CN
Search Within
A1330000
应用筛选条件
关键词:'A1330000'
显示 1-30 共 77 条结果 关于 "A1330000" 范围 论文
Jing-Li Gan et al.
Psychiatry research, 223(1), 23-27 (2014-05-17)
Early onset schizophrenia (EOS) is often associated with poorer outcomes, including lack of school education, higher risk of mental disability and resistance to treatment. But the knowledge of the neurobiological mechanism of EOS is limited. Here, using proton magnetic resonance
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.
Wilson I Gonsalves et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III
Xin Yang et al.
Annals of neurology, 75(4), 492-507 (2013-11-19)
Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined whether glutamate receptors were involved in hypoglycemic WM injury. Mouse optic nerves (MON), CNS WM tracts, were maintained at 37°C with oxygenated
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
D Machover
Bulletin du cancer, 81 Suppl 2, 74s-77s (1994-12-01)
Jenna Friedt et al.
Nucleic acids research, 42(6), 3857-3870 (2013-12-29)
Pseudouridine synthases introduce the most common RNA modification and likely use the same catalytic mechanism. Besides a catalytic aspartate residue, the contributions of other residues for catalysis of pseudouridine formation are poorly understood. Here, we have tested the role of
Susumu Ohtani et al.
Journal of forensic sciences, 50(5), 1020-1027 (2005-10-18)
The estimation of chronological age has been performed by various methods in forensic science. Among these, racemization methods, which are based on the age-dependent non-enzymatic changes of L-form amino acids to D-form mainly using aspartic acid, are one of the
Giles S Kendall et al.
Radiology, 271(1), 230-238 (2014-01-31)
To determine (a) whether diffuse white matter injury of prematurity is associated with an increased choline (Cho)-to-creatine (Cr) ratio and a reduced N-acetylaspartate (NAA)-to-Cho ratio and whether these measures can be used as biomarkers of outcome and (b) if changes
Vinay Parikh et al.
Neurochemistry international, 75, 54-65 (2014-06-10)
Recent evidence suggests that diminished ability to control cocaine seeking arises from perturbations in glutamate homeostasis in the nucleus accumbens. However, the neurochemical substrates underlying cocaine-induced neuroadaptations in the dorsal striatum and how these mechanisms link to behavioral plasticity is
E R Waite et al.
Forensic science international, 103(2), 113-124 (1999-09-11)
Accurate age determination of adult cadavers and human remains is a key requirement in forensic practice. The current morphological methods lack accuracy and precision, require specialist training and are costly. The use of aspartic acid racemization (AAR) in human dentine
Anja K K Rahn et al.
Food chemistry, 166, 301-308 (2014-07-24)
Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino acid and it should
Jo-Il Kim et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2427-2436 (2014-10-11)
The solid matrices used for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) enable the analysis of small molecules by preventing fragmentations of organic matrix molecules in the low mass-to-charge ratio (m/z) range. In this work, a nylon nanoweb with TiO(2)
Alexandra Deviers et al.
International journal of radiation oncology, biology, physics, 90(2), 385-393 (2014-08-12)
Because lactate accumulation is considered a surrogate for hypoxia and tumor radiation resistance, we studied the spatial distribution of the lactate-to-N-acetyl-aspartate ratio (LNR) before radiation therapy (RT) with 3D proton magnetic resonance spectroscopic imaging (3D-(1)H-MRSI) and assessed its impact on
Ahmad Farooq et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(7), G732-G740 (2014-08-12)
Activation of the cytosolic inflammasome machinery is responsible for acute and chronic liver inflammation, but little is known about its regulation. The N-methyl-d-aspartate (NMDA) receptor families are heterotetrameric ligand-gated ion channels that are activated by a range of metabolites, including
N Andres Parra et al.
International journal of radiation oncology, biology, physics, 90(2), 376-384 (2014-07-30)
Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by
Ma Paz Lorenzo et al.
Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)
Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health
Stefanie Ritz-Timme et al.
Ageing research reviews, 1(1), 43-59 (2002-06-01)
Aspartic acid racemization (AAR) represents one of the major types of non-enzymatic covalent modification that leads to an age-dependent accumulation of abnormal protein in numerous human tissues. In vivo racemization is an autonomic process during the "natural" ageing of proteins
Edi Erwan et al.
Life sciences, 109(1), 65-71 (2014-06-03)
L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this study, we therefore examined the effects of L-Asp and D-Asp in
Marco Flores-Méndez et al.
Toxicology letters, 229(1), 126-133 (2014-06-24)
Fluoride is an environmental pollutant present in dental products, food, pesticides and water. The latter, is the greatest source of exposure to this contaminant. Structural and functional damages to the central nervous system are present in exposed population. An established
R A Azevedo et al.
Amino acids, 30(2), 143-162 (2006-03-10)
Aspartate is the common precursor of the essential amino acids lysine, threonine, methionine and isoleucine in higher plants. In addition, aspartate may also be converted to asparagine, in a potentially competing reaction. The latest information on the properties of the
Sara Llufriu et al.
JAMA neurology, 71(7), 840-847 (2014-05-21)
Predicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple sclerosis pathologic damage typically includes demyelination, neuro-axonal loss, and astrogliosis. To evaluate the potential of magnetic resonance markers of central nervous system injury to
Rim Benali-Cherif et al.
Acta crystallographica. Section C, Structural chemistry, 70(Pt 7), 689-692 (2014-07-06)
Two polymorphs of L-aspartic acid hydrochloride, C4H8NO4(+)·Cl(-), were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic
Michaela M Kraus et al.
Life sciences, 102(1), 49-54 (2014-03-13)
Thalamostriatal fibers are involved in cognitive tasks such as acquisition, learning, processing of sensory events, and behavioral flexibility and might play a role in Parkinson's disease. The aim of the present study was the in vivo electrochemical characterization of the
Ruei-Yue Liang et al.
Journal of molecular biology, 426(24), 4049-4060 (2014-10-15)
Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress response, endoplasmic reticulum proteolysis, and DNA repair. Rad23 binds the proteasome
Yanmei Si et al.
The Analyst, 139(21), 5466-5471 (2014-09-02)
A simple, rapid, sensitive, selective, and field-deployable detection protocol has been initially proposed for the early warning and diagnosis of exposure to organophosphates (OPs) by electrochemically monitoring the direct biomarkers of free OPs in blood. Phosphorylation-sensitive tyrosine (Tyr), which was
Production of L-aspartic acid.
T Sato et al.
Bioprocess technology, 16, 15-24 (1993-01-01)
Daisuke Torii et al.
Odontology, 103(1), 27-35 (2014-01-09)
The periodontal ligament (PDL) consists of a group of specialized connective tissue fibers embedded in the alveolar bone and cementum that are believed to contain progenitors for mineralized tissue-forming cell lineages. These progenitors may contribute to regenerative cell therapy or
Mireia Burnat et al.
Journal of bacteriology, 196(23), 4026-4035 (2014-09-10)
Heterocyst-forming cyanobacteria grow as chains of cells (known as trichomes or filaments) that can be hundreds of cells long. The filament consists of individual cells surrounded by a cytoplasmic membrane and peptidoglycan layers. The cells, however, share a continuous outer
Qin Wu et al.
The Biochemical journal, 461(2), 247-255 (2014-04-25)
The first crystal trans-structure of a naturally occurring split intein has been determined for the Npu (Nostoc punctiforme PCC73102) DnaE split intein. Guided by this structure, the residues NArg50 and CSer35, well conserved in DnaE split inteins, are identified to
T Kajikawa et al.
Journal of dental research, 93(4), 400-405 (2014-01-24)
PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region. In this study, we hypothesized that the D repeat polymorphism of PLAP-1/asporin
Helen N Saada et al.
International journal of radiation biology, 90(12), 1179-1183 (2014-06-18)
To evaluate the modulator role of fish oil (FO) on some biochemical changes in the brain of gamma-irradiated rats (RAD). Male albino rats Sprague Dawley were divided into four groups (n = 10). (i) received vehicle via gavages during 28
1/3