A3759

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关键词:'A3759'

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Involvement of sex hormones, oxidative stress, ACE and ACE2 activity in the impairment of renal function and remodelling in SHR.

Antonio F Melo Junior et al.

Life sciences, 257, 118138-118138 (2020-07-28)

Hypertension is a relevant sex and sex hormones-dependent risk factor where the cardiovascular and renal health of the population are concerned. Men experience greater losses of renal function (RF) than women, but the mechanisms remain somewhat unclear. Our goal was

Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.

Martin Alexander Schick et al.

PloS one, 10(9), e0137247-e0137247 (2015-09-05)

Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). In sepsis HES should be avoided due to a higher risk for acute kidney injury

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.

Andrew A Udy et al.

Critical care (London, England), 18(6), 657-657 (2014-11-30)

The aim of this study was to explore changes in glomerular filtration (GFR) and renal tubular function in critically ill patients at risk of augmented renal clearance (ARC), using exogenous marker compounds. This prospective, observational pharmacokinetic (PK) study was performed

Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy.

Chiao-Shih Tseng et al.

Advances in pharmacological sciences, 2011, 204501-204501 (2011-07-09)

The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).

Chi Chun Wong et al.

Biochemical pharmacology, 81(7), 942-949 (2011-01-20)

Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

Nadiya Bakhiya et al.

Toxicology, 264(1-2), 74-79 (2009-08-01)

Aristolochic acid (AA), present in Aristolochia species, is the major causative agent in the development of severe renal failure and urothelial cancers in patients with AA nephropathy. It may also be a cause of Balkan endemic nephropathy. Epithelial cells of

Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).

M M Al-Bataineh et al.

Journal of veterinary pharmacology and therapeutics, 35(3), 209-215 (2011-06-01)

Mammary epithelial cells express a diversity of membrane transporters including members of organic cation and organic anion (OAT) transporter subfamilies. Four mammal OAT isoforms have been identified: OAT-1, OAT-2, OAT-3, and OAT-4. The pharmacological significance of OAT isoforms has been

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