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Kirk E Hevener et al.
Journal of medicinal chemistry, 53(1), 166-177 (2009-11-11)
Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the target of the sulfonamide class of antibacterials. Resistance and toxicities associated with sulfonamides have led to a decrease in their clinical use. Compounds that bind to the
P R Durie et al.
The Journal of pediatrics, 121(3), 413-416 (1992-09-01)
We assessed the diagnostic capability of the bentiromide test using a high-pressure liquid-chromatography method to analyze p-aminobenzoic acid and its metabolites in plasma as an indirect measure of exocrine pancreatic function. Mean total amine concentration in pancreatic-insufficient subjects was significantly
D Laufer et al.
Gastroenterology, 101(1), 207-213 (1991-07-01)
The bentiromide test was evaluated using plasma p-aminobenzoic acid as an indirect test of pancreatic insufficiency in young children between 2 months and 4 years of age. To determine the optimal test method, the following were examined: (a) the best
Petia Kovatcheva-Datchary et al.
Cell reports, 26(13), 3772-3783 (2019-03-28)
The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To
Magdalena Wysocka et al.
Protein and peptide letters, 19(12), 1237-1244 (2012-06-08)
In this work the efficient and simple method of improvement specificity and solubility of low molecular weight proteinase substrates is described. The series of fluorescent substrates of selected proteolytic enzymes (neutrophil elastase, cathepsin G and proteinase 3 along with human
A Szewczuk et al.
Clinica chimica acta; international journal of clinical chemistry, 84(1-2), 27-31 (1978-03-01)
A simple colorimetric method for the assay of cobalt-activated acylase activity in human serum using new and less toxic N-chloroacetyl-gamma-L-glutamyl-p-aminobenzoic acid as substrate has been described. The values obtained with this method are almost the same as with the previously
Peter J McNamara et al.
Antimicrobial agents and chemotherapy, 53(5), 1898-1906 (2009-02-19)
Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-1 production. We report here on
M Torkashvand et al.
Materials science & engineering. C, Materials for biological applications, 55, 209-217 (2015-06-29)
A novel electrochemical sensor based on mesalamine molecularly imprinted polymer (MIP) film on a glassy carbon electrode was fabricated. Density functional theory (DFT) in gas and solution phases was developed to study the intermolecular interactions in the pre-polymerization mixture and
Muhammed Alzweiri et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 420-429 (2014-07-30)
An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid analogues was characterized by vacancy (negative) peak intensity
Synthesis, Structure and Characterization of Some Metal Organic Framework Based on 4-Aminobenzoic Acid Schiff Base Linker
RJ Deghadi, et al.
Journal of Basic and Environmental Sciences, 8, 29-31 (2021)
Zhiqiang Zhao et al.
Bioresource technology, 191, 140-145 (2015-05-20)
Syntrophic metabolism of alcohols and fatty acids is a critical step in anaerobic digestion, which if enhanced can better stabilize the process and enable shorter retention times. Direct interspecies electron transfer (DIET) has recently been recognized as an alternative route
Dudu Demir et al.
Artificial cells, blood substitutes, and immobilization biotechnology, 40(6), 391-395 (2012-07-12)
Prophenoloxidase (PPO) was purified from Galleria mellonella L. A 67-fold purification of the proenzyme with 352% yield was achieved by using a Sepharose 4B-L-tyrosine-p-amino benzoic acid affinity column. The purified enzyme was migrated as a single band on SDS-polyacrylamide gel
Loyola D'Silva et al.
Magnetic resonance in chemistry : MRC, 50(6), 443-448 (2012-05-04)
Longitudinal multispin order (LOMO) corresponds to a nonequilibrium population distribution in spin systems that exhibit scalar (J), dipolar, or quadrupolar coupling. We investigated the relaxation of longitudinal two-spin order (2-LOMO) in systems that had either weakly or strongly J-coupled spins.
Reza Forghani et al.
Radiology, 263(2), 451-460 (2012-03-23)
To evaluate myeloperoxidase (MPO) as a newer therapeutic target and bis-5-hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium (Gd) (MPO-Gd) as an imaging biomarker for demyelinating diseases such as multiple sclerosis (MS) by using experimental autoimmune encephalomyelitis (EAE), a murine model of MS. Animal experiments were approved
Dorothea Dierolf et al.
Toxicology, 302(1), 1-10 (2012-07-28)
Cyanamide has been used for decades for medical intentions in the treatment of alcoholism and for agricultural purposes as a plant growth regulator and bud-breaking agent. Its therapeutic effect is mediated by reversible inhibition of aldehyde dehydrogenase and it was
J C Aristizabal et al.
European journal of clinical nutrition, 69(7), 831-836 (2014-10-09)
Fat-free mass (FFM) is the major predictor of resting metabolic rate (RMR). As protein supplementation during resistance training may augment gains in FFM, we investigated the effects of resistance training combined with protein supplementation on RMR and whether RMR responses
Bhupinder Virk et al.
BMC biology, 10, 67-67 (2012-08-02)
Gut microbes influence animal health and thus, are potential targets for interventions that slow aging. Live E. coli provides the nematode worm Caenorhabditis elegans with vital micronutrients, such as folates that cannot be synthesized by animals. However, the microbe also
Jens O Krömer et al.
Journal of biotechnology, 163(2), 184-193 (2012-05-15)
Aromatics are amongst the most important bulk feedstocks for the chemical industry, however, no viable bioprocess exists today and production is still dependent on petro-chemistry. In this article the production of aromatic precursors such as p-hydroxybenzoic acid (PHBA) and p-amino
Yuanjiao Feng et al.
Talanta, 140, 128-133 (2015-06-07)
Herein, an innovative and simple method for synthesizing carbon dots (CDs) with satisfactory fluorescence has been successfully established while rose flowers served as carbon source for the first time. Meanwhile, the fluorescence (FL) mechanism of current CDs was elucidated in
Patricia Alvarez-Sieiro et al.
Food chemistry, 168, 439-444 (2014-08-31)
For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrogen, was developed for screening for microorganisms with gliadinase
Valentina Rebuttini et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(35), 12465-12474 (2015-07-17)
4-Carboxyphenyl groups are covalently grafted onto graphene oxide via diazonium chemistry for studying their role on the adsorption of iron oxide nanoparticles. The nanoparticles are deposited via a novel phase-transfer approach involving specific interactions at the interface between two immiscible
Lucia Carrano et al.
BioMed research international, 2015, 419383-419383 (2015-09-09)
With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules. They are ribosomally synthetized and posttranslationally modified peptides possessing potent antimicrobial activity against aerobic and anaerobic Gram-positive pathogens
Joachim Michael Matz et al.
Cell reports, 26(2), 356-363 (2019-01-10)
Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing cell populations, including tumors and malaria parasites. Genome data suggest that Plasmodium has retained its capacity to generate folates de novo. However, the metabolic plasticity of
Electropolymerized 4-aminobenzoic acid based voltammetric sensor for the simultaneous determination of food azo dyes
G Ziyatdinova
Polymers, 14, 5429-5429 (2022)
Felipe Conzuelo et al.
Biosensors & bioelectronics, 36(1), 81-88 (2012-04-28)
The preparation and performance of a disposable amperometric immunosensor, based on the use of a selective capture antibody and screen-printed carbon electrodes (SPCEs), for the specific detection and quantification of sulfonamide residues in milk is reported. The antibody was covalently
Rupesh K Mishra et al.
Analytica chimica acta, 889, 106-112 (2015-09-08)
Contamination of food by mycotoxin occurs in minute/trace quantities. Nearly 92.5% of the cocoa samples present Ochratoxin A (OTA) levels at trace quantity. Hence, there is a necessity for a highly sensitive and selective device that can detect and quantify
Kenshi Sankoda et al.
Archives of environmental contamination and toxicology, 68(2), 217-224 (2014-12-07)
This study aimed to investigate the behavior of organic ultraviolet (UV) filters released by recreational activities along the Japanese coastline. Seasonal variations of organic UV filters in seawater were investigated at four different recreational beaches (Mogushi, Wakamiya, Tsurugahama, and Otachimisaki
P G Lankisch et al.
Gastroenterology, 90(2), 350-354 (1986-02-01)
Serum fluorescein and p-aminobenzoic acid were measured during a urine pancreolauryl and an N-benzoyl-l-tyrosyl-p-aminobenzoic acid (NBT-PABA) test in 22 healthy controls, 17 patients with gastrointestinal nonpancreatic diseases (normal secretin-pancreozymin test), and 31 patients with abnormal exocrine pancreatic function due to
Lei Zhou et al.
Water research, 47(1), 153-162 (2012-10-23)
Dissolved organic matter (DOM) is an important photosensitizer for the phototransformation of organic contaminants in sunlit natural waters. This article focuses on the photolysis kinetics and mechanism of sunscreen agent p-aminobenzoic acid (PABA) in the presence of four kinds of
Daisuke Koma et al.
Bioscience, biotechnology, and biochemistry, 78(2), 350-357 (2014-07-19)
The production of chemical compounds from renewable resources is an important issue in building a sustainable society. In this study, Escherichia coli was metabolically engineered by introducing T7lac promoter-controlled aroF(fbr), pabA, pabB, and pabC genes into the chromosome to overproduce
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