). Treatment consisted of bortezomib (1.3 mg/m) plus
Anna Gillio-Tos et al.
BMC cancer, 12, 618-618 (2012-12-26)
The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV
Henrik Zetterberg et al.
Archives of neurology, 65(8), 1102-1107 (2008-08-13)
We used a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of
Brian J Gebhardt et al.
American journal of clinical oncology, 37(6), 535-538 (2013-02-23)
To evaluate the efficacy of definitive radiotherapy (RT) for the treatment of base of the tongue cancer in a private practice. We retrospectively reviewed the medical records of 48 patients with squamous cell carcinoma of the base of the tongue
Thijs van der Vaart et al.
The Lancet. Neurology, 12(11), 1076-1083 (2013-10-05)
Neurofibromatosis type 1 is a common genetic disorder characterised by neurocutaneous manifestations and cognitive and behavioural problems. Statins were shown to reduce analogous learning deficits in a mouse model of the disease, but a short-term trial in humans was inconclusive.
Claudine Angela Blum et al.
Lancet (London, England), 385(9977), 1511-1518 (2015-01-23)
Clinical trials yielded conflicting data about the benefit of adding systemic corticosteroids for treatment of community-acquired pneumonia. We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia. In this double-blind, multicentre
E Aboulmagd et al.
Applied and environmental microbiology, 67(5), 2176-2182 (2001-04-25)
Synechocystis sp. strain PCC6308 cyanophycin synthetase was purified 72-fold in three steps by anion exchange chromatography on Q Sepharose, affinity chromatography on the triazine dye matrix Procion Blue HE-RD Sepharose, and gel filtration on Superdex 200 HR from recombinant cells
Takako Kawasaki et al.
BMC cancer, 8, 33-33 (2008-01-31)
Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Evidence suggests that MSI/CIMP+ colorectal cancer may arise through the serrated
P Vdb Morkel et al.
Journal of wildlife diseases, 46(1), 236-245 (2010-01-22)
Posture, ventilation, and acid-base balance using auricular venous blood values (pH, lactate, base excess [BE], HCO(3)(-), PO(2), SO(2), and PCO(2)), oxygen saturation of hemoglobin (SpO(2)), and end-tidal carbon dioxide (P(ET)CO(2)) were compared between sternal (STE) and lateral (LAT) recumbency in
Andrew M Bellizzi
Histopathology, 76(2), 251-264 (2019-06-25)
Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation. Transcription factor immunohistochemistry is
U Rauch et al.
The Journal of biological chemistry, 266(22), 14785-14801 (1991-08-05)
A panel of monoclonal antibodies prepared to the chondroitin sulfate proteoglycans of rat brain was used for their immunocytochemical localization and isolation of individual proteoglycan species by immunoaffinity chromatography. One of these proteoglycans (designated 1D1) consists of a major component
J Schmider et al.
Biopharmaceutics & drug disposition, 18(3), 227-240 (1997-04-01)
Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well established as an index reaction for CYP2D6.
Essi K Ahokas et al.
Journal of strength and conditioning research, 33(6), 1488-1495 (2019-04-23)
Ahokas, EK, Ihalainen, JK, Kyröläinen, H, and Mero, AA. Effects of water immersion methods on postexercise recovery of physical and mental performance. J Strength Cond Res 33(6): 1488-1495, 2019-The aim of this study was to compare the effectiveness of 3
Katsuyuki Ando et al.
The lancet. Diabetes & endocrinology, 2(12), 944-953 (2014-12-04)
Renin-angiotensin system inhibitors have renoprotective effects in patients with chronic kidney disease, but most patients treated with these drugs have residual urinary albumin excretion. Some small clinical studies show that mineralocorticoid receptor blockade reduces albuminuria. Our study aimed to examine
J A Hansen et al.
Journal of animal science, 75(7), 1810-1821 (1997-07-01)
We evaluated the effects of recombinant porcine somatotropin (pST) and the beta-adrenergic agonist salbutamol on plasam endocrine and metabolite profiles and muscle chemistry in three genotypes of growing barrows (n = 96, 139 d old). Treatments were in a 2
Md Arshad Ali et al.
Frontiers in microbiology, 11, 618601-618601 (2021-02-05)
Bacteria belonging to the genus Paenibacillus were frequently isolated from legume nodules. The nodule-inhabiting Paenibacillus as a resource of biocontrol and plant growth-promoting endophytes has rarely been explored. This study explored the nodule-inhabiting Paenibacillus' antifungal activities and biocontrol potentials against
Sarah J Collins et al.
Nephron. Experimental nephrology, 104(1), e23-e34 (2006-06-01)
Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) are observed in patients with obesity, hypertension and diabetes, and several observations suggest that PAI-1 mediates diabetic vascular complications. Although increased intrarenal expression of PAI-1 is also a feature of diabetic nephropathy
Angel Chamorro et al.
The Lancet. Neurology, 13(5), 453-460 (2014-04-08)
Uric acid is an antioxidant with neuroprotective effects in experimental models of stroke. We assessed whether uric acid therapy would improve functional outcomes at 90 days in patients with acute ischaemic stroke. URICO-ICTUS was a randomised, double-blind, placebo-controlled, phase 2b/3
Kassoum Kayentao et al.
JAMA, 309(6), 594-604 (2013-02-14)
Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen. However, 2 doses may not provide protection during the last 4 to
Patricia Diana Sørensen et al.
Journal of cancer research and clinical oncology, 139(6), 1005-1013 (2013-03-14)
The aim of this study was to determine the sensitivity, specificity, and predictive values of serum HER-2 for detecting metastatic recurrence in breast cancer patients. In the period 2004-2009, serum HER-2 was measured in 1,348 patients with breast cancer: 837
Xi Yang et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 27(9), 1085-1089 (2013-11-28)
To assess the mid-term effectiveness of anterior decompression and fusion with nanohydroxyapatite/polyamide 66 (n-HA/PA66) cage in treatment of cervical spondylotic myelopathy. A retrospective study was made on 48 patients with cervical spondylotic myelopathy who underwent anterior decompression and fusion with
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