Zbigniew Darzynkiewicz et al.
Methods (San Diego, Calif.), 44(3), 250-254 (2008-03-04)
Activation of endonucleases that cleave chromosomal DNA preferentially at internucleosomal sections is a hallmark of apoptosis. DNA fragmentation revealed by the presence of a multitude of DNA strand breaks, therefore, is considered to be the gold standard for identification apoptotic