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A6779
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关键词:'A6779'
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Yu-Li Cheng et al.
Immunology, 145(2), 258-267 (2015-01-13)
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infection in humans can cause acute haemorrhagic colitis and severe haemolytic uraemic syndrome. The role of enterohaemolysin (Ehx) in the pathogenesis of O157:H7-mediated disease in humans remains undefined. Recent studies have revealed the importance of
Alessandra S K Tamajusuku et al.
Journal of cellular biochemistry, 109(5), 983-991 (2010-01-14)
Gliomas have one of the worst prognosis among cancers. Their resistance to cell death induced by endogenous neurotoxic agents, such as extracellular ATP, seems to play an important role in their pathobiology since alterations in the degradation rate of extracellular
Rosario Gajardo-Gómez et al.
International journal of molecular sciences, 21(7) (2020-04-09)
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are
Hung-Chun Tung et al.
PloS one, 10(5), e0124654-e0124654 (2015-05-02)
Splanchnic angiogenesis in liver cirrhosis often leads to complications as gastroesophageal variceal hemorrhage and the treatment efficacy is adversely affected by poor portal-systemic collateral vasoresponsiveness related to nitric oxide (NO). Purinergic receptor subtype P2X7 participates in the modulation of inflammation
L Baron et al.
Cell death & disease, 6, e1629-e1629 (2015-02-06)
The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the innate immune system, but its mechanism of activation by a wide range of molecules remains largely unknown. Widely used nano-sized inorganic metal oxides such as silica
Liqiong Song et al.
Frontiers in microbiology, 11, 1788-1788 (2020-09-15)
Objective: The aim of this study was to investigate the molecular mechanism of inflammasome activation in response to Streptococcus suis serotype 2 (SS2) infection and its contribution to the development of streptococcal toxic shock-like syndrome (STSS). Methods: To verify the
Iolanda D'Alimonte et al.
Purinergic signalling, 11(3), 331-346 (2015-05-16)
Glioblastoma multiforme (GBM), the most common and aggressive brain tumor in humans, comprises a population of stem-like cells (GSCs) that are currently investigated as potential target for GBM therapy. Here, we used GSCs isolated from three different GBM surgical specimens
Charline Giroud et al.
Journal of virology, 89(18), 9368-9382 (2015-07-03)
HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to promote HIV-1 fusion, other host factors can modulate this process.
Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells
Derangere V, et al.
Cell Death and Differentiation, 21(12), 1914-1914 (2014)
Yu-Qing He et al.
PloS one, 8(2), e57505-e57505 (2013-02-26)
P2X purinoceptor 7 (P2X7R), an ATP-gated ion channel, plays an important role during the innate immune response in mammals. However, relatively little is known about the role of P2X7R in the fish immune system. Here, we cloned a cDNA sequence
Irma Lemaire et al.
Journal of immunology (Baltimore, Md. : 1950), 187(7), 3878-3887 (2011-08-26)
The P2X(7) receptor (P2X(7)R), an ATP-gated ion channel, has been implicated in the process of cell-to-cell fusion into multinucleated macrophages (MA), but its contribution to MA fusion driven by physiological/pathological stimuli is not clearly established. Based on several lines of
Shih Han Tsai et al.
Immunity, 42(2), 279-293 (2015-02-19)
Crosslinking of the immunoglobulin receptor FcεRI activates basophils and mast cells to induce immediate and chronic allergic inflammation. However, it remains unclear how the chronic allergic inflammation is regulated. Here, we showed that ecto-nucleotide pyrophosphatase-phosphodiesterase 3 (E-NPP3), also known as
Lih-Chyang Chen et al.
EMBO molecular medicine, 4(12), 1276-1293 (2012-10-16)
Inflammasomes sense infection and cellular damage and are critical for triggering inflammation through IL-1β production. In carcinogenesis, inflammasomes may have contradictory roles through facilitating antitumour immunity and inducing oncogenic factors. Their function in cancer remains poorly characterized. Here we show
Juan C Sáez et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118720-118720 (2020-04-18)
Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the formation of the atherosclerotic plaque. Although the uncontrolled opening of connexin hemichannels underpins the progression of
Alessandro Fulgenzi et al.
BMC immunology, 6, 18-18 (2005-07-27)
We previously showed that local use of periodate oxidized ATP (oATP, a selective inhibitor of P2X7 receptors for ATP) in rat paw treated with Freund's adjuvant induced a significant reduction of hyperalgesia Herein we investigate the role of oATP, in
Ji-Eun Kim et al.
Journal of neuroinflammation, 7, 65-65 (2010-10-14)
In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models. Status epilepticus (SE) was induced by pilocarpine in rats that were intracerebroventricularly infused with either saline, 2',3'-O-(4-benzoylbenzoyl)-adenosine
Activation of P2X receptors induces apoptosis in human retinal pigment epithelium.
Yang D, Elner SG, Clark AJ, et al.
Investigative Ophthalmology & Visual Science, 52, 152201530-152201530 (2011)
Mélody Dutot et al.
Molecular vision, 14, 889-897 (2008-05-21)
The purpose of this study was to investigate responses to toxic cellular stresses in different human ocular epithelia. Reactivity with a specific anti-P2X7 antibody was studied using confocal fluorescence microscopy on conjunctival, corneal, lens, and retinal cell lines as well
Benjamin H Lee et al.
PloS one, 7(4), e35812-e35812 (2012-05-05)
Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses. Indeed, overactive host innate immune responses to viral vectors have led to devastating consequences. Macrophages are
Kiram Lee et al.
Molecules (Basel, Switzerland), 24(10) (2019-05-30)
Chronic obstructive pulmonary disease (COPD) is a major inflammatory lung disease characterized by irreversible and progressive airflow obstruction. Although corticosteroids are often used to reduce inflammation, steroid therapies are insufficient in patients with refractory COPD. Both serum amyloid A (SAA)
Grace Hudson et al.
The Journal of pharmacology and experimental therapeutics, 370(1), 44-53 (2019-04-21)
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcriptional events that regulate drug detoxification and efflux
Jorge L Torres-Fuentes et al.
Journal of cellular physiology, 230(12), 3068-3075 (2015-05-20)
The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse with the oocyte plasma membrane, and it occurs only in
Srabani Mitra et al.
Purinergic signalling, 15(1), 119-123 (2018-12-14)
The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been described to be involved in the release pathway of bioactive
Ursula Schenk et al.
Science signaling, 1(39), ra6-ra6 (2008-10-02)
T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to
J A Sullivan et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(7), 1512-1522 (2014-05-29)
IL17-dependent autoimmunity to collagen type V (Col V) has been associated with lung transplant obliterative bronchiolitis. Unlike the T helper 1 (Th1)-dependent immune responses to Tetanus Toxoid (TT), the Th17 response to Col V in lung transplant patients and its
Sonia Carta et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2835-2840 (2015-03-03)
Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated periodic syndromes (CAPS) release greater amounts of IL-1β than monocytes from unaffected subjects. Here we show that
Pablo J Sáez et al.
Mediators of inflammation, 2013, 216402-216402 (2013-06-06)
Microglia are the immune cells in the central nervous system. After injury microglia release bioactive molecules, including cytokines and ATP, which modify the functional state of hemichannels (HCs) and gap junction channels (GJCs), affecting the intercellular communication via extracellular and
P2times 7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation
Rodrigues AM, et al.
PLoS ONE, 9(6), e97452-e97452 (2014)
Juliana Maia Teixeira et al.
European journal of pharmacology, 644(1-3), 55-60 (2010-07-14)
Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in inflammatory states, we hypothesized that the activation of the P2X7 receptor by endogenous ATP contributes to carrageenan-induced mechanical
Xuejing Cui et al.
Small (Weinheim an der Bergstrasse, Germany), 12(43), 5998-6011 (2016-09-21)
Exocytosis of single-walled carbon nanotubes (SWCNTs) determines therapeutic efficiency and toxicity of nanoproducts but its underlying mechanism remains elusive. In this study, it is found that the exocytosis mechanism of SWCNTs is mediated mainly through the activation of P2X7 receptor
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