CN
Search Within
A8199
应用筛选条件
关键词:'A8199'
显示 1-30 共 800 条结果 关于 "A8199" 范围 论文
Development of new treatments for Batten disease.
Sara E Mole
The Lancet. Neurology, 13(8), 749-751 (2014-07-07)
Qing-Shuo Zhang et al.
Pediatric blood & cancer, 61(4), 740-742 (2013-10-12)
Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants
François Singh et al.
Biochimica et biophysica acta, 1853(7), 1574-1585 (2015-03-15)
Even though oxidative stress damage from excessive production of ROS is a well known phenomenon, the impact of reductive stress remains poorly understood. This study tested the hypothesis that cellular reductive stress could lead to mitochondrial malfunction, triggering a mitochondrial
Uthra Rajamani et al.
Journal of diabetes research, 2014, 790902-790902 (2015-01-23)
Diabetic retinopathy (DR) causes visual impairment in working age adults and hyperglycemia-mediated inflammation is central in DR. Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. However, scanty data is available on their role in DR.
Xin Chen et al.
Oncotarget, 5(19), 9118-9132 (2014-09-07)
Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance to IM and second generation tyrosine kinase inhibitors (TKI). Therefore it
Peter Göttle et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 906-919 (2015-01-23)
Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axonal damage and permanent
[Clinical toxicology of mushroom poisoning. Amanita virosa].
Makoto Onodera
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 26(3), 210-214 (2013-11-15)
Gaurav Kaushik et al.
Indian journal of experimental biology, 50(12), 853-861 (2013-08-31)
The present study demonstrates that curcumin acts as pro-oxidant and sensitizes human lung adenocarcinoma epithelial cells (A549) to apoptosis via intracellular redox status mediated pathway. Results indicated that curcumin induced cell toxicity (light microscopy and MTT assay) and apoptosis (AnnexinV-FITC/PI
Sowmya Parameswaran et al.
Stem cells (Dayton, Ohio), 33(6), 1743-1758 (2015-03-11)
Glaucoma, where the retinal ganglion cells (RGCs) carrying the visual signals from the retina to the visual centers in the brain are progressively lost, is the most common cause of irreversible blindness. The management approaches, whether surgical, pharmacological, or neuroprotective
Olsi Gjyshi et al.
PLoS pathogens, 10(10), e1004460-e1004460 (2014-10-24)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS) and primary effusion B-cell lymphoma. KSHV induces reactive oxygen species (ROS) early during infection of human dermal microvascular endothelial (HMVEC-d) cells that are critical for virus entry. One
Bo Ra You et al.
Molecular medicine reports, 11(2), 1428-1434 (2014-11-06)
Auranofin (Au), an inhibitor of thioredoxin reductase, is a known anti‑cancer drug. In the present study, the anti‑growth effect of Au on HeLa cervical cancer cells was examined in association with levels of reactive oxygen species (ROS) and glutathione (GSH).
Patrice Njomnang Soh et al.
Antimicrobial agents and chemotherapy, 53(3), 1100-1106 (2008-11-19)
Malaria is one of the most significant causes of infectious disease in the world. The search for new antimalarial chemotherapies has become increasingly urgent due to the parasites' resistance to current drugs. Ellagic acid is a polyphenol found in various
Shunli Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(2), 499-508 (2015-05-15)
Treatments targeting cancer stem cells (CSCs) are most effective cancer therapy, whereas determination of CSCs is challenging. We have recently reported that Lgr5-positive cells are cancer stem cells (CSCs) in human skin squamous cell carcinoma (SCC). Ginsenoside Rh2 (GRh2) has
Yusaku Watanabe et al.
International journal of oncology, 45(5), 1857-1866 (2014-08-15)
Cancer stem cells (CSCs) have been studied for their self-renewal capacity and pluripotency, as well as their resistance to anticancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their population is quite low
Kyung Hwa Cho et al.
The Prostate, 74(5), 528-536 (2014-01-18)
Epidermal growth factor (EGF) has been known to induce epithelial-mesenchymal transition (EMT) and prostate cancer cell progression. However, a detailed underlying mechanism by which EGF induces EMT and prostate cancer cell progression remained to be answered. Hypoxia-inducible factor (HIF)-1α and
Tong Li et al.
Gastrointestinal endoscopy, 81(5), 1243-1250 (2015-03-12)
High-intensity focused US (HIFU) is becoming more widely used for noninvasive and minimally invasive ablation of benign and malignant tumors. Recent studies suggest that HIFU can also enhance targeted drug delivery and stimulate an antitumor immune response in many tumors.
Fengyun Zhang et al.
International journal of molecular medicine, 36(2), 415-423 (2015-06-03)
Nicorandil, an adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channel opener, has been shown to exert a significant protective effect against ischemic heart injury. In the present study, we investigated the anti-apoptotic effects of nicorandil on rat mesenchymal stem cells (MSCs) subjected
Pei-Hsuan Lin et al.
Journal of biomedical science, 22, 44-44 (2015-06-24)
The epidermis forms a critical barrier that is maintained by orchestrated programs of proliferation, differentiation, and cell death. Gene mutations that disturb this turnover process may cause skin diseases. Human GASDERMIN A (GSDMA) is frequently silenced in gastric cancer cell
Mingzhe Sun et al.
Developmental and comparative immunology, 52(1), 1-9 (2015-04-29)
Autophagy is a highly conserved intracellular homeostatic process involved in numerous responses in both vertebrate and invertebrate. In the present study, autophagy in hemocytes of Chinese mitten crab Eriocheir sinensis was observed by Western-blot and immunofluorescence assay, and its induction
Biomedical research. Antioxidants could spur tumors by acting on cancer gene.
Jocelyn Kaiser
Science (New York, N.Y.), 343(6170), 477-477 (2014-02-01)
E Soheili Majd et al.
Biomaterials, 24(1), 3-9 (2002-11-06)
Previous in vitro studies on the cytotoxicity of eight dental restorative materials including composites, compomers, resin-modified glass ionomer cements and glass ionomer cements have demonstrated a depletion of intracellular glutathione in gingival fibroblasts incubated with eluates of these materials and
Flavia Dei Zotti et al.
PloS one, 13(7), e0200352-e0200352 (2018-07-12)
Reduced bioavailability of nitric oxide (NO) is a major feature of endothelial dysfunction characteristic of cardiovascular and metabolic diseases but the short half-life of NO precludes its easy quantification in circulating blood for early diagnosis. In erythrocytes, NO can react
Pramod Kadaba Srinivasan et al.
The Journal of surgical research, 191(2), 469-475 (2014-06-04)
Due to the shortage of suitable organs, the demand for partial liver transplantation from living donors has increased worldwide. N-acetylcysteine (NAC) has shown protective effects as a free radical scavenger during hypothermic preservation and warm ischemia-reperfusion liver injury; however, no
Luigi Franchi et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4214-4222 (2014-09-17)
The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1β and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.
Reliability of the reported ingested dose for predicting the requirement of N-acetylcysteine in paracetamol overdose patients.
Hossein Sanaei-Zadeh
Clinical toxicology (Philadelphia, Pa.), 51(10), 1239-1239 (2013-10-22)
Murray G Blackmore et al.
Molecular and cellular neurosciences, 44(1), 43-54 (2010-02-18)
Neurons in the central nervous system lose their intrinsic capacity for axon regeneration as they mature, and it is widely hypothesized that changes in gene expression are responsible. Testing this hypothesis and identifying the relevant genes has been challenging because
Zhihong Chen et al.
Glia, 68(10), 2148-2166 (2020-07-09)
Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being genetically heterogeneous, GBMs are also immunologically heterogeneous. However, whether the differences in immune microenvironment are driven by genetic driver mutation is unexplored. By leveraging the versatile RCAS/tv-a
Resveratrol protects PC12 cells from high glucose-induced neurotoxicity via PI3K/Akt/FoxO3a pathway.
Mi-Hua Liu et al.
Cellular and molecular neurobiology, 35(4), 513-522 (2014-12-05)
Diabetes is known to be associated with neurodegenerative diseases. Resveratrol, a plant-derived polyphenolic compound found in red wine, possesses antioxidant properties. In this study, we aimed to investigate the effects of resveratrol on the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway in
Ping Liu et al.
Analytical chemistry, 86(19), 9765-9773 (2014-09-16)
Here we developed a novel strategy of isotope labeling in combination with high-performance liquid chromatography-double precursor ion scan mass spectrometry (IL-LC-DPIS-MS) analysis for nontargeted profiling of thiol-containing compounds. In this strategy, we synthesized a pair of isotope labeling reagents (ω-bromoacetonylquinolinium
Fang Chen et al.
Food & function, 6(12), 3828-3837 (2015-10-10)
Ginsenoside Rh2 (GRh2), isolated from Panax ginseng C. A. Meyer, has been proven as an anticancer compound both in vitro and in vivo. In the present study, we investigated the role of the lysosomes during the apoptosis of HepG2 cells
1/27