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Hossein Mirmiranpour et al.
Indian journal of pathology & microbiology, 55(2), 211-214 (2012-07-10)
Angiogenesis contributes to different physiological and pathological conditions. The aim of this study was to investigate for the first time the antiangiogenic effects of amygdalin on the cultured endothelial cells of diabetic rats. A total of 20 streptozotocin-induced diabetic rats
Juan J Perez
Future medicinal chemistry, 5(7), 799-808 (2013-05-09)
Psoriasis is one of the most prevalent immune-mediated illness worldwide. The disease can still only be managed rather than cured, so treatments are aimed at clearing skin lesions and preventing their recurrence. Several treatments are available depending on the extent
Islamiyat Folashade Bolarinwa
Journal of food protection, 78(7), 1408-1413 (2015-07-22)
Consumption of cyanogenic plants can cause serious health problems for humans. The ability to detect and quantify cyanogenic glycosides, capable of generating cyanide, could contribute to prevention of cyanide poisoning from the consumption of improperly processed cyanogenic plants. Hapten-protein conjugates
Li Liu et al.
Journal of ethnopharmacology, 139(2), 381-387 (2011-11-30)
Persicae Semen (Taoren) and Carthami Flos (Honghua) used in pair which is named as Taoren-Honghua (TH) herb pair has been used in traditional Chinese medicine (TCM) for promoting blood circulation to dissipate blood stasis for many years in China. This
Amygdalin (Laetrile) and veterinary medicine.
D W Macy
Journal of the American Veterinary Medical Association, 171(3), 284-286 (1977-08-01)
Soo-Jin Jeong et al.
Biological & pharmaceutical bulletin, 38(3), 425-434 (2015-03-12)
Gyejibokryeong-hwan (GJBRH; Keishi-bukuryo-gan in Japan and Guizhi Fuling Wan in China) is a traditional herbal formula comprising five medicinal herbs and is used to treat climacteric syndrome. GJBRH has been shown to exhibit biological activity against diabetes, diabetic nephropathy, atherosclerosis
Hai-Ke Du et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 28(4), 260-263 (2010-05-15)
To evaluate effect of amygdalin on expression of four biomarkers in the animal model of pulmonary fibrosis induced by bleomycin. Rats were given one dose (5 mg/kg) of bleomycin in bleomycin-treated groups, amygdalin-treated groups and saline in controls by intratracheal
The beta-glucosidases responsible for bioactivation of hydroxynitrile glucosides in Lotus japonicus.
Anne Vinther Morant et al.
Plant physiology, 147(3), 1072-1091 (2008-05-10)
Lotus japonicus accumulates the hydroxynitrile glucosides lotaustralin, linamarin, and rhodiocyanosides A and D. Upon tissue disruption, the hydroxynitrile glucosides are bioactivated by hydrolysis by specific beta-glucosidases. A mixture of two hydroxynitrile glucoside-cleaving beta-glucosidases was isolated from L. japonicus leaves and
Ha-Jeong Kwon et al.
Archives of pharmacal research, 33(1), 81-86 (2010-03-02)
Armeniacae Semen contains not only amygdalin but also emulsin, which is an enzyme that hydrolyzes amygdalin. This hydrolysis reaction has been a major problem associated with the water extraction of Armeniacae Semen powder. In this study, the emulsin was inactivated
Raquel Sánchez-Pérez et al.
Plant physiology, 158(4), 1916-1932 (2012-02-23)
Amygdalin is a cyanogenic diglucoside and constitutes the bitter component in bitter almond (Prunus dulcis). Amygdalin concentration increases in the course of fruit formation. The monoglucoside prunasin is the precursor of amygdalin. Prunasin may be degraded to hydrogen cyanide, glucose
Cui-Ping Zhang et al.
Journal of food science, 76(1), C75-C79 (2011-05-04)
Extraction and assay conditions for β-glucosidase from propolis were optimized. Highest enzyme activity was obtained in a citric acid-disodium hydrogen phosphate buffer at pH 6.0 with 2.5% insoluble polyvinylpyrrolidone at incubation temperature of 57 °C. β-Glucosidase activities were found in
Minfeng Fang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(20), 2684-2688 (2011-01-21)
To study the influence of processing on metabolism of the main component of bitter almond-amygdalin in rat. The blood was collected at different times after amygdalin given by injection and oral, bitter almond and its processed production given by oral
Yu Chen et al.
Immunopharmacology and immunotoxicology, 35(1), 43-51 (2012-11-10)
Amygdalin, a naturally occurring substance, has been suggested to be efficacious as an anticancer substance. The effect of amygdalin on cervical cancer cells has never been studied. In this study, we found that the viability of human cervical cancer HeLa
Ivan M Savic et al.
Frontiers in plant science, 6, 276-276 (2015-05-15)
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both
George John et al.
Langmuir : the ACS journal of surfaces and colloids, 26(23), 17843-17851 (2010-05-15)
Molecular gels, the macroscopic products of a nanoscale bottom-up strategy, have emerged as a promising functional soft material. The prospects of tailoring the architecture of gelator molecules have led to the formation of unique, highly tunable gels for a wide
Takushi Miyoshi et al.
Cell reports, 34(5), 108708-108708 (2021-02-04)
Fast-dissociating, specific antibodies are single-molecule imaging probes that transiently interact with their targets and are used in biological applications including image reconstruction by integrating exchangeable single-molecule localization (IRIS), a multiplexable super-resolution microscopy technique. Here, we introduce a semi-automated screen based
Claudia Cervellati et al.
Journal of biotechnology, 159(4), 312-319 (2011-09-24)
In apricot the bitter flavor of seeds is determined by the amount of amygdalin, a cyanogenic glucoside whose cleavage by endogenous enzymes, upon seed crushing, releases toxic hydrogen cyanide. The presence of such a poisonous compound is an obstacle to
Stefania Milazzo et al.
The Cochrane database of systematic reviews, (11)(11), CD005476-CD005476 (2011-11-11)
Laetrile is the name for a semi-synthetic compound which is chemically related to amygdalin, a cyanogenic glycoside from the kernels of apricots and various other species of the genus Prunus. Laetrile and amygdalin are promoted under various names for the
De-Bin Yang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 687-690 (2013-06-04)
To establish an HPLC method for the determination of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule. Pheny ether chromatographic column (4.6 mm x 250 mm, 5 microm) was adopted, with acetonitrile-0.1% phosphoric acid (containing 0.1% three ethylamine)
Bahman Moradipoodeh et al.
Molecular biology reports, 47(9), 7139-7151 (2020-09-16)
Amygdalin induces apoptotic death in several carcinoma cells. Affibody is an engineered protein with a high affinity for human epidermal receptor 2 (HER2). We assessed the cytotoxic effects of the amygdalin-ZHER2 affibody conjugate on two breast carcinoma cell lines. The
Véronique J Barthet et al.
Journal of AOAC International, 93(2), 478-484 (2010-05-20)
A reference method (higher accuracy) and a routine method (higher throughput) were developed for the extraction of cyanogenic glycosides from flaxseed. Conditions of (essentially) complete extraction were identified by comparing grinding methods and extraction solvent composition, and optimizing solvent-to-meal ratio
Lishuang Yu et al.
Electrophoresis, 32(2), 218-222 (2011-01-22)
A new method for separation and determination of amygdalin and its epimer (neoamygdalin) in the epimerization of amygdalin by MEEKC is proposed. For the chiral separation of amygdalin and neoamygdalin, a running buffer composed of 80 mM sodium cholate, 5.0% v/v
Geraldine A Wright et al.
Current biology : CB, 20(24), 2234-2240 (2010-12-07)
Avoiding toxins in food is as important as obtaining nutrition. Conditioned food aversions have been studied in animals as diverse as nematodes and humans [1, 2], but the neural signaling mechanisms underlying this form of learning have been difficult to
Mengkai Zheng et al.
Journal of ethnopharmacology, 164, 22-29 (2015-02-11)
Mahuang decoction, Ephedra combined with Cassia twig, Bitter apricot kernel and Prepared licorice, has been widely used as a multi-herb prescription in traditional Chinese medicine (TCM). Many modern pharmacological studies have shown that the compatibility application of these four herbs
Stephen Abban et al.
International journal of food microbiology, 161(1), 31-35 (2012-12-25)
Cyanogenic food crops abound in nature with important crops like cassava forming the staple food for over half a billion people. Detoxification by hydrolysis of cassava cyanogenic glycosides often involves acid fermentation, and in some of these processes Bacillus species
Kejin Zhu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(8), 1015-1018 (2011-08-04)
To investigate pharmacokinetic parameters of peoniflorin, albiflorin and amygdaloside after administration of Guizhi Fuling capsule in beagle dogs. Plasma was collected from forelimb vein of Beagle dogs after oral administration of Guizhi Fuling capsule. HPLC-MS/MS method was used to determine
Xue-mei Li et al.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 30(1), 58-63 (2010-04-01)
To explore the method and significance for studying active anti-liver fibrosis ingredients consisted Chinese medicine compound prescription based on Chinese medicine theory. Optimized prescription was screened out, adopting uniform block design with 4-factor 8-level table and regression analysis, through applying
Y Turan
Biochemistry. Biokhimiia, 73(8), 912-919 (2008-09-09)
Since At2g25630 is an intronless gene with a premature stop codon, its cDNA encoding the predicted mature beta-glucosidase isoenzyme was synthesized from the previously isolated Arabidopsis thaliana genomic DNA. The stop codon was converted to a sense codon by site-directed
Deng Jiagang et al.
Biochemical and biophysical research communications, 411(3), 523-529 (2011-07-16)
Regulatory T cells (Tregs) play a critical role in the regulation of T cell-mediated immune responses in atherosclerosis, a chronic autoimmune-like disease. Therefore, in this study, we aimed to investigate the therapeutic effect of amygdalin on atherosclerosis of apolipoprotein E
[Advances in the study of amygdalin].
Jing Mu
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 25(5), 366-369 (2004-02-06)
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