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Stelios Tzellos et al.
Journal of virology, 88(16), 8743-8753 (2014-05-23)
Sequence differences in the EBNA-2 protein mediate the superior ability of type 1 Epstein-Barr virus (EBV) to transform human B cells into lymphoblastoid cell lines compared to that of type 2 EBV. Here we show that changing a single amino
Production of L-alanine and D-aspartic acid.
S Takamatsu et al.
Bioprocess technology, 16, 25-35 (1993-01-01)
Dan-ju Tso et al.
Journal of molecular biology, 426(10), 2112-2129 (2014-03-25)
The G-loop is a 10-residue glycine-rich loop that protrudes from the surface of the mature bacteriophage HK97 capsid at the C-terminal end of the long backbone helix of major capsid protein subunits. The G-loop is essential for assembly, is conserved
D L Birken et al.
Neuroscience and biobehavioral reviews, 13(1), 23-31 (1989-01-01)
N-acetyl aspartic acid (NAA), discovered in 1956 by Tallan, is the major peak seen in water-suppressed NMR proton (hydrogen) spectroscopy. NAA makes up about one thousandth of the wet weight of human brain and appears to be limited solely to
Sergei P Balashov et al.
Biochemistry, 53(48), 7549-7561 (2014-11-07)
A group of microbial retinal proteins most closely related to the proton pump xanthorhodopsin has a novel sequence motif and a novel function. Instead of, or in addition to, proton transport, they perform light-driven sodium ion transport, as reported for
Hao-wei Shen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5649-5657 (2014-04-18)
Reducing the enduring vulnerability to relapse is a therapeutic goal in treating drug addiction. Studies with animal models of drug addiction show a marked increase in extrasynaptic glutamate in the core subcompartment of the nucleus accumbens (NAcore) during reinstated drug
R A Azevedo
Amino acids, 22(3), 217-230 (2002-06-27)
Amino acid metabolism is a fundamental process for plant growth and development. Although a considerable amount of information is available, little is known about the genetic control of enzymatic steps or regulation of several pathways. Much of the information about
Melissa E Murray et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16247-16255 (2014-12-05)
Proton magnetic resonance spectroscopy ((1)H-MRS) is sensitive to early neurodegenerative processes associated with Alzheimer's disease (AD). Although (1)H-MRS metabolite ratios of N-acetyl aspartate (NAA)/creatine (Cr), NAA/myoinositol (mI), and mI/Cr measured in the posterior cingulate gyrus reveal evidence of disease progression
G Z Teoh et al.
The British journal of surgery, 102(2), e140-e150 (2015-01-30)
Congenital tracheal defects and prolonged intubation following premature birth have resulted in an unmet clinical need for tracheal replacement. Advances in stem cell technology, tissue engineering and material sciences have inspired the development of a resorbable, nanocomposite tracheal and bronchial
Massimo Filippi et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 851-858 (2013-09-14)
In Assessment of OraL Laquinimod in PrEventing ProGRession in Multiple SclerOsis (ALLEGRO), a phase III study in relapsing-remitting multiple sclerosis (RRMS), oral laquinimod slowed disability and brain atrophy progression, suggesting laquinimod may reduce tissue damage in MS. MRI techniques sensitive
Yun Zhou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(40), 13472-13485 (2014-10-03)
The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despite the lower level of EAAT2 expression in glutamatergic terminals, when hippocampal slices
Hilary A Kenny et al.
Nature communications, 6, 6220-6220 (2015-02-06)
The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in monolayers. Here we show that a multilayered culture containing primary human fibroblasts, mesothelial cells and
A R Hart et al.
Clinical radiology, 69(8), 870-879 (2014-06-18)
To study the associations between magnetic resonance proton spectroscopy (MRS) data and apparent diffusion coefficients (ADC) from the preterm brain with developmental outcome at 18 months corrected age and clinical variables. A prospective observational cohort study of 67 infants born
Sara Sarig
Bone, 35(1), 108-113 (2004-06-23)
This review concentrates on the physical state of bone mineral at the nanosize range, where it exists as ultrathin, tiny, platelike particles. They have a distinct X-ray pattern, different from that of apatite crystals, but shared by all bone matter
Marina Yazigi Solis et al.
The British journal of nutrition, 111(7), 1272-1274 (2013-12-03)
The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (¹H-MRS). Dietary Cr intake
Giselle C Yeo et al.
The Journal of biological chemistry, 289(50), 34815-34826 (2014-10-25)
Tropoelastin is an extracellular matrix protein that assembles into elastic fibers that provide elasticity and strength to vertebrate tissues. Although the contributions of specific tropoelastin regions during each stage of elastogenesis are still not fully understood, studies predominantly recognize the
Sunanda Margrett Williams et al.
The Journal of biological chemistry, 289(16), 11042-11058 (2014-02-28)
Dps (DNA-binding protein from starved cells) are dodecameric assemblies belonging to the ferritin family that can bind DNA, carry out ferroxidation, and store iron in their shells. The ferritin-like trimeric pore harbors the channel for the entry and exit of
Daniel Foshag et al.
Biochimica et biophysica acta, 1844(9), 1619-1630 (2014-06-25)
Escherichia coli C-glycosyltransferase IroB catalyzes the formation of a CC bond between enterobactin and the glucose moiety of UDP-glucose, resulting in the production of mono-, di- and tri-glucosylated enterobactin (MGE, DGE, TGE). To identify catalytic residues, we generated a homology
M J Collins et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 354(1379), 51-64 (1999-03-26)
The increase in proportion of the non-biological (D-) isomer of aspartic acid (Asp) relative to the L-isomer has been widely used in archaeology and geochemistry as a tool for dating. the method has proved controversial, particularly when used for bones.
Xiuliang Rong et al.
Molecular pharmacology, 86(6), 657-664 (2014-10-01)
Excitatory amino acid transporter 1 plays an important role in keeping the synaptic glutamate concentration below neurotoxic levels by translocating this neurotransmitter into the cell. Both reentrant hairpin loops, HP1 and -2, have been shown to take part in binding
Toni E Newsome et al.
Journal of chromatography. A, 1364, 261-270 (2014-09-15)
Nanofibrous silica-based stationary phases for electrospun ultra-thin layer chromatography (E-UTLC) are described. Nanofibers were produced by electrospinning a solution of silica nanoparticles dispersed in polyvinylpyrrolidone solutions to create composite silica/polymer nanofibers. Stationary phases were created from as-spun nanofibers, or the
L D Stegink
Journal of toxicology and environmental health, 2(1), 215-242 (1976-09-01)
The dicarboxylic amino acids, asparate and glutamate, occupy unique positions in intermediary metabolism, particularly in the mitochondria, where they play important roles in nitrogen and energy metabolism. Administration of large quantities of glutamate and asparate to the newborn mouse produces
Katelyn A Walzer et al.
Eukaryotic cell, 13(12), 1507-1518 (2014-10-05)
Toxoplasma gondii and its nearest extant relative, Hammondia hammondi, are phenotypically distinct despite their remarkable similarity in gene content, synteny, and functionality. To begin to identify genetic differences that might drive distinct infection phenotypes of T. gondii and H. hammondi
Yumi Endo et al.
Japanese journal of clinical oncology, 44(7), 619-623 (2014-05-08)
Human epidermal growth factor receptor 2 (HER2) gene amplification is a major therapeutic target in breast cancer, and has been introduced as a predictive biomarker to identify patients who may benefit from therapy with anti-human epidermal growth factor receptor 2
Teymur Kazakov et al.
Journal of bacteriology, 196(19), 3377-3385 (2014-07-09)
Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase. The product of mccE, a gene from the plasmid-borne McC biosynthetic
Mary Ellenbecker et al.
Antimicrobial agents and chemotherapy, 58(12), 7405-7415 (2014-10-01)
Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of
Suwipa Saen-Oon et al.
The Journal of biological chemistry, 289(49), 33815-33825 (2014-10-08)
The phosphobase methylation pathway catalyzed by the phosphoethanolamine methyltransferase in Plasmodium falciparum (PfPMT), the malaria parasite, offers an attractive target for anti-parasitic drug development. PfPMT methylates phosphoethanolamine (pEA) to phosphocholine for use in membrane biogenesis. Quantum mechanics and molecular mechanics
N M Tun et al.
Letters in applied microbiology, 60(1), 20-26 (2014-10-07)
HOM6 is a major gene in the aspartate pathway which leads to biosynthesis of threonine and methionine. The phenotypes of the gene deletion mutant (hom6∆) in a variety of cultural conditions have previously provided meaningful insights into the biological roles of
Jie Zhang et al.
The Biochemical journal, 461(3), 497-508 (2014-05-13)
Lantibiotics are ribosomally synthesized antimicrobial peptides containing unusual amino acids. As promising alternatives to conventional antibiotics, they have a high potential for alleviating the problem of emergent antibiotic resistance, with possible applications in many industries that have antibacterial demand. Bovicin
Ying Zhou et al.
The Analyst, 139(12), 3122-3126 (2014-05-03)
A new type of rapid, sensitive, and selective fluorescence turn-on assay was developed for detection of histidine using a DNA-scaffolded silver nanocluster/Cu(2+) ensemble (DNA-AgNC/Cu(2+)). Cu(2+) was first bound to nucleic acids of the DNA-AgNCs forming a DNA-AgNC/Cu(2+) ensemble and then
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