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P C Chan
Toxicity report series, (67)(67), 1-G12-1-G12 (2004-05-18)
[Structure-see text] 2-Methylimidazole and 4-methylimidazole are intermediate/starting materials or components in the manufacture of pharmaceuticals, photographic and photothermographic chemicals, dyes and pigments, agricultural chemicals, and rubber; these chemicals have been identified as undesirable by-products in several foods and have been
Edwin K Jackson et al.
Clinical and experimental pharmacology & physiology, 35(1), 29-34 (2007-12-01)
1. The aim of the present study was to determine whether inhibition of dipeptidyl peptidase IV (DPP IV) elevates arterial blood pressure and whether any such effect is dependent on genetic background, the sympathetic nervous system and Y(1) receptors. The
Jason S Biswas et al.
Infection control and hospital epidemiology, 36(8), 975-977 (2015-04-11)
Clostridium difficile was recovered from 33 (34%) of 98 rooms of patients who were excretors compared with 36 (49%) of 73 rooms of patients with active infection. Not all laboratory algorithms can distinguish between these 2 groups, yet both may
Jan Stadler et al.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 193(6), 486-493 (2011-11-15)
Even now, sepsis remains a major problem in modern clinical medicine, leading to systemic inflammatory response including altered leukocyte subset distribution and increased cytokine release. As immune cells are known to express NPY receptors, we investigated the effects of a
Surendra S Bisht et al.
European journal of medicinal chemistry, 45(12), 5965-5978 (2010-10-26)
A series of [4-(aryloxy)phenyl]cyclopropyl methanones were synthesized by reaction of different benzyl alcohols with 4-chloro-4'-fluorobutyrophenone in DMF in the presence of NaH/TBAB. The methanones were further reduced to respective methanols. The antitubercular activity of these compounds was evaluated in vitro
Emiko Ando et al.
Public health nutrition, 1-11 (2020-08-05)
Recent research supports the importance of PUFA intake in children, particularly of EPA and DHA; however, few verified methods to assess whether PUFA intake is adequate are available. We assessed the correlation between serum PUFA and lipid concentrations with seafood
Bunpei Ishizuka et al.
Fertility and sterility, 96(5), 1170-1174 (2011-09-29)
To define the number of CGG repeats in the FMR1 gene of Japanese patients with primary ovarian insufficiency (POI) and normal controls. Retrospective, controlled cohort study. Outpatient department of an academic tertiary center. One hundred twenty-eight consecutive Japanese patients with
F S Kibenge et al.
The Journal of general virology, 81(Pt 1), 143-150 (2000-01-21)
Infectious salmon anaemia virus (ISAV) is a new orthomyxovirus-like virus. Thirteen isolates of ISAV (11 from Canada, one from Norway and one from Scotland) were studied for their replication in the CHSE-214 cell line compared with that in the SHK-1
M H Lyda et al.
Human pathology, 31(8), 980-987 (2000-09-15)
The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the
Keiji Yashio et al.
Bioorganic & medicinal chemistry letters, 22(1), 115-119 (2011-12-14)
The synthesis and in vivo evaluation of (11)C -labeled uric acid ([(11)C]1), a potential imaging agent for the diagnosis of urate-related life-style diseases, was performed using positron emission tomography (PET) image analysis. First, the synthesis of [(11)C]1 was achieved by
Elias A Kazos et al.
Chemosphere, 68(11), 2104-2110 (2007-03-23)
A simple, rapid and sensitive GC-MS method for the determination of dithiocarbamate fungicide propineb [polymeric zinc propylenebis (dithiocarbamate)] and an improved HPLC procedure for the simultaneous determination of its main metabolite, propylenethiourea, and ethylenethiourea, the main metabolite of all ethylenedithiocarbamates
C M Escobedo-Bonilla et al.
Diseases of aquatic organisms, 74(2), 85-94 (2007-04-17)
White spot syndrome virus (WSSV) causes disease and mortality in cultured and wild shrimp. A standardized WSSV oral inoculation procedure was used in specific pathogen-free (SPF) Litopenaeus vannamei (also called Penaeus vannamei) to determine the primary sites of replication (portal
Sajith Vellappally et al.
Acta microbiologica et immunologica Hungarica, 64(3), 343-351 (2017-09-12)
Oral streptococci are the major group of microbes isolated from oral microflora. They represent frequent pathogens of infective endocarditis (IE), and it is assumed that in most of the cases oral streptococci are acquired via mucosa layer of oral cavity.
Said H Audi et al.
Shock (Augusta, Ga.), 48(4), 467-476 (2017-09-16)
Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was
A Franco et al.
Transplantation proceedings, 47(8), 2364-2367 (2015-11-01)
Calcineurin inhibitors (CNI) have failed to improve long-term outcomes in renal transplantation. Anti-proliferative and anti-angiogenic effects of mammalian target of rapamycin inhibitors (m-TOR) without nephrotoxicity could improve long-term survival in selected transplant recipients. We examined the evolution of 98 low-immunological
Xiao Jun Xiang et al.
Molecular medicine reports, 12(2), 1935-1940 (2015-04-23)
Dickkopf-1 (DKK1) is a negative regulator of the Wnt/β-catenin signaling pathway, which is expressed in various human cancers. It was hypothesized that DKK1 was oncogenic and involved in invasive growth in non-small cell lung cancer (NSCLC) cells. The present study
A Royer et al.
Journal of chromatography. A, 1108(1), 129-135 (2006-01-31)
An analytical method has been developed for the determination of residues of ethephon (2-chloroethyl phosphonic acid) in drinking and surface water. The procedure is based on de-ionisation with an anion/cation-exchange resin, solid phase extraction by means of anion-exchange polystyrene-divinylbenzene extraction
Younghoon Kim et al.
Anaerobe, 18(5), 539-545 (2012-09-27)
The effect of Bifidobacterium spp. on the production of quorum-sensing (QS) signals and biofilm formation by enterohemorrhagic Escherichia coli (EHEC) O157:H7 was investigated. In an AI-2 bioassay, cell extracts of Bifidobacterium longum ATCC 15707 resulted in a 98-fold reduction in
Patrick J Riss et al.
Bioorganic & medicinal chemistry, 17(22), 7630-7634 (2009-10-23)
PR04.MZ 8-(4-fluoro-but-2-ynyl)-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (1) and LBT999 8-((E)-4-fluoro-but-2-enyl)-3b-p-tolyl-8-aza-bicyclo[3.2.1]octane-2beta-carboxylic acid methyl ester (2) are selective dopamine reuptake inhibitors, derived from cocaine. Compounds 1 and 2 were labelled with fluorine-18 at their terminally fluorinated N-substituents employing microwave enhanced direct nucleophilic fluorination.
R Maruyama et al.
Cancer research, 61(24), 8659-8663 (2001-12-26)
We investigated the aberrant promoter methylation profile of bladder cancers and correlated the data with clinicopathological findings. The methylation status of 10 genes was determined in 98 surgically resected bladder cancers, and we calculated the median methylation index (MI), a
Elizabeth Maunsell et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(14), 1427-1436 (2014-04-09)
Exemestane, a steroidal aromatase inhibitor, reduced invasive breast cancer incidence by 65% among 4,560 postmenopausal women randomly assigned to exemestane (25 mg per day) compared with placebo in the National Cancer Institute of Canada (NCIC) Clinical Trials Group MAP.3 (Mammary
Gary Fraser et al.
Public health nutrition, 18(3), 537-545 (2014-03-19)
To compare cardiovascular risk factors between vegetarians and non-vegetarians in black individuals living in the USA. A cross-sectional analysis of a sub-set of 592 black women and men enrolled in the Adventist Health Study-2 (AHS-2) cohort of Seventh-day Adventists. Members
S Soize et al.
AJNR. American journal of neuroradiology, 35(10), 1903-1909 (2014-06-07)
Four-dimensional, contrast-enhanced MRA is a useful technique for the diagnosis and classification of brain AVM. The purpose of this study was to evaluate its usefulness in the follow-up of treated brain AVM. Patients with treated brain AVM (embolization, radiosurgery, and/or
Monika Brzychczy-Wloch et al.
Annals of clinical microbiology and antimicrobials, 12, 41-41 (2013-12-24)
Multi-drug resistant coagulaso-negative staphylococci (CNS) have become an increasing problem in nosocomial infections connected with the presence of medical devices. The paper aimed to analyze the prevalence of antibiotic resistance in CNS isolated from invasive infection in very low birth
François Girodon et al.
Haematologica, 93(11), 1723-1727 (2008-08-30)
We analyzed the effect of hydroxyurea on the JAK2V617F allelic ratio (%JAK2V617F), measured in purified blood granulocytes, of patients with polycythemia vera and essential thrombocythemia. Thirty-six patients were examined sequentially prior to and after start of hydroxy-urea therapy (8 polycythemia
Sahar Ghassem-Zadeh et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Identification of disease-associated autoantibodies is of high importance. Their assessment could complement current diagnostic modalities and assist the clinical management of patients. We aimed at developing and validating high-throughput protein microarrays able to screen patients' sera to determine disease-specific autoantibody-signatures
Salvatore Carbone et al.
Diabetes/metabolism research and reviews, 36(8), e3335-e3335 (2020-05-18)
Canagliflozin reduces hospitalizations for heart failure (HF) in type 2 diabetes mellitus (T2DM). Its effect on cardiorespiratory fitness and cardiac function in patients with established HF with reduced ejection fraction (HFrEF) is unknown. We conducted a double-blind randomized controlled trial
T B Vree et al.
British journal of clinical pharmacology, 35(5), 467-472 (1993-05-01)
1. The pharmacokinetics of 500 mg naproxen given orally were described in 10 subjects using a direct h.p.l.c. analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. 2. The mean elimination half-life of naproxen was 24.7 +/-
Yoichi Sakakibara et al.
Gene, 285(1-2), 39-47 (2002-06-01)
By employing reverse transcription-polymerase chain reaction (RT-PCR) in conjunction with 5'-rapid amplification of cDNA ends technique, we have cloned a novel mouse sulfotransferase cDNA. Database search led to the identification of a human gene encoding the homologue of this newly
Norman E Buroker et al.
Clinica chimica acta; international journal of clinical chemistry, 411(19-20), 1466-1473 (2010-06-24)
Acute (AMS) and chronic (CMS) mountain sicknesses are illnesses that occur among humans visiting or inhabiting high-altitude environments, respectively. Some individuals are genetically less fit than others when stressed by an extreme high-altitude environment. Seven blood physiological parameters and five
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