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Yu-Qing He et al.
PloS one, 8(2), e57505-e57505 (2013-02-26)
P2X purinoceptor 7 (P2X7R), an ATP-gated ion channel, plays an important role during the innate immune response in mammals. However, relatively little is known about the role of P2X7R in the fish immune system. Here, we cloned a cDNA sequence
Hung-Chun Tung et al.
PloS one, 10(5), e0124654-e0124654 (2015-05-02)
Splanchnic angiogenesis in liver cirrhosis often leads to complications as gastroesophageal variceal hemorrhage and the treatment efficacy is adversely affected by poor portal-systemic collateral vasoresponsiveness related to nitric oxide (NO). Purinergic receptor subtype P2X7 participates in the modulation of inflammation
Irma Lemaire et al.
Journal of immunology (Baltimore, Md. : 1950), 187(7), 3878-3887 (2011-08-26)
The P2X(7) receptor (P2X(7)R), an ATP-gated ion channel, has been implicated in the process of cell-to-cell fusion into multinucleated macrophages (MA), but its contribution to MA fusion driven by physiological/pathological stimuli is not clearly established. Based on several lines of
Iolanda D'Alimonte et al.
Purinergic signalling, 11(3), 331-346 (2015-05-16)
Glioblastoma multiforme (GBM), the most common and aggressive brain tumor in humans, comprises a population of stem-like cells (GSCs) that are currently investigated as potential target for GBM therapy. Here, we used GSCs isolated from three different GBM surgical specimens
Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells
Derangere V, et al.
Cell Death and Differentiation, 21(12), 1914-1914 (2014)
Lih-Chyang Chen et al.
EMBO molecular medicine, 4(12), 1276-1293 (2012-10-16)
Inflammasomes sense infection and cellular damage and are critical for triggering inflammation through IL-1β production. In carcinogenesis, inflammasomes may have contradictory roles through facilitating antitumour immunity and inducing oncogenic factors. Their function in cancer remains poorly characterized. Here we show
Alessandra S K Tamajusuku et al.
Journal of cellular biochemistry, 109(5), 983-991 (2010-01-14)
Gliomas have one of the worst prognosis among cancers. Their resistance to cell death induced by endogenous neurotoxic agents, such as extracellular ATP, seems to play an important role in their pathobiology since alterations in the degradation rate of extracellular
Yu-Li Cheng et al.
Immunology, 145(2), 258-267 (2015-01-13)
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infection in humans can cause acute haemorrhagic colitis and severe haemolytic uraemic syndrome. The role of enterohaemolysin (Ehx) in the pathogenesis of O157:H7-mediated disease in humans remains undefined. Recent studies have revealed the importance of
Liqiong Song et al.
Frontiers in microbiology, 11, 1788-1788 (2020-09-15)
Objective: The aim of this study was to investigate the molecular mechanism of inflammasome activation in response to Streptococcus suis serotype 2 (SS2) infection and its contribution to the development of streptococcal toxic shock-like syndrome (STSS). Methods: To verify the
L Baron et al.
Cell death & disease, 6, e1629-e1629 (2015-02-06)
The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the innate immune system, but its mechanism of activation by a wide range of molecules remains largely unknown. Widely used nano-sized inorganic metal oxides such as silica
Charline Giroud et al.
Journal of virology, 89(18), 9368-9382 (2015-07-03)
HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to promote HIV-1 fusion, other host factors can modulate this process.
Rosario Gajardo-Gómez et al.
International journal of molecular sciences, 21(7) (2020-04-09)
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are
Ji-Eun Kim et al.
Journal of neuroinflammation, 7, 65-65 (2010-10-14)
In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models. Status epilepticus (SE) was induced by pilocarpine in rats that were intracerebroventricularly infused with either saline, 2',3'-O-(4-benzoylbenzoyl)-adenosine
Activation of P2X receptors induces apoptosis in human retinal pigment epithelium.
Yang D, Elner SG, Clark AJ, et al.
Investigative Ophthalmology & Visual Science, 52, 152201530-152201530 (2011)
Juan C Sáez et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118720-118720 (2020-04-18)
Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the formation of the atherosclerotic plaque. Although the uncontrolled opening of connexin hemichannels underpins the progression of
Alessandro Fulgenzi et al.
BMC immunology, 6, 18-18 (2005-07-27)
We previously showed that local use of periodate oxidized ATP (oATP, a selective inhibitor of P2X7 receptors for ATP) in rat paw treated with Freund's adjuvant induced a significant reduction of hyperalgesia Herein we investigate the role of oATP, in
Jorge L Torres-Fuentes et al.
Journal of cellular physiology, 230(12), 3068-3075 (2015-05-20)
The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse with the oocyte plasma membrane, and it occurs only in
Benjamin H Lee et al.
PloS one, 7(4), e35812-e35812 (2012-05-05)
Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses. Indeed, overactive host innate immune responses to viral vectors have led to devastating consequences. Macrophages are
Mélody Dutot et al.
Molecular vision, 14, 889-897 (2008-05-21)
The purpose of this study was to investigate responses to toxic cellular stresses in different human ocular epithelia. Reactivity with a specific anti-P2X7 antibody was studied using confocal fluorescence microscopy on conjunctival, corneal, lens, and retinal cell lines as well
Grace Hudson et al.
The Journal of pharmacology and experimental therapeutics, 370(1), 44-53 (2019-04-21)
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcriptional events that regulate drug detoxification and efflux
Kiram Lee et al.
Molecules (Basel, Switzerland), 24(10) (2019-05-30)
Chronic obstructive pulmonary disease (COPD) is a major inflammatory lung disease characterized by irreversible and progressive airflow obstruction. Although corticosteroids are often used to reduce inflammation, steroid therapies are insufficient in patients with refractory COPD. Both serum amyloid A (SAA)
Shih Han Tsai et al.
Immunity, 42(2), 279-293 (2015-02-19)
Crosslinking of the immunoglobulin receptor FcεRI activates basophils and mast cells to induce immediate and chronic allergic inflammation. However, it remains unclear how the chronic allergic inflammation is regulated. Here, we showed that ecto-nucleotide pyrophosphatase-phosphodiesterase 3 (E-NPP3), also known as
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation
Baba M, et al.
Journal of Bone and Mineral Research, 33(10), 1785-1798 (2018)
Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.
Daniela Gentile et al.
Frontiers in pharmacology, 8, 638-638 (2017-09-29)
N Riteau et al.
Cell death & disease, 3, e403-e403 (2012-10-13)
Deposition of uric acid crystals in joints causes the acute and chronic inflammatory disease known as gout and prolonged airway exposure to silica crystals leads to the development of silicosis, an irreversible fibrotic pulmonary disease. Aluminum salt (Alum) crystals are
William Foulsham et al.
Scientific reports, 9(1), 8617-8617 (2019-06-15)
Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor
Ester Gangoso et al.
Frontiers in molecular neuroscience, 10, 418-418 (2018-01-13)
The non-receptor tyrosine kinase c-Src is an important mediator in several signaling pathways related to neuroinflammation. Our previous study showed that cortical injection of kainic acid (KA) promoted a transient increase in c-Src activity in reactive astrocytes surrounding the neuronal
John M Taylor et al.
PloS one, 5(12), e15784-e15784 (2010-12-29)
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) are major sources of acute and chronic hepatitis. HDV requires the envelope proteins of HBV for the processes of assembly and infection of new cells. Both viruses are able to infect
P Kelk et al.
Cell death & disease, 2, e126-e126 (2011-03-11)
Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the
Leonardo C Monção-Ribeiro et al.
PloS one, 9(10), e110185-e110185 (2014-10-14)
Silicosis is an occupational lung disease, characterized by irreversible and progressive fibrosis. Silica exposure leads to intense lung inflammation, reactive oxygen production, and extracellular ATP (eATP) release by macrophages. The P2X7 purinergic receptor is thought to be an important immunomodulator
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