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Valerie P J Saw et al.
The American journal of pathology, 175(6), 2406-2415 (2009-11-17)
Interleukin-13 (IL-13) is the dominant effector cytokine of fibrosis in pulmonary and liver disease. Excessive conjunctival fibrosis in the immunobullous disease ocular mucous membrane pemphigoid (MMP) causes blindness; the pathogenesis of scarring in this disease is incompletely understood. To determine
Philip J Johnson et al.
Journal of biomedical materials research. Part A, 92(1), 152-163 (2009-01-24)
The purpose of this study was to evaluate the effects of fibrin scaffolds on subacute rat spinal cord injury (SCI). Long-Evans rats were anesthetized and underwent a dorsal hemisection injury; two weeks later, the injury site was re-exposed, scar tissue
J Allen Crow et al.
Biochimica et biophysica acta, 1801(1), 31-41 (2009-09-19)
Two major isoforms of human carboxylesterases (CEs) are found in metabolically active tissues, CES1 and CES2. These hydrolytic enzymes are involved in xenobiotic and endobiotic metabolism. CES1 is abundantly expressed in human liver and monocytes/macrophages, including the THP1 cell line;
Naomi J Logsdon et al.
PloS one, 6(11), e28127-e28127 (2011-12-02)
Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiviral immune responses, and contributes to lifelong persistence within infected hosts.
Gayathri Kanika et al.
Journal of biochemical and molecular toxicology, 29(8), 349-359 (2015-03-17)
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine
Lili Chen et al.
Frontiers in cellular and infection microbiology, 10, 530190-530190 (2020-10-13)
Streptococcus oralis (S. oralis) has been recognized as a fatal pathogen to cause multiorgan failure by contributing to the formation of microthrombus. Coagulation and fibrinolysis systems have been found under the control of circadian clock genes. This study aimed to
Xin Jin et al.
Autophagy, 18(3), 643-660 (2021-07-08)
There is increasing evidence that mitophagy, a specialized form of autophagy to degrade and clear long-lived or damaged mitochondria, is impaired in aging and age-related disease. Previous study has demonstrated the obesity-exposed oocytes accumulate and transmit damaged mitochondria due to
Shuang Wang et al.
Human vaccines & immunotherapeutics, 10(2), 461-468 (2013-11-21)
Nizatidine (NIZ), closely related to Cimetidine, is a histamine H2 receptor inverse agonist used primarily as an anti-acid drug. Recent studies showed that this class of compounds may also modulate immune responses. To evaluate adjuvant effects of NIZ on vaccine
Shanhe Wang et al.
Frontiers in cell and developmental biology, 9, 800157-800157 (2022-01-08)
Wool is the critical textile raw material which is produced by the hair follicle of sheep. Therefore, it has important implications to investigate the molecular mechanism governing hair follicle development. Due to high cellular heterogeneity as well as the insufficient
Multi-spectroscopic characterization of bovine serum albumin upon interaction with atomoxetine
Buddanavar AT and Nandibewoor ST
Journal of Pharmaceutical Analysis, 7(3), 148-155 (2017)
Bo Kyoung Kim et al.
Methods in molecular biology (Clifton, N.J.), 2475, 259-274 (2022-04-23)
Difficulties with poor reproducibility and translatability of animal model-based research, along with increased efforts to abide by the 3Rs tenet of animal welfare, are driving demand for more relevant human cellular systems. This is especially true for central nervous system
Liuba Taccola et al.
International journal of nanomedicine, 6, 1129-1140 (2011-06-24)
It has recently been demonstrated that zinc oxide nanoparticles (ZnO NPs) induce death of cancerous cells whilst having no cytotoxic effect on normal cells. However, there are several issues which need to be resolved before translation of zinc oxide nanoparticles
Luis E F Almeida et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(40), 12702-12710 (2009-10-09)
cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB). However, in mouse cortical neuron cultures, prior to synaptogenesis, neither cAMP nor dopamine, which acts via cAMP, stimulated CREB-dependent gene
M Lango-Chavarría et al.
International journal of oncology, 50(2), 432-440 (2017-01-20)
Breast cancer ranks first in incidence and mortality in working age women. Cancer initiation and progression relies on accumulation of genetic and epigenetic aberrations that alter cellular processes, among them, epithelial to mesenchymal transition (EMT) denotes particularly aggressive neoplasias given
Sulhee Kim et al.
STAR protocols, 2(3), 100642-100642 (2021-07-15)
Leucyl-tRNA synthetase 1 (LARS1) synthesizes Leu-tRNALeu for protein synthesis and plays an important role in mTORC1 activation by sensing intracellular leucine concentrations. Here, we describe a protocol for the purification, reductive methylation, binding affinity measurement by microscale thermophoresis, T i
Livia Lai et al.
PLoS pathogens, 7(10), e1002296-e1002296 (2011-10-25)
Eimeria spp. are a highly successful group of intracellular protozoan parasites that develop within intestinal epithelial cells of poultry, causing coccidiosis. As a result of resistance against anticoccidial drugs and the expense of manufacturing live vaccines, it is necessary to
Joanna Kubler-Kielb et al.
Vaccine, 26(29-30), 3587-3593 (2008-06-10)
Bordetellae are Gram-negative bacilli causing respiratory tract infections of mammals and birds. Clinically important are B. pertussis, B. parapertussis and B. bronchiseptica. B. pertussis vaccines have been successful in preventing pertussis in infants and children. Veterinary vaccines against B. bronchiseptica
Yuelin Zhang et al.
Cell reports, 30(8), 2791-2806 (2020-02-27)
Intervertebral disc degeneration might be amenable to stem cell therapy, but the required cells are scarce. Here, we report the development of a protocol for directed in vitro differentiation of human pluripotent stem cells (hPSCs) into notochord-like and nucleus pulposus (NP)-like
Chad Slawson et al.
Molecular biology of the cell, 19(10), 4130-4140 (2008-07-26)
O-linked beta-N-acetylglucosamine (O-GlcNAc) is a highly dynamic intracellular protein modification responsive to stress, hormones, nutrients, and cell cycle stage. Alterations in O-GlcNAc addition or removal (cycling) impair cell cycle progression and cytokinesis, but the mechanisms are not well understood. Here
Edwin A Pena et al.
Environmental toxicology and chemistry, 34(9), 1946-1958 (2015-04-14)
Raw menhaden fish oil was developed for biomonitoring polycyclic aromatic hydrocarbons (PAHs) using fluorescence spectroscopy. Menhaden (Genus Brevoortia) were collected in 2010 and/or 2011 from Delaware Bay, New Jersey, USA; James River, Virginia, USA; Vermillion Bay, Louisiana, USA (VBLA); and
Wenwen Si et al.
Frontiers in cellular neuroscience, 14, 559384-559384 (2020-09-29)
As a sensitive cold-shock protein, RNA binding protein motif 3 (RBM3) exhibits a neuroprotective function in the condition of brain injury. However, how RBM3 is involved in acute ischemic stroke by affecting stress granules (SGs) remains unclear. Here, we established
Meng-Meng Wang et al.
Talanta, 171, 173-178 (2017-05-30)
By virtue of the flexible structure of polyoxometalates, Ni
Shuaifeng Li et al.
Nature communications, 13(1), 3486-3486 (2022-06-18)
Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 (FUNDC2) is transcriptionally upregulated in primary
Limin Shang et al.
STAR protocols, 3(2), 101406-101406 (2022-05-26)
Elucidating the molecular interactions between virus and host is fundamental to understanding the mechanism of viral pathogenesis. Here, we present a protocol to screen SARS-CoV-2 protein interactors using an antibody-based TurboID proximity labeling approach. This technique directly identifies biotinylated peptides
Carl Pc Chen et al.
Proteome science, 9, 65-65 (2011-10-13)
Proteome analysis is frequently applied in identifying the proteins or biomarkers in knee synovial fluids (SF) that are associated with osteoarthritis and other arthritic disorders. The 2-dimensional gel electrophoresis (2-DE) is the technique of choice in these studies. Disease biomarkers
The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.
Ruben M Markosyan et al.
PLoS pathogens, 17(9), e1009488-e1009488 (2021-09-08)
Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). The mechanisms of GPC-mediated membrane fusion and of virus targeting to late endosomes are not well understood.
Ana Carolina Vieira et al.
PloS one, 6(2), e17411-e17411 (2011-03-03)
Endogenous electric fields and currents occur naturally at wounds and are a strong signal guiding cell migration into the wound to promote healing. Many cells involved in wound healing respond to small physiological electric fields in vitro. It has long
M Geldof et al.
British journal of pharmacology, 154(6), 1369-1378 (2008-05-22)
The pharmacokinetic-pharmacodynamic (PK-PD) correlation of fluvoxamine 5-HT transporter (SERT) occupancy was determined in rat frontal cortex ex vivo. Rats (n=47) with permanent arterial and venous cannulas received a 30 min intravenous infusion of fluvoxamine (1 or 7.3 mg kg(-1)). At
Daniel Gotthardt et al.
World journal of gastroenterology, 15(46), 5821-5826 (2009-12-10)
To investigate whether the secretion of phosphatidylcholine (PC) in intestinal mucus occurs by apical secretion or via basolateral excretion and to determine its subsequent passage across the tight junctions to the apical mucus. We addressed this question using the polarized
Konstantinos Ioannidis et al.
PloS one, 13(9), e0198649-e0198649 (2018-09-11)
Root canal irrigation with sodium hypochlorite (NaOCl) is an indispensable part of the chemomechanical preparation of infected root canals in Endodontology. However, there is limited information on the emergence of toxic or hazardous volatile compounds (VOCs) from the interaction of
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