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显示 1-27 共 27 条结果 关于 "97-78-9" 范围 论文
Aron D Mosnaim et al.
Neurochemical research, 38(4), 842-846 (2013-02-08)
Phenylethylamine and its monomethylated derivatives p-methylphenylethylamine, α-methylphenylethylamine, phenylethylamine itself, N-methylphenylethylamine, o-methylphenylethylamine, and β-methylphenylethylamine, readily cross the blood-brain barrier showing a brain-uptake index (%) ± SD (water considered 100 %), of 108 ± 11, 98 ± 14, 83 ± 6, 78
Yu-Zhen Feng et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(17), 6133-6138 (2005-09-08)
Although several gene abnormalities have been reported in endometrial carcinoma, the genetic alterations have not fully been elucidated. Recent studies have revealed frequent activating mutations of the gene for BRAF, an effector of Ras protein in the mitogen-activated protein kinase
Stephen J Plumb et al.
The American Journal of dermatopathology, 26(6), 447-451 (2004-12-25)
The differentiation of primary cutaneous adnexal neoplasms (CANs) from dermal-based metastatic lesions can be difficult. Cytokeratin 5/6 (CK 5/6) has a relatively limited expression profile, being relatively specific for mesothelium and other "pavement" type epithelium such as squamous epithelium. To
Joshua D Groman et al.
American journal of human genetics, 74(1), 176-179 (2003-12-20)
An abbreviated tract of five thymidines (5T) in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is found in approximately 10% of individuals in the general population. When found in trans with a severe CFTR mutation, 5T
Chanjuan Shi et al.
Archives of pathology & laboratory medicine, 138(2), 220-228 (2014-01-31)
PAM4 is a monoclonal antibody that shows high specificity for pancreatic ductal adenocarcinoma (PDAC) and its neoplastic precursor lesions. A PAM4-based serum immunoassay is able to detect 71% of early-stage patients and 91% with advanced disease. However, approximately 20% of
Isabell Klawonn et al.
The ISME journal, 13(8), 1960-1974 (2019-03-27)
Ammonium is a central nutrient in aquatic systems. Yet, cell-specific ammonium assimilation among diverse functional plankton is poorly documented in field communities. Combining stable-isotope incubations (15N-ammonium, 15N2 and 13C-bicarbonate) with secondary-ion mass spectrometry, we quantified bulk ammonium dynamics, N2-fixation and
Michael C Heinrich et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(33), 5352-5359 (2008-10-29)
Most gastrointestinal stromal tumors (GISTs) harbor mutant KIT or platelet-derived growth factor receptor alpha (PDGFRA) kinases, which are imatinib targets. Sunitinib, which targets KIT, PDGFRs, and several other kinases, has demonstrated efficacy in patients with GIST after they experience imatinib
Berit A Payer et al.
European journal of clinical investigation, 42(6), 599-606 (2011-11-29)
A polymorphism near the IL28B gene has been shown to be associated with virologic response to antiviral treatment in HCV-infected patients. The predictive value of interferon-gamma inducible protein 10 (IP10) on treatment outcome has been described in HCV patients. Data
Bo Zhang et al.
Cancer research, 78(11), 3087-3097 (2018-03-25)
Genome-wide association studies have identified more than 90 susceptibility loci for breast cancer. However, the missing heritability is evident, and the contributions of coding variants to breast cancer susceptibility have not yet been systematically evaluated. Here, we present a large-scale
Ferdinando Maggioni et al.
The journal of headache and pain, 6(4), 322-324 (2005-12-20)
We conducted a study on 367 patients (86% female, 14% male; mean age 37+/-15 years) suffering from migraine with and without aura and chronic tension-type headache to evaluate the incidence of weight gain, an undesirable side effect observed during prophylactic
C Koh et al.
Alimentary pharmacology & therapeutics, 37(9), 887-894 (2013-03-07)
Although the short-term benefits of a sustained virological response (SVR) to interferon-based therapies of chronic hepatitis C (CHC) are well known, the long-term consequences of SVR are less clear. To assess changes in markers of disease activity and fibrosis in
Thierry Lebret et al.
Cancer, 98(5), 970-977 (2003-08-28)
Heat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the
E Shiigi et al.
Journal of bone and mineral metabolism, 19(5), 308-311 (2001-08-11)
Ossification of spinal ligaments (OSL) is a common form of myelopathy characterized by heterotopic bone formation in the spinal ligaments, predominantly in men. Although the etiology of OSL is not fully understood, previous studies have strongly suggested the involvement of
Jamie S Harmon et al.
The Journal of biological chemistry, 280(12), 11107-11113 (2005-01-25)
Glucose toxicity in pancreatic islet beta cells causes loss of insulin gene expression, content, and secretion due to loss of binding of transcription factors, most notably PDX-1 and RIPE-3b1 activator, to the promoter region of the insulin gene. Recently, RIPE-3b1
Ying-Bei Chen et al.
The American journal of surgical pathology, 38(5), 627-637 (2014-01-21)
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is an autosomal dominant disorder in which germline mutations of fumarate hydratase (FH) gene confer an increased risk of cutaneous and uterine leiomyomas and renal cancer. HLRCC-associated renal cancer is highly aggressive
Rachel E Harris et al.
Journal of Crohn's & colitis, 14(5), 608-616 (2020-01-01)
Increased risk of opportunistic infection-e.g., varicella zoster infection-secondary to therapies is a cause of morbidity in inflammatory bowel disease [IBD] patients. The UK vaccination schedule does not include varicella immunisation. We aimed to evaluate the varicella screening and immunisation programme
Ali H Alhasan et al.
Molecular pharmaceutics, 16(8), 3577-3587 (2019-07-11)
Engineered superparamagnetic iron oxide nanoparticles (SPIONs) have been studied extensively for their localized homogeneous heat generation in breast cancer therapy. However, challenges such as aggregation and inability to produce sub-10 nm SPIONs limit their potential in magnetothermal ablation. We report
Thomas J Scriba et al.
The Lancet. Infectious diseases, 21(3), 354-365 (2021-01-29)
Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy of signature-guided preventive therapy in parallel, using a hybrid three-group
S Mallal et al.
Lancet (London, England), 359(9308), 727-732 (2002-03-13)
The use of abacavir--a potent HIV-1 nucleoside-analogue reverse-transcriptase inhibitor--is complicated by a potentially life-threatening hypersensitivity syndrome in about 5% of cases. Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles
Christos Haritoglou et al.
Retina (Philadelphia, Pa.), 26(6), 618-622 (2006-07-11)
To report on long-term results of macular hole surgery with peeling of the internal limiting membrane (ILM) in a prospective nonrandomized study. Sixty-four consecutive patients with a follow-up of at least 36 months were included. Only idiopathic macular holes were
Jian-Yong Zhu et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 30(12), 912-917 (2008-03-14)
To investigate the association between polymorphisms of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome (OSAHS), and therefore to explore the genotypes related to OSAHS. The T102C and A1438G polymorphisms of the serotonin 2A receptor genes and
Li-Li Dai et al.
World journal of gastroenterology, 9(3), 622-626 (2003-03-13)
To observe the synthesis of endotoxin receptor CD14 protein and its mRNA expression in Kupffer cells (KCs), and evaluate the role of CD14 in the pathogenesis of liver injury in rats with alcohol-induced liver disease (ALD). Twenty-eight Wistar rats were
Joo Han Oh et al.
The American journal of sports medicine, 42(11), 2567-2573 (2014-09-07)
The failure of subacromial decompression may be attributed to persistent symptoms of acromioclavicular joint (ACJ) arthritis, while inferior clavicular spurs of the ACJ may be associated with failed healing of repaired rotator cuffs. To evaluate the clinical effectiveness of arthroscopic
Reza Yaesoubi et al.
PLoS medicine, 15(1), e1002495-e1002495 (2018-01-25)
The introduction of a conjugate vaccine for serogroup A Neisseria meningitidis has dramatically reduced disease in the African meningitis belt. In this context, important questions remain about the performance of different vaccine policies that target remaining serogroups. Here, we estimate
Sebastien de Feraudy et al.
The American journal of surgical pathology, 32(8), 1111-1122 (2008-06-12)
Atypical fibroxanthoma (AFX) (dermal pleomorphic sarcoma) remains a somewhat controversial entity. Some authors have averred that AFX is a fiction, suggesting that such lesions merely represent misclassified examples of spindled squamous cell carcinoma. In addition, the immunoperoxidase confirmation of AFX
Christophe Hézode et al.
Lancet (London, England), 385(9986), 2502-2509 (2015-04-04)
Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and
Jeffrey A Cohen et al.
Lancet (London, England), 380(9856), 1819-1828 (2012-11-06)
The anti-CD52 monoclonal antibody alemtuzumab reduced disease activity in a phase 2 trial of previously untreated patients with relapsing-remitting multiple sclerosis. We aimed to assess efficacy and safety of first-line alemtuzumab compared with interferon beta 1a in a phase 3
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