A2408

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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family.

Xiaohu Guo et al.

eLife, 10 (2021-02-11)

The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5'-methyl-thioadenosine (MTA) and L-homoserine. From environmental phages, we recently discovered three SAMases

Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation

Shan Z, et al.

The Journal of biological chemistry, 288(49), 35093-35103 (2013)

S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.

Tao Guo et al.

Cell death & disease, 12(4), 306-306 (2021-03-24)

Nonalcoholic fatty liver disease (NAFLD) has emerged globally and is associated with inflammatory signaling. The underlying mechanisms remain poorly delineated, although NAFLD has attracted considerable attention and been extensively investigated. Recent publications have determined that angiotensin II (Ang II) plays

Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.

Christopher D Dawson et al.

Cell chemical biology, 28(9), 1333-1346 (2021-03-28)

Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we present a 2.7 Å resolution X-ray structure of wild-type IslA from

Accurate and sensitive detection of Catechol-O-methyltransferase activity by liquid chromatography with fluorescence detection.

Yang-Liu Xia et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1157, 122333-122333 (2020-09-01)

Catechol-O-methyltransferase (COMT) is a major drug metabolizing enzyme in humans. COMT expression is directedly associated with various mental diseases and cancers due to its essential role in catalyzing metabolic inactivation of endogenous catecholamines and catechol estrogens. However, a practical method

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Jimmy Alarcan et al.

Toxicology letters, 307, 17-25 (2019-03-03)

13-Desmethylspirolide C (13-SPX-C) is a phycotoxin produced by dinoflagellates which can accumulate in shellfish. 13-SPX-C induces neurotoxic effects in rodents through blockade of nicotinic acetylcholine receptors. As no human intoxication has been to date attributed to the consumption of 13-SPX-C-contaminated

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation.

Soumi Ghosh et al.

Biochemistry, 59(6), 780-789 (2020-01-25)

The radical SAM enzyme, viperin, exerts a wide range of antiviral effects through both the synthesis of the antiviral nucleotide 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) and through its interactions with various cellular and viral proteins. Here we investigate the interaction of viperin with

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

Guillermo A Senisterra et al.

Journal of biomolecular screening, 15(3), 314-320 (2010-02-13)

Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. Methods such as differential scanning fluorimetry (DSF) and differential static light scattering (DSLS) have been employed in the 384-well format and have been useful in

Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.

You Feng et al.

The Journal of biological chemistry, 288(52), 37010-37025 (2013-11-20)

The mammalian protein arginine methyltransferase 7 (PRMT7) has been implicated in roles of transcriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and metastasis. However, the type of reaction that it catalyzes and its substrate specificity remain controversial. In this

A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.

Mahmoud Hajj Chehade et al.

Cell chemical biology, 26(4), 482-492 (2019-01-29)

Ubiquinone (UQ) is a polyprenylated lipid that is conserved from bacteria to humans and is crucial to cellular respiration. How the cell orchestrates the efficient synthesis of UQ, which involves the modification of extremely hydrophobic substrates by multiple sequential enzymes

Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro differentiation of a putative hepatocyte progenitor.

Jesús Rafael Rodríguez-Aguilera et al.

Scientific reports, 10(1), 7822-7822 (2020-05-10)

A basic question linked to differential patterns of gene expression is how cells reach different fates despite using the same DNA template. Since 5-hydroxymethylcytosine (5hmC) emerged as an intermediate metabolite in active DNA demethylation, there have been increasing efforts to

Discovery and characterization of new O-methyltransferase from the genome of the lignin-degrading fungus Phanerochaete chrysosporium for enhanced lignin degradation.

Le Thanh Mai Pham et al.

Enzyme and microbial technology, 82, 66-73 (2015-12-18)

Using bioinformatic homology search tools, this study utilized sequence phylogeny, gene organization and conserved motifs to identify members of the family of O-methyltransferases from lignin-degrading fungus Phanerochaete chrysosporium. The heterologous expression and characterization of O-methyltransferases from P. chrysosporium were studied.

The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme.

Allison B Norvil et al.

Nucleic acids research, 48(7), 3761-3775 (2020-03-04)

We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the

Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.

Ling Li et al.

Molecular cell, 80(3), 525-540 (2020-10-18)

Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of

Fetal Programming by Methyl Donors Modulates Central Inflammation and Prevents Food Addiction-Like Behavior in Rats.

Gabriela Cruz-Carrillo et al.

Frontiers in neuroscience, 14, 452-452 (2020-06-26)

Fetal programming by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not been characterized. We employed a nutritional programming

Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.

Susanne M Henning et al.

Food & function, 11(5), 4114-4122 (2020-04-30)

We evaluated if chronic consumption of quercetin (Q) with green tea extract (GTE) enhances the bioavailability of GT polyphenols (GTPs) and reduces methylation activity as previously observed in mouse xenograft tumors. In this prospective, randomized, parallel design, placebo controlled study

Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial

Thompson MA, et al.

Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(5), 523-529 (2009)

Lupus autoimmunity altered by cellular methylation metabolism

Yang ML, et al.

Autoimmunity, 46(1), 21-31 (2013)

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