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C H Macphee et al.
Journal of immunology (Baltimore, Md. : 1950), 161(11), 6273-6279 (1998-12-02)
A new CC chemokine, designated CKbeta-8 or myeloid progenitor inhibitor factor-1, was recently identified in a large scale sequencing effort and was cloned from a human aortic endothelial library. CKbeta-8 cDNA encodes a signal sequence of 21 amino acids, followed
Yahya Tamimi et al.
Mutation research, 601(1-2), 46-50 (2006-07-04)
To determine whether PAX-2 and PAX-8 are involved in Wilms tumor (WT) pathogenesis, we sought mutations in these two genes in 99 Wilms tumors of favorable histology. We screened the entire protein coding sequences as well as the intronic regions
Liang Ma et al.
Zhongguo shi yan xue ye xue za zhi, 18(6), 1386-1389 (2010-12-24)
The aim of this study was to analyze the frequency of flt3 length mutation (flt3-LM) in de novo acute myeloid leukemia patients and the relationship between flt3-LM and chromosome alterations, FAB subgroups, as well as efficiency of therapy. Genomic DNA
Harry W Gibson et al.
The Journal of organic chemistry, 72(15), 5759-5770 (2007-06-27)
Chiral acid chlorides were reacted with isoquinoline and 6,7-dimethoxy-3,4-dihydroisoquinoline to form diastereomeric Reissert compounds 8-11 and 18-21, respectively. The best diastereoselectivity (80:20) was achieved in formation of the 9-phenylmenthyl derivative 20. The diastereomers of 2-l-menthoxycarbonyl-1,2-dihydroisoquinaldonitriles (S)-8/(R)-8), formed in equal amounts
Diana M Padgett et al.
The American journal of surgical pathology, 32(1), 123-127 (2007-12-29)
Immunohistochemistry using a broad panel of markers is an invaluable tool for diagnosing sarcomatoid mesothelioma. Membranous podoplanin staining has been proposed as a specific and sensitive marker to distinguish epithelioid mesothelioma from adenocarcinoma. We found that cytoplasmic podoplanin staining was
Yolanda Picó et al.
Analytical and bioanalytical chemistry, 407(15), 4247-4259 (2015-01-31)
The accurate determination of perfluoroalkyl substances (PFSAs) in water, sediment, fish, meat, and human milk was achieved by ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QqTOF-MS) with an ABSciex Triple TOF®. A group of 21 PFSAs was selected as target to
David G Kent et al.
Blood, 112(3), 560-567 (2008-05-27)
Hematopoietic stem cells (HSCs) regenerated in vivo display sustained differences in their self-renewal and differentiation activities. Variations in Steel factor (SF) signaling are known to affect these functions in vitro, but the cellular and molecular mechanisms involved are not understood.
Opas Bunkoed et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 47(2), 167-175 (2012-01-17)
A simple and high collection efficiency sampling method was developed for the monitoring of carbonyl compounds, i.e., formaldehyde, acetaldehyde, benzaldehyde, acetone and butanone. The determination is based on the reaction of these compounds in a sensitive absorbing solution of 2,4-DNPH.
Jamshid Shirani et al.
The American journal of cardiology, 112(9), 1293-1297 (2013-07-23)
In patients with obstructive coronary artery disease, electrocardiographic (ECG) ST-segment elevation (STE) is frequently seen during dobutamine stress echocardiography (DSE) in leads overlying previous transmural left ventricular (LV) myocardial infarction. The mechanism of occasional STE during DSE in LV region
Anna M Steele et al.
JAMA, 311(3), 279-286 (2014-01-17)
Glycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting hyperglycemia from birth, resulting in an elevated glycated hemoglobin (HbA1c) level that mimics recommended levels for type 1 and
J Kotyza et al.
Scandinavian journal of clinical and laboratory investigation, 69(1), 73-78 (2008-09-30)
An anaerobic type of glycolysis exemplified by hyperproduction of the lactate dehydrogenase (LDH) subunit M has been detected in lung tumours, while a similar pattern has been found in concomitant pleural effusions (PE). The aim of this study was to
P F Erickson et al.
Cancer research, 54(7), 1782-1786 (1994-04-01)
The 8;21 translocation, t(8;21)(q22;q22.3), is seen only in acute myelogenous leukemia and is characteristically associated with the M2 subtype. Subsequent to our identification of the t(8;21) breakpoint region on chromosome 21, we reported that the translocation results in the fusion
A Alkushi et al.
Virchows Archiv : an international journal of pathology, 442(3), 271-277 (2003-03-21)
Adenocarcinomas of the uterine cervix show a wide range of morphological features, and can be confused with endometrial adenocarcinoma in biopsy or curetting specimens. The objective of this study was to use tissue microarray technology to evaluate the immunoprofile of
Sujiang Zhang et al.
Leukemia & lymphoma, 49(4), 696-699 (2008-04-10)
Recent studies have shown that Janus tyrosine kinase 2 (JAK2) V617F mutation is found in nearly all patients with polycythemia vera (PV) and underlie the basis of PV molecular pathogenesis. Moreover, JAK2 V617F patients with essential thrombocythemia (ET) have been
A N Balamurugan et al.
Transplantation, 93(7), 693-702 (2012-02-10)
The optimal enzyme blend that maximizes human islet yield for transplantation remains to be determined. In this study, we evaluated eight different enzyme combinations (ECs) in an attempt to improve islet yield. The ECs consisted of purified, intact or truncated
Kristen A Neville et al.
Clinical endocrinology, 82(5), 657-662 (2015-01-20)
It is unclear whether the rate of vitamin D deficiency in paediatric cancer survivors is higher than in the background population, and whether this is of pathological significance. 25OHD was measured in a previously studied group of 208 survivors (n
Mohammad Rubayet Hasan et al.
Journal of virological methods, 265, 42-48 (2018-12-24)
Commercial multiplex assays, built on different chemistries and platforms are widely available for simultaneous detection of pathogens that cause respiratory infections. However, these tests are often difficult to implement in a resource limited setting because of high cost. In this
Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.
Christine L Jones et al.
The Journal of investigative dermatology, 132(8), 2042-2049 (2012-04-13)
T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed as a biomarker for SS;
Michael J Rock et al.
The Journal of pediatrics, 147(3 Suppl), S73-S77 (2005-10-06)
To describe the development and follow-up confirmatory results of the routine cystic fibrosis (CF) newborn screening (NBS) program in Wisconsin. CF NBS has been performed on a routine clinical basis in Wisconsin since July 1994. The 2-tiered immunoreactive trypsinogen (IRT)/DNA
Adoke Yeka et al.
PloS one, 8(1), e53772-e53772 (2013-01-26)
The treatment of falciparum malaria poses unique challenges in settings where malaria transmission intensity is high because recurrent infections are common. These could be new infections, recrudescences, or a combination of the two. Though several African countries continue to use
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
Hiroaki Yanagimoto et al.
The American surgeon, 80(1), 36-42 (2014-01-10)
The objective of this study was to examine whether the development of cholangitis after preoperative biliary drainage (PBD) can increase the incidence of postoperative pancreatic fistula (POPF). The study population included 185 consecutive patients who underwent pancreaticoduodenectomy from April 2006
I Del Giudice et al.
Leukemia, 20(7), 1231-1237 (2006-04-28)
B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes
R Kappe et al.
Mycoses, 47 Suppl 1, 55-59 (2005-01-26)
The clinical significance of Aspergillus antibody assays for the diagnosis of invasive aspergillosis (IA) is unclear. In two studies, three different antibody assays were evaluated with patients suffering from proven IA: (i) a commercial haemagglutination test (HAT), (ii) a commercial
Remberto C Paulo et al.
The Journal of clinical endocrinology and metabolism, 93(11), 4440-4447 (2008-08-14)
Acylated ghrelin is the putatively bioactive GH secretagogue. Estradiol (E2) stimulates the synthesis rather than inhibits the metabolic clearance of acylated ghrelin. The study took place at an academic medical center. Healthy postmenopausal women participated. Interventions included prospectively randomized, double-blind
Akira Shimada et al.
Pediatric blood & cancer, 50(2), 264-269 (2007-09-01)
Mixed-lineage leukemia (MLL)-partial tandem duplication (PTD) is associated with poor prognosis in adult acute myeloid leukemia (AML), but its relationship to pediatric AML is unknown. One hundred fifty-eight newly diagnosed AML patients, including 13 FAB-M3 and 10 Down syndrome (DS)
Martin Stockmann et al.
HPB : the official journal of the International Hepato Pancreato Biliary Association, 12(2), 139-146 (2010-05-25)
Liver failure has remained a major cause of mortality after hepatectomy, but it is difficult to predict preoperatively. This study describes the introduction into clinical practice of the new LiMAx test and provides an algorithm for its use in the
Iva Karacić et al.
Molecular genetics and metabolism, 97(3), 165-171 (2009-04-28)
Specific mutations in the gene encoding phenylalanine hydroxylase (PAH), located on chromosome 12q22-24.1, are linked to tetrahydrobiopterin (BH4; sapropterin)-responsive phenylketonuria (PKU). Diagnosis is usually done through the newborn screening for PKU, followed by a BH4 loading test. So far, more
Beatrice Barda et al.
The Lancet. Infectious diseases, 18(8), 864-873 (2018-06-03)
The recommended anthelmintics show low efficacy in a single-dose regimen against Trichuris trichiura. Moxidectin, a new treatment for river blindness, might complement the drug armamentarium for the treatment and control of soil-transmitted helminthiasis. However, its efficacy against T trichiura has
S J Garcés-Eisele et al.
Journal of clinical pharmacy and therapeutics, 39(4), 368-375 (2014-04-08)
Hydralazine is an inhibitor of DNA methyltransferases, whereas valproate interferes with histone deacetylation. In combination, they show a marked synergism in reducing tumour growth as well as development of metastasis and inducing cell differentiation. Hydralazine is metabolized by the highly
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