A55004

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Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.

Anthony Bertucci et al.

Bioorganic & medicinal chemistry, 18(6), 2300-2303 (2010-02-24)

The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K(A) in

Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 17(15), 4107-4112 (2007-06-02)

An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by L-/D-His, dopamine and serotonin (K(A)s of

Dual site-controlled and lysosome-targeted intramolecular charge transfer?photoinduced electron transfer?fluorescence resonance energy transfer fluorescent probe for monitoring pH changes in living cells.

Dong B, et al.

Analytical Chemistry, 88(7), 4085-4091 (2016)

Design, synthesis, and structure? activity relationships of benzophenone-based tetraamides as novel antibacterial agents.

Vooturi S K, et al.

Journal of Medicinal Chemistry, 52(16), 5020-5031 (2009)

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione.

Małgorzata Góra et al.

International journal of molecular sciences, 21(16) (2020-08-17)

The present study aimed to design and synthesize a new series of hybrid compounds with pyrrolidine-2,5-dione and thiophene rings in the structure as potential anticonvulsant and antinociceptive agents. For this purpose, we obtained a series of new compounds and evaluated

Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin.

Danford Mhule et al.

International journal of pharmaceutics, 550(1-2), 149-159 (2018-08-21)

Stimuli-responsive nano-drug delivery systems can optimize antibiotic delivery to infection sites. Identifying novel lipids for pH responsive delivery to acidic conditions of infection sites will enhance the performance of nano-drug delivery systems. The aim of the present investigation was to

Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.

Semra Isik et al.

Bioorganic & medicinal chemistry letters, 19(6), 1662-1665 (2009-02-24)

The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, was investigated for its activation with amines and amino acids. scCA was poorly activated by amino acids such as l-/d-His, Phe

Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.

Alessio Innocenti et al.

Bioorganic & medicinal chemistry letters, 18(23), 6194-6198 (2008-10-22)

Activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases (CAs, EC 4.2.1.1) with a series of natural and non-natural amino acids and aromatic/heterocyclic amines has been investigated. Cab, Zn-Cam and Co-Cam showed an activation profile with natural, L-

Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.

Alessio Innocenti et al.

Bioorganic & medicinal chemistry, 18(3), 1034-1037 (2010-01-12)

The proteins encoded by the Nce103 genes of Candida albicans and Cryptococcus neoformans are catalytically active beta-carbonic anhydrases (CAs, EC 4.2.1.1) playing various roles in the life cycle of these fungal pathogens, such as CO(2) sensing, regulation of capsule biosynthesis

Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.

Alessio Innocenti et al.

Bioorganic & medicinal chemistry letters, 20(5), 1701-1704 (2010-02-05)

The protein encoded by the NCE103 gene of Candida glabrata, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as CgCA, was investigated for its activation with amines and amino acids. CgCA was weakly activated by amino acids such as l-/d-His, l-Phe

Design, Synthesis and Antiproliferative Activities of Oxidative Stress Inducers Based on 2-Styryl-3,5-dihydro-4H-imidazol-4-one Scaffold.

Abdelsattar M Omar et al.

Chemical & pharmaceutical bulletin, 66(10), 967-975 (2018-07-27)

The 2-styryl-3,5-dihydro-4H-imidazol-4-one might be considered as a system with isosteric properties similar to trans-cinnamaldehyde (styrylaldehyde), a safe natural compound that exhibited interesting activities against various cancers. We synthesized a series of compounds that differ structurally in having different alkyl, aryl

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Silvia Pastorekova et al.

Bioorganic & medicinal chemistry, 16(7), 3530-3536 (2008-02-26)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aromatic/heterocyclic amines is reported. hCA IX was

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 18(15), 4303-4307 (2008-07-17)

An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA III (cytosolic) and IV (membrane-associated) with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. hCA III was efficiently activated by d-His, serotonin

4-Amino-1,8-naphthalimide-based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds.

Emma B Veale et al.

Organic letters, 11(18), 4040-4043 (2009-08-18)

The synthesis and photophysical and biological investigation of fluorescent 1,8-naphthalimide conjugated Troger's bases 1-3 are described. These structures bind strongly to DNA in competitive media at pH 7.4, with concomitant modulation in their fluorescence emission. These structures also undergo rapid

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Isao Nishimori et al.

Bioorganic & medicinal chemistry, 15(15), 5351-5357 (2007-05-15)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration reaction proved hCA VI to possess a k(cat) of 3.4

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells.

Liu T, et al.

Organic Letters, 15(9), 2310-2313 (2013)

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.

Alessio Innocenti et al.

Bioorganic & medicinal chemistry letters, 19(13), 3430-3433 (2009-05-26)

An activation study of the membrane-associated carbonic anhydrase (CA, EC 4.2.1.1) isoform XV with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. Murine CA XV was strongly activated by some amino acids (d-Phe, l-/d-DOPA, d-Trp

Self-calibrated fluorescent probe resembled as an indicator of the lysosomal phosphatase pertaining to the cancer cells.

Arup Podder et al.

Journal of photochemistry and photobiology. B, Biology, 177, 105-111 (2017-11-08)

A self-calibrated fluorescent probe Lyso-Phos has synthesized followed by a straightforward synthetic pathway. Lyso-Phos acts as an indicator for lysosomal phosphatase. Its photophysical property including cellular imaging was described. Lyso-Phos showed ratiometric UV-Vis- absorption changes from λ

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Seppo Parkkila et al.

Bioorganic & medicinal chemistry letters, 16(15), 3955-3959 (2006-05-30)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and

Synthesis of some new 1, 2, 4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities.

Bayrak H, et al.

European Journal of Medicinal Chemistry, 44(3), 1057-1066 (2009)

Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 17(5), 1336-1340 (2006-12-19)

The mitochondrial isozymes of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VA and hCA VB, were investigated for activation with a series of amino acids and amines. D-His, L-DOPA, histamine, dopamine, and 4-(2-aminoethyl)morpholine were excellent hCA VA activators, with KAs

A multi-responsive pyranone based Schiff base for the selective, sensitive and competent recognition of copper metal ions.

Apurva Goel et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 249, 119221-119221 (2020-12-02)

Exploring a new multi-responsive pyranone chemosensor capable of sensing copper ions specifically and selectively through colorimetric, UV-Vis absorption and fluorescence methods is of great importance. In this piece of work, a novel pyranone based Schiff base ligand 4-Hydroxy-6-methyl-3-[1-(2-morpholin-4-yl-ethylimino)-ethyl]-pyran-2-one (DM) was

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