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显示 1-18 共 18 条结果 关于 "AB1557" 范围 论文
Shui-Bing Liu et al.
Journal of neurochemistry, 153(2), 252-263 (2019-10-31)
Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral
Jeanne Ster et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(26), 8716-8727 (2014-06-27)
Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However, its neuronal function during postnatal development remains unknown. We generated a knock-out mouse to characterize calsyntenin-1
Zeyang Ji et al.
Cell reports, 26(8), 2064-2077 (2019-02-21)
Kibra is a synaptic scaffold protein regulating learning and memory. Alterations of Kibra-encoding gene WWC1 cause various neuronal disorders, including Alzheimer's disease and Tourette syndrome. However, the molecular mechanism underlying Kibra's function in neurons is poorly understood. Here we discover
Annika van Hummel et al.
PloS one, 11(10), e0163236-e0163236 (2016-10-14)
Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term
Kevin K Ogden et al.
PLoS genetics, 13(1), e1006536-e1006536 (2017-01-18)
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits
Ren-Hao Liu et al.
iScience, 26(6), 106790-106790 (2023-05-26)
Migraines are a common medical condition. From a basic science point of view, the central mechanism for migraine and headache is largely unknown. In the present study, we demonstrate that cortical excitatory transmission is significantly enhanced in the anterior cingulate
Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis.
Barrow, SL; Constable, JR; Clark, E; El-Sabeawy, F; McAllister, AK; Washbourne, P
Neural Dev. null
Shuang Qiu et al.
Molecular brain, 11(1), 54-54 (2018-09-23)
Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little
Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.
Yumeng Shen et al.
Cell death & disease, 10(12), 905-905 (2019-12-04)
Progressive degeneration of retinal ganglion cells (RGCs) will cause a blinding disease. Most of the study is focusing on the RGCs itself. In this study, we demonstrate a decline of the presynaptic rod bipolar cells (RBCs) response precedes RGCs loss
Evgeny Pryazhnikov et al.
Scientific reports, 8(1), 6464-6464 (2018-04-25)
Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid synaptogenesis, which may underlie its antidepressant effect. To test whether repeated exposure to ketamine triggers sustained synaptogenesis, we administered a
Karim S Ibrahim et al.
eNeuro, 9(3) (2022-04-22)
Type 3 vesicular glutamate transporter (VGLUT3) represents a unique modulator of glutamate release from both nonglutamatergic and glutamatergic varicosities within the brain. Despite its limited abundance, VGLUT3 is vital for the regulation of glutamate signaling and, therefore, modulates the activity
Sharon A Swanger et al.
American journal of human genetics, 99(6), 1261-1280 (2016-11-15)
Epilepsy and intellectual disability are associated with rare variants in the GluN2A and GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain development and function. By assessing genetic
Liu-Kun Yang et al.
Molecular pain, 16, 1744806920972241-1744806920972241 (2020-11-28)
Visceral pain is a common clinical symptom, which is caused by mechanical stretch, spasm, ischemia and inflammation. Fragile X syndrome (FXS) with lack of fragile X mental retardation protein (FMRP) protein is an inherited disorder that is characterized by moderate
Danielle M Gerhard et al.
The Journal of clinical investigation, 130(3), 1336-1349 (2019-11-20)
A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and
Fatou Amar et al.
Science signaling, 10(478) (2017-05-11)
Oligomeric forms of amyloid-forming proteins are believed to be the principal initiating bioactive species in many neurodegenerative disorders, including Alzheimer's disease (AD). Amyloid-β (Aβ) oligomers are implicated in AD-associated phosphorylation and aggregation of the microtubule-associated protein tau. To investigate the
Christopher W Yee et al.
Neuroscience, 393, 61-72 (2018-10-13)
Cellular communication through chemical synapses is determined by the nature of the neurotransmitter and the composition of postsynaptic receptors. In the excitatory synapse between bipolar and ganglion cells of the retina, postsynaptic AMPA receptors mediate resting activity. During evoked response
Jan Klooster et al.
PloS one, 11(3), e0152967-e0152967 (2016-04-01)
Here we studied the ultrastructural organization of the outer retina of the European silver eel, a highly valued commercial fish species. The retina of the European eel has an organization very similar to most vertebrates. It contains both rod and
Subhrajit Bhattacharya et al.
Journal of neuroscience research, 96(7), 1324-1335 (2018-03-27)
N-methyl-D-aspartate receptors (NMDARs) are ion channels comprising tetrameric assemblies of GluN1 and GluN2 receptor subunits that mediate excitatory neurotransmission in the central nervous system. Of the four different GluN2 subunits, the GluN2D subunit-containing NMDARs have been suggested as a target
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