CN
Search Within
A47052
应用筛选条件
关键词:'A47052'
显示 1-26 共 26 条结果 关于 "A47052" 范围 论文
K B Delclos et al.
Cancer research, 47(23), 6272-6277 (1987-12-01)
6-Nitrochrysene (NC) and 6-aminochrysene (AC) have been shown to be potent lung and liver carcinogens when administered in multiple i.p. doses to preweanling mice. 1,6-Dinitropyrene has been shown to be a strong hepatocarcinogen but a weak lung carcinogen in this
Y L Cheung et al.
Toxicology, 81(1), 69-86 (1993-07-11)
The genotoxicity in the Ames test of chrysene, of its six methyl and of two benzo-derivatives, and their ability to induce rat hepatic CYP1A and epoxide hydrolase activities, and stimulate their own bioactivation were determined. The primary objective is to
S M Morris et al.
Mutation research, 310(1), 45-54 (1994-10-01)
Cells from the human lymphoblastoid cell line, AHH-1, were exposed to two direct-acting mutagens, ethyl methanesulfonate (EMS) and ethyl nitrosourea (ENU), and to three carcinogens that require metabolic activation to an electrophile, benzo[a]pyrene (B(a)P), 6-aminochrysene (6-AC), and 6-nitrochrysene (6-NC); mutation
S Lahmy et al.
Toxicology, 29(4), 345-356 (1984-02-01)
By microspectrofluorimetry on single living cells (murine fibroblasts 3T3), we have obtained monoexponential decreases of fluorescence intensity for benzo[a]pyrene (B[a]P) and 6-aminochrysene (6a-chrysene) metabolism. These kinetics are characteristics of B[a]P and 6a-chrysene metabolism and histograms can be drawn from the
F K Friedman et al.
Pharmacology, 31(4), 194-202 (1985-01-01)
The microsomal cytochrome P-450-dependent aryl hydrocarbon hydroxylase is important in the detoxification of polycyclic hydrocarbons as well as their activation to cytotoxic or carcinogenic derivatives. We have studied compounds that can modify the activity of this enzyme system. Three types
Yi Zhang et al.
Environmental toxicology and chemistry, 25(7), 1920-1925 (2006-07-13)
Chrysene is one of the basic polycyclic aromatic hydrocarbons that are toxic environmental pollutants. The photoproducts of 6-aminochrysene (6AC) include 5,6-chrysenequinone (5,6-CQ) along with some minor products. In this study, cytotoxicity and genotoxicity of 6AC and 5,6-CQ to a human
K B Delclos et al.
Mutation research, 279(3), 153-164 (1992-06-01)
6-Nitrochrysene, 6-aminochrysene and several of their metabolites were assayed for mutagenic activity at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in DNA-repair-proficient Chinese hamster ovary (CHO-K1) cells and excision-repair-deficient CHO-UV5 cells. Mutagen-DNA adducts were analyzed by 32P-postlabeling in cells treated under
C H Yun et al.
Molecular pharmacology, 40(5), 679-685 (1991-11-01)
Cytochrome P-450 (P-450) 2A6 was purified by chromatography of human liver microsomes. The final preparation was electrophoretically homogeneous and contained 16 nmol of P-450/mg of protein. The amino-terminal amino acid sequence of the protein (first 13 residues) matched that of
S Lahmy et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(2), 197-201 (1987-02-01)
The purpose of this study was to determine if dibenzo(c,h)acridine could be used as a probe for the N-heterocyclic aromatic compound detoxification system. The determination was achieved by cell population studies (histograms) using microspectrofluorimetry on single living cells. The results
T Marczylo et al.
Mutagenesis, 9(3), 233-239 (1994-05-01)
6-Aminochrysene was converted into mutagen(s), in the Ames test in the presence of Aroclor 1254-induced hepatic S9, microsomal and cytosolic fractions, the first being the least and the last the most efficient activation system. The cytosolic activation of 6-aminochrysene decreased
R A Lubet et al.
Mutation research, 212(2), 275-284 (1989-06-01)
6-Aminochrysene and 2-aminoanthracene were activated to metabolites which were mutagenic to Salmonella typhimurium TA98 by hepatocytes or hepatic 9000 X g supernatants (S9s) from control or xenobiotic-treated rats. Hepatocytes from Aroclor-1254-treated rats were more efficient than hepatocytes from untreated rats
Carcinogenicity of 6-aminochrysene in mice.
G Lambelin et al.
European journal of cancer, 11(5), 327-334 (1975-05-01)
H Yamazaki et al.
Carcinogenesis, 14(7), 1271-1278 (1993-07-01)
We reported previously that the potent mutagen 6-aminochrysene is catalyzed principally by rat liver microsomal P4501A and P4502B enzymes to reactive metabolites that induce umu gene expression in O-acetyltransferase-over-expressing strain Salmonella typhimurium NM2009; the proposal was made that there are
D Lautier et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 36(6), 685-691 (1988-06-01)
Previous reports on the inhibitory effect of 6-amino-chrysene (6AC) on benzo(a)pyrene (BP) metabolism using single living cells have suggested that aryl hydrocarbon hydroxylase (AHH) is not the only pathway for 6AC metabolism. We present here results demonstrating that direct glucuronidation
Victoria Yoxall et al.
Mutagenesis, 20(1), 23-28 (2004-12-16)
Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day (short-term) or 1 month (long-term), while controls received water. After exposure, all animals received a single oral dose of 6-aminochrysene and urine was
B G Lake et al.
Toxicology and applied pharmacology, 138(2), 231-241 (1996-06-01)
Precision-cut liver slices were prepared from male Sprague-Dawley rats (pretreated with or without Aroclor 1254), male Dunkin-Hartley guinea pigs, male cynomolgus monkeys, and humans. Liver slices were cultured for 24 hr using a dynamic organ culture system in medium containing
J M Salmon et al.
Cytometry, 9(1), 25-32 (1988-01-01)
The identification and quantification of fluorescent compounds in a complex fluorescence spectra are always difficult, especially in the case of low signal:noise ratio. We propose a computerised method that allows the resolution of low light level complex fluorescence spectra into
Determination of polycyclic aromatic amines in skin by liquid chromatography with electrochemical detection.
L J Felice et al.
Journal of chromatography, 354, 442-448 (1986-02-28)
Y Oda et al.
Carcinogenesis, 20(6), 1079-1083 (1999-06-05)
Human NAT1 and NAT2 genes were subcloned into pACYC184 vector and the plasmids thus obtained were introduced into Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1, 8-DNP/pSK1002), establishing new strains NM6001 and NM6002, respectively. We compared the sensitivities of these two strains
H Yamazaki et al.
Carcinogenesis, 15(3), 465-470 (1994-03-01)
In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat and
F S Catterall et al.
Mutation research, 492(1-2), 7-11 (2001-05-30)
The relative mutagenic potentials of 11-amino-16,17-dihydro-15H-cyclopenta[a]phenanthrene, its 17-keto derivative, and 2- and 5-aminochrysene have been compared in Salmonella typhimurium TA98 and TA100 in the presence of a postmitochondrial liver preparation from Aroclor 1254 induced rats. The 11-amino hydrocarbon is a
Kui Zeng et al.
Journal of photochemistry and photobiology. B, Biology, 72(1-3), 95-100 (2003-12-04)
The effect of the photosensitizer riboflavin (0, 10, 25, 50, 100 microM) and a river humic acid (0, 20, 40, 80 ppm) on the photolysis of 6-aminochrysene (6AC) in 10 mM PBS solution (pH 7.0) was studied. The presence of
M Mimura et al.
Drug metabolism and disposition: the biological fate of chemicals, 21(6), 1048-1056 (1993-11-01)
A cytochrome P-450 (P-450) enzyme of the CYP2B subfamily was partially purified from human liver microsomes and characterized with respect to immunochemical properties, N-terminal amino acid sequence, and catalytic activities toward typical P-450 substrates. P-450 enzymes were monitored in chromatographic
H Yamazaki et al.
Biochemical pharmacology, 44(5), 913-920 (1992-09-01)
Metabolic activation of a potent mutagen, 6-aminochrysene, to genotoxic products in a newly developed tester strain, Salmonella typhimurium NM2009, was studied in a rat liver microsomal monooxygenase system containing cytochrome P450 (P450). Since the tester strain was constructed by introducing
K B Delclos et al.
IARC scientific publications, (124)(124), 79-86 (1993-01-01)
Carcinogenic arylamines and nitroaromatic hydrocarbons are chemicals that present occupational health hazards and share pathways of metabolic activation. The 32P-postlabelled DNA adducts formed in Chinese hamster ovary (CHO) cells treated with metabolites from two pathways that are common to the
K B Delclos et al.
Carcinogenesis, 8(11), 1703-1709 (1987-11-01)
Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of their metabolic activation pathways and the nature of the carcinogen-DNA adducts that may be formed. N-Hydroxy-6-aminochrysene (N-hydroxy-AC), a candidate proximate or ultimate carcinogen and
1/1