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Michelle R Goulart et al.
NPJ precision oncology, 5(1), 61-61 (2021-07-01)
Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. A multi-center cohort of PDAC patients and controls (chronic pancreatitis, intra-ductal papillary neoplasms, gallstones and otherwise
Aron D Mosnaim et al.
Neurochemical research, 38(4), 842-846 (2013-02-08)
Phenylethylamine and its monomethylated derivatives p-methylphenylethylamine, α-methylphenylethylamine, phenylethylamine itself, N-methylphenylethylamine, o-methylphenylethylamine, and β-methylphenylethylamine, readily cross the blood-brain barrier showing a brain-uptake index (%) ± SD (water considered 100 %), of 108 ± 11, 98 ± 14, 83 ± 6, 78
I Davidkin et al.
Vaccine, 13(16), 1617-1622 (1995-11-01)
A two-dose vaccination program against measles, mumps, and rubella (MMR) viruses was started in Finland in 1982. In this program the trivalent MMR-II vaccine (MSD, USA) was offered to children at the ages of 14-18 months and 6 years followed
Yan-Rong Jiang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3271-3276 (2014-01-16)
Porous silica was used as a carrier to prepare tanshinone solid dispersions (SDs). sThe effect of the spray drying method or the solvent method on the drug dissolution of SD was studied. The structure characteristics of SDs was analyzed by
B Velan et al.
The Journal of biological chemistry, 260(9), 5498-5504 (1985-05-10)
The bovine genome contains a gene family of interferon-alpha s (bIFN-alpha) that consists of at least five distinct members. Four of the bIFN-alpha genes isolated show a high degree of homology (97% in the nucleotide sequence and 93% in amino
Asuman Mutlu et al.
British journal of haematology, 163(3), 377-384 (2013-09-17)
The cell plasma membrane is tightly coupled with the vital processes of apoptosis and activation. In the current study, we investigated exposure of the apoptosis marker phosphatidylserine (PS) and activation marker P-selectin (CD62) on the plasma membrane of anucleate platelets.
Ferdinando Maggioni et al.
The journal of headache and pain, 6(4), 322-324 (2005-12-20)
We conducted a study on 367 patients (86% female, 14% male; mean age 37+/-15 years) suffering from migraine with and without aura and chronic tension-type headache to evaluate the incidence of weight gain, an undesirable side effect observed during prophylactic
L Saucedo et al.
Journal of immunology (Baltimore, Md. : 1950), 155(10), 5022-5028 (1995-11-15)
We studied the molecular bases for C8 beta deficiency in 34 unrelated families from the United States and the former Soviet Union. These families represented 69 unrelated null alleles of which 59 (86%) were found to be due to a
Atef Hanna et al.
Diagnostic cytopathology, 38(4), 264-269 (2010-02-11)
The diagnosis of malignant mesothelioma in serosal effusions continues to be a major challenge because some of its cytomorphological features closely resemble adenocarcinomas. Immunohistochemistry is a valuable tool in the differentiation of epithelioid mesothelioma from metastatic adenocarcinomas. However, no single
F Gloria-Bottini et al.
Acta diabetologica, 43(4), 99-102 (2007-01-11)
Currently there is a surge of interest in the association of obesity with growth hormone (GH). Our hypothesis is that genetic variation within the hGH area could predispose to obesity in type 2 diabetes. We examined 68 Caucasian subjects with
Mikhail Lisovsky et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(1), 31-38 (2007-09-22)
More recent techniques to characterize the genetic profile of soft-tissue tumors include the use of gene arrays. Using this technique, Apolipoprotein D (Apo D), a 33-kDa glycoprotein component of high-density lipoprotein, has been found to be highly expressed in dermatofibrosarcoma
Maria Santacana et al.
Human pathology, 45(12), 2394-2403 (2014-10-06)
Histologic typing may be difficult in a subset of endometrial carcinoma (EC) cases. In these cases, interobserver agreement improves when immunohistochemistry (IHC) is used. A series of endometrioid type (EEC) grades 1, 2, and 3 and serous type (SC) were
J Z Zhang et al.
American journal of physiology. Cell physiology, 280(5), C1277-C1283 (2001-04-05)
We showed previously that GLUT-1 glucose transporter is associated with stomatin (band 7.2b) in human red blood cell membranes and in Clone 9 cells. We show here that in a mixed population of stably transfected cells, overexpression of either murine
T Hølmebakk et al.
Annals of surgical oncology, 26(13), 4730-4736 (2019-09-15)
Peritoneal tumor penetration (PP) strongly affects prognosis in gastrointestinal carcinomas. In gastrointestinal stromal tumor (GIST), its significance in the absence of tumor rupture has not been subjected to detailed analysis. Patients undergoing complete resection for non-metastatic GIST from 2000 to
V C Constantinides et al.
AJNR. American journal of neuroradiology, 39(6), 1047-1051 (2018-04-07)
Differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration from Parkinson disease on clinical grounds is often difficult. MR imaging biomarkers could assist in a more accurate diagnosis. We examined the utility of MR imaging surface measurements
P Forde et al.
Environmental technology, 36(9-12), 1188-1204 (2014-11-22)
In this laboratory study, a novel wastewater treatment technology, the air suction flow-biofilm reactor (ASF-BR) - a sequencing batch biofilm reactor technology with a passive aeration mechanism - was investigated for its efficiency in removing organic carbon, nitrogen and phosphorus
Noriyuki Omura et al.
Cancer biology & therapy, 7(7), 1146-1156 (2008-06-07)
Many genes undergo aberrant methylation in human cancers, and microarray platforms enable more comprehensive profiling of aberrant DNA methylation patterns. 1,010 of 87,922 probes on the 88 K promoter array (606 genes) had a higher signal (log(2) > 2) in
Jens Brøndum Frøkjær et al.
Abdominal radiology (New York), 45(5), 1497-1506 (2020-04-09)
This feasibility and validation study addresses the potential use of magnetic resonance imaging (MRI) texture analysis of the pancreas in patients with chronic pancreatitis (CP). Extraction of 851 MRI texture features from diffusion weighted imaging (DWI) of the pancreas was
Meinolf Suttorp et al.
Leukemia, 32(7), 1657-1669 (2018-06-22)
A total of 156 patients (age range 1.3-18.0 years, median 13.2 years; 91 (58.3%) male) with newly diagnosed CML (N = 146 chronic phase (CML-CP), N = 3 accelerated phase (CML-AP), N = 7 blastic phase (CML-BP)) received imatinib up-front (300, 400, 500 mg/m2, respectively) within a
Felix Stonek et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(5), 425-429 (2007-10-05)
The purpose of this article is to investigate the frequency of the tumor necrosis factor-alpha (TNF-alpha) -308 G/A single nucleotide polymorphism in women with intrauterine fetal death, preeclampsia, preterm delivery, and small-for-gestational-age (SGA) infants. In a prospective cohort study, DNA
J R Hamilton et al.
Journal of clinical microbiology, 29(2), 333-339 (1991-02-01)
Cryptococcal antigen titers in 97 serum and 42 cerebrospinal fluid (CSF) specimens from 37 AIDS patients with culture-proven cryptococcal infection were determined with the Meridian kit (Meridian Diagnostics Inc., Cincinnati, Ohio) before and after treatment with pronase. The geometric mean
F Ferrara et al.
Letters in applied microbiology, 59(3), 253-262 (2014-05-20)
Several serological diagnostics rely on enzyme-linked immunosorbent assay (ELISA) to detect bacterial infections. However, for some pathogens, including Bartonella henselae, diagnosis still depends on manually intensive, time-consuming assays including micro-immunofluorescence, Western blotting or indirect immunofluorescence. For such pathogens, there is
María Ibáñez et al.
Journal of chromatography. A, 1081(2), 145-155 (2005-07-26)
This paper describes a method for the sensitive and selective determination of glyphosate, glufosinate and aminomethylphosphonic acid (AMPA) residues in water and soil samples. The method involves a derivatization step with 9-fluorenylmethylchloroformate (FMOC) in borate buffer and detection based on
Travis J Hollmann et al.
The American journal of surgical pathology, 36(6), 789-798 (2012-03-01)
Digital fibromyxoma (first described by Fetsch and colleagues as superficial acral fibromyxoma) is a distinctive soft tissue tumor with a predilection for the subungual or periungual region of the hands and feet. This report details the histologic, immunophenotypic, and clinical
Francesco Lo-Coco et al.
The New England journal of medicine, 369(2), 111-121 (2013-07-12)
All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic
Elizabeth S Fernandes et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(4), 1664-1673 (2012-12-29)
The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B₄ (LTB₄) that is up-regulated in common skin diseases. Intradermal injection of LTB4 (0.1 nmol/site) into female CD1 mice induced significant scratching movements
H Ono et al.
Immunogenetics, 38(1), 1-10 (1993-01-01)
The beta 2-microglobulin (beta 2m) is a protein found in the serum in a free form and on the cell surface in a form noncovalently associated with the alpha chain of the class I major histocompatibility complex (Mhc) molecules. In
Li-Li Dai et al.
World journal of gastroenterology, 9(3), 622-626 (2003-03-13)
To observe the synthesis of endotoxin receptor CD14 protein and its mRNA expression in Kupffer cells (KCs), and evaluate the role of CD14 in the pathogenesis of liver injury in rats with alcohol-induced liver disease (ALD). Twenty-eight Wistar rats were
Babita Ghai et al.
Pain physician, 18(3), 237-248 (2015-05-23)
Epidural injections (EI) are the most commonly performed minimally invasive intervention to manage chronic low back pain (CLBP) with lumbosacral radicular pain (LRP). Local anesthetic (LA) and/or steroids are frequently used injectates for EI and are reported with variable effectiveness.
Christophe Hézode et al.
Lancet (London, England), 385(9986), 2502-2509 (2015-04-04)
Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and
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